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Study of MT1-MMP in cancer

Research Project

Project/Area Number 22220014
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Tumor biology
Research InstitutionThe University of Tokyo

Principal Investigator

SEIKI Motoharu  東京大学, 医科学研究所, 名誉教授 (10154634)

Co-Investigator(Kenkyū-buntansha) FUKADA Satoshi  高知大学, 教育研究部医療学系, 助教 (80527599)
Co-Investigator(Renkei-kenkyūsha) KOSHIKAWA Naohiko  東京大学, 医科学研究所, 准教授 (70334282)
SAKAMOTO Takeharu  東京大学, 医科学研究所, 助教 (70511418)
HOSHINO Daisuke  東京大学, 医科学研究所, 助教 (30571434)
SYUUO Takuya  東京大学, 医科学研究所, 特任研究員 (90399006)
NAGANO Makoto  摂南大学, 薬学部, 助教 (50572715)
Project Period (FY) 2010-05-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥214,240,000 (Direct Cost: ¥164,800,000、Indirect Cost: ¥49,440,000)
Fiscal Year 2013: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2012: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2011: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2010: ¥66,820,000 (Direct Cost: ¥51,400,000、Indirect Cost: ¥15,420,000)
Keywordsがん / 浸潤・転移 / 腫瘍形成 / プロテアーゼ / MT1-MMP / コラーゲン / HB-EGF / HIF-1 / がん細胞 / 浸潤 / 増殖 / FIH-1 / Mint3 / リン酸化 / 細胞運動 / ZF21 / p27RF-Rho / HIH-1
Research Abstract

Cancer cells are usually destructive against surrounding tissue and this activity is necessary for the cells to continue grow abnormally, invade and form metastatic tumor nodules. Cancer cells also alter the tumor microenvironment by producing different tissue constituents from the normal ones and by changing the integrity of extracellular proteins via protein processing. Degradation and processing of proteins in the tissue space are mediated by extracellular proteases. Membrane type 1 matrix metalloproteinase (MT1-MMP) is one of such extracellular proteases expressed in cancer cells. In this study, we analyzed multidimensional functions of MT1-MMP and their coordinated action with intracellular systems regulating cell growth and invasion. The results suggest that MT1-MMP is important acting as a nordal point regulator during acquisition of malignant phenotype of cancer cells.

Assessment Rating
Verification Result (Rating)

A

Report

(6 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (116 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (58 results) (of which Peer Reviewed: 31 results) Presentation (43 results) (of which Invited: 6 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 5 results)

  • [Journal Article] Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP2014

    • Author(s)
      Sakamoto, T., Weng, J. S., Hara, T., Yoshino, S., Kozuka-Hata, H., Oyama, M., and Seiki, M
    • Journal Title

      Mol Cell Biol

      Volume: 34(1) Pages: 30-42

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.2014

    • Author(s)
      Sakamoto T, Weng JS, Hara T, Yoshino S, Kozuka-Hata H, Oyama M, Seiki M.
    • Journal Title

      Mol Cell Biol.

      Volume: 34(1) Issue: 1 Pages: 30-42

    • DOI

      10.1128/mcb.01169-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.2014

    • Author(s)
      Weaver SA, Wolters B, Ito N, Woskowicz AM, Kaneko K, Shitomi Y, Seiki M, Itoh Y.
    • Journal Title

      J Cell Sci.

      Volume: 127(Pt6) Pages: 1203-13

    • DOI

      10.1242/jcs.135236

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis2013

    • Author(s)
      Hoshiko, S., Kawaguchi, M., Fukushima, T., Haruyama, Y., Yorita, K., Tanaka, H., Seiki, M., Inatsu, H., Kitamura, K., and Kataoka, H
    • Journal Title

      Cancer Res

      Volume: 73(8) Pages: 2659-70

    • Related Report
      2013 Final Research Report
  • [Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia2013

    • Author(s)
      Hoshino, D., Nagano, M., Saitoh, A., Koshikawa, N., Suzuki, T., and Seiki, M
    • Journal Title

      PLos One

      Volume: 8(1)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β12013

    • Author(s)
      Mori, H., Lo, A. T., Inman, J. L., Alcaraz, J., Ghajar, C. M., Mott, J. D., Nelson, C. M., Chen, C. S., Zhang, H., Bascom, J. L., Seiki, M., and Bissell, M. J
    • Journal Title

      Development

      Volume: 140(2) Pages: 343-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] MT1-MMP-dependent control of skeletal stem cell commitment via a beta 1-integrin/YAP/TAZ signaling axis2013

    • Author(s)
      Tang, Y., Rowe, R. G., Botvinick, E. L., Kurup, A., Putnam, A. J., Seiki, M., Weaver, V. M., Keller, E. T., Goldstein, S., Dai, J., Begun, D., Saunders, T., and Weiss, S. J
    • Journal Title

      Dev Cell

      Volume: 25(4) Pages: 402-16

    • Related Report
      2013 Final Research Report
  • [Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia2013

    • Author(s)
      Watanabe, A., Hoshino, D., Koshikawa, N., Seiki, M., Suzuki, T., and Ichikawa, K
    • Journal Title

      PLos Comput Biol

      Volume: 9(5)

    • Related Report
      2013 Final Research Report
  • [Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells.2013

    • Author(s)
      Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R.
    • Journal Title

      Mol Cancer Res.

      Volume: 11(6) Issue: 6 Pages: 628-37

    • DOI

      10.1158/1541-7786.mcr-12-0544

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.2013

    • Author(s)
      Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
    • Journal Title

      Cancer Res.

      Volume: 73(8) Issue: 8 Pages: 2659-70

    • DOI

      10.1158/0008-5472.can-12-3337

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.2013

    • Author(s)
      Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ.
    • Journal Title

      Dev Cell.

      Volume: 25(4) Issue: 4 Pages: 402-16

    • DOI

      10.1016/j.devcel.2013.04.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia.2013

    • Author(s)
      Watanabe A, Hoshino D, Koshikawa N, Seiki M, Suzuki T, Ichikawa K.
    • Journal Title

      PLoS Comput Biol.

      Volume: 9(5) Issue: 5 Pages: e1003086-e1003086

    • DOI

      10.1371/journal.pcbi.1003086

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCalpha invasive signaling axis2012

    • Author(s)
      Hoshino, D., Jourquin, J., Emmons, S. W., Miller, T., Goldgof, M., Costello, K.Tyson, D. R., Brown, B., Lu, Y., Prasad, N. K., Zhang, B., Mills, G. B., Yarbrough, W. G., Quaranta, V., Seiki, M., and Weaver, A. M
    • Journal Title

      Sci Signal

      Volume: 5(241)

    • Related Report
      2013 Final Research Report
  • [Journal Article] The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects2012

    • Author(s)
      Host, L., Paye, A., Detry, B., Blacher, S., Munaut, C., Foidart, J. M., Seiki, M., Sounni, N. E., and Noel, A
    • Journal Title

      Int. J Cancer

      Volume: 131(7) Pages: 1537-48

    • Related Report
      2013 Final Research Report
  • [Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells2012

    • Author(s)
      Nishida, C., Kusubata, K., Tashiro, Y., Gritli, I., Sato, A., Ohki-Koizumi, M., Morita, Y., Nagano, M., Sakamoto, T., Koshikawa, N., Kuchimaru, T., Kizaka-Kondoh, S., Seiki, M., Nakauchi, H., Heissig, B., and Hattori, K
    • Journal Title

      Blood

      Volume: 119(23) Pages: 5405-16

    • Related Report
      2013 Final Research Report
  • [Journal Article] Control and inhibition analysis of complex formation processes2012

    • Author(s)
      Saitou, T., Itano, K., Hoshino, D., Koshikawa, N., Seiki, M., Ichikawa, K., and Suzuki, T
    • Journal Title

      Theor Biol Med Model

      Volume: 9 Pages: 33-33

    • Related Report
      2013 Final Research Report
  • [Journal Article] Detection of the heterogeneous O-glycosylation profile of MT1-MMP expressed in cancer cells by a simple MALDI-MS method2012

    • Author(s)
      Shuo, T., Koshikawa, N., Hoshino, D., Minegishi, T., Ao-Kondo, H., Oyama, M., Sekiya, S., Iwamoto, S., Tanaka, K., and Seiki, M
    • Journal Title

      PLos One

      Volume: 7(8)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of proteins that associate with integrin alpha2 by proteomic analysis in human fibrosarcoma HT-1080 cells2012

    • Author(s)
      Uematsu, T., C. Konishi, D. Hoshino, X. Han, Taizotomari, N. Egawa, Y. Takada, T. Isobe, M. Seiki, and N. Koshikawa
    • Journal Title

      J Cell Physiol

      Volume: 8 Pages: 3072-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012

    • Author(s)
      Hoshino, D., N. Koshikawa, T . Suzuki, V . Quaranta, A. Weaver, M. Seiki and K. Ichikawa
    • Journal Title

      PLos Computational Biology

      Volume: 8(4)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Turnover of focal adhesions and cancer cell migration2012

    • Author(s)
      Nagano, M., D. Hoshino, N. Koshikawa, T. Akizawa, and M. Seiki
    • Journal Title

      Int J Cell Biol

      Volume: 2012 Pages: 310616-310616

    • Related Report
      2013 Final Research Report
  • [Journal Article] The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects.2012

    • Author(s)
      Host L, Paye A, Detry B, Blacher S, Munaut C, Foidart JM, Seiki M, Sounni NE, Noel A.
    • Journal Title

      Int J Cancer

      Volume: 131(7) Issue: 7 Pages: 1537-48

    • DOI

      10.1002/ijc.27436

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012

    • Author(s)
      Hoshino, D., Koshikawa, N., Suzuki, T., Quaranta, V., Weaver, A.M., (Seiki, M.), Ichikawa, K.
    • Journal Title

      PLoS Comp.Biol.

      Volume: 8 Issue: 4 Pages: e1002479-e1002479

    • DOI

      10.1371/journal.pcbi.1002479

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library.2012

    • Author(s)
      Yoshino S, Hara T, Weng JS, Takahashi Y, Seiki M, Sakamoto T.
    • Journal Title

      PLoS One.

      Volume: 7(4) Issue: 4 Pages: e35590-e35590

    • DOI

      10.1371/journal.pone.0035590

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues.2012

    • Author(s)
      Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell MJ.
    • Journal Title

      Am J Pathol.

      Volume: 180(6) Issue: 6 Pages: 2249-56

    • DOI

      10.1016/j.ajpath.2012.02.032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control and inhibition analysis of complex formation processes.2012

    • Author(s)
      Saitou T, Itano K, Hoshino D, Koshikawa N, Seiki M, Ichikawa K, Suzuki T.
    • Journal Title

      Theor Biol Med Model.

      Volume: 3 Issue: 1 Pages: 33-33

    • DOI

      10.1186/1742-4682-9-33

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis.2012

    • Author(s)
      Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM.
    • Journal Title

      Sci Signal.

      Volume: 5(241) Issue: 241

    • DOI

      10.1126/scisignal.2002964

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.2012

    • Author(s)
      Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ.
    • Journal Title

      Development

      Volume: 140(2) Issue: 2 Pages: 343-52

    • DOI

      10.1242/dev.084236

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.2012

    • Author(s)
      Hoshino D, Nagano M, Saitoh A, Koshikawa N, Suzuki T, Seiki M.
    • Journal Title

      PLoS One.

      Volume: 8(1) Issue: 1 Pages: 1-8

    • DOI

      10.1371/journal.pone.0050825

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Turnover of focal adhesions and cancer cell migration.2012

    • Author(s)
      Nagano M, Hoshino D, Koshikawa N, Akizawa T, Seiki M.
    • Journal Title

      Int J Cell Biol.

      Volume: 2012 Pages: 310616-310616

    • DOI

      10.1155/2012/310616

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mathematical modeling of invadopodia formation2012

    • Author(s)
      T.Saitou, M.Rouzimaimaiti, N.Koshikawa, M.Seiki, K.Ichikawa, T.Suzuki
    • Journal Title

      J.Theoretical Biology

      Volume: 298 Pages: 138-146

    • DOI

      10.1016/j.jtbi.2011.12.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock2011

    • Author(s)
      Hara, T., K. Mimura, T. Abe, G. Shioi, M. Seiki, and T. Sakamoto
    • Journal Title

      J Biol Chem

      Volume: 286(37) Pages: 32542-51

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion2011

    • Author(s)
      Hara, T., K. Mimura, M. Seiki, and T. Sakamoto
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413(2) Pages: 277-81

    • Related Report
      2013 Final Research Report
  • [Journal Article] p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011

    • Author(s)
      Hoshino, D., N. Koshikawa, and M. Seiki
    • Journal Title

      J Biol Chem

      Volume: 286(4) Pages: 3139-48

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer2011

    • Author(s)
      Itoh, Y., R. Palmisano, N. Anilkumar, H. Nagase, A. Miyawaki, and M. Seiki
    • Journal Title

      Biochem J

      Volume: 440(3) Pages: 319-26

    • Related Report
      2013 Final Research Report
  • [Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011

    • Author(s)
      Koshikawa, N., H. Mizushima, T. Minegishi, F. Eguchi, F. Yotsumoto, K. Nabeshima, S. Miyamoto, E. Mekada, and M. Seiki
    • Journal Title

      Cancer Sci

      Volume: 102(1) Pages: 111-6

    • NAID

      10029288679

    • Related Report
      2013 Final Research Report
  • [Journal Article] ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center2011

    • Author(s)
      Nagano, M., D. Hoshino, T. Sakamoto, T. Akizawa, N. Koshikawa, and M. Seiki
    • Journal Title

      Cell Adh Migr

      Volume: 5(1) Pages: 23-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase2011

    • Author(s)
      Sakamoto, T., D. Niiya, and M. Seiki
    • Journal Title

      J Biol Chem

      Volume: 286(16) Pages: 14691-704

    • Related Report
      2013 Final Research Report
  • [Journal Article] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix2011

    • Author(s)
      Sakamoto T, Niiya D, Seiki M
    • Journal Title

      metalloproteinase.

      Volume: J Biol Chem 22;286(16) Issue: 16 Pages: 14691-704

    • DOI

      10.1074/jbc.m110.188714

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2011

    • Author(s)
      Nagano M, Hoshino D, Koshiba S, Shuo T Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M
    • Journal Title

      J Biol Chem.

      Volume: 286(36) Issue: 36 Pages: 31598-609

    • DOI

      10.1074/jbc.m110.199430

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock2011

    • Author(s)
      Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T.
    • Journal Title

      J Biol Chem.

      Volume: 16;286(37) Issue: 37 Pages: 32542-51

    • DOI

      10.1074/jbc.m111.271726

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells.2011

    • Author(s)
      Shirakabe K, Hattori S, Seiki M. Koyasu S, Okada Y.
    • Journal Title

      J Biol Chem.

      Volume: 16;286(50) Issue: 50 Pages: 43154-63

    • DOI

      10.1074/jbc.m111.275586

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion.2011

    • Author(s)
      Hara T, Mimura K, Seiki M, Sakamoto T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 23;413(2) Issue: 2 Pages: 277-81

    • DOI

      10.1016/j.bbrc.2011.08.085

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.2011

    • Author(s)
      Itoh Y, Palmisano R, Anilkumar N, Nagase H, Miyawaki A, Seiki M.
    • Journal Title

      Biochem J.

      Volume: 15;440(3) Issue: 3 Pages: 319-26

    • DOI

      10.1042/bj20110424

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of laminin 5-Y2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.2011

    • Author(s)
      Hamasaki H, Koga K, Aoki M, Hamasaki M, Koshikawa N, Seiki M, Iwasaki H, Nakayama J, Nabeshima K
    • Journal Title

      Br J Cancer.

      Volume: 6;105(6) Issue: 6 Pages: 824-32

    • DOI

      10.1038/bjc.2011.283

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion.2011

    • Author(s)
      Koga K, Aoki M, Sameshima T, Hamasaki M, Egawa N, Seiki M, Toole BP, Suzumiya J, Nabeshima K.
    • Journal Title

      Int J Oncol.

      Volume: 39(3) Pages: 657-64

    • DOI

      10.3892/ijo.2011.1060

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011

    • Author(s)
      越川直彦、清木元治, 9/9番目
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 111-6

    • NAID

      10029288679

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011

    • Author(s)
      星野大介、清木元治, 3/3番目
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 3139-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water bomeostasis in mice2011

    • Author(s)
      Srichai MB、清木元治, 7/10番目
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor2010

    • Author(s)
      Koshikawa, N., H. Mizushima, T. Minegishi, R. Iwamoto, E. Mekada, and M. Seiki
    • Journal Title

      Cancer Res

      Volume: 70(14) Pages: 6093-103

    • Related Report
      2013 Final Research Report
  • [Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2010

    • Author(s)
      Nagano, M., D. Hoshino, S. Koshiba, T. Shuo, N. Koshikawa, T. Tomizawa, F. Hayashi, N. Tochio, T. Harada, T. Akizawa, S. Watanabe, N. Handa, M. Shirouzu, T. Kigawa, S. Yokoyama, and M. Seiki
    • Journal Title

      J Biol Chem

      Volume: 286(36) Pages: 31598-609

    • Related Report
      2013 Final Research Report
  • [Journal Article] ZF21 protein regulates cell adhesion and motility2010

    • Author(s)
      Nagano, M., D. Hoshino, T. Sakamoto, N. Kawasaki, N. Koshikawa, and M. Seiki
    • Journal Title

      J Biol Chem

      Volume: 285(27) Pages: 21013-22

    • Related Report
      2013 Final Research Report
  • [Journal Article] A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mecha nism2010

    • Author(s)
      Sakamoto, T. and M. Seiki
    • Journal Title

      J Biol Chem

      Volume: 285(39) Pages: 29951-64

    • Related Report
      2013 Final Research Report
  • [Journal Article] ZF21 protein regulates cell adhesion and motility2010

    • Author(s)
      長野真、清木元治, 6/6番目
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 21013-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor2010

    • Author(s)
      越川直彦、清木元治, 6/6番目
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 6093-103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism2010

    • Author(s)
      坂本毅治、清木元治, 2/2番目
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 29951-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center2010

    • Author(s)
      長野真、清木元治, 6/6番目
    • Journal Title

      Cell Adh Migr.

      Volume: 5 Pages: 23-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice2010

    • Author(s)
      Onozuka I、清木元治, 12/14番目
    • Journal Title

      BBRC

      Volume: 406 Pages: 134-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library

    • Author(s)
      Yoshino, S., T . Hara, J. S. Weng, Y . Takahashi, M. Seiki, and T . Sakamoto
    • Journal Title

      PLos One

      Volume: 7(4)

    • Related Report
      2013 Final Research Report
  • [Presentation] Membrane type- 1 matrix metalloproteinase promotes invasive growth signals of cancer cells by cell surface proteolysis2013

    • Author(s)
      Koshikawa, N., Seiki, M
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Mint3 promotes tumor malignancy in cancer and stromal cells2013

    • Author(s)
      Sakamoto,T. Hara,T., and Seiki,M
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      USA, Maui
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 新規HIF活性化分子Mint3のマクロファージでのがん悪性化における役割2013

    • Author(s)
      坂本 毅治、原 敏朗、清木 元治
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規HIF活性化分子Mint3のマクロファージでのがん悪性化における役割2013

    • Author(s)
      坂本 毅治、原 敏朗、清木 元治
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] マクロファージにおけるMint3 はがん転移を促進する2013

    • Author(s)
      坂本 毅治、原 敏朗、清木 元治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規HIF 活性化分子Mint3は単球・マクロファージにおいてがん転移を促進する2013

    • Author(s)
      坂本 毅治、原 敏朗、清木 元治
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Membrane type-1 matrix metalloproteinase promotes invasive growth signals of cancer cells by cell surface proteolysis2013

    • Author(s)
      Koshikawa, N., Seiki, M.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mint3 is a new molecular target for metastasis suppression2012

    • Author(s)
      Sakamoto T, Seiki M.
    • Organizer
      The 16th JFCR-ISCC
    • Place of Presentation
      東京
    • Year and Date
      2012-01-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mint3 promotes tumor malignancy in cancer and stromal cells2012

    • Author(s)
      Sakamoto,T., Hara,T., and Seiki, M
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 卵巣がんにおけるMT1-MMPによるHB-EGFの活性化についての研究2012

    • Author(s)
      越川直彦、清木元治
    • Organizer
      第21回 日本がん転移学会学術集会・総会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト癌細胞においてインテグリンα2β1と複合体を形成する蛋白質のプロテオミクスによる同定と解析2012

    • Author(s)
      小西知江子、星野大輔、越川直彦、清木元治
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規HIF活性化因子・Mint3の生体における機能の解析2012

    • Author(s)
      坂本 毅治、原 敏朗、清木 元治
    • Organizer
      第85回日本生化学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Ubiquitin ligase RNF126 serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011

    • Author(s)
      Seiko Yoshino, Sakamoto T Seiki M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloprotease2011

    • Author(s)
      Sakamoto T, Seiki M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mint3 in tumor stromal cells promotes tumor metastasis2011

    • Author(s)
      Mimura K, Hara T, Sakamoto T, Seiki M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of the regulatory mechanism of HIF-1 activation by Mint3 during normoxia2011

    • Author(s)
      Jane S. Weng, Sakamoto T, Seiki M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Deletion of the Mint3/Apba3 Gene in Mice Abrogates Macrophage Functions and Increases Resistance to Lipopolysaccharide-induced Septic Shock.2011

    • Author(s)
      Hara T Mimura K, Hara T, Sakamoto T, Seiki M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mint3/APBA3 regulating HIF-1 activation in macrophages play a critical role in LPS-induced septic shock in a mouse model2011

    • Author(s)
      Hara T, Hara T, Sakamoto T, Seiki M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] ZF21, a novel focal adhesion-related protein, promotes cancer cell invasion2011

    • Author(s)
      Nagano M, Hoshino D, Sakamoto T, Okihara R, Konishi M, Ko-shikawa N, Akizawa T, Seiki M
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ubiquitin ligase RNF126 serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011

    • Author(s)
      Yoshino S, Sakamoto T Seiki M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloprotease2011

    • Author(s)
      Sakamoto T, Seiki M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of the regulatory mechanism of HIF-1 activation by Mint3 during normoxia2011

    • Author(s)
      Jane S. Weng, Sakamoto T, Seiki M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性乳がんにおける、造腫瘍機能促進に関与する新規NF-κB標的遺伝子の解析2011

    • Author(s)
      呉羽拓、山口憲孝、越川直彦、渡辺慎哉、清木元治、仙波健太郎、井上純一郎
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mint3 in tumor stromal cells promotes tumor metastasis2011

    • Author(s)
      Mimura K, Hara T, Sakamoto T, Seiki M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteolytic activation of HB-EGF by MT1-MMP in ovarian carcinoma cells2011

    • Author(s)
      越川直彦、鍋島一樹、宮本新吾、目加田英輔、清木元治
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Deletion of the Mint3 gene in mice abrogates macrophage functions and increases resistance to cancer metastasis2011

    • Author(s)
      原敏朗、三村耕平、坂本毅治、清木元治
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      長野
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ring finger protein 126, RNF126, is a new E3 ubiquitin ligase that serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011

    • Author(s)
      芳野聖子、坂本毅治、清木元治
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      長野
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROLES OF THE CYTOPLASMIC TAIL OF MT1-MMP; INVADOPODIAFORMATION AND HIF-1 ACTIVATION2011

    • Author(s)
      清木元治
    • Organizer
      Stony Brook 大学 特別セミナー
    • Place of Presentation
      New York,米国(招待講演)
    • Year and Date
      2011-08-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん細胞膜上の微小環境-悪性化制御因子としてのMT1-MMP-2011

    • Author(s)
      越川直彦、清木元治
    • Organizer
      第20回日本がん転移学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] MT1-MMP/Mint3は通常酸素下でHIF-1を活性化しマクロファージおよび癌細胞の解糖系を亢進させる2011

    • Author(s)
      Sakamoto T, Seiki M.
    • Organizer
      日本がん分子標的治療学会第15回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] MT1-MMP is a potent regulator of malignant progression in tumor microenvironment.2011

    • Author(s)
      Koshikawa, N., Seiki. M.
    • Organizer
      Mathematical Methods in Cancer Cell Biology
    • Place of Presentation
      Hiroshima
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] MT1-MMP is a multidimensional regulator of tumor microenvironment2011

    • Author(s)
      Seiki, M
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Smithfield, U.S.A
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ROLES OF THE CYTOPLASMIC TAIL OF MT1-MMP; INVADOPODIAFORMATION AND HIF-1 ACTIVATION2011

    • Author(s)
      清木元治
    • Organizer
      国際プロテオリシス学会
    • Place of Presentation
      San Diego、米国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systemic survey of substrates and regulators of MT1-MMP2011

    • Author(s)
      清木元治
    • Organizer
      韓国分子生物学会総会
    • Place of Presentation
      ソウル、韓国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] MT1-MIMP is a multidimensional regulator of tumor microenvironment2011

    • Author(s)
      清木元治
    • Organizer
      ゴードン会議
    • Place of Presentation
      Rhode Island、米国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] MT1-MMP: a multidimensional regulator of tumor microenvironment2011

    • Author(s)
      清木元治
    • Organizer
      第3回CREST-SBM国際会議「がん細胞の数理科学」
    • Place of Presentation
      広島大学医学部広仁会館(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん微小環境での悪性化制御因子としてのMT1-MMPの役割2010

    • Author(s)
      越川直彦、清木元治
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] MT1-MMPはプロテアーゼ活性非依存的にHIF-1を活性化しマクロファージのエネルギー産生を制御する2010

    • Author(s)
      坂本毅治、清木元治
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲノムワイドsiRNAライブラリーを用いた新規低酸素適応因子の同定2010

    • Author(s)
      芳野聖子、清木元治
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] MT1-MMPによるLuのプロセシングを介した細胞接着制御についての検討2010

    • Author(s)
      越川直彦、清木元治
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mint3 enhances the activity of HIF-1 in macrophages by suppressing the activity of FIH-12010

    • Author(s)
      坂本毅治、清木元治
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mint3 enhances the activity of hypoxia inducible factor-1 in macrophages by suppressing the activity of factor inhibiting HIF-12010

    • Author(s)
      Sakamoto, T. and Seiki,M
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and Japanese Cancer Association
    • Place of Presentation
      Waikoloa, Hawai, U.S.A
    • Related Report
      2013 Final Research Report
  • [Presentation] MT1-MMP/Mint3を介した mTORによるHIF-1活性化

    • Author(s)
      坂本毅治、清木元治
    • Organizer
      第1回がんと代謝研究会
    • Place of Presentation
      鶴岡
    • Related Report
      2013 Annual Research Report
  • [Book] がん基盤生物学-革新的シーズ育成に向けて-2013

    • Author(s)
      清木元治(総編集)
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] がんの浸潤・転移 第20章 細胞外マトリックス(ECM)2011

    • Author(s)
      坂本毅治, 清木元治
    • Publisher
      南山堂
    • Related Report
      2011 Annual Research Report
  • [Book] 「がん生物学」分担項目:細胞運動と浸潤2011

    • Author(s)
      星野大輔、長野真、清木元治
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.motoharu-seiki.com/esults/

    • Related Report
      2013 Final Research Report
  • [Remarks] 腫瘍細胞社会学分野

    • URL

      http://www.motoharu-seiki.com/esults/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 腫瘍細胞社会学分野

    • URL

      http://www.motoharu-seiki.com

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] がんの検査方法及び検査用キット2014

    • Inventor(s)
      清木元治, 越川直彦
    • Industrial Property Rights Holder
      清木元治, 越川直彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-13
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] がんの検査方法及び検査用キット2014

    • Inventor(s)
      清木元治, 越川直彦
    • Industrial Property Rights Holder
      清木元治, 越川直彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-13
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がんの検査方法及び検査用キット2014

    • Inventor(s)
      清木元治、越川直彦
    • Industrial Property Rights Holder
      清木元治、越川直彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-026026
    • Filing Date
      2014-02-13
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] がんの検査方法及び検査用キット2014

    • Inventor(s)
      清木元治、越川直彦
    • Industrial Property Rights Holder
      清木元治、越川直彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-13
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 同一試料中の2種の物質を検出又は測定する方法2013

    • Inventor(s)
      清木元治, 越川直彦
    • Industrial Property Rights Holder
      清木元治, 越川直彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-05
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHODS OF PROGNOSIS AND DIAGNOSIS FOR CANCER2012

    • Inventor(s)
      清木元治, 越川直彦, 中川将利, 吉田栄作, 吉村徹
    • Industrial Property Rights Holder
      清木元治, 越川直彦, 中川将利, 吉田栄作, 吉村徹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-13
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHODS OF PROGNOSIS AND DIAGNOSIS FOR CANCER2012

    • Inventor(s)
      清木元治,越川直彦,中川将利,吉田栄作,吉村徹
    • Industrial Property Rights Holder
      清木元治,越川直彦,中川将利,吉田栄作,吉村徹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-13
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 同一試料中の2種の物質を検出又は測定する方法2012

    • Inventor(s)
      清木元治、越川直彦
    • Industrial Property Rights Holder
      清木元治、越川直彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-151610
    • Filing Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 泌尿器科がんの検査方法および検査用キット2011

    • Inventor(s)
      清木元治, 越川直彦, 執印太朗, 鎌田雅行
    • Industrial Property Rights Holder
      清木元治, 越川直彦, 執印太朗, 鎌田雅行
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-03-08
    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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