| Budget Amount *help |
¥224,510,000 (Direct Cost: ¥172,700,000、Indirect Cost: ¥51,810,000)
Fiscal Year 2014: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2013: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2012: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2011: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2010: ¥62,920,000 (Direct Cost: ¥48,400,000、Indirect Cost: ¥14,520,000)
|
|---|
| Outline of Final Research Achievements |
We have built up the informatics system to explore human chromosome dynamics by Next Generation Sequencer Based Technology. Then by using this technology we have analyzed chromosome behavior during cell cycle, aging, and in cell line established from developmental disease patient. Our main achievements can be summarized as follows. 1) Discovery of cohesin deacetylase and its function during cell cycle, 2) Identification of cohesin as an essential component that link chromosome high order structure and transcriptional elongation, 3) identification of condensin's role as a masker of R-loop during mitosis, and 4) Establishment of new chromosomal informatics system (DROMPA) to understand chromosome dynamics.
|
