| Budget Amount *help |
¥138,710,000 (Direct Cost: ¥106,700,000、Indirect Cost: ¥32,010,000)
Fiscal Year 2014: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2013: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2012: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2011: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2010: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
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| Outline of Final Research Achievements |
By epigenomics approach using various mutants of Arabidopsis thaliana, we analyzed effects of mutation in the IBM1 gene, which encodes a protein removing H3K9 methylation, a mark of silent chromatin. The results showed that this enzyme removes H3K9 methylation from transcribed sequences, contributing to differentiation of active and inactive sequences. We also identified a transposon which targets to centromere, through analysis of a transposon of Arabidopsis lyrata, which shows sequence similarity to a mobile transposon of Arabidopsis thaliana. I addition, by characterizing another mobile transposon, we identified a novel anti-silencing factor encoded by the transposon.
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