| Budget Amount *help |
¥217,620,000 (Direct Cost: ¥167,400,000、Indirect Cost: ¥50,220,000)
Fiscal Year 2014: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2013: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2012: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2011: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2010: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
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| Outline of Final Research Achievements |
We have provided a new concept on the basis of the discovery of gonadotropin-inhibitory hormone (GnIH), a hypothalamic neuropeptide inhibiting pituitary gonadotropin release. Our studies have demonstrated that GnIH acts on gonadotropes in the pituitary and gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus via GnIH receptor to reduce reproduction by the decrease of gonadotropin release. We have further demonstrated that GnIH has an evolutionarily conserved role in controlling reproduction across chordates, from amphioxus to human. Following the discovery of GnIH in humans, we have shown that GnIH is a player for induction of reproductive dysfunction. We have also demonstrated that GnIH inhibits not only reproduction but also reproductive behavior. It appears that GnIH acts on the pituitary and the brain to serve physiological and behavioral functions. Thus, our studies focused on GnIH have demonstrated novel brain molecular mechanisms regulating reproduction.
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