| Budget Amount *help |
¥197,080,000 (Direct Cost: ¥151,600,000、Indirect Cost: ¥45,480,000)
Fiscal Year 2014: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2013: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2012: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000)
Fiscal Year 2011: ¥57,720,000 (Direct Cost: ¥44,400,000、Indirect Cost: ¥13,320,000)
Fiscal Year 2010: ¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
|
|---|
| Outline of Final Research Achievements |
It was revealed that brown adipose tissue (BAT) presents in human adult and it function as the organ acting consumption of extra energy depot in adult. The loss or less of BAT correlates closely with the onset of diabetes and obesity, hence it is recently recognized the importance of classical brown adipocyte and non-classical adipocyte (Beige cell) in human health.
In this study, we elucidated about the following points. (1) The transgenic mouse expressing the specific fluoresce protein in BAT were developed. The mouse used to analysis of expression and function of classical brown adipocyte and non-classical adipocyte (Beige cell) by food factors and others in vivo. (2) The molecular analysis of differentiation and functional suppression of BAT were conducted. (3) The systematic analysis of food components to intensify BAT development and function was conducted. These results suggest the key to the success of solution of obesity disease and metabolic syndrome.
|
