| Budget Amount *help |
¥217,620,000 (Direct Cost: ¥167,400,000、Indirect Cost: ¥50,220,000)
Fiscal Year 2014: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2013: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2012: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2011: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2010: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
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| Outline of Final Research Achievements |
In this work, we revealed transcriptional regulatory network induced by infection of morbilliviruses using a novel technique and bioinformatics analysis. As to highly pathogenic morbilliviruses and Nipah virus, which belong to the order mononegavirus, we analyzed the interaction between viral and cellular proteins and their post-translational modifications after infection, and revealed consequent influence on the virus life cycle and pathogenicity. In addition, we generated Tg mice expressing virus N protein as a model of persistent infection, and clarified a series of expression mechanisms of the unique pathogenicity.
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