| Budget Amount *help |
¥217,360,000 (Direct Cost: ¥167,200,000、Indirect Cost: ¥50,160,000)
Fiscal Year 2014: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2011: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2010: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
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| Outline of Final Research Achievements |
Autophagy is a process that leads to the bulk degradation of subcellular constituents through the creation of autophagosomes/ autolysosomes. Previously, it was believed that Atg5 is essential for induction of autophagy. However, we found that cells lacking Atg5 can still induce autophagy. Therefore, we here analyzed Atg5-independent alternative autophagy. We first discovered that alternative autophagy is conserved phylogenetically from yeast to mammals. We next identified 14 novel genes that are required for alternative autophagy and unveiled the molecular mechanisms. Using 11 different types of alternative autophagy-deficient mice, we discovered the involvement of alternative autophagy in the development and cell differentiation. We also identified the defect of alternative autophagy causes various diseases, including cancer and neurodegenerative diseases. We further discovered autophagy-inducing small compounds for applying “Autophagy Diseases”
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