| Budget Amount *help |
¥217,490,000 (Direct Cost: ¥167,300,000、Indirect Cost: ¥50,190,000)
Fiscal Year 2014: ¥39,910,000 (Direct Cost: ¥30,700,000、Indirect Cost: ¥9,210,000)
Fiscal Year 2013: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Fiscal Year 2012: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2011: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2010: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
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| Outline of Final Research Achievements |
We studied molecular mechanisms of newly established homeostasis regulation system by analyzing the molecular functions of α-Kl, β-Kl and circulating FGF subfamily. The followings were clarified. 1) Crystal structure analysis of α-Kl and its MD simulation study revealed α-Kl acts as a novel lectin that recognizes 3S-GlcA/HNK-1 sugars. 2) We found novel functions of glycans in protein- protein interaction and in FGF23 signal trasduction. By analyzing the functions of β-Kl we discovered that 3) Robustness of cholesterol metabolism, 4) Decreased body weight in β-Kl KO is not depend on the increased bile acids synthesis, and 5) β-Kl is involved in the regulation of amino acid metabolism. We also found that 6) Calpain1 inhibitor administration improves the aging related phenotypes of α-Kl KO mice, and that 7) α-Kl gradually decreases during aging and reversely correlates with FGF23 levels. Taken together, animal homeostasis regulation mechanisms are intensively clarified.
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