Functional Analysis of Newly Identified "Natural Helper"Cells

• Project/Area Number: 22229004
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research (2012-2014); Keio University (2010-2011)
• Principal Investigator: KOYASU Shigeo 独立行政法人理化学研究所, 統合生命医科学研究センター, センター長 (90153684)
• Co-Investigator(Renkei-kenkyūsha): MORO Kazuyo 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90468489) ; FURUSAWA Jun-ichi 東京医科大学, 医学総合研究所 免疫制御研究部門, 博士研究員 (80570796)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥216,840,000 (Direct Cost: ¥166,800,000、Indirect Cost: ¥50,040,000); Fiscal Year 2014: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000); Fiscal Year 2013: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000); Fiscal Year 2012: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000); Fiscal Year 2011: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000); Fiscal Year 2010: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
• Keywords: 自然リンパ球 / IL-5 / IL-13 / 寄生虫 / アレルギー性炎症 / ステロイド抵抗性 / Notch / IL-7 / IFN / IL-27 / 肺 / 好酸球 / 免疫学 / 感染症 / アレルギー・ぜんそく / 細胞・組織 / 免疫 / サイトカイン / リンパ球 / 自然免疫 / アレルギー / 感染免疫

Outline of Final Research Achievements

Natural helper (NH) cells newly discovered by the principal investigator produce large amounts of type 2 cytokines such as IL-5 and IL-13. NH cells play a pivotal role in the protection against helminth infection by IL-5-dependent eosinophilia and IL-13-dependent goblet cell hyperplasia. NH cells are also involved in the pathophysiology of allergic inflammation such as asthma. Epithelia-derived cytokine thymic stromal lymphopoietin (TSLP) induces steroid resistance in lung inflammation through activation of NH cells that become resistant to steroid treatment. We found that inhibition of Stat5 downstream of TSLP receptor was able to cancel steroid resistance. We also examined in this study the differentiation pathway of NH cells and showed that common lymphoid progenitor cells differentiated to NH cells by actions of IL-7 and Notch signals.

Assessment Rating

Verification Result (Rating)

B

Research Products

• [Journal Article] Isolation and analysis of group 2 innate lymphoid cells in mice. (2015)
  • Author(s): Moro K, Ealey KN, Kabata H, Koyasu S
  • Journal Title: Nat Protoc. Volume: 10 Issue: 5 Pages: 792-806
  • DOI: 10.1038/nprot.2015.047
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. (2015)
  • Author(s): Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A
  • Journal Title: Nat Immunol. Volume: 16 Issue: 3 Pages: 276-285
  • DOI: 10.1038/ni.3085
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inflammatory ILC2 cells: disguising themselves as progenitors? (2015)
  • Author(s): Koyasu S
  • Journal Title: Nat Immunol. Volume: 16 Issue: 2 Pages: 133-134
  • DOI: 10.1038/ni.3080
• [Journal Article] Innate lymphoid cells, possible interaction with microbiota. (2015)
  • Author(s): Moro K, Koyasu S
  • Journal Title: Semin Immunopathol. Volume: 37 Issue: 1 Pages: 27-37
  • DOI: 10.1007/s00281-014-0470-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development, differentiation, and diversity of innate lymphoid cells (2014)
  • Author(s): Diefenbach A, Colonna M, Koyasu S
  • Journal Title: Immunity Volume: 41 Issue: 3 Pages: 354-365
  • DOI: 10.1016/j.immuni.2014.09.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. (2014)
  • Author(s): Yoshioka K, Ishii K, Kuramoto T, Nagai S, Funao H, Ishihama H, Shiono Y, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
  • Journal Title: PLoS One Volume: 9 Issue: 9 Pages: e106367-e106367
  • DOI: 10.1371/journal.pone.0106367
  • Peer Reviewed / Open Access
• [Journal Article] Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. (2014)
  • Author(s): Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M
  • Journal Title: Immunity Volume: 40 Issue: 5 Pages: 758-771
  • DOI: 10.1016/j.immuni.2014.04.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus. (2014)
  • Author(s): Yasui F, Kohara M, Kitabatake M, Nishiwaki T, Fujii H, Tateno C, Yoneda M, Morita K, Matsushima K, Koyasu S, Kai C
  • Journal Title: Virology Volume: 454-455 Pages: 157-168
  • DOI: 10.1016/j.virol.2014.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Th2-type innate immune responses mediated by natural helper cells. (2013)
  • Author(s): Koyasu S, Moro K.
  • Journal Title: Ann N Y Acad Sci. Volume: 1283 Issue: 1 Pages: 43-9
  • DOI: 10.1111/nyas.12106
  • Peer Reviewed
• [Journal Article] Critical role of p38 and GATA3 in natural helper cell function. (2013)
  • Author(s): Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H, Kubo M, Koyasu S.
  • Journal Title: J Immunol. Volume: 191 Issue: 4 Pages: 1818-26
  • DOI: 10.4049/jimmunol.1300379
  • Peer Reviewed
• [Journal Article] Critical role of p38 and GATA3 in natural helper cell function. (2013)
  • Author(s): Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, Betsuyaku T, Koyasu S, Asano K.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 2675-2675
  • DOI: 10.1038/ncomms3675
  • Peer Reviewed
• [Journal Article] The prostaglandin E2 receptor EP4 is involved in a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis. (2013)
  • Author(s): Nishimura T., Zhao X., Gan H., Koyasu S., Remold HG.
  • Journal Title: FASEB J Volume: 27 Issue: 9 Pages: 3827-3836
  • DOI: 10.1096/fj.13-228858
  • Peer Reviewed
• [Journal Article] proteomic approach for the elucidation of stimulus- and substrate-specificity of ectodomain shedding. (2013)
  • Author(s): Shirakabe K., Shibagaki Y., Yoshimura A., Koyasu S., Hattori S.
  • Journal Title: J Proteomics Volume: 98 Pages: 233-243
  • DOI: 10.1016/j.jprot.2014.01.012
  • Peer Reviewed / Open Access
• [Journal Article] Innate lymphoid cells--a proposal for uniform nomenclature. (2013)
  • Author(s): Spits H., Artis D., Colonna M., Diefenbach A., Di Santo J., Eberl G., Koyasu S., Locksley R., McKenzie A., Mebius R., Powrie F., Vivier E.
  • Journal Title: Nat Rev Immunol Volume: 13 Issue: 2 Pages: 145-149
  • DOI: 10.1038/nri3365
  • Peer Reviewed
• [Journal Article] mTORC1 in Intestinal CD11c+CD11b+Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production (2012)
  • Author(s): Ohtani M, Hoshii T, Fujii H, Koyasu S, Hirao A, Matsuda S.
  • Journal Title: J Immunol Volume: 188 Issue: 10 Pages: 4736-40
  • DOI: 10.4049/jimmunol.1200069
  • Peer Reviewed
• [Journal Article] Role of innate lymphocytes in infection and inflammation. (2012)
  • Author(s): Koyasu S., Moro K.
  • Journal Title: Front Immunol Volume: 3 Pages: 101-101
  • DOI: 10.3389/fimmu.2012.00101
  • Peer Reviewed
• [Journal Article] Distinct subnuclear cyclin D3 compartments associated with proliferation and Ig variable gene repression. (2012)
  • Author(s): Powers S.E., Mandal M., Matsuda S., Miletic A.V., Gato M.H., Tanaka A., Rickert R.C., Koyasu S., Clark M.R.
  • Journal Title: J Exp Med Volume: 209 Issue: 12 Pages: 2199-2213
  • DOI: 10.1084/jem.20120800
  • Peer Reviewed
• [Journal Article] PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ (2012)
  • Author(s): Kurebayashi Y. Nagai S. Ikejiri A. Ohtani M. Ichiyama K. Baba Y. Yamada T. Egami S. Hoshii T. Hirao A. Matsuda S. Koyasu S.
  • Journal Title: Cell Reports Volume: 1 Issue: 4 Pages: 360-373
  • DOI: 10.1016/j.celrep.2012.02.007
  • Peer Reviewed
• [Journal Article] Role of Innate lymphocytes in infection and inflammation (2012)
  • Author(s): Koyasu, S., Moro, K.
  • Journal Title: Frontiers in Inflammation Volume: (in press)
  • Peer Reviewed
• [Journal Article] Type 2 innate immune responses and the natural helper cell. (2011)
  • Author(s): Koyasu, S., Moro, K.
  • Journal Title: Immunology Volume: 132 Pages: 475-481
• [Journal Article] Innate Th2-type immune responses and the Natural Helper Cell, a newly identified lymphocyte population. (2011)
  • Author(s): Koyasu, S., Moro, K.
  • Journal Title: Curr.Opin.Allergy Clin.Immunol. Volume: 11 Pages: 109-114
• [Journal Article] Natural Helper Cells : a new player in the innate immune response against helminth infection. (2010)
  • Author(s): Koyasu, S., et al.
  • Journal Title: Adv.Immunol. Volume: 108 Pages: 21-44
• [Presentation] 寄生虫感染における2型自然リンパ球「ナチュラルヘルパー細胞」の役割 (2015)
  • Author(s): 小安重夫，茂呂和世
  • Organizer: 第84回日本寄生虫学会大会
  • Place of Presentation: 三鷹、杏林大学三鷹キャンパス
  • Year and Date: 2015-03-22
  • Invited
• [Presentation] Group 2 innate lymphoid cells and allergic inflammation (2015)
  • Author(s): Shigeo Koyasu
  • Organizer: The 9th World Immune Regulation Meeting
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] Role of Natural Helper cells, a member of group 2 ILCs, in obesity (2014)
  • Author(s): Takaharu Sasaki, Kazuyo Moro, Shigeo Koyasu
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-12-12
• [Presentation] Innate lymphoid cells and inflammation. (2014)
  • Author(s): Kazuyo Moro, Shigeo Koyasu
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-12-11
  • Invited
• [Presentation] Critical role of IL-7 and Notch signaling in natural helper cell development. (2014)
  • Author(s): Satoshi Koga, Kazuyo Moro, Shigeo Koyasu
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-12-10
• [Presentation] Role of natural helper cells, a member of group 2 innate lymphoid cells (ILC2), in allergic inflammation. (2014)
  • Author(s): Shigeo Koyasu
  • Organizer: The 24th Hot Spring Harbor International Symposium “Recent Advances in Immunology and Inflammation 2014”
  • Place of Presentation: 福岡、九州大学病院キャンパスコラボステーション
  • Year and Date: 2014-11-08
  • Invited
• [Presentation] Role of natural helper cells, a member of group 2 innate lymphoid cells (ILC2s), in allergic inflammation (2014)
  • Author(s): Shigeo Koyasu
  • Organizer: 2014 NHRI/IBMS Joint International Conference on Inflammation & Disease
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] 寄生虫感染防御に対する自然免疫反応とナチュラルヘルパー細胞 (2014)
  • Author(s): 小安重夫，田邉将信，茂呂和世
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] The role of basophils in the activation of lung ILC2 in allergic inflammation in the lung. (2014)
  • Author(s): Shigeo Koyasu, Yasutaka Motomura, Kazuyo Moro
  • Organizer: EMBO Conference on Innate Lymphoid Cells 2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-10-01
  • Invited
• [Presentation] Role of Natural Helper Cells, a member of group 2 innate lymphoid cells (ILC2s), in health and diseases. (2014)
  • Author(s): Shigeo Koyasu, Kazuyo Moro
  • Organizer: Cold Spring Harbor Asia Conferences “Frontiers of Immunology in Health and Diseases”
  • Place of Presentation: Suzhou, China
  • Year and Date: 2014-09-02
  • Invited
• [Presentation] Involvement of natural helper cells in the onset of diet-induced obesity. (2014)
  • Author(s): Takaharu Sasaki, Kazuyo Moro, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Shigeo Koyasu
  • Organizer: The 22nd International Symposium on Molecular Cell Biology of Macrophages “Macrophage in Maintenance of Tissue Homeostasis and Diseases”
  • Place of Presentation: 神戸、神戸商工会議所
  • Year and Date: 2014-06-02
• [Presentation] システインプロエアーゼによって誘導される肺のアレルギー炎症における好塩基球由来のIL-4の役割 (2014)
  • Author(s): 本村泰隆，森田英明，茂呂和世，中江進，遠藤高帆，黒木陽子，小原収，小安重夫，久保允人
  • Organizer: Kyoto T Cell Conference 第24回学術集会
  • Place of Presentation: 京都、京都平安ホテル
  • Year and Date: 2014-05-17
• [Presentation] ナチュラルヘルパー細胞の分化機構解明 (2014)
  • Author(s): 古賀諭，茂呂和世，小安重夫
  • Organizer: Kyoto T Cell Conference 第24回学術集会
  • Place of Presentation: 京都、京都平安ホテル
  • Year and Date: 2014-05-17
• [Presentation] アレルギー性炎症と自然リンパ球 (2014)
  • Author(s): 小安重夫
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-05-11
  • Invited
• [Presentation] 重症喘息におけるナチュラルヘルパー細胞の関与と治療法の探索 (2014)
  • Author(s): 加畑宏樹，茂呂和世，小安重夫，浅野浩一郎
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2014-05-09
• [Presentation] Th2-type innate immune responses and the natural helper cell (2011)
  • Author(s): Kazuyo Moro, Shigeo Koyasu
  • Organizer: The 15^<th> International Congress of Mucosal Immunology (July 5-9, 2011)
  • Place of Presentation: Universite Paris Descartes (Paris, France)
  • Year and Date: 2011-07-05
• [Presentation] Natural helper cells and Th2-type innate immunity (2011)
  • Author(s): Shigeo Koyasu
  • Organizer: The 11^<th> Annual Meeting of the Federation of Clinical Immunology Societies
  • Place of Presentation: Marriott Wardman Park Hotel (Washington D.C., USA)(招待講演)
  • Year and Date: 2011-06-26
• [Presentation] ナチュラルヘルパー細胞のアレルギー性喘息における役割 (2011)
  • Author(s): 茂呂和世, 小安重夫
  • Organizer: Kyoto T Cell Conference第21回学術集会(2011年6月10-11日)
  • Place of Presentation: 京都平安ホテル(京都)
  • Year and Date: 2011-06-11
• [Presentation] Th2-type innate immune responses and the natural helper cell (2011)
  • Author(s): Shigeo Koyasu
  • Organizer: The Joint International Meeting of the 76^<th> Annual Meeting of the Japanese Society for Interferon and Cytokine Research, The 19^<th> International Symposium of Macrophage Molecular and Cell Biology 2011 (May 25-27, 2011)
  • Place of Presentation: ANA Gate Tower Hotel Osaka (Osaka)(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] ナチュラルヘルパー細胞:寄生虫感染防御とアレルギー病態に関与する新たな自然免疫リンパ球 (2011)
  • Author(s): 小安重夫
  • Organizer: 日本分子生物学会第11回春季シンポジウム金沢国際がん生物学シンポジウム(2011年5月25-26日)
  • Place of Presentation: 石川県立音楽堂交流ホール(石川)(招待講演)
  • Year and Date: 2011-05-25
• [Presentation] Natural helper cell : innate lymphocyte producing Th2 cytokines. (2010)
  • Author(s): Koyasu, S.
  • Organizer: Annual Meeting of the Austrian Society for All ergology and Immunology in co-operation with the national societies of Croatia, Czech Republic, Hungary, Slovakia and Slovenia
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-12-05
• [Presentation] The role of natural helper cell in helminth infection. (2010)
  • Author(s): Moro, K., Koyasu.S.
  • Organizer: The 10^<th> Awaji International Forum on Infection and Immunity(第10回あわじしま感染症.免疫フォーラム)
  • Place of Presentation: 兵庫
  • Year and Date: 2010-09-08
• [Presentation] Innate production of TH_2 cytokines by adipose tissue-associated c-Kit^+ Sca-1^+ lymphoid cells. (2010)
  • Author(s): Moro, K., et al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-25
• [Presentation] Natural helper cell : a newly identified innate lymphocyte producing Th2 cytokines. (2010)
  • Author(s): Koyasu, S.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-24
• [Presentation] 樹状細胞の機能制御を介した免疫調節の可能性 (2010)
  • Author(s): 小安重夫
  • Organizer: 第14回日本適応医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-02
• [Presentation] ナチュラルヘルパー細胞による自然免疫機構の活性化 (2010)
  • Author(s): 茂呂和世, 小安重夫
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2010-06-05
• [Presentation] Innate inflammation by Th2 cytokines derived from "Natural Helper" cell. (2010)
  • Author(s): Koyasu, S.
  • Organizer: 18^<th> International Symposium on Molecular Cell Biology of Macrophages 2010
  • Place of Presentation: 熊本
  • Year and Date: 2010-05-20
• [Presentation] Innate production of Th2 cytokines by adipose tissue-associated c-Ki^<t+> Sca-1^+ lymphoid cells. (2010)
  • Author(s): Moro, K., Koyasu, S.
  • Organizer: Immunology 2010 : 97^<th> Annual Meeting, The American Association of Immunologists
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2010-05-09
• [Presentation] Innate production of Th2 cytokines by "natural helper cells" (2010)
  • Author(s): Koyasu, S.
  • Organizer: 28^<th> Symposium, Collegium Internationale Allergologicum, Translational Science : From Basic to Clinical Immunology and Allergy
  • Place of Presentation: Ischia, Italy
  • Year and Date: 2010-04-27
• [Presentation] Role of natural helper cell, a member for the ILC (ILC2) in steroid resistance of allergic inflammation.
  • Author(s): Shigeo Koyasu
  • Organizer: Keystone Symposia “Advances in the Knowledge and Treatment of Autoimmunity”
  • Place of Presentation: British Columbia, Canada
  • Invited
• [Presentation] Natural helper cells and type-2 innate immune responses.
  • Author(s): Shigeo Koyasu
  • Organizer: 5th Symposium & Master Classes on Mucosal Immunology: “Cytokines and border patrol”
  • Place of Presentation: Rotterdam, Kingdom of Netherlands
  • Invited
• [Presentation] Allergic inflammation and a newly identified innate lymphocyte, natural helper (NH) cell.
  • Author(s): Shigeo Koyasu
  • Organizer: The 3rd McGill-RIKEN Workshop on Advanced Biomedical Sciences
  • Place of Presentation: Montreal, Canada
• [Presentation] Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells in the inflamed airways.
  • Author(s): Shigeo Koyasu
  • Organizer: 6th International Conference on Autoimmunity: Mechanism and Novel Treatments
  • Place of Presentation: Corfu, Greece
  • Invited
• [Presentation] Role of natural helper cells, a member of group 2 innate lymphoid cells, in helminth infection
  • Author(s): Shigeo Koyasu
  • Organizer: RIKEN RCAI International Summer Program 2013
  • Place of Presentation: Yokohama
• [Presentation] アレルギー性炎症とナチュラルヘルパー細胞
  • Author(s): 小安 重夫
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 自然リンパ球．
  • Author(s): 小安 重夫
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
  • Invited
• [Presentation] Role of natural helper cells in obesity
  • Author(s): Takaharu Sasaki, Kazuyo Moro, Shigeo Koyasu
  • Organizer: Annunal Meeting of the Japanese Society for Immunology, 2013
  • Place of Presentation: Makuhari
• [Presentation] Critical role of basophil derived IL-4 in natural helper cell-mediated lung inflammation
  • Author(s): Yasutaka Motomura, Kazuyo Moro, Hideaki Morita, Susumu Nakae, Shigeo Koyasu, Masato Kubo
  • Organizer: Annunal Meeting of the Japanese Society for Immunology, 2013
  • Place of Presentation: Makuhari
• [Presentation] Natural helper cells and Th2-type innate immunity
  • Author(s): Shigeo Koyasu
  • Organizer: 99th Annual Meeting: The American Association of Immunologists
  • Place of Presentation: Boston, USA
• [Presentation] Natural helper cell, a novel innate lymphocyte producing Th2 cytokines
  • Author(s): Shigeo Koyasu
  • Organizer: Xth Latin-American Congress of Immunology-ALAI2012
  • Place of Presentation: Lima, Peru
  • Invited
• [Presentation] Critical role of GATA3 in natural helper cell differentiation and function
  • Author(s): Shigeo Koyasu, Jun-ichi Furusawa, Kazuyo Moro
  • Organizer: Cold Spring Harbor Asia Conferences “Frontiers of Immunology in Health and Diseases”
  • Place of Presentation: Suzuhou, China
  • Invited
• [Presentation] Role of natural helper cells in the lung inflammation
  • Author(s): Shigeo Koyasu
  • Organizer: 29th Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Jeju, Korea
• [Presentation] Type 2 innate immune responses and the natural helper cell
  • Author(s): Shigeo Koyasu
  • Organizer: Keystone Symposia “Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology”
  • Place of Presentation: Santa Fe, USA
  • Invited
• [Presentation] Critical role of GATA3 in natural helper cell differentiation and function
  • Author(s): Shigeo Koyasu
  • Organizer: RCAI-JSI International Symposium on Immunology 2012
  • Place of Presentation: Yokohama
• [Presentation] GATA-3はナチュラルヘルパー細胞のマスター転写因子である
  • Author(s): 古澤純一，茂呂和世，本村泰隆，久保允人，小安重夫
  • Organizer: Kyoto T Cell Conference 第22回学術集会
  • Place of Presentation: 京都
• [Presentation] ナチュラルヘルパー細胞とTh2型自然免疫反応
  • Author(s): 小安 重夫
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Structural characteristics of fat-associated lymphoid cluster in adipose tissue
  • Author(s): Kazuyo Moro, Shigeo Koyasu
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Critical role of GATA3 in the differentiation and Th2 cytokine production of natural helper cell
  • Author(s): Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Masato Kubo, Kazuo Okamoto, Hiroshi Takayanagi, Shigeo Koyasu
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Thyimic stromal lymphopoietin induces corticosteroid resistance in natural helper cells
  • Author(s): Hiroki Kabata, Kazuyo Moro, Koichi Fukunaga, Jun Miyata Katsunori Masaki, Shigeo Koyasu, Koichiro Asano
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Negative regulation of Th2-type cytokine production by IRF4 in natural helper cells
  • Author(s): Kiri Honma, Daisuke Kimura, Kazumi Kimura, Mana Miyakoda, Kazuyo Moro, Shigeo Koyasu, Toshifumi Matsuyama, Katsuyuki Yui
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Remarks] 理化学研究所 統合生命医科学研究センター 免疫細胞システム研究グループ
  • URL: http://www.riken.jp/research/labs/ims/immun_cell_sys/
• [Remarks] 理化学研究所 統合生命医科学研究センター 免疫細胞システム研究グループ
  • URL: http://www.riken.jp/research/labs/ims/immun_cell_sys/