| Budget Amount *help |
¥217,620,000 (Direct Cost: ¥167,400,000、Indirect Cost: ¥50,220,000)
Fiscal Year 2014: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2013: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2012: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2011: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2010: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
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| Outline of Final Research Achievements |
The Kruppel-like factor family consists of 17 zinc-finger-type transcription factors. This project aimed to elucidate pathological roles of KLF5 and KLF6 in cardiovascular, metabolic, and renal diseases and cancer. We found that KLF6 expressed in cardiomyocytes and KLF5 expressed in cardiac fibroblasts control cardiac responses to stress, such as cardiac hypertrophy and fibrosis. KLF6 is also important for controlling aortic inflammation. In kidneys KLF5 controls renal inflammation, which underlies chronic kidney disease. KLF5 also control intestinal stem cell function and associates with colon cancer. The mechanisms and pathways identified in this project would be attractive targets for the development of new therapeutic and diagnostic strategies.
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