| Budget Amount *help |
¥207,870,000 (Direct Cost: ¥159,900,000、Indirect Cost: ¥47,970,000)
Fiscal Year 2014: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2013: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2012: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2011: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2010: ¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
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| Outline of Final Research Achievements |
Together with genetic predisposition for the development of life style-related diseases, environmental factors are greatly involved. Stimuli from the environment are responded through changes in the epigenome (i.e. DNA methylation and histone modifications) and chromatin 3D structure. We, from research in the fat cells, discovered a new “bivalent chromatin structure” that epigenome modifying enzyme forms to poise precursor fat cells undifferentiated. We also discovered that the initial response to environmental change such as cold was phosphorylation of epigenome modifying enzyme and the following protein complex formation plays a key role in response to cold for the regulate thermogenic gene transcription.
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