Functional analysis of the molecular markers of the growth cone

• Project/Area Number: 22240040
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Niigata University
• Principal Investigator: IGARASHI MICHIHIRO 新潟大学, 医歯学系, 教授 (50193173)
• Co-Investigator(Kenkyū-buntansha): TAKAO Keizou 生理学研究所, 行動・代謝分子解析センター, 特任准教授 (80420397)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000); Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2011: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2010: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
• Keywords: 成長円錐 / 神経細胞極性 / コンドロイチン硫酸 / ヘパラン硫酸 / M6a / シンタキシン / 軸索再生 / 極性形成機構 / 小胞輸送 / アクチン繊維 / ノックアウトマウス / 行動解析 / GAP-43 / 神経極性形成 / 遺伝子改変マウス

Research Abstract

We produced the CSGalNAcT1 (T1)-KO mice for anlyzing the in vivo growth cone functions. By producing the spinal cord injury (SCI) model, we observed that in T1-KO, markerd axon regrowth occurred. In these mice, nor only chondroitin sulfate (CS), an inhibitor of the growth cone, was decreased, but also heparan sulfate (HS), one of its stimulators, also was up-regulated. We concluded that CS/HS balance is very important for the effective axon regeneration. We also obtained the evidence that GPM6a is invovled in the determination of the neuronal polarity.

Research Products

• [Journal Article] Pioneering axons regulate neuronal polarization in the developing cerebral cortex (2014)
  • Author(s): Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., Oda, K., Wada, Y., Masuda, T., Sakakibara, A., Igarashi, M., Miyata, T., Faivre-Sarrailh, C., Takeuchi, K., Kaibuchi, K
  • Journal Title: Neuron Volume: 81 Pages: 814-829
  • Peer Reviewed
• [Journal Article] The Wnt/Planar Cell Polarity Pathway Component Vangl2 Induces Synapse Formation through Direct Control of N-Cadherin (2014)
  • Author(s): Nagaoka, T., Ohashi, R., Inutsuka, A., Sakai, S., Fujisawa, N., Yokoyama, M., Huang, YH., Igarashi, M., Kishi, M
  • Journal Title: Cell Rep Volume: 6 Pages: 916-927
  • Peer Reviewed
• [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia (2014)
  • Author(s): Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T
  • Journal Title: Molecular Brain Volume: 7 Pages: 21-21
  • Peer Reviewed
• [Journal Article] Contextual and cued fear conditioning test using a video analyzing system in mice (2014)
  • Author(s): Shoji H, Takao K, Hattori S, Miyakawa T
  • Journal Title: Journal of Visualized Experiments Volume: 85
  • Peer Reviewed
• [Journal Article] Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice (2014)
  • Author(s): Koshimizu H, Takao K, Matozaki T, Ohnishi H, Miyakawa T
  • Journal Title: PLoS One Volume: 9(2)
  • Peer Reviewed
• [Journal Article] Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders (2014)
  • Author(s): Kobayashi M, Nakatani T, Koda T, Matsumoto K, Ozaki R, Mochida N, Takao K, Miyakawa T, Matsuoka I
  • Journal Title: Molecular Brain Volume: 7 Pages: 12-12
  • Peer Reviewed
• [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia (2014)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura H.K, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton N.M, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T
  • Journal Title: Neuropsychopharmacology Volume: 38(8) Pages: 1409-25
  • Peer Reviewed
• [Journal Article] Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex. (2014)
  • Author(s): Namba T, Kibe Y, Funahashi Y, Nakamuta S, Takano T, Ueno T, Shimada A, Kozawa S, Okamoto M, Shimoda Y, Oda K, Wada Y, Masuda T, Sakakibara A, Igarashi M, Miyata T, F-S Catherine, Takeuchi K, Kaibuchi K.
  • Journal Title: Neuron Volume: 81(4) Issue: 4 Pages: 814-829
  • DOI: 10.1016/j.neuron.2013.12.015
  • Peer Reviewed / Open Access
• [Journal Article] The Wnt/Planar Cell Polarity Pathway Component Vangl2 Induces Synapse Formation through Direct Control of N-Cadherin. (2014)
  • Author(s): Nagaoka T, Ohashi R, Inutsuka A, Sakai S, Fujisawa N, Yokoyama M, Huang YH, Igarashi M, Kishi M
  • Journal Title: Cell Rep Volume: 6 Issue: 5 Pages: 916-27
  • DOI: 10.1016/j.celrep.2014.01.044
  • Peer Reviewed
• [Journal Article] A simple and highly efficient method to identify the integration site of a transgene in the animal genome (2013)
  • Author(s): Uemura, S., Nagaoka, T., Yokoyama, M., Igarashi, M., Kishi, M
  • Journal Title: Neurosci. Res Volume: S0168-0102(13) Pages: 267-8
  • Peer Reviewed
• [Journal Article] Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity (2013)
  • Author(s): Watanabe, Y., Katayama, N., Takeuchi, K., Togano, T., Itoh, R., Sato, M., Yamazaki, M., Abe, M., Sato, T., Oda, K., Yokoyama, M., Takao, K., Fukaya, M., Miyakawa, T., Watanabe, M., Sakimura, K., Manabe, T., Igarashi, M
  • Journal Title: J. Biol. Chem Volume: 288 Pages: 34906-34919
  • Peer Reviewed
• [Journal Article] Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury (2013)
  • Author(s): Takeuchi, K., Yoshioka, N., Higa Onaga, S., Watanabe, Y., Miyata, S., Wada, Y., Kudo, C., Okada, M., Ohko, K., Oda, K., Sato, T., Yokoyama, M., Matsushita, N., Nakamura, M., Okano, H., Sakimura, K., Kawano, H., Kitagawa, H., Igarashi, M
  • Journal Title: Nat. Commun Volume: 4 Pages: 2740-2740
  • Peer Reviewed
• [Journal Article] Calmodulin-dependent regulation of neurotransmitter release differs in subsets of neuronal cells (2013)
  • Author(s): Ando, K., Kudo, Y., Aoyagi, K., Ishikawa, R., Igarashi, M., Takahashi, M
  • Journal Title: Brain Res Volume: 1535 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition (2013)
  • Author(s): Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 7 Pages: 216-216
  • Peer Reviewed
• [Journal Article] PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders (2013)
  • Author(s): Paemka L, Mahajan V.B, Skeie J.M, Sowers L.P, Ehaideb S.N, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro B.W, Ferguson P.J, Pieper A.A, Britt J.K, Wemmie J.A, Rudd D.S, Wassink T, El-Shanti H, Mefford H.C, Carvill G.L, Manak J.R, Bassuk A.G
  • Journal Title: PLoS One Volume: 3; 8(12)
  • Peer Reviewed
• [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice (2013)
  • Author(s): Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
  • Journal Title: Molecular Brain Volume: 6 Pages: 35-35
  • Peer Reviewed
• [Journal Article] Immature dentate gyrus : an endophenotype of neuropsychiatric disorders (2013)
  • Author(s): Hagihara H, Takao K, Walton N, Matsumoto M, Miyakawa T
  • Journal Title: Neural Plasticity Pages: 318596-318596
  • Peer Reviewed
• [Journal Article] ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response (2013)
  • Author(s): Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T
  • Journal Title: BMC Research Notes Volume: 6(1) Pages: 203-203
  • Peer Reviewed
• [Journal Article] Synaptosomal-associated protein 25 mutationinduces immaturity of the dentate granule cellsof adult mice (2013)
  • Author(s): Ohira K, Kobayashi K, Toyama K, Nakamura H.K, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T
  • Journal Title: Molecular Brain Volume: 6 Pages: 12-12
  • Peer Reviewed
• [Journal Article] Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly (2013)
  • Author(s): Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T, Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsunea S
  • Journal Title: Scientific Reports Volume: 3 Pages: 1224-1224
  • Peer Reviewed
• [Journal Article] Increased astrocytic ATP release results in enhanced excitability of the hippocampus (2013)
  • Author(s): Lee H.U, Yamazaki Y, Tanaka K.F, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K
  • Journal Title: Glia Pages: 22427-22427
  • Peer Reviewed
• [Journal Article] N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury. (2013)
  • Author(s): Kosei Takeuchi, Nozomu Yoshioka, Susumu Higa Onaga, Yumi Watanabe, et. al.
  • Journal Title: Nature Communications Volume: 4 Issue: 1 Pages: 2740-2740
  • DOI: 10.1038/ncomms3740
  • Peer Reviewed
• [Journal Article] Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short-term Plasticity. (2013)
  • Author(s): Yumi Watanabe, Norikazu Kata yama, Kosei Takeuchi, et. al.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 48 Pages: 34906-34919
  • DOI: 10.1074/jbc.m113.504050
  • Peer Reviewed / Open Access
• [Journal Article] Calmodulin-dependent regulation of neurotransmitter release differs in subsets of neuronal cells. (2013)
  • Author(s): Ando K, Kudo Y, Aoyagi K, Ishikawa R, Igarashi M, Takahashi M
  • Journal Title: Brain Res Volume: 1535 Pages: 1-13
  • DOI: 10.1016/j.brainres.2013.08.018
  • Peer Reviewed
• [Journal Article] DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles (2012)
  • Author(s): Suzuki K, Zhou J, Sato T, Takao K, Miyakawa T, Oyake M, Yamada M, Takahashi H, Takahashi Y, Goto J, Tsuji S
  • Journal Title: Neurobiology of Disease Volume: 46(2) Pages: 336-350
  • Peer Reviewed
• [Journal Article] Behavioral abnormalities observed in Zfhx2-deficient mice (2012)
  • Author(s): Komine Y, Takao K, Miyakawa T, Yamamori T
  • Journal Title: PLoS ONE Volume: 7(12)
  • Peer Reviewed
• [Journal Article] Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice (2012)
  • Author(s): Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T
  • Journal Title: Molecular Brain Volume: 5 Pages: 43-43
  • NAID: 120005323021
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice (2012)
  • Author(s): Hattori S, Takao K, Tanda K, Toyama K, Shintani N, Baba A, Hashimoto H, *Miyakawa T
  • Journal Title: Frontier of Behavioral Neuroscience Volume: 6 Pages: 58-58
  • Peer Reviewed
• [Journal Article] Morphological assessment of early axonal regeneration in end-to-side nerve coaptation models (2012)
  • Author(s): Oyamatsu, H., Koga, D., Igarashi, M., Shibata, M., Ushiki, T
  • Journal Title: J. Plast. Surg. Hand. Surg Volume: 46 Pages: 299-307
  • Peer Reviewed
• [Journal Article] 成長円錐の蛋白質構成から観たその機能的分子基盤 (2012)
  • Author(s): 五十嵐 道弘
  • Journal Title: 生化学 Volume: 84 Pages: 753-766
  • Peer Reviewed
• [Journal Article] Morphological assessment of early axonal regeneration in end-to-side nerve coaptation models. (2012)
  • Author(s): Oyamatsu H, Koga D, Igarashi M, Shibata M, Ushiki T
  • Journal Title: J Plast Surg Hand Surg. Volume: 46 Pages: 299-307
  • Peer Reviewed
• [Journal Article] 成長円錐の分子構成 (2012)
  • Author(s): 五十嵐 道弘
  • Journal Title: 生化学 Volume: 84 Pages: 753-66
  • Peer Reviewed
• [Journal Article] A morphological assessment of early axonal regeneration in end-to-side nerve coaptation models (2012)
  • Author(s): Oyamatasu H, Koga D, Igarashi M, Shibata M, Ushiki T
  • Journal Title: J Plastic Surg Hand Surg Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] 成長円錐の分子構成 (2012)
  • Author(s): 五十嵐道弘
  • Journal Title: 生化学 Volume: 84(印刷中)
  • Peer Reviewed
• [Journal Article] Predicted expansion of the claudin multigene family (2011)
  • Author(s): Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K, Tsukita S
  • Journal Title: FEBS Lett Volume: 585(4) Pages: 606-612
  • Peer Reviewed
• [Journal Article] Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells (2011)
  • Author(s): Lu J, Nozumi M, Takeuchi K, Abe H, Igarashi M
  • Journal Title: Neurosci Res Volume: 70(1) Pages: 85-90
  • Peer Reviewed
• [Journal Article] Predicted expansion of the claudin multigene family (2011)
  • Author(s): Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K, Tsukita S
  • Journal Title: FEBS Lett. Volume: 585 Pages: 606-612
  • Peer Reviewed
• [Journal Article] Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells (2011)
  • Author(s): Lu J, Nozumi M, Takeuchi K, Abe H, Igarashi M
  • Journal Title: Neurosd Res. Volume: 70 Pages: 85-90
  • Peer Reviewed
• [Journal Article] Predicted expansion of the claudin multigene family. (2011)
  • Author(s): Mineta K, et al.(11人中8番目)
  • Journal Title: FEBS Lett Volume: 585 Pages: 606-612
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate N-Acetylgalactosaminyltransferase-1 is required for normal cartilage development (2010)
  • Author(s): Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, Natsume R, Li M, Furuichi T, Saeki M, Izumikawa T, Hasegawa A, Yokoyama M, Ikegawa S, Sakimura K, Amizuka N, Kitagawa H, Igarashi M
  • Journal Title: Biochem J Volume: 427 Pages: 47-55
  • Peer Reviewed
• [Journal Article] A stochastic model of neuronal growth cone guidance regulated by multiple sensors (2010)
  • Author(s): Kobayashi T, Terajima K, Nozumi M, Igarashi M, Akazawa K
  • Journal Title: J Theor Biol Volume: 266 Pages: 712-722
  • Peer Reviewed
• [Journal Article] Astochastic model of neuronal growth cone guidance regulated by multiple sensors. (2010)
  • Author(s): Kobayashi T, et al.(5人中4番目)
  • Journal Title: JTheor Biol Volume: 266 Pages: 712-722
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate N-Acetylgalactosaminyltransferase-1 is required for normal cartilage development. (2010)
  • Author(s): Watanabe, Y., et al.(18人中18番目)
  • Journal Title: Biochem J Volume: 427 Pages: 47-55
  • Peer Reviewed
• [Presentation] CSGalNAcT1, an Enzyme Required for Chondroitin Sulfate Synthesis, is Critical to Recovery from Neural Injury (2013)
  • Author(s): 武内恒成, 吉岡望, 岡田正康, 五十嵐道弘
  • Organizer: Neuroscience2013
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2013-11-10
• [Presentation] Abnormal brain development/maturation in mice lacking in chondroitin sulfate-synthesizing enzymes (2013)
  • Author(s): 武内恒成, 五十嵐道弘
  • Organizer: ECMNET(European cooeration in science and technology)
  • Place of Presentation: Hotel Remes(ポーランド)
  • Year and Date: 2013-09-11
• [Presentation] Brain development/maturation in mice lacking in chondroitin sulfate synthesizing enzymes (2013)
  • Author(s): 吉岡望, 武内恒成, 五十嵐道弘
  • Organizer: 25th 国際神経化学学会(ISN)/米国神経化学学会(ASN)サテライトミーティング(ISN2013 Glial Satellite)
  • Place of Presentation: Hotel El Castellano(メキシコ)
  • Year and Date: 2013-04-19
• [Presentation] グリコサミノグリカン発現制御による神経再生・発生 (2013)
  • Author(s): 武内恒成, 吉岡望, 比嘉進, 川野仁, 五十嵐道弘
  • Organizer: 第118回日本解剖学会総会
  • Place of Presentation: 香川国際会議場
  • Invited
• [Presentation] 神経極性決定に関与する4回膜貫通glycoprotein M6aの機能解析 (2013)
  • Author(s): 武内恒成、本多敦子、伊藤泰行、峯田克彦、五十嵐道弘
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
  • Invited
• [Presentation] GAP-43の新規のリン酸化は軸索伸長を促進する (2013)
  • Author(s): 河嵜麻実、岡田正康、吉岡望、野住素広、武内恒成、五十嵐道弘
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 前シナプス可塑性の変化に関する、変異シンタキシン１Ａ（Ｒ１５１Ｇ）ノックインマウスと、カルシウム/カルモジュリン依存性プロテインキナーゼII (CaMKII)改変マウスの類似性 (2013)
  • Author(s): 渡邊裕美、 片山憲和、武内恒成、 高雄啓三、宮川剛、崎村建司、真鍋俊也、五十嵐道弘
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] M6a-M6BP-Rap2タンパク質複合体を介した大脳皮質におけるラミニン依存性の神経極性決定制御 (2013)
  • Author(s): 本多敦子、武内恒成、五十嵐道弘
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 成長円錐におけるアクチン再編に伴う小胞輸送 (2013)
  • Author(s): 野住素広、加藤薫、武内恒成、五十嵐道弘
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] プロテオグライカン合成系の調節と神経損傷の修復機構 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 第19回プロテオグライカンフォーラム
  • Place of Presentation: 東京医科歯科大学(東京)
  • Year and Date: 2012-02-11
  • Invited
• [Presentation] プロテオグライカン合成系の調節と神経損傷の修復機構 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 第19回プロテオグライカンフォーラム
  • Place of Presentation: 東京医科歯科大学(東京都)(招待講演)
  • Year and Date: 2012-02-11
• [Presentation] 網羅的アプローチによる新しい神経科学の世界観 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 第1回群馬シナプトインフォマティクス研究会
  • Place of Presentation: 群馬大学刀城会館(群馬)
  • Year and Date: 2012-02-03
  • Invited
• [Presentation] 網羅的アプローチによる新しい神経科学の世界観 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 第一回群馬シナプトインフォマティクス研究会
  • Place of Presentation: 群馬大学刀城会館(群馬県)(招待講演)
  • Year and Date: 2012-02-03
• [Presentation] Proteomic Analysis Revolves the Growth Cone Resear (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 日本脳科学情報交換セミナー
  • Place of Presentation: New Orleans Hilton(米国)
  • Invited
• [Presentation] 神経成長・再生を調整する分子群の役割 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 神経科学・構造生物学融合研究会
  • Place of Presentation: 大阪大学蛋白質研究所
  • Invited
• [Presentation] リン酸化プロテオミクスの威力とそれに基づく新しい世界観 (2012)
  • Author(s): 五十嵐道弘
  • Organizer: 包括脳夏のワークショップ
  • Place of Presentation: 仙台国際会議場
  • Invited
• [Presentation] The in vivo GAP-43 phosphorylation sites involved in axon growth or regeneration (2012)
  • Author(s): 河嵜麻実、吉岡望、野住素広、武内恒成、五十嵐道弘
  • Organizer: 第55回日本神経化学大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 神経発生/再生に関与する神経成長円錐GAP-43の新規リン酸化部位とその解析 (2012)
  • Author(s): 河嵜麻実、武内恒成、野住素広、和田芳野、五十嵐道弘
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Cooperative rearrangement of cytoskeletons and transported vesicles in the growth cone. (2012)
  • Author(s): Nozumi M, Kato K, Igarashi M.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Invited
• [Presentation] コンドロイチン硫酸はマウス視覚野においてＯｔｘ２取り込みと臨界期可塑性を制御する (2012)
  • Author(s): 候旭濱、武内恒成、五十嵐道弘、杉山清佳
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Proteomic Analysis Revolves the Growth Cone Research (2012)
  • Author(s): Igarashi M
  • Organizer: 日米脳科学情報交換セミナー
  • Place of Presentation: New Orleans Hilton （アメリカ合衆国）
  • Invited
• [Presentation] 神経成長・再生を調節する 分子群の役割 (2012)
  • Author(s): 五十嵐 道弘
  • Organizer: 神経科学・構造生物学融合研究会
  • Place of Presentation: 大阪大学蛋白質研究所
  • Invited
• [Presentation] Glycoprotein M6a-organized protein complex contributes to determination of neuronal polarity (2012)
  • Author(s): Honda A, Takeuchi K, Igarashi M
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans Convention Center（アメリカ合衆国）
• [Presentation] Mice lacking in an enzyme involved in chondroitin sulfate synthesis shows better recovery from spinal cord injury (2011)
  • Author(s): 武内恒成, 比嘉進, 工藤千佳, 渡邊裕美, 五十嵐道弘
  • Organizer: Annual Meeting of Society for Neuroscience
  • Place of Presentation: ワシントン D.C.コンベンションセンター(アメリカ合衆国)
  • Year and Date: 2011-11-14
• [Presentation] Mice lacking in an enzyme involved in chondroitin sulfate synthesis shows better recovery from spinal cord injury (2011)
  • Author(s): 武内恒成、比嘉進、工藤千佳、渡邉裕美、五十嵐道弘
  • Organizer: Annual Meeting of Society for Neuroscience
  • Place of Presentation: ワシントンD.C.コンベンションセンター(アメリカ合衆国・Washington D.C.)
  • Year and Date: 2011-11-14
• [Presentation] 神経科学でプロテオミクスをどう使うか-成長円錐研究の実例- (2011)
  • Author(s): 五十嵐道弘
  • Organizer: 第33回神経組織の培養研究会
  • Place of Presentation: 東京医科大学(東京)
  • Year and Date: 2011-10-28
  • Invited
• [Presentation] 神経科学でプロテオミクスをどう使うか-成長円錐研究の実例- (2011)
  • Author(s): 五十嵐道弘
  • Organizer: 第33回神経組織の培養研究会
  • Place of Presentation: 東京医科大学(東京都)(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Lacking in an enzyme synthesizing chondroitin sulfate CSGal NAcT1 improves axon regeneration (2011)
  • Author(s): Michihiro Igarashi, Kosei Takeuchi
  • Organizer: CSHL Asia meeting "Assembly, Plasticity, Dysf unction and Repair of Neural Circuits"
  • Place of Presentation: CSHL Asia Conference Center(中国・蘇州)
  • Year and Date: 2011-10-18
• [Presentation] Lacking in an enzyme synthesizing chondroitin sulfate CSGal NAcT1 improves axon regeneration (2011)
  • Author(s): Michihiro Igarashi, Kosei Takeuchi
  • Organizer: CSHL Asia meeting "Assembly, Plasticity, Dysfunction and Repair of Neural Circuits"
  • Place of Presentation: CSHL Asia Conference Center(中国・蘇州)
  • Year and Date: 2011-10-18
• [Presentation] Searching for functional molecules in growth cones (2011)
  • Author(s): 五十嵐道弘
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 瑠璃光(石川)
  • Year and Date: 2011-09-27
  • Invited
• [Presentation] Two different ways of vesicle transport are mediated by actincytoskeleton and microtubules in the growth cone (2011)
  • Author(s): 野住素広、加藤薫、五十嵐道弘
  • Organizer: 第54回日本神経化学会
  • Place of Presentation: 瑠璃光(石川県)
  • Year and Date: 2011-09-27
• [Presentation] Searching for functional molecules in growth cones (2011)
  • Author(s): 五十嵐道弘
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 瑠璃光(石川県)(招待講演)
  • Year and Date: 2011-09-27
• [Presentation] 成長円錐の形態を制御する神経成長関連蛋白質(nGAPs) (2011)
  • Author(s): 野住素広、呂嘉、武内恒成、五十嵐道弘
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2011-09-23
• [Presentation] Abnormality in the SNARE-related complex in the syntaxin-1A (R151G) knock-in Mice (2011)
  • Author(s): 渡邊裕美、渡部通寿、崎村建司、五十嵐道弘
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] 神経極性における糖タンパク質M6a結合蛋白質複合体の関与 (2011)
  • Author(s): 本多敦子、武内恒成、五十嵐道弘
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Brain development abnormality and axon regeneration in the mice lacking in the enzymes synthesizing chondroitin sulfate (2011)
  • Author(s): Kosei Takeuchi, Susumu Higa, Hitoshi Kawano, Michihiro Igarashi
  • Organizer: 8th international meeting
  • Place of Presentation: フィレンツェ
  • Year and Date: 2011-07-16
• [Presentation] Neuronal growth-associated protein (nGAPs) regulate growth cone morphology (2011)
  • Author(s): Nozumi M, Kato K, Igarashi M
  • Organizer: IBRO 8th international meeting
  • Place of Presentation: フィレンツェ
  • Year and Date: 2011-07-16
• [Presentation] Neuronal growth-associated proteins (nGAPs) regulate growthcone morphology (2011)
  • Author(s): Nozumi M, Kato K, Igarashi M
  • Organizer: IBRO 8^<th> international meeting
  • Place of Presentation: バッソ要塞(イタリア共和国・フィレンツェ)
  • Year and Date: 2011-07-16
• [Presentation] Brain development abnormality and axon regeneration in the mice lacking in the enzymes synthesizing chondroitin sulfate (2011)
  • Author(s): Kosei Takeuchi, Susumu Higa, Hitoshi Kawano, Michihiro Igarashi
  • Organizer: 8^<th> IBRO World Congress of Neurosciences
  • Place of Presentation: バッソ要塞(イタリア共和国・フィレンツェ)
  • Year and Date: 2011-07-16
• [Presentation] コンドロイチン硫酸合成酵素KOマウスにおける機能解析 (2011)
  • Author(s): 武内恒成、比嘉進、北川裕之、渡邉裕美、川野仁、五十嵐道弘
  • Organizer: 第30回日本糖質科学会年会
  • Place of Presentation: ハイブ長岡(新潟県)
  • Year and Date: 2011-07-11
• [Presentation] Proteomics Reveals Novel Sets of Proteins Involved in Axonal Growth (2011)
  • Author(s): Igarashi M, Nozumi M
  • Organizer: EMBO meeting Cell Biology of the Neuron
  • Place of Presentation: フォデーレビーチホテル(ギリシア・イラクリオン)
  • Year and Date: 2011-05-07
• [Presentation] テトラスパニン Ma6 関連タンパク質による単一神経突起伸長の制御メカニズム (2011)
  • Author(s): 武内恒成, 本多敦子, 峯田克彦, 五十嵐道弘
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学
  • Invited
• [Presentation] テトラスパニンM6a関連タンパク質による単一神経突起伸長の制御メカニズム (2011)
  • Author(s): 武内恒成、本多敦子、峯田克彦、五十嵐道弘
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(北海道)(招待講演)
• [Presentation] コンドロイチン硫酸合成に関する遺伝子改変マウスの神経系発生解析 (2011)
  • Author(s): 武内恒成、比嘉進、川野仁、北川裕之、五十嵐道弘
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)
• [Presentation] コンドロイチン硫酸合成酵素ノックアウトマウスは脊髄損傷回復が速い (2011)
  • Author(s): 武内恒成、比嘉進、吉岡望、工藤千佳、川野仁、五十嵐道弘
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 瑠璃光(石川県)
• [Presentation] 細胞外基質コンドロイチン硫酸基は如何に神経発生・神経再生に機能する (2011)
  • Author(s): 武内恒成、五十嵐道弘
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: パシフィコ横浜(大会未開催も誌上開催とされた)
• [Presentation] Newly identified neuronal growth-associated proteins(nGAPs) using proteomics (2010)
  • Author(s): Nozumi M et al.
  • Organizer: American Society for Cell Biology
  • Place of Presentation: フィラデルフィア
  • Year and Date: 2010-12-14
• [Presentation] Newly identified neuronal growth-associated proteins(nGAPs)using proteomics. (2010)
  • Author(s): Nozumi M, et al.(4人中4番目)
  • Organizer: American Society for Cell Biology
  • Place of Presentation: フィラデルフィア(アメリカ合衆国)
  • Year and Date: 2010-12-14
• [Presentation] 成長円錐の機能に係る分子群の役割 (2010)
  • Author(s): 五十嵐道弘
  • Organizer: 大阪大学蛋白質研究所・包括脳ネットワーク合同シンポジウム
  • Place of Presentation: 大阪大学蛋白質研究所
  • Year and Date: 2010-10-29
• [Presentation] 成長円錐機能を支配する分子群とその役割 (2010)
  • Author(s): 五十嵐道弘
  • Organizer: 第1回脳表現型の分子メカニズム研究会
  • Place of Presentation: 大阪大学医学部
  • Year and Date: 2010-10-23
• [Presentation] 成長円錐のプロテオミクスによる新しい成長円錐分子マーカー群の発見 (2010)
  • Author(s): 五十嵐道弘
  • Organizer: 第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会 合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-04
• [Presentation] 新規バキュロウイルス発現細胞と膜タンパク質応用解析技術 (2010)
  • Author(s): 武内恒成、五十嵐道弘
  • Organizer: JST・キャンパス・イノベーションセンター 新技術説明会
  • Place of Presentation: キャンパス・イノベーションセンター東京
  • Year and Date: 2010-07-30
• [Presentation] The novel neuronal growth-associated proteins revealed by the proteomic analysis of the growth cone (2010)
  • Author(s): Igarashi M
  • Organizer: 1st NeuroTalk Symposium
  • Place of Presentation: シンガポール共和国
  • Year and Date: 2010-06-25
• [Presentation] The novel neuronal growth-associated proteins revealed by the proteomicanalysis of the growth cone (2010)
  • Author(s): Igarashi M.
  • Organizer: 1^<St> NeuroTalk Symposium
  • Place of Presentation: シンガポール共和国
  • Year and Date: 2010-06-25
• [Presentation] プロテオミクスを用いた成長円錐の分子基盤研究 (2010)
  • Author(s): 五十嵐道弘
  • Organizer: 平成22年度日本生化学会関東支部例会、第51回新潟生化学懇話会 合同研究集会
  • Place of Presentation: 長岡技術学大学
  • Year and Date: 2010-05-28
• [Presentation] Brain development abnormality in the mice lacking in the enzymes synthesizing chondroitin sulfate (2010)
  • Author(s): Higa S. et al.
  • Organizer: SFN2010(米国神経科学会)
  • Place of Presentation: サンディエゴ
• [Presentation] How to use the proteomic results f or the growth cone research (2010)
  • Author(s): Igarashi M
  • Organizer: Cold Spring Harbor Symposium
  • Place of Presentation: コールドスプリングハーバー(アメリカ合衆国)
• [Presentation] Functional analyses of mice lacking an enzyme for chondroitin sulfate synthesis (2010)
  • Author(s): Takeuchi K. et. Al
  • Organizer: 7th Forum of European Neurosciences
  • Place of Presentation: アムステルダム
• [Presentation] Syntaxin-1A(R151 G)knock-in mice that cannot be associated with CaMKII show the impaired vesicle recycling after stimulation (2010)
  • Author(s): Watanabe Y, Igarashi M
  • Organizer: Synapse Symposium 2010(FENS Satellite symposium)
  • Place of Presentation: アムステルダム
• [Presentation] Proteomic analysis of the growth cone reveals the novel molecular markers nGAPS (2010)
  • Author(s): Jia L., et al.
  • Organizer: Cold Spring Harbor Asia Conference
  • Place of Presentation: 蘇州(中国)
• [Presentation] 成長円錐プロテオームに基づいた神経成長関連蛋白質(nGAPs)の同定 (2010)
  • Author(s): 野住素広, 他(4人中4番目)
  • Organizer: 平成22年度日本生化学会関東支部例会、第51回新潟生化学懇話会 合同研究集会
  • Place of Presentation: 長岡技術学大学
• [Presentation] テトラスパニンM6a結合蛋白質群による軸索突起形成の制御機構 (2010)
  • Author(s): 本多敦子, 他(3人中3番目)
  • Organizer: 平成22年度日本生化学会関東支部例会、第51回新潟生化学懇話会 合同研究集会
  • Place of Presentation: 長岡技術学大学
• [Presentation] コンドロイチン硫酸合成酵素欠損マウスにおける脳発達異常 (2010)
  • Author(s): 比嘉進, 他(7人中7番目)
  • Organizer: 第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会 合同大会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] 変異シンタキシン1Aノックインマウス由来海馬神経細胞におけるシナプス開口放出機構の解析 (2010)
  • Author(s): 渡邊裕美, 他(4人中4番目)
  • Organizer: 第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会 合同大会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Neuronal growth-associated proteins(nGAPs)regulate neurite the growthcone morphology through rearrangement of F-actin (2010)
  • Author(s): Jia L, et al.(4人中4番目)
  • Organizer: 第33回日本分子生物学会年会、第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Proteomic analysis of the growth cone reveals the novel molecular markersnGAPS (2010)
  • Author(s): Jia L, et al.(4人中4番目)
  • Organizer: Cold Spring Harbor Asia Conference
  • Place of Presentation: 蘇州(中華人民共和国)
• [Presentation] How to use the proteomic results for the growth cone research (2010)
  • Author(s): Igarashi M.
  • Organizer: Cold Spring Harbor Symposium
  • Place of Presentation: コールドスプリングハーバー(アメリカ合衆国)
• [Presentation] Brain development abnormality in the mice lacking in the enzymessynthesizing chondroitin sulfate (2010)
  • Author(s): Higa S., et al.(4人中4番目)
  • Organizer: SFN 2010(米国神経科学会)
  • Place of Presentation: サンディエゴ(アメリカ合衆国)
• [Presentation] Functional analyses of mice lacking an enzyme for chondroitin sulfatesynthesis (2010)
  • Author(s): Takeuchi K., et al.(4人中4番目)
  • Organizer: 7th Forum of European Neurosciences
  • Place of Presentation: アムステルダム(オランダ大国)
• [Presentation] Syntaxin-IA(R151G)knock-in mice that cannot be associated with CaMKIIshow the impaired vesicle recycling after stimulation (2010)
  • Author(s): Watanabe Y, Igarashi M.
  • Organizer: Synapse Symposium 2010 (FENS Satellitesymposium)
  • Place of Presentation: アムステルダム(オランダ大国)
• [Remarks]
  • URL: http://www.med.niigata-u.ac.jp/bc2
• [Remarks] 新潟大学医学部生化学第二
  • URL: http://www.med.niigata-u.ac.jp/bc2/
• [Remarks] 私たちの研究
  • URL: http://www.med.niigata-u.ac.jp/bc2/study/index.html
• [Remarks]
  • URL: http://www.med.niigata-u.ac.jp/bc2/
• [Remarks]
  • URL: http://www.med.niigata-u.ac.jp/bc2/
• [Patent(Industrial Property Rights)] 抗Gap43抗体 (2013)
  • Inventor(s): Michihiro Igarashi, Kosei TAKEUCHI, Motohiro NOZUMI, Asami KAWASAKI
  • Industrial Property Rights Holder: 国立大学法人新潟大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-25
  • Overseas
• [Patent(Industrial Property Rights)] WO2013058388A1 (2013)
  • Inventor(s): Takeuchi K, Igarashi M
  • Industrial Property Rights Holder: Takeuchi K, Igarashi M
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-25
• [Patent(Industrial Property Rights)] 抗GAP43抗体 (2011)
  • Inventor(s): 五十嵐道弘, 武内恒成, 野住素広
  • Industrial Property Rights Holder: 新潟大学
  • Industrial Property Number: 2011-230577
  • Filing Date: 2011-10-20