Investigation of common neural mechanisms for motor and cognitive control towards the development of cognitive enhancement technique

• Project/Area Number: 22240049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fusional brain recording science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: HONDA Manabu 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第七部, 部長 (40321608)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000); Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 脳機能操作 / 経頭蓋磁気刺激 / 経頭蓋電気刺激

Outline of Final Research Achievements

We have performed various basic investigations for the development of cognitive rehabilitation using non-invasive brain stimulation. It was shown that tDCS is useful for the improvement of lower limb weakness due to subcortical infarction. It was revealed that tDCS to the bilateral parietal cortex (anodal stimulation to the left and cathodal stimulation to the right) improved the performance of mental calculation and the degree of improvement could be predicted by the preceding fMRI. Using animal study, it was shown that the cathodal tDCS to the rat cortex increased extracellular dopamine levels in the striatum. All of these findings are thought to contribute the development of cognitive rehabilitation using tDCS.

Research Products

• [Journal Article] Frequencies of inaudible high-frequency sounds differentially affect brain activity: positive and negative hypersonic effects. (2014)
  • Author(s): Fukushima A, Yagi R, Kawai N, Honda M, *Nishina E, Oohashi T
  • Journal Title: PLoS One Volume: 9 Issue: 4 Pages: 1-8
  • DOI: 10.1371/journal.pone.0095464
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evolutionary Acquisition of a Mortal Genetic Program: The Origin of an Altruistic Gene. (2013)
  • Author(s): Oohashi T, Maekawa T, Ueno O, Kawai N, Nishina N, Honda M
  • Journal Title: Artificial Life Volume: 20 Issue: 1 Pages: 95-110
  • DOI: 10.1162/artl_a_00098
  • Peer Reviewed / Open Access
• [Journal Article] Structural complexity of sounds necessary for the emergence of the hypersonic effect: Estimation of autocorrelation order. (2013)
  • Author(s): MaekawaT, Honda M, Nishina E, Kawai N, Oohashi T
  • Journal Title: Asiagraph Journal Volume: 8 Pages: 35-40
  • Peer Reviewed
• [Journal Article] Larger right posterior parietal volume in action video game experts : abehavioral and voxel-based morphometry (VBM) study. (2013)
  • Author(s): Tanaka, S., Ikeda, H., Kasahara, K., Kato, R., Tsubomi, H., Sugawara, S. K., Mori, M., Hanakawa, T, Sadato, N., Hond, M, Watanabe, K.
  • Journal Title: PLoS ONE Volume: 8(6) Issue: 6 Pages: e66998-e66998
  • DOI: 10.1371/journal.pone.0066998
  • Peer Reviewed / Open Access
• [Journal Article] Lateralization of activity in the parietal cortex predicts the effectiveness of bilateral transcranial direct current stimulation on performance of a mental calculation task. (2013)
  • Author(s): Kasahara K, Tanaka S, Hanakawa T, Senoo A, Honda M
  • Journal Title: NEUROSCIENCE LETTERS Volume: 545 Pages: 86-90
  • DOI: 10.1016/j.neulet.2013.04.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum. (2013)
  • Author(s): Tanaka T
  • Journal Title: Frontiers in System Neuroscience Volume: 7 Pages: 6-6
  • DOI: 10.3389/fnsys.2013.00006
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic neural network reorganization associated with second language vocabulary acquisition: a multimodal imaging study. (2013)
  • Author(s): Hosoda C, Tanaka K, Nariai T, Honda M, Hanakawa T
  • Journal Title: J Neurosci Volume: 33 Issue: 34 Pages: 13663-13672
  • DOI: 10.1523/jneurosci.0410-13.2013
  • Peer Reviewed
• [Journal Article] Lateralization of activity in the parietal cortex predicts the effectiveness of bilateral transcranial direct current stimulation on performance of a mental calculation task. (2013)
  • Author(s): Kasahara K
  • Journal Title: Neuroscience letters Volume: in press
  • Peer Reviewed
• [Journal Article] Abacus in the brain: a longitudinal functional MRI study of a skilled abacus user with a right hemispheric lesion. (2012)
  • Author(s): Tanaka S
  • Journal Title: Frontiers in Psychology Volume: 3 Pages: 315-315
  • DOI: 10.3389/fpsyg.2012.00315
  • Peer Reviewed
• [Journal Article] Single session of transcranial direct-current stimulation transiently increases knee extensor force in patients with hemiparetic stroke (2011)
  • Author(s): Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T, Watanabe K
  • Journal Title: Neurorehabil Neural Repair Volume: 25 Issue: 6 Pages: 565-569
  • DOI: 10.1177/1545968311402091
  • Peer Reviewed
• [Journal Article] Time course and spatial distribution of fMRI signal changes during single-pulse transcranial magnetic stimulation to the primary motor cortex (2011)
  • Author(s): Shitara H, Shinozaki T, Takagishi K, Honda M, Hanakawa T
  • Journal Title: Neuroimage Volume: 56 Issue: 3 Pages: 1469-1479
  • DOI: 10.1016/j.neuroimage.2011.03.011
  • Peer Reviewed
• [Journal Article] Differential contribution of the supplementary motor area to stabilization of a procedural motor skill acquired through different practice schedules. (2010)
  • Author(s): Tanaka S, Honda M, Hanakawa T, Cohen LG
  • Journal Title: Cereb Cortex Volume: 20 Pages: 2114-2121
  • Peer Reviewed
• [Journal Article] 複数日連続した経頭蓋直流電気刺激により電極直下の皮膚に発赤を生じた2例 (2010)
  • Author(s): 笠原和美, 田中悟志, 渡邊克巳, 花川隆, 本田学
  • Journal Title: 臨床神経生理学 Volume: 39 Pages: 24-27
  • NAID: 10029428624
  • Peer Reviewed
• [Presentation] Inaudible high-frequency sounds affect brain activity and improve sound quality: hypersonic effect (2014)
  • Author(s): Honda M
  • Organizer: International Symposium on “Future of Shitsukan Research”
  • Place of Presentation: 東京大学生産技術研究所コンベンションホール、東京
  • Year and Date: 2014-07-16
  • Invited
• [Presentation] 脳と情報環境～精神神経疾患に対する新しいアプローチ～ (2014)
  • Author(s): 本田 学
  • Organizer: 第48回広島神経医科学研究会
  • Place of Presentation: 広島大学臨床講堂、広島市
  • Year and Date: 2014-07-02
  • Invited
• [Presentation] Monitoring Fundamental Brain Activity and Mental Health: Application to the Development of “Information Therapy” (2014)
  • Author(s): Honda M
  • Organizer: MindCare 2014
  • Place of Presentation: 東京大学山上会館、東京
  • Year and Date: 2014-05-08
  • Invited
• [Presentation] 緩徐なα波は脳深部の脳活動を反映：EEG-fMRI同時計測 (2014)
  • Author(s): 小俣圭, 花川隆, 本田学
  • Organizer: 日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル、仙台市
  • Year and Date: 2014-03-06
• [Presentation] Cortical gray matter volume correlated with control performance of an electroencephalography-based brain-computer interface (2013)
  • Author(s): Kasahara K, DaSalla CS, Nishimoto A, Honda M, Hanakawa T
  • Organizer: 2nd International Joint Symposium “Ultra High Field-MRI”
  • Place of Presentation: 東京大学福武ホール、東京都
  • Year and Date: 2013-11-14
• [Presentation] Effects of the transcranial direct current stimulation on multi-unit neural activities in the rat motor cortex (2013)
  • Author(s): Tanaka T, Isomura Y, Hanakawa T, Tanaka S , Honda M
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都会館、京都市
  • Year and Date: 2013-06-21
• [Presentation] Dorsal premotor cortex structure correlated with control performance for an electroencephalography-based brain-computer interface: A voxel-based morphometry study． (2013)
  • Author(s): Kasahara K, DaSalla CS, Honda M, Hanakawa T
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都会館、京都市
  • Year and Date: 2013-06-20
• [Presentation] Effects of bihemispheric transcranial direct current stimulation (tDCS) over the parietal cortex on a calculation task (2011)
  • Author(s): Kasahara K, Tanaka S, Hanakawa T, Senoo A, Honda M
  • Organizer: Society of Neuroscience 2011 Annual Meeting
  • Place of Presentation: Walter E.Washington (Convention Center, Washington, DC, USA)
  • Year and Date: 2011-11-15
• [Presentation] Long-term effect of the transcranial direct current stimulation on the extracellular dopamine levels in the striatum (2011)
  • Author(s): Tanaka T, Takano Y, Tanaka S, Hanakawa T, Hironaka N, Kobayashi K, Honda M
  • Organizer: Society of Neuroscience 2011 Annual Meeting
  • Place of Presentation: Walter E.Washington (Convention Center, Washington, DC, USA)
  • Year and Date: 2011-11-13
• [Presentation] Adverse effect of the non-invasive brain stimulation : A case report (2011)
  • Author(s): Honda M
  • Organizer: The 34th Annual meeting of the Japanese Neuroscience Society, Neuroethics symposium
  • Place of Presentation: PACIFICO YOKOHAMA, Yokohama, Japan(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] 経頭蓋直流電気刺激の線条体細胞外ドパミン濃度に対する遠隔影響 (2011)
  • Author(s): 田中智子, 高野裕治, 田中悟志, 花川隆, 廣中直行, 小林和人, 本田学
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜,横浜市,日本
• [Presentation] 経頭蓋直流電気刺激を用いた線条体ドパミン濃度の調節 (2011)
  • Author(s): 田中智子, 高野裕二, 田中悟志, 花川隆, 廣中直行, 小林和人, 本田学
  • Organizer: 第5回Motor Control研究会
  • Place of Presentation: 自然科学研究機構岡崎コンファレンスセンター,岡崎市,日本
• [Presentation] Modulation of extracellular dopamine levels in the striatum by transcranial direct current stimulation (2010)
  • Author(s): Tanaka T, Takano Y, Tanaka S, Watanabe K, Hanakawa T, Honda M, Hironaka N
  • Organizer: The Society for Neuroscience 40th Annual Meeting
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2010-11-13
• [Presentation] 数の認処理に対する経頭蓋直流電気刺激の影響 (2010)
  • Author(s): 笠原和美, 田中悟志, 花川隆, 渡邊克巳, 本田学
  • Organizer: 第40回臨床神経生理学会学術大会
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-11-02
• [Presentation] 経頭蓋直流電気刺激による慢性期脳卒中患者の下肢筋力増強 (2010)
  • Author(s): 田中悟志, 武田湖太郎, 大高洋平, 北佳保里, 大須理英子, 花川隆, 渡邊克己
  • Organizer: 第40回臨床神経生理学会学術大会
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-11-02
• [Presentation] Differential function of fronto-parietal network in mental operation. (2010)
  • Author(s): Honda M
  • Organizer: 29th International Congress of Clinical Neurophysiology ICCN2010
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-11-01
• [Presentation] Effect of Practice Schedules on Memory Stabilization of a Procedural Motor Skill. (2010)
  • Author(s): Tanaka S, Honda M, Hanakawa T, Cohen LG
  • Organizer: 29th International Congress of Clinical Neurophysiology ICCN2010
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-10-30
• [Presentation] 経頭蓋直流電気刺激を用いた線条体細胞外ドパミンレベルの調節 (2010)
  • Author(s): 田中智子, 高野裕治, 田中悟志, 渡邊克己, 花川隆, 本田学, 廣中直行
  • Organizer: Neuro2010
  • Place of Presentation: 神戸市神戸国際会議場
  • Year and Date: 2010-09-04
• [Presentation] Effects of the transcranical direct currect stimulation on multi-unit neural activities in the rat motor cortex.
  • Author(s): Tanaka T
  • Organizer: Society for Neuroscience 41st Annual Meeting
  • Place of Presentation: New Orleans Ernest N. Morial Convention Center, New Orleans, USA
• [Book] 感性と情動を生み出す脳、「質感の科学」第2部第3章 (2015)
  • Author(s): 本田学
  • Total Pages: 200
  • Publisher: 朝倉書店
• [Book] Information environment and brain function in "Neurodegenerative Disorders as Systemic Diseases" (2015)
  • Author(s): Honda M
  • Total Pages: 400
  • Publisher: Springer
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r7/index.html