| Project/Area Number |
22240054
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOU Imachi 東京大学, 医学(系)研究科(研究院), 名誉教授 (10010076)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Yusuke 東京大学, 大学院・医学系研究科, 准教授 (90193010)
ISOYAMA Takashi 東京大学, 大学院・医学系研究科, 講師 (20302789)
SAITO Itsuro 東京大学, 大学院・医学系研究科, 特任研究員 (80334225)
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| Research Collaborator |
VASKU Jaromir チェコマサリク大学, 医学部, 名誉教授
DOBSAK Petr チェコマサリク大学, 医学部, 教授
ONO Toshiya 東京大学, 大学院・医学系研究科, 技術専門職員
INOUE Yusuke 東京大学, 大学院・工学系研究科, 特任研究員 (80611079)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2012: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2011: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2010: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | 血行動態 / 微小循環 / 人工心臓 / 顕微鏡 / 血管新生 / 足場材料 / カメラ / スキャッフォルド / 生体内観察 / 完全人工心臓 / TAH / 拍動流 / 連続流 / 波動型人工心臓 / Scaffold |
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| Research Abstract |
It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40 Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was half yeart and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.
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