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Development of dynamic culture technology using tissue elements for 3-dimensional tissue regeneration

Research Project

Project/Area Number 22240058
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

USHIDA Takashi  東京大学, 医学(系)研究科(研究院), 教授 (50323522)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Katsuko  東京大学, 大学院・工学系研究科, 准教授 (90343144)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2010: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Keywords細胞・組織工学 / 動的培養技術 / 動的組織培養 / 再生軟骨 / 非侵襲計測
Research Abstract

We developed the dynamic tissue culture system enabling 3-dimensional tissue regeneration of articular cartilages, and the non-invasive method for evaluating the degrees of their regeneration. We adopted the stress-strain controlled dynamic compression system and the terahertz time-domain spectroscopy for that purpose. The results showed that the production of the matrices such as collagen type I and sGAG significantly increased under the dynamic culture conditions. We found also the correlation between complex dielectric constants and the degree of tissue regeneration in cartilages according to the data obtained by terahertz time-domain spectroscopy, showing the feasibility of non-invasive evaluation of regenerated cartilages.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (105 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (25 results) (of which Peer Reviewed: 9 results) Presentation (65 results) (of which Invited: 1 results) Book (11 results) Remarks (4 results)

  • [Journal Article] Hydrostatic pressure decreases membrane fluidity and lipid desaturase expression in chondrocyte progenitor cells2014

    • Author(s)
      Kevin Montagne, Hiroki Uchiyama, Katsuko S. Furukawa, Takashi Ushida
    • Journal Title

      Journal of Biomechanics

      Volume: 47(2) Pages: 354-9

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Micropit surfaces designed for accelerating osteogenic differentiation of murine mesenchymal stem cells via enhancing focal adhesion and actin polymerization2014

    • Author(s)
      Chang Ho Seo, Heonuk Jeong, Takashi Ushida, Kevin Montagne, Feng Yue, Yuji Suzuki and Katsuko S. Furukawa
    • Journal Title

      Biomaterials Feb

      Volume: 35(7) Pages: 2245-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] The use of sonication treatment to decellularize aortic tissues for preparation of bioscaffolds2014

    • Author(s)
      Azhim A, Syazwani N, Morimoto Y, Furukawa K, Ushida T
    • Journal Title

      J Biomater Appl

    • Related Report
      2013 Final Research Report
  • [Journal Article] Micropit surfaces designed for accelerating osteogenic differentiation of murine mesenchymal stem cells via enhancing focal adhesion and actin polymerization2014

    • Author(s)
      Chang Ho Seo, Heonuk Jeong, Takashi Ushida, Kevin Montagne, Feng Yue, Yuji Suzuki and Katsuko S. Furukawa
    • Journal Title

      Biomaterials

      Volume: 35(7) Pages: 2245-2252

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] テラヘルツ時間領域分光分析法を用いた軟骨組織の分光計測2013

    • Author(s)
      金子知世, 津川由紀子, 古川克子, 岩本敏志, 西澤誠治, 牛田多加志
    • Journal Title

      臨床バイオメカニクス

      Volume: vol.34 Pages: 412-426

    • NAID

      40019874459

    • Related Report
      2013 Final Research Report
  • [Journal Article] Control of cell differentiation by mechanical stress2013

    • Author(s)
      J. H. Park, T. Ushida, T. Akimoto
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 2(1) Pages: 1-14

    • NAID

      10031159016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] The switching of focal adhesion maturation sites and actin filament activation for MSCs by topography of well-defined micropatterned surfaces2013

    • Author(s)
      Chang Ho Seo, Heonuk Jeong, Katsuko S. Furukawa, Yuji Suzuki, Takashi Ushida
    • Journal Title

      Biomaterials

      Volume: 34 Pages: 1764-1771

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Development of bioactive porous α-TCP/HAp beads for bone tissue engineering2013

    • Author(s)
      Asaoka T, Ohtake S, Furukawa KS, Tamura A, Ushida T
    • Journal Title

      J Biomed Mater Res A. Nov

      Volume: 101(11) Pages: 3295-300

    • Related Report
      2013 Final Research Report
  • [Journal Article] Application of α-TCP/HAp functionally graded porous beads for bone regenerative scaffold2013

    • Author(s)
      A. Tamura, T. Asaoka, K. Furukawa, T. Ushida and T. Tateishi
    • Journal Title

      Advances in Science and Technology

      Volume: Vol.86 Pages: 63-69

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of bioactive porous α-TCP/HAp beads for bone tissue engineering2013

    • Author(s)
      Asaoka T, Ohtake S, Furukawa KS, Tamura A, Ushida T
    • Journal Title

      J Biomed Mater Res A

      Volume: 101(11) Pages: 3295-3300

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of α-TCP/HAp functionally graded porous beads for bone regenerative scaffold2013

    • Author(s)
      A.Tamura, T.Asaoka, K.Furukawa, T.Ushida and T.Tateishi
    • Journal Title

      Advances in Science and Technology

      Volume: 86 Pages: 63-69

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of scaffold for bone regeneration by taylor made stereolithography2013

    • Author(s)
      Kumagai K
    • Journal Title

      Advances in Science and Technology

      Volume: 86 Pages: 70-74

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Time Resolution Time-Lapse Imaging Reveals Continuous Existence and Rotation of Stress Fibers under Cyclic Stretch in HUVEC2012

    • Author(s)
      Yusuke MITSUOKA, Akira TSUKAMOTO, Shunsuke IWAYOSHI, Katsuko S. FURUKAWA and Takashi USHIDA
    • Journal Title

      J Biomech Sci & Eng

      Volume: 7(2) Pages: 188-198

    • NAID

      130002066902

    • Related Report
      2013 Final Research Report
  • [Journal Article] Feasibility and limitations of round robin test for assessment of evaluation protocols in tissue-engineered medical product2012

    • Author(s)
      Masako Yokoi, Koji Hattori, Koichi Narikawa, Hajime Ohgushi, Mika Tadokoro, Kazuto Hoshi, Tsuyoshi Takato, Akira Myoui, Katsuhiko Nanno, Yukio Kato, Masami Kanawa, Katsura Sugawara, Tomoko Kobo and Takashi Ushida
    • Journal Title

      Journal of Tissue Engineering and Regenerative Medicine

      Volume: 6 Pages: 550-558

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Mechanical stretch maintains Nanog expression through PI3K/Akt signals in mouse embryonic stem cells2012

    • Author(s)
      R. Horiuchi, T. Akimoto, Z. Hong, T. Ushida
    • Journal Title

      Exp Cell Res

      Volume: 318(14) Pages: 1726-1732

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] The switching of focal adhesion maturation sites and actin filament activation for MSCs by topography of well-defined micropatterned surfaces.2012

    • Author(s)
      Seo CH
    • Journal Title

      Biomaterials

      Volume: 34 Pages: 1764-1771

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Topographically Optimized Substrate with Well-Ordered Lattice Micropatterns for Enhancing the Osteogenic Differentiation of Murine Mesenchymal Stem Cells2011

    • Author(s)
      Chang Ho Seo, Katsuko Furukawa, Yuji Suzuki, Nobuhide Kasagi, Takanori Ichiki and Takashi Ushida
    • Journal Title

      MACROMOLECULAR BIOSCIENCE

      Volume: 11(7) Pages: 938-945

    • Related Report
      2013 Final Research Report
  • [Journal Article] Analysis of Cell Acculuation Mechanicsm in a Rotational Culture System2011

    • Author(s)
      Koji Fukagata, Katsuko S Furukawa, Takashi Ushida
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 11(2) Pages: 407-421

    • Related Report
      2013 Final Research Report
  • [Journal Article] The effect of substrate microtopography on focal adhesion maturation and actin organization via the RhoA/ROCK pathway2011

    • Author(s)
      Seo CH, Furukawa K, Montagne K, Jeong H, Ushida T
    • Journal Title

      Biomaterials

      Volume: 32(36) Pages: 9568-75

    • Related Report
      2013 Final Research Report
  • [Journal Article] Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product2011

    • Author(s)
      Masako Yokoi, et al.
    • Journal Title

      JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

      Volume: (掲載確定)(印刷中)) Issue: 7 Pages: 550-558

    • DOI

      10.1002/term.460

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell accumulation mechanism in a rotational culture system2011

    • Author(s)
      K.Fukagata, K.S.Furukawa, T.Ushida
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 11 Issue: 02 Pages: 407-421

    • DOI

      10.1142/s0219519410003745

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 旋回培養によるスキャフォールドフリー再生軟骨の粘弾性特性評価2011

    • Author(s)
      古川克子, 遊見釣, 宮田昌悟, 立石哲 也, 里見忠篤, 牛田多加志
    • Journal Title

      日本臨床バイオメカニクス学会誌

      Volume: 31(印刷中)

    • NAID

      10027911514

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell accumulation mechanism in a rotational culture system2011

    • Author(s)
      Koji Fukagata, Katsuko S Furu kawa, Takashi Ushida
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 印刷中(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Evaluation of Tissue Engineered Cartilage with Time-Resolved Laser-Induced Fluorescence Spectroscopy2010

    • Author(s)
      Kutsuna T, Sato M, Ishihara M, Katsuko S Furukawa, Nagai T, Kikuchi M, Ushida T, Mochida J
    • Journal Title

      Tissue Eng. Part C Methods

      Volume: 16(3) Pages: 365-73

    • Related Report
      2013 Final Research Report
  • [Journal Article] Influence of cassette design on three-dimensional perfusion culture of artificial bone

    • Author(s)
      D Du, T Ushida, KS Furukawa
    • Journal Title

      Journal of Biomedical Materials Research : Part B - Applied Biomaterials

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 大規模微細三次元担体造形のための高速光造形システムの開発2014

    • Author(s)
      篠原誠, 牛島宏太, 小林洋次郎, 須鎌隆, 角南嘉一, 影山知紀, 浅岡照夫, 牛田多加志, 古川克子
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 軟骨前駆細胞における静水圧力による膜流動性とデサチュラーゼ遺伝子の発現の変更2014

    • Author(s)
      モンターニュ ケヴィン, 内山 博樹, 古川 克子, 牛田 多加志
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] in vitro 骨再生のための動的培養システム2014

    • Author(s)
      古川克子, Dajiang Du, 牛田多加志
    • Organizer
      東大病院先端医療開発フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Decellularized matrices and negative pressure reseeding for cartilage tissue engineering2014

    • Author(s)
      Stephanie Yin Wai Ting, Yoshihide HASHIMOTO, Akio KISHIDA,Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] 静水圧刺激による軟骨細胞の分化制御と組織形成2014

    • Author(s)
      牛田多加志
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] Decellularized matrices and negative pressure reseeding for cartilage tissue engineering2014

    • Author(s)
      Stephanie Yin Wai Ting, Yoshihide HASHIMOTO, Akio KISHIDA,Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 静水圧刺激による軟骨細胞の分化制御と組織形成2014

    • Author(s)
      牛田多加志
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 再生医療のためのバイオリアクター化技術2013

    • Author(s)
      古川 克子, 立石 哲也, 牛田 多加志
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      つくば市
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhanced chondrogenesis in cartilage tissue engineering via cell aggregate models in hydrogels2013

    • Author(s)
      Wu Andy Tsung Hsun, Takashi Ushida, Katsuko Furukawa
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity pulsed ultrasound and rotational culture for cartilage tissue engineering2013

    • Author(s)
      Ting Stephanie, Yoshihiro Nishimura, Takashi Ushida, Katsuko Furukawa
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Biodegradable scaffold design for tissue-engineered vascular graft with non-linear mechanical characteristic2013

    • Author(s)
      Katsuko S Furukawa, Masashi Yoshimoto, Takashi Ushida
    • Organizer
      第13回東京大学生命科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-Invasive Evaluation of Tissue-Engineered Cartilage by Terahertz Time Domain Spectroscopy2013

    • Author(s)
      Takashi Ushida,Tomoyo Kaneko, Yukiko Tsugawa, Katsuko S Furukawa
    • Organizer
      7th International Conference on Advanced Vibrational Spectroscopy
    • Place of Presentation
      Kobe
    • Related Report
      2013 Final Research Report
  • [Presentation] Micro-Topographical Effects on Focal Adhesion Kinase (FAK) Activation and Focal Adhesion Maturation Sites2013

    • Author(s)
      Chang Ho SEO, Takashi USHIDA, Katsuko S. FURUKAWA
    • Organizer
      The 7th Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Seol, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] テラヘルツ時間領域分光分析法の軟骨組織非侵襲評価への応用2013

    • Author(s)
      津川由紀子, 金子知世, 岩本敏志(先端赤外), 西澤誠治, 古川克子, 牛田多加志
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] 圧縮応力負荷下における関節軟骨組織の動的特性の計測2013

    • Author(s)
      長坂南, 中村亮介, 古川克子, 牛田多加志
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity pulsed ultrasound modulates hypertrophic effects of rotational culture on scaffoldfree cartilage tissues2013

    • Author(s)
      Stephanie Yin Wai Ting, Takashi Ushida, Katsuko S Furukawa
    • Organizer
      Joint International Congress 2013 in Yokohama
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Feasibility of Terahertz Time Domain Spectroscopy for in vitro Evaluating Regenerated Cartilatges as a Non-Invasive Measurement2013

    • Author(s)
      Takashi Ushida, Tomoyo Kaneko, Yukiko Tsugawa, Seiji Nishizawa, Katsuko Furukawa
    • Organizer
      Termis AP Annual Conference
    • Place of Presentation
      Shanghai & Wuzen, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Scaffold-free Cartilage Tissue by Mechanical Stress Loading for Tissue Engineering Tenth2013

    • Author(s)
      Katsuko S Furukawa
    • Organizer
      International Conference on Flow Dynamics
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-Invasive Evaluation of Tissue-Engineered Cartilage by Terahertz Time Domain Spectroscopy2013

    • Author(s)
      Takashi Ushida,Tomoyo Kaneko, Yukiko Tsugawa, Katsuko S Furukawa
    • Organizer
      7th International Conference on Advanced Vibrational Spectroscopy
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Micro-Topographical Effects on Focal Adhesion Kinase (FAK) Activation and Focal Adhesion Maturation Sites2013

    • Author(s)
      Chang Ho SEO, Takashi USHIDA, Katsuko S. FURUKAWA
    • Organizer
      The 7th Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Seol,Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Feasibility of Terahertz Time Domain Spectroscopy for in vitro Evaluating Regenerated Cartilatges as a Non-Invasive Measurement"2013

    • Author(s)
      Takashi Ushida, Tomoyo Kaneko, Yukiko Tsugawa, Seiji Nishizawa, Katsuko Furukawa
    • Organizer
      Termis AP Annual Conference
    • Place of Presentation
      Shanghai & Wuzen, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Scaffold-free Cartilage Tissue by Mechanical Stress Loading for Tissue Engineering2013

    • Author(s)
      Katsuko S Furukawa
    • Organizer
      Tenth International Conference on Flow Dynamics
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced chondrogenesis in cartilage tissue engineering via cell aggregate models in hydrogels2013

    • Author(s)
      Wu Andy (Ushida T)
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Topographical Switching of Focal Adhesion Maturation Sites and Actin Filament Activation On the Well-defined Grid Micropatterns2013

    • Author(s)
      Seo CH (Ushida T)
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hydrostatic Pressure and Regenerative Medicine-Differentiation Control of Chondrocytes and Regeneration of Cartilage2012

    • Author(s)
      Takashi Ushida
    • Organizer
      International Symposium on Cellular Mechanobiology
    • Place of Presentation
      University of Kyoto (Kyoto)(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] High-hydrostatic pressurization treatment for the decellularization of bovine articular cartilage for tissue engineering2012

    • Author(s)
      Stephanie Yin Wai TING, Yoshihide HASHIMOTO, Akio KISHIDA,Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第4回GMSI 国際シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] The Use of Sonication Treatment to Completely Decellularize Aorta Tissue2012

    • Author(s)
      Azran Azhim, K. Yamagami, K. Muramatsu, Y. Morimoto, K.S. Furukawa, M. Tanaka, Y. Fukui, T. Ushida
    • Organizer
      World Congress 2012 Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanical Stress Loading for Scaffold-Free Cartilage Model2012

    • Author(s)
      Katsuko Furukawa, Tetsuya Tateishi, Takashi Ushida
    • Organizer
      World Congress 2012 Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing
    • Related Report
      2013 Final Research Report
  • [Presentation] Hydrostatic Pressure Modulates Microrna Expression In MC3T3-E1 Cells2012

    • Author(s)
      Kevin Montagne, Katsuko Furukawa, Takashi Ushida
    • Organizer
      World Congress 2012 Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing
    • Related Report
      2013 Final Research Report
  • [Presentation] Fabrication and 3D culture of customized artificial bone by oscillatory flow2012

    • Author(s)
      Du DJ, Furukawa KS, Asaoka T, Shao L, Ushida T
    • Organizer
      3rd TERMIS World Congress 2012
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2013 Final Research Report
  • [Presentation] Synergistic effects of growth factors with diffusion in scaffold-free cartilage tissue under shear flow conditions2012

    • Author(s)
      Furukawa KS, Tateishi T, Ushida T
    • Organizer
      3rd TERMIS World Congress
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] High-hydrostatic pressurization decellularized bovine articular cartilage scaffolds for cartilage tissue engineering2012

    • Author(s)
      Ting S, Hashimoto Y, Kishida A, Ushida T, Furukawa K
    • Organizer
      3rd TERMIS World Congress 2012
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生組織の非侵襲性評価の為のテラヘルツ時間領域分光分析2012

    • Author(s)
      金子知世, 松山裕幸, 守友郁也, 津川由紀子, 岩本敏志, 西澤誠治, 古川克子, 牛田多加志
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] ウシ膝軟骨細胞の静水圧負荷に対するシグナル伝達機構の解明(Modulation of bovine chondrocyte signaling pathways through hydrostatic pressure)2012

    • Author(s)
      呉 東益, モンターニュ ケヴィン, 牛田多加志, 古川 克子
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] フォーカルアドヒージョンの空間特性における微細パターンの効果(Effects of Micropattern on Spatial Property of Focal Adhesion)2012

    • Author(s)
      ジョン ホンオク, ソウ チャンホ, 古川克子, 牛田多加志
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] 大規模微細三次元生体内分解性担体造形のための高速光造形システムの設計(レーザ強度モデルによる造形パラメータと分解能の関係解明および造形プロセスの最適化アルゴリズムの開発)2012

    • Author(s)
      篠原 誠, 小松 和磨, 牛田 多加志, 古川 克子
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] テラヘルツ時間領域分光分析法を用いた軟骨組織の分光計測2012

    • Author(s)
      金子 知世, 松山 裕幸, 守友 郁也, 津川 由紀子, 岩本 敏志, 西沢 誠治, 古川克子, 牛田 多加志
    • Organizer
      第39回臨床バイオメカニクス学会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanical Stress Loading for Scaffold-Free Cartilage Model2012

    • Author(s)
      Furukawa K (Ushida T)
    • Organizer
      World Congress 2012 Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] High-hydrostatic pressurization decellularized bovine articular cartilage scaffolds for cartilage tissue engineering2012

    • Author(s)
      Ting S (Furukawa K)
    • Organizer
      3rd TERMIS World Congress
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pulsed low intensity ultrasound and transforming growth factor-b3 0n scaffold free cartilage tissue2011

    • Author(s)
      Stephanie Ting
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京・新宿)
    • Year and Date
      2011-03-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 圧縮・せん断流れの同時負荷装置による再生軟骨の構築2011

    • Author(s)
      古川克子
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京・新宿)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光音響法を用いた生体組織の弾性率測定法の開発2011

    • Author(s)
      田中文, 古川克子, 平沢壮, 石原美弥, 菊池眞, 牛田多加志
    • Organizer
      日本機械学会第23回バイオエンジニアリング講演会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 圧縮・せん断流れの同時負荷装置による再生軟骨の構築2011

    • Author(s)
      古川克子
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 格子微細パターンによるマウス間葉系幹細胞の骨分化に地形的に最適化された基板2011

    • Author(s)
      Changho Seo, Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of pulsed low-intensity ultrasound and transforming growth factor- β 3 on the redifferentiation of dedifferentiated2011

    • Author(s)
      Stephanie Yin Wai TING, Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] テラヘルツ波技術の再生軟骨分析への応用2011

    • Author(s)
      松山裕幸, 牛田多加志, 古川克子
    • Organizer
      日本機械学会関東支部講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 共焦点顕微鏡とImageJ による再生軟骨の階層性評価2011

    • Author(s)
      土屋信篤, 牛田多加志, 古川克子
    • Organizer
      日本機械学会関東支部講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 高静水圧負荷時における細胞骨格のリアルタイムイメージング2011

    • Author(s)
      松浦正嗣, 牛田多加志, 古川克子
    • Organizer
      日本機械学会関東支部講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 光造形法を用いた担体作製におけるNA の造形精度に及ぼす影響評価2011

    • Author(s)
      小松和磨, 牛田多加志, 古川克子
    • Organizer
      日本機械学会関東支部講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity pulsed ultrasound and transforming growth factor- β 3on scaffold-free cartilage tissues2011

    • Author(s)
      Stephanie Yin Wai TING, Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 脱細胞化した半月板の組織学的解析および生体耐久性の評価に関する研究2011

    • Author(s)
      小野樹, 守本祐司, 田中眞人, 古川克子, 牛田多加志, Azran Azhim
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      長野
    • Related Report
      2013 Final Research Report
  • [Presentation] Cyclic, uniaxial compression modulates the chondrogenesis of human bone marrow mesenchymal stem cells in scaffold-free form2011

    • Author(s)
      Stephanie Yin Wai TING, Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      World Conference on Regenerative Medicine
    • Place of Presentation
      Leipzig, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Chondrogenesis of scaffold-free human bone-marrow mesenchymal stem cells through compressive loading2010

    • Author(s)
      Stephanie Yin Wai TING, Katsuko FURUKAWA, Takashi USHIDA
    • Organizer
      2nd GMSI International Symposium
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Study on Bone Cell Adaptability of α-TCP/HAp Functionally Graded Porous Beads for Biomaterials ApplicationVia Amendola 2I-51016 Montecatini Terme (PT)2010

    • Author(s)
      Shoji Otake,Teruo Asaoka, Katsuko Furukawa, Takashi Ushida, Ushida, Tetsuya Tateishi
    • Organizer
      CIMTEC 2010
    • Place of Presentation
      Montecatini Terme, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of subcellular traction force in cells under uniaxial stretch for mechanobiology2010

    • Author(s)
      Akira Tsukamoto; Yuusuke Mitsuoka; Taro Watanabe; Katsuko Furukawa; Takashi Ushida
    • Organizer
      6TH WORLD CONGRESS ON BIOMECHANICS
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] 光造形技術による生体内分解性材料の3次元造形2010

    • Author(s)
      古川克子, 五味俊介, 福本真二, 牛田多加志
    • Organizer
      日本機械学会2010年度年次大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 3D Fabrication of Biodegradable Material using Stereo-lithography2010

    • Author(s)
      Katsuko S.Furukawa. Kazuma Komatsu, Syunsuke Gomi, Shinji Fukumoto, Yasuyuki Sakai, Takashi Ushida
    • Organizer
      International Conference on Biofabrication
    • Place of Presentation
      Philadelphia
    • Related Report
      2013 Final Research Report
  • [Presentation] Noninvasive assay for regenerative cartilage tissue2010

    • Author(s)
      Katsuko Furukawa, Hiroyuki Matsuyama, Takashi Ushida
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of low-intensity pulsed ultrasound and transforming growth factor-β3 on scaffold-free dedifferentiated bovine chondrocyteon preventative and regenerative medicine2010

    • Author(s)
      Stephanie Yin Wai TING, Katsuko FURUKAWA, Takashi USHIDA
    • Organizer
      5th World Congress on Preventive & Regenerative Medicine
    • Place of Presentation
      Hannover, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Scaffold-free cartilage tissue by mechanical stress loading for tissue engineering2010

    • Author(s)
      Stephanie Yin Wai TING, Takashi USHIDA, Katsuko FURUKAWA
    • Organizer
      5th World Congress on Preventive & Regenerative Medicine
    • Place of Presentation
      Hannover, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Medical application of terahertz technology for regenerative cartilage tissue2010

    • Author(s)
      Katuko S. Furukawa
    • Organizer
      日本分光学会テラヘルツ分光部会 国際シンポジウム
    • Place of Presentation
      松本市
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生医工学とバイオメカニクス-再生軟骨における力学特性評価-2010

    • Author(s)
      牛田多加志, 古川克子, 宮田昌悟
    • Organizer
      第37回日本臨床バイオメカニクス学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] A Topographically Optimized Substrate for the Osteogenic Differentiation of Stem Cell by Systematic Analysis2010

    • Author(s)
      Chang Ho Seo, Furukawa, and T. Ushida
    • Organizer
      stem cell society singapore symposium 2010
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] BMP-2と旋回培養によるScaffold-free 再生軟骨モデルの構築2010

    • Author(s)
      古川克子
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanical Stress Loading for Scaffold-free Cartilage Tissue BIT Life Sciences2010

    • Author(s)
      Katsuko S Furukawa
    • Organizer
      3rd Annual World Congress of Regenerative Medicine & Stem Cells
    • Place of Presentation
      Shanghai
    • Related Report
      2013 Final Research Report
  • [Book] 再生医療における3要素+1要素2014

    • Author(s)
      牛田多加志
    • Publisher
      日本機械学会誌
    • Related Report
      2013 Final Research Report
  • [Book] 軟骨組織培養のための静水圧負荷技術, 細胞の3次元組織化 -その最先端技術と材料技術-, 田畑泰彦編修, 遺伝時医学MOOK別冊2013

    • Author(s)
      牛田多加志
    • Related Report
      2013 Final Research Report
  • [Book] バイオリアクター技術の課題と現状- 骨組織再生用バイオリアクター, 整形・災害外科の増刊号562013

    • Author(s)
      古川克子, 牛田多加志
    • Related Report
      2013 Final Research Report
  • [Book] バイオリアクター技術の課題と現状- 骨組織再生用バイオリアクター2013

    • Author(s)
      牛田多加志,Dajiang Du,古川克子
    • Total Pages
      300
    • Publisher
      金原出版
    • Related Report
      2013 Annual Research Report
  • [Book] 細胞の3次元組織化 ―その最先端技術と材料技術―2013

    • Author(s)
      牛田多加志
    • Total Pages
      360
    • Publisher
      遺伝子医学
    • Related Report
      2013 Annual Research Report
  • [Book] バイオリアクター技術の課題と現状- 骨組織再生用バイオリアクター -2013

    • Author(s)
      古川克子,牛田多加志
    • Total Pages
      300
    • Publisher
      金原出版
    • Related Report
      2012 Annual Research Report
  • [Book] 再生医工学におけるメカノバイオロジーI2013

    • Author(s)
      牛田多加志,古川克子
    • Total Pages
      275
    • Publisher
      化学同人
    • Related Report
      2012 Annual Research Report
  • [Book] 関節軟骨における力学環境と細胞動態2012

    • Author(s)
      牛田多加志
    • Total Pages
      329
    • Publisher
      日本医学館
    • Related Report
      2012 Annual Research Report
  • [Book] Regenerative Medicine and Tissue Engineering ; From Cells to Organs2011

    • Author(s)
      D.Du, T.Ushida, K Furukawa
    • Total Pages
      548
    • Publisher
      Daniel Eberli Ed.,, InTech
    • Related Report
      2011 Annual Research Report
  • [Book] バイオリアクターと力学刺激2010

    • Author(s)
      牛田多加志, Dajiang Du, 古川克子
    • Related Report
      2013 Final Research Report
  • [Book] Blast-induced traumatic brain injury (bTBI): multidisciplinary team による病態解明から機器開発まで, 神経外傷2010

    • Author(s)
      中川敦寛 , 他
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.cdbim.m.u-tokyo.ac.jp/research/03.php

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.tissue.t.u-tokyo.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学大学院医学系研究科疾患生命工学センター再生医療工学部門

    • URL

      http://www.cdbim.m.u-tokyo.ac.jp/research/03.php

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院工学系研究科再生医工学研究室

    • URL

      http://www.tissue.t.u-tokyo.ac.jp

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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