| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2010: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Research Abstract |
We developed the dynamic tissue culture system enabling 3-dimensional tissue regeneration of articular cartilages, and the non-invasive method for evaluating the degrees of their regeneration. We adopted the stress-strain controlled dynamic compression system and the terahertz time-domain spectroscopy for that purpose. The results showed that the production of the matrices such as collagen type I and sGAG significantly increased under the dynamic culture conditions. We found also the correlation between complex dielectric constants and the degree of tissue regeneration in cartilages according to the data obtained by terahertz time-domain spectroscopy, showing the feasibility of non-invasive evaluation of regenerated cartilages.
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