| Co-Investigator(Kenkyū-buntansha) |
DOI Hisashi 東京医科歯科大学, 生体材料工学研究所, 助教 (30251549)
ASHIDA Maki 東京医科歯科大学, 生体材料工学研究所, 助教 (50708386)
TSUTSUMI Yusuke 東京医科歯科大学, 生体材料工学研究所, 助教 (60447498)
陳 鵬 東京医科歯科大学, 生体材料工学研究所, 特任助教 (70708388)
野村 直之 東北大学, 工学(系)研究科(研究院), 准教授 (90332519)
右田 聖 山形大学, 大学院理工学研究科, 助教 (00512302)
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| Budget Amount *help |
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2010: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Outline of Final Research Achievements |
The mechanism of the inhibition of bacterial adhesion and biofilm formation on titanium with electrodeposition of PEG was elucidated. RGD-immobilized through electrodeposited PEG on titanium is effective to improve the hard tissue compatibility of titanium when the material was implanted into rat tibia. Moreover, the ccurrent density was large when concetration of NH2-PEG-NH2 in electrolite. This indicated thatNH2-PEG-NH2 electricallly disociated and undisociated repeatedly near titanium surface during electrodeposition and fibnally the amino terminals bond to titanium surface, generating the immbolization with U-shape. On the other hand, MPC polymer is also electrodeposited to titanium surafce by electrodeposition and the surafce inhibited eh adhesion of fibrin network formation.
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