| Budget Amount *help |
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
Recently, importance of physical activity in patients with chronic respiratory disease is being generally recognized. A group of cytokines, called "myokines", which is secreted from skeletal muscles is supposed to be one of the mechanisms of the effects. Myokines are stored in vesicles of muscle cells as like cocktails, and selected the selected molecules out of the cocktails under the certain stimullation or stress. In human exercise tests, blood IL-6, one of main myokines, was increased during and after the exercise, whereas blood myostatin seemed to be biphasic. The trigger of the secretion is mainly considered to be the muscle constriction. However, other mechanisms are possively invloved as the triggers. Baseline IL-6 blood level, contrally to myostatin, is lower in physically active subjects than in not active.
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