Evaluation of the Effects of Rehabilitation Based on SerumProteome and Free Amino Acid Levels
| Project/Area Number |
22240067
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Fujita Health University |
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Principal Investigator |
BEPPU Hidehiro (BEPPU Hidehiko) 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (30142582)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Nobuhiro 東京工業大学, 生命理工学研究科, 准教授 (80267955)
近藤 晶子 藤田保健衛生大学, 総合医科学研究所, 助教 (90396838)
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| Co-Investigator(Renkei-kenkyūsha) |
SONODA Sigeru 藤田保健衛生大学, 医学部, 教授 (10197022)
MIZUTANI Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 助教 (30351068)
YAMAGUCHI Kumiko 藤田保健衛生大学, 藤田記念七栗研究所, 技術員 (50526308)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Keywords | リハビリ訓練 / 脳卒中回復期 / 微量成分検索 / サイトカイン / 筋肉成分 / 脳卒中回復期リハビリ / リハ運動訓練 / 生体成分 / 遊離アミノ酸 / 微量検体分析 / 質量分析 / 遺伝子産物 / UPLC / 低侵襲 / アミノ酸 |
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| Research Abstract |
With a view to the establishment of an index marker applicable to patients undergoing rehabilitation, based on biogenic factors, this study aimed to develop a method to evaluate the effects of such approaches, based on serum free amino acid levels. Serum collected from post-acute rehabilitation ward patients was analyzed using UPLC-MS. On single regression analysis of rehabilitation items and changes in amino acid levels, a positive correlation was observed between the lengths of time from the onset to discharge and hospital stay and L-arginine levels, and between FIM gain and L-serine and L-arginine levels, suggesting that changes in serum free amino acidlevels during rehabilitation may depend on the levels of exercise and daily activities.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Inhibition of ENNG-induced Pyloric Stomach and Small Intestinal Carcinogenesis in Mice by High2012
Author(s)
Kaneko T, Shimpo K, Chihara T, Beppu H, Tomatsu A, Shinzato M, Yanagida T, Ieike T, Sonoda S, Futamura A, Ito A, Higashiguchi T
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Journal Title
Asian Pacific J Cancer Prev
Volume: 13
Pages: 1-6
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Peer Reviewed
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[Presentation] Development of human serum proteomics.2012
Author(s)
Ken Hirosaki, Hidehiko Beppu, Lumi Negishi, Paxton Thanai, Takayuki Yonezawa, Shigeru Sonoda, Ung-il Chung, Nobuhiro Hayashi
Organizer
The 85th Annual Meeting of the Japanese Biochemical Society
Place of Presentation
Fukuoka, Japan
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