Genome-wide association study of elite sprint athletes

• Project/Area Number: 22240072
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: TANAKA Masashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)
• Co-Investigator(Kenkyū-buntansha): FUKU Noriyuki 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (40392526)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000); Fiscal Year 2012: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2011: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000); Fiscal Year 2010: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: エネルギー代謝 / ゲノム全領域関連解析 / エクソン全領域関連解析 / ミトコンドリアゲノム多型 / 一塩基多型 / 全エクソン塩基配列解析 / 核ゲノム多型 / 瞬発系運動能力 / 陸上短距離走 / ジャマイカ人

Research Abstract

Elite human athletic performance is a multifactorial trait and previous candidate gene studies have been inconclusive. Three genome-wide association studies of elite Jamaican, African-American and Japanese sprint athletes and their matched controls were performed to identify common genetic variants associated with this elite trait. No SNPs exceeded the conventional GWAS significance threshold of 5 x 10-8 in the respective cohorts. Two SNPs within the GALNT13 (Pcombined = 4.66 x 10-7 for rs10196189) and the CREM genes (Pcombined= 1.88 x 10-6 for rs1531550) attained P < 2 x 10-6 after meta-analysis. Two putative loci for elite sprint performance across Jamaicans, African-Americans and Japanese sprinters have been discovered using a genome-wide association approach followed by meta-analysis. Further validation of these signals requires replication before functional dissection can be carried out.

Research Products

• [Journal Article] Efficacy of pyruvate therapy in patients with mitochondrial disease: A semi-quantitative clinical evaluation study (2014)
  • Author(s): Tatsuya Fujii, Fumihito Nozaki, Keiko Saito, Anri Hayashi, Yutaka Nishigaki, Kei Murayama, Masashi Tanaka, Yasutoshi Koga, Ikuko Hiejima, Tomohiro Kumada
  • Journal Title: Molecular genetics and metabolism Volume: 112: 2 Pages: 133-138
• [Journal Article] New MT-ND6 and NDUFA1 mutations in mitochondria respiratory chain disorders (2014)
  • Author(s): Natsumi Uehara, Masato Mori, Yoshimi Tokuzawa, Yosuke Mizuno, Shunsuke Tamaru, Masakazu Kohda, Yohsuke Moriyama, Yutaka Nakachi, Nana Matoba, Tetsuro Sakai, Taro Yamazaki, Hiroko Harashima, Kei Murayama, Keisuke Hattori, Jun-Ichi Hayashi, Takanori Yamagata, Yasunori Fujita, Masafumi Ito, Masashi Tanaka, Ken-ichi Nibu, Akira Ohtake, Yasushi Okazaki
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 1:5 Pages: 361-369
• [Journal Article] Evolution of mitochondrial power in vertebrate metazoans (2014)
  • Author(s): Yasuhiro Kitazoe, Masashi Tanaka
  • Journal Title: PloS One Volume: 9: 6 Pages: 6-6
• [Journal Article] High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for type 2 diabetes mellitus in non-diabetic Japanese men (2014)
  • Author(s): Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Ryuken Ise, Satomi Oshima, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
  • Journal Title: Physiological genomics
• [Journal Article] Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels (2014)
  • Author(s): Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
  • Journal Title: Physiological genomics Volume: 46: 6 Pages: 207-215
• [Journal Article] ACTN3 R577X genotype is associated with sprinting in elite Japanese athletes (2014)
  • Author(s): E Mikami, N Fuku, H Murakami, H Tsuchie, H Takahashi, N Ohiwa, H Tanaka, Y P Pitsiladis, M Higuchi, M Miyachi, T Kawahara, M Tanaka
  • Journal Title: International journal of sports medicine Volume: 35: 2 Pages: 172-177
• [Journal Article] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers (2013)
  • Author(s): Guan Wang, Eri Mikami, Li-Ling Chiu, Alessandra DE Perini, Michael Deason, Noriyuki Fuku, Motohiko Miyachi, Koji Kaneoka, Haruka Murakami, Masashi Tanaka, Ling-Ling Hsieh, Sandy S Hsieh, Daniela Caporossi, Fabio Pigozzi, Alan Hilley, Rob Lee, Stuart D R Galloway, Jason Gulbin, Viktor A Rogozkin, Ildus I Ahmetov, Nan Yang, Kathryn N North, Saraslanidis Ploutarhos, Hugh E Montgomery, Mark E S Bailey, Yannis P Pitsiladis
  • Journal Title: Med Sci Sports Exerc Volume: 45: 5 Pages: 892-900
• [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes (2013)
  • Author(s): Kumpei Tanisawa, Eri Mikami, Noriyuki Fuku, Yoko Honda, Shuji Honda, Ikuro Ohsawa, Masafumi Ito, Shogo Endo, Kunio Ihara, Kinji Ohno, Yuki Kishimoto, Akihito Ishigami, Naoki Maruyama, Motoji Sawabe, Hiroyoshi Iseki, Yasushi Okazaki, Sanae Hasegawa-Ishii, Shiro Takei, Atsuyoshi Shimada, Masanori Hosokawa, Masayuki Mori, Keiichi Higuchi, Toshio Takeda, Mitsuru Higuchi, Masashi Tanaka
  • Journal Title: BMC Genomics Volume: 14: 1 Pages: 248-248
  • NAID: 120006651025
• [Journal Article] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status (2013)
  • Author(s): Eri Mikami
  • Journal Title: Scand J Med Sci Sports Volume: (Epub ahead of print)
  • DOI: 10.1111/j.1600-0838.2011.01424.x
  • Peer Reviewed
• [Journal Article] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers. (2013)
  • Author(s): Guan Wang
  • Journal Title: Med Sci Sports Exerc Volume: 45 Pages: 892-900
  • DOI: 10.1249/mss.0b013e31827c501f
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Exome sequencing of senescence-accelerated mice (sam) reveals deleterious mutations in degenerative disease-causing genes (2013)
  • Author(s): Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
  • Journal Title: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes Volume: 14(1): Pages: 1-15
  • DOI: 10.1186/1471-2164-14-248
  • NAID: 120006651025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An alternative model for the early peopling of southern South america revealed by analyses of three mitochondrial DNA haplogroups (2012)
  • Author(s): Michelle de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
  • Journal Title: PLoS One Volume: 7: 9 Pages: 9-9
• [Journal Article] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations (2012)
  • Author(s): Kenjiro Kami, Yasunori Fujita, Saori Igarashi, Sayaka Koike, Shoko Sugawara, Satsuki Ikeda, Naomi Sato, Masafumi Ito, Masashi Tanaka, Masaru Tomita, Tomoyoshi Soga
  • Journal Title: Mitochondrion Volume: 12: 6 Pages: 644-653
• [Journal Article] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2012)
  • Author(s): Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Noriyuki Fuku, Taku Ito, Eri Mikami, Ken Kitamura,Masashi Tanaka
  • Journal Title: J Hum Genet Volume: 57: 12 Pages: 772-775
  • NAID: 10031145884
• [Journal Article] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans (2012)
  • Author(s): Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J Szewczyk, Noriaki Ishioka, Shuji Honda
  • Journal Title: Sci Rep Volume: 2: 7
• [Journal Article] Association of 29C>T polymorphism in the transforming growth factor-61 gene with lean body mass in community-dwelling Japanese population (2012)
  • Author(s): Noriyuki Fuku, Seijiro Mori, Haruka Murakami, Yuko Gando, Heying Zhou, Hideki Ito, Masashi Tanaka, Motohiko Miyachi
  • Journal Title: Geriatr Gerontol Int Volume: 12: 2 Pages: 292-297
• [Journal Article] Synergistic effects of genetic variants of APOA5 and BTN2A1on dyslipidemia or metabolic syndrome (2012)
  • Author(s): Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • Journal Title: Int J Mol Med Volume: 30: 1 Pages: 185-192
• [Journal Article] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry (2012)
  • Author(s): M Deason, R Scott, L Irwin, V Macaulay, N Fuku, M Tanaka, R Irving, V Charlton, E Morrison, K Austin, Y P Pitsiladis
  • Journal Title: Scand J Med Sci Sports Volume: 22: 2 Pages: 217-223
• [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH Ela gene (2012)
  • Author(s): Yasutoshi Koga, Nataliya Povalko, Koujyu Katayama, Noriko Kakimoto, Toyojiro Matsuishi, Etsuo Naito, Masashi Tanaka
  • Journal Title: Brain Dev Volume: 34: 2 Pages: 87-91
• [Journal Article] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids:a potential therapeutic target for melatonin (2012)
  • Author(s): Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
  • Journal Title: J Pineal Res Volume: 52: 1 Pages: 93-106
• [Journal Article] Pyruvate therapy for mitochondrial DNA depletion syndrome (2012)
  • Author(s): Keiko Saito, Nobusuke Kimura, Nozomi Oda, Hideki Shimomura, Tomohiro Kumada, Tomoko Miyajima, Kei Murayama, Masashi Tanaka, Tatsuya Fujii
  • Journal Title: Biochim Biophys Acta Volume: 1820: 5 Pages: 632-636
• [Journal Article] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status (2012)
  • Author(s): E Mikami, N Fuku, H Takahashi, N Ohiwa, Y P Pitsiladis, M Higuchi, T Kawahara, M Tanaka
  • Journal Title: Scand J Med Sci Sports Jan
• [Journal Article] Mitochondrial macrohaplogroup associated with muscle power in healthy adults (2012)
  • Author(s): N Fuku, H Murakami, M Iemitsu, K Sanada, M Tanaka, M Miyachi
  • Journal Title: Int J Sports Med Volume: 33: 5 Pages: 410-414
• [Journal Article] Biochemistry of mitochondria, life and intervention 2010 (2012)
  • Author(s): Yasutoshi Koga, Masashi Tanaka, Shigeo Ohta, Yau-Huei Wei
  • Journal Title: Biochim Biophys Acta Volume: 1820: 5 Pages: 551-552
• [Journal Article] The mitochondrial T1095C mutation increases gentamicin-mediatedapoptosis (2012)
  • Author(s): Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
  • Journal Title: Mitochondrion Volume: 12: 4 Pages: 465-471
• [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene (2012)
  • Author(s): Koga Y, Povalko N, Katayama K, Kakimoto N, Matsuishi T, Naito E, Tanaka M
  • Journal Title: Brain Dev Volume: 34 Pages: 87-91
  • DOI: 10.1016/j.braindev.2011.03.003
  • NAID: 10031049678
  • Peer Reviewed
• [Journal Article] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin (2012)
  • Author(s): Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
  • Journal Title: J Pineal Res Volume: 52 Pages: 93-106
  • DOI: 10.1111/j.1600-079x.2011.00923.x
  • Peer Reviewed
• [Journal Article] An alternative model for the early peopling of southern South America revealed by analyses of three mitochondrial DNA haplogroups (2012)
  • Author(s): Michelle de de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0043486
  • Peer Reviewed
• [Journal Article] Association of 29C>T polymorphism in the transforming growth factor-beta1 gene with lean body mass in community-dwelling Japanese population (2012)
  • Author(s): Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
  • Journal Title: Geriatr Gerontol Int Volume: 12 Pages: 292-297
  • DOI: 10.1111/j.1447-0594.2011.00768.x
  • Peer Reviewed
• [Journal Article] The mitochondrial T1095C mutation increases gentamicin-mediated apoptosis (2012)
  • Author(s): Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
  • Journal Title: Mitochondrion Volume: 12 Pages: 465-471
  • DOI: 10.1016/j.mito.2012.06.006
  • Peer Reviewed
• [Journal Article] Extended Screening for Major Mitochondrial DNA Point Mutations in Patients with Hereditary Hearing Loss (2012)
  • Author(s): Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M.
  • Journal Title: J Hum Genet. Volume: 57 Pages: 772-5
  • DOI: 10.1038/jhg.2012.109
  • NAID: 10031145884
  • Peer Reviewed
• [Journal Article] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome (2012)
  • Author(s): Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • Journal Title: Int J Mol Med Volume: 30 Pages: 185-192
  • DOI: 10.3892/ijmm.2012.976
  • Peer Reviewed
• [Journal Article] Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans (2011)
  • Author(s): Yoko Honda, Yasunori Fujita, Hiroe Maruyama, Yoko Araki, Kenji Ichihara, Akira Sato, Toshio Kojima, Masashi Tanaka, Yoshinori Nozawa, Masafumi Ito, Shuji Honda
  • Journal Title: PLoS One Volume: 6: 8 Pages: 8-8
• [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • Author(s): Yoshiji Yamada, Tamotsu Nishida, Sahoko Ichihara, Motoji Sawabe, Noriyuki Fuku, Yutaka Nishigaki, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Fujiwara, Hiroto Yoshida, Shoji Shinkai, Kei Satoh, Kimihiko Kato, Tetsuo Fujimaki, Kiyoshi Yokoi, Mitsutoshi Oguri, Tetsuro Yoshida, Sachiro Watanabe, Yoshinori Nozawa, Aki Hasegawa, Toshio Kojima, Bok-Ghee Han, Younjin Ahn, Meehee Lee, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang
  • Journal Title: Atherosclerosis Volume: 215: 1 Pages: 145-152
• [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease (2011)
  • Author(s): Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
  • Journal Title: Int J Mol Med Volume: 27: 5 Pages: 745-752
• [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles (2011)
  • Author(s): Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
  • Journal Title: Mol Med Report Volume: 4: 3 Pages: 511-518
• [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals (2011)
  • Author(s): Hideki Horibe, Kimihiko Kato, Mitsutoshi Oguri, Tetsuro Yoshida, Tetsuo Fujimaki, Toshiki Kawamiya, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Toyoaki Murohara, Yoshiji Yamada
  • Journal Title: Am J Hypertens Volume: 24: 8 Pages: 924-929
• [Journal Article] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals (2011)
  • Author(s): M Hiramatsu, M Oguri, K Kato, T Yoshida, T Fujimaki, H Horibe, K Yokoi, S Watanabe, K Satoh, Y Aoyagi, M Tanaka, H Yoshida, S Shinkai, Y Nozawa, T Murohara, Y Yamada
  • Journal Title: Diabet Med Volume: 28: 11 Pages: 1381-1387
• [Journal Article] Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations (2011)
  • Author(s): Mitsutoshi Oguri, Kimihiko Kato, Tetsuro Yoshida, Tetsuo Fujimaki, Hideki Horibe, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Dong-jik Shin, Jon Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • Journal Title: J Med Genet Volume: 48: 11 Pages: 787-792
• [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • Author(s): Eri Mikami, Noriyuki Fuku, Hideyuki Takahashi, Nao Ohiwa, Robert A Scott, Yannis P Pitsiladis, Mitsuru Higuchi, Takashi Kawahara, Masashi Tanaka
  • Journal Title: Br J Sports Med Volume: 45: 15 Pages: 1179-1183
• [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients (2011)
  • Author(s): Motoji Sawabe, Masashi Tanaka, Kouji Chida, Tomio Arai, Yutaka Nishigaki, Noriyuki Fuku, Makiko Naka Mieno, Aya Kuchiba, Noriko Tanaka
  • Journal Title: J Atheroscler Thromb Volume: 18: 2 Pages: 166-175
  • NAID: 130004444492
• [Journal Article] Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity (2011)
  • Author(s): Yasuhiro Kitazoe, Hirohisa Kishino, Masami Hasegawa, Atsushi Matsui, Nick Lane, Masashi Tanaka
  • Journal Title: Genome Biol Evol Volume: 3 Pages: 1233-1244
• [Journal Article] Mitochondrial DNA analysis of Hokkaido Jomon skeletons: remnants of archaic maternal lineages at the southwestern edge of former Beringia (2011)
  • Author(s): Noboru Adachi, Ken-ichi Shinoda, Kazuo Umetsu, Takashi Kitano, Hirofumi Matsumura, Ryuzo Fujiyama, Junmei Sawada, Masashi Tanaka
  • Journal Title: Am J Phys Anthropol Volume: 146: 3 Pages: 346-360
• [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • Author(s): Mikami E, Fuku N, Takahashi H, Ohiwa N, Scott RA, Pitsiladis YP, Higuchi M, Kawahara T, Tanaka M
  • Journal Title: Br J Sports Med Volume: 45 Pages: 1179-1183
  • DOI: 10.1136/bjsm.2010.072371
  • Peer Reviewed
• [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : An autopsy study of 1,536 patients (2011)
  • Author(s): Sawabe M., et al.
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 166-175
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA analysis of Hokkaido Jomon skeletons : Remnants of archaic maternal lineages at the southwestern edge of former Beringia (2011)
  • Author(s): Adachi N., et al.
  • Journal Title: Am J Phys Anthropol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations (2011)
  • Author(s): Fujimaki T., et al.
  • Journal Title: Exp Ther Med Volume: 2 Pages: 745-749
  • Peer Reviewed
• [Journal Article] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry (2011)
  • Author(s): Deason M., et al.
  • Journal Title: Scand J Med Sci Sports Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • Author(s): Mikami E., et al.
  • Journal Title: Scand J Med Sci Sports Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E 1α gene (2011)
  • Author(s): Koga Y., et al.
  • Journal Title: Brain Dev Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals (2011)
  • Author(s): Hiramatsu M., et al.
  • Journal Title: Diabetic Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals (2011)
  • Author(s): Horibe H., et al.
  • Journal Title: Am J Hypertens Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus, or chronic kidney disease (2011)
  • Author(s): Yoshida T., et al.
  • Journal Title: Int J Mol Med Volume: 27 Pages: 745-752
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus (2011)
  • Author(s): Yoshida T., et al.
  • Journal Title: Mol Med Rep Volume: 4 Pages: 511-518
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A 1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus (2011)
  • Author(s): Yoshida T., et al.
  • Journal Title: Exp Ther Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • Author(s): Yamada Y., et al.
  • Journal Title: Atherosclerosis Volume: 215 Pages: 145-152
  • Peer Reviewed
• [Journal Article] 人類の遺伝的多様性と運動能力 (2011)
  • Author(s): 田中雅嗣
  • Journal Title: 体育の科学 Volume: 61 Pages: 351-356
• [Journal Article] ミトコンドリア病ならびにシトリン欠損症に対するピルビン酸ナトリウム療法 (2011)
  • Author(s): 田中雅嗣
  • Journal Title: 日本先天性代謝異常学会雑誌 Volume: 27 印刷中
  • NAID: 10031002727
• [Journal Article] Trehalose extends longevity in the nematode Caenorhabditis elegans (2010)
  • Author(s): Yoko Honda, Masashi Tanaka, Shuji Honda
  • Journal Title: Aging Cell Volume: 9: 4 Pages: 558-569
• [Journal Article] Redox regulation, gene expression and longevity (2010)
  • Author(s): Yoko Honda, Masashi Tanaka, Shuji Honda
  • Journal Title: Geriatr Gerontol Int Volume: 10 Suppl 1
  • NAID: 10027273063
• [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5KgammaActivity through Deacetylation of Specific LysineResidues in Mammals (2010)
  • Author(s): Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou
  • Journal Title: PLoS One Volume: 5: 7 Pages: 7-7
• [Journal Article] Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis (2010)
  • Author(s): Seijiro Mori, Noriyuki Fuku, Yuko Chiba, Fumiaki Tokimura, Takayuki Hosoi, Yoshiyuki Kimbara, Yoshiaki Tamura, Atsushi Araki, Masashi Tanaka, Hideki Ito
  • Journal Title: J Bone Miner Metab Volume: 28: 4 Pages: 446-450
• [Journal Article] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males (2010)
  • Author(s): Robert A Scott, Mark E S Bailey, Colin N Moran, Richard H Wilson, Noriyuki Fuku, Masashi Tanaka, Athanasios Tsiokanos, Athanasios Z Jamurtas, Evangelia Grammatikaki, George Moschonis, Yannis Manios, Yannis P Pitsiladis
  • Journal Title: Eur J Hum Genet Volume: 18: 12 Pages: 1339-1343
• [Journal Article] Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency (2010)
  • Author(s): Hirofumi Komaki, Yutaka Nishigaki, Noriyuki Fuku, Hiroko Hosoya, Kei Murayama, Akira Ohtake, Yu-Ichi Goto, Hiroyuki Wakamoto, Yasutoshi Koga, Masashi Tanaka
  • Journal Title: Biochim Biophys Acta Volume: 1800: 3 Pages: 313-315
• [Journal Article] Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease (2010)
  • Author(s): Noriko Tanaka, Yu-ichi Goto, Jun Akanuma, Mayuko Kato, Toru Kinoshita, Fumio Yamashita, Masashi Tanaka, Takashi Asada
  • Journal Title: Mitochondrion Volume: 10: 1 Pages: 32-37
• [Journal Article] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells (2010)
  • Author(s): Takamitsu Yano, Masashi Tanaka, Noboru Fukuda, Takuya Ueda, Hiroki Nagase
  • Journal Title: Int J Mol Med Volume: 25: 1 Pages: 153-158
• [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • Author(s): Yutaka Nishigaki, Hitomi Ueno, Jorida Coku, Yasutoshi Koga, Tatsuya Fujii, Ko Sahashi, Kazutoshi Nakano, Makoto Yoneda, Michiko Nonaka, Linya Tang, Chia-Wei Liou, Veronique Paquis-Flucklinger, Yasuo Harigaya, Tohru Ibi, Yu-ichi Goto, Hiroko Hosoya, Salvatore DiMauro, Michio Hirano, Masashi Tanaka
  • Journal Title: Mitochondrion Volume: 10: 3 Pages: 300-308
• [Journal Article] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • Author(s): Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Hitomi Ueno, Hiroko Hosoya, Taku Ito, Yurika Kimura, Ken Kitamura, Masashi Tanaka
  • Journal Title: J Hum Genet Volume: 55: 3 Pages: 147-154
  • NAID: 10030733907
• [Journal Article] Macrophages that survive hyperoxia exposure have higher superoxide dismutase activities in their mitochondria (2010)
  • Author(s): Kenichi Kokubo, Saki Soeda, Toshihiro Shinbo, Minoru Hirose, Noriyuki Fuku, Yutaka Nishigaki, Masashi Tanaka, Hirosuke Kobayashi
  • Journal Title: Adv Exp Med Biol Volume: 662 Pages: 63-69
• [Journal Article] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population (2010)
  • Author(s): Yutaka Nishigaki, Noriyuki Fuku, Masashi Tanaka
  • Journal Title: Geriatr Gerontol Int Volume: 10 Suppl 1
  • NAID: 10027274092
• [Journal Article] Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function (2010)
  • Author(s): I-Chien Wu, Ikuroh Ohsawa, Noriyuki Fuku, Masashi Tanaka
  • Journal Title: Ann N Y Acad Sci Volume: 1201 Pages: 111-120
• [Journal Article] Energy States in mitochondrial cardiomyopathy. In vivo functional imaging and L-arginine therapy (2010)
  • Author(s): Masamichi Ikawa, Makoto Yoneda, Masashi Tanaka
  • Journal Title: Circ J Volume: 74: 12 Pages: 2560-2561
  • NAID: 10027424125
• [Journal Article] Trehalose extends longevity in the nematode Caenorhabditis elegans (2010)
  • Author(s): Honda Y., et al.
  • Journal Title: Aging Cell Volume: 9 Pages: 145-152
  • Peer Reviewed
• [Journal Article] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population (2010)
  • Author(s): Nishigaki Y., et al.
  • Journal Title: Geriatr Gerontol Int Volume: 10 Suppl 1
  • Peer Reviewed
• [Journal Article] Redox regulation, gene expression and longevity (2010)
  • Author(s): Honda Y., et al.
  • Journal Title: Geriatr Gerontol Int Volume: 10 Suppl 1
  • Peer Reviewed
• [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • Author(s): Komaki H., et al.
  • Journal Title: Biochim Biophys Acta Volume: 1800 Pages: 313-315
  • Peer Reviewed
• [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • Author(s): Nishigaki Y., et al.
  • Journal Title: Mitochondrion Volume: 10 Pages: 300-308
  • Peer Reviewed
• [Journal Article] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • Author(s): Kato T., et al.
  • Journal Title: J Hum Genet Volume: 55 Pages: 300-308
  • Peer Reviewed
• [Journal Article] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells (2010)
  • Author(s): Yano T., et al.
  • Journal Title: Int J Mol Med Volume: 25 Pages: 153-158
  • Peer Reviewed
• [Journal Article] ミトコンドリアゲノム多型と健康・長寿 (2010)
  • Author(s): 福典之・田中雅嗣
  • Journal Title: 公衆衛生 Volume: 9 Pages: 754-760
• [Presentation] Mitochondrial DNA in human longevity and in age-associated diseases (2010)
  • Author(s): Tanaka M.
  • Organizer: The 6th Conference of Asian Society of Mitochondrial Research and Medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-12-17
• [Presentation] ピルビン酸療法 (2010)
  • Author(s): 田中雅嗣
  • Organizer: 第52回日本先天性代謝異常学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-22
• [Presentation] Mitopenia contributes to sarcopenia, osteopenia, diabetes, and metabolic syndrome : Practical approaches to verify this hypothesis (2010)
  • Author(s): Tanaka M.
  • Organizer: The 12th Asian-Pacific Conference of Clinical Biochemistry
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-04
• [Presentation] ミトコンドリアと光感受性 (2010)
  • Author(s): 田中雅嗣
  • Organizer: 第32回日本光医学・光生物学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-31
• [Remarks]
  • URL: http://publicationslist.org/masashi.tanaka
• [Remarks] Masashi Tanaka Journal articles
  • URL: http://publicationslist.org/masashi.tanaka
• [Remarks] Human Mitochondrial Genome Polymorphism Database
  • URL: http://mtsnp.tmig.or.jp/mtsnp/index_e.shtml
• [Remarks] 健康長寿ゲノム探索研究チーム
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/A40.html
• [Remarks]
  • URL: http://mtsnp.tmig.or.jp/mtsnp/index.shtml