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Genome-wide association study of elite sprint athletes

Research Project

Project/Area Number 22240072
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

TANAKA Masashi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)

Co-Investigator(Kenkyū-buntansha) FUKU Noriyuki  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (40392526)
Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2012: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2011: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2010: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Keywordsエネルギー代謝 / ゲノム全領域関連解析 / エクソン全領域関連解析 / ミトコンドリアゲノム多型 / 一塩基多型 / 全エクソン塩基配列解析 / 核ゲノム多型 / 瞬発系運動能力 / 陸上短距離走 / ジャマイカ人
Research Abstract

Elite human athletic performance is a multifactorial trait and previous candidate gene studies have been inconclusive. Three genome-wide association studies of elite Jamaican, African-American and Japanese sprint athletes and their matched controls were performed to identify common genetic variants associated with this elite trait. No SNPs exceeded the conventional GWAS significance threshold of 5 x 10-8 in the respective cohorts. Two SNPs within the GALNT13 (Pcombined = 4.66 x 10-7 for rs10196189) and the CREM genes (Pcombined= 1.88 x 10-6 for rs1531550) attained P < 2 x 10-6 after meta-analysis. Two putative loci for elite sprint performance across Jamaicans, African-Americans and Japanese sprinters have been discovered using a genome-wide association approach followed by meta-analysis. Further validation of these signals requires replication before functional dissection can be carried out.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (89 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (80 results) (of which Peer Reviewed: 30 results,  Open Access: 1 results) Presentation (4 results) Remarks (5 results)

  • [Journal Article] Efficacy of pyruvate therapy in patients with mitochondrial disease: A semi-quantitative clinical evaluation study2014

    • Author(s)
      Tatsuya Fujii, Fumihito Nozaki, Keiko Saito, Anri Hayashi, Yutaka Nishigaki, Kei Murayama, Masashi Tanaka, Yasutoshi Koga, Ikuko Hiejima, Tomohiro Kumada
    • Journal Title

      Molecular genetics and metabolism

      Volume: 112: 2 Pages: 133-138

    • Related Report
      2013 Final Research Report
  • [Journal Article] New MT-ND6 and NDUFA1 mutations in mitochondria respiratory chain disorders2014

    • Author(s)
      Natsumi Uehara, Masato Mori, Yoshimi Tokuzawa, Yosuke Mizuno, Shunsuke Tamaru, Masakazu Kohda, Yohsuke Moriyama, Yutaka Nakachi, Nana Matoba, Tetsuro Sakai, Taro Yamazaki, Hiroko Harashima, Kei Murayama, Keisuke Hattori, Jun-Ichi Hayashi, Takanori Yamagata, Yasunori Fujita, Masafumi Ito, Masashi Tanaka, Ken-ichi Nibu, Akira Ohtake, Yasushi Okazaki
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 1:5 Pages: 361-369

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evolution of mitochondrial power in vertebrate metazoans2014

    • Author(s)
      Yasuhiro Kitazoe, Masashi Tanaka
    • Journal Title

      PloS One

      Volume: 9: 6 Pages: 6-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for type 2 diabetes mellitus in non-diabetic Japanese men2014

    • Author(s)
      Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Ryuken Ise, Satomi Oshima, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
    • Journal Title

      Physiological genomics

    • Related Report
      2013 Final Research Report
  • [Journal Article] Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels2014

    • Author(s)
      Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
    • Journal Title

      Physiological genomics

      Volume: 46: 6 Pages: 207-215

    • Related Report
      2013 Final Research Report
  • [Journal Article] ACTN3 R577X genotype is associated with sprinting in elite Japanese athletes2014

    • Author(s)
      E Mikami, N Fuku, H Murakami, H Tsuchie, H Takahashi, N Ohiwa, H Tanaka, Y P Pitsiladis, M Higuchi, M Miyachi, T Kawahara, M Tanaka
    • Journal Title

      International journal of sports medicine

      Volume: 35: 2 Pages: 172-177

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers2013

    • Author(s)
      Guan Wang, Eri Mikami, Li-Ling Chiu, Alessandra DE Perini, Michael Deason, Noriyuki Fuku, Motohiko Miyachi, Koji Kaneoka, Haruka Murakami, Masashi Tanaka, Ling-Ling Hsieh, Sandy S Hsieh, Daniela Caporossi, Fabio Pigozzi, Alan Hilley, Rob Lee, Stuart D R Galloway, Jason Gulbin, Viktor A Rogozkin, Ildus I Ahmetov, Nan Yang, Kathryn N North, Saraslanidis Ploutarhos, Hugh E Montgomery, Mark E S Bailey, Yannis P Pitsiladis
    • Journal Title

      Med Sci Sports Exerc

      Volume: 45: 5 Pages: 892-900

    • Related Report
      2013 Final Research Report
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes2013

    • Author(s)
      Kumpei Tanisawa, Eri Mikami, Noriyuki Fuku, Yoko Honda, Shuji Honda, Ikuro Ohsawa, Masafumi Ito, Shogo Endo, Kunio Ihara, Kinji Ohno, Yuki Kishimoto, Akihito Ishigami, Naoki Maruyama, Motoji Sawabe, Hiroyoshi Iseki, Yasushi Okazaki, Sanae Hasegawa-Ishii, Shiro Takei, Atsuyoshi Shimada, Masanori Hosokawa, Masayuki Mori, Keiichi Higuchi, Toshio Takeda, Mitsuru Higuchi, Masashi Tanaka
    • Journal Title

      BMC Genomics

      Volume: 14: 1 Pages: 248-248

    • NAID

      120007100717

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers2013

    • Author(s)
      Guan Wang
    • Journal Title

      Med Sci Sports Exerc

      Volume: 45 Issue: 5 Pages: 892-900

    • DOI

      10.1249/mss.0b013e31827c501f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      BMC Genomics.

      Volume: 14(1): Issue: 1 Pages: 248-248

    • DOI

      10.1186/1471-2164-14-248

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An alternative model for the early peopling of southern South america revealed by analyses of three mitochondrial DNA haplogroups2012

    • Author(s)
      Michelle de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
    • Journal Title

      PLoS One

      Volume: 7: 9 Pages: 9-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations2012

    • Author(s)
      Kenjiro Kami, Yasunori Fujita, Saori Igarashi, Sayaka Koike, Shoko Sugawara, Satsuki Ikeda, Naomi Sato, Masafumi Ito, Masashi Tanaka, Masaru Tomita, Tomoyoshi Soga
    • Journal Title

      Mitochondrion

      Volume: 12: 6 Pages: 644-653

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss2012

    • Author(s)
      Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Noriyuki Fuku, Taku Ito, Eri Mikami, Ken Kitamura,Masashi Tanaka
    • Journal Title

      J Hum Genet

      Volume: 57: 12 Pages: 772-775

    • NAID

      10031145884

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans2012

    • Author(s)
      Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J Szewczyk, Noriaki Ishioka, Shuji Honda
    • Journal Title

      Sci Rep

      Volume: 2: 7

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Association of 29C>T polymorphism in the transforming growth factor-61 gene with lean body mass in community-dwelling Japanese population2012

    • Author(s)
      Noriyuki Fuku, Seijiro Mori, Haruka Murakami, Yuko Gando, Heying Zhou, Hideki Ito, Masashi Tanaka, Motohiko Miyachi
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12: 2 Pages: 292-297

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synergistic effects of genetic variants of APOA5 and BTN2A1on dyslipidemia or metabolic syndrome2012

    • Author(s)
      Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
    • Journal Title

      Int J Mol Med

      Volume: 30: 1 Pages: 185-192

    • Related Report
      2013 Final Research Report
  • [Journal Article] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry2012

    • Author(s)
      M Deason, R Scott, L Irwin, V Macaulay, N Fuku, M Tanaka, R Irving, V Charlton, E Morrison, K Austin, Y P Pitsiladis
    • Journal Title

      Scand J Med Sci Sports

      Volume: 22: 2 Pages: 217-223

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH Ela gene2012

    • Author(s)
      Yasutoshi Koga, Nataliya Povalko, Koujyu Katayama, Noriko Kakimoto, Toyojiro Matsuishi, Etsuo Naito, Masashi Tanaka
    • Journal Title

      Brain Dev

      Volume: 34: 2 Pages: 87-91

    • Related Report
      2013 Final Research Report
  • [Journal Article] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids:a potential therapeutic target for melatonin2012

    • Author(s)
      Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
    • Journal Title

      J Pineal Res

      Volume: 52: 1 Pages: 93-106

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pyruvate therapy for mitochondrial DNA depletion syndrome2012

    • Author(s)
      Keiko Saito, Nobusuke Kimura, Nozomi Oda, Hideki Shimomura, Tomohiro Kumada, Tomoko Miyajima, Kei Murayama, Masashi Tanaka, Tatsuya Fujii
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820: 5 Pages: 632-636

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status2012

    • Author(s)
      E Mikami, N Fuku, H Takahashi, N Ohiwa, Y P Pitsiladis, M Higuchi, T Kawahara, M Tanaka
    • Journal Title

      Scand J Med Sci Sports Jan

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial macrohaplogroup associated with muscle power in healthy adults2012

    • Author(s)
      N Fuku, H Murakami, M Iemitsu, K Sanada, M Tanaka, M Miyachi
    • Journal Title

      Int J Sports Med

      Volume: 33: 5 Pages: 410-414

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Biochemistry of mitochondria, life and intervention 20102012

    • Author(s)
      Yasutoshi Koga, Masashi Tanaka, Shigeo Ohta, Yau-Huei Wei
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820: 5 Pages: 551-552

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] The mitochondrial T1095C mutation increases gentamicin-mediatedapoptosis2012

    • Author(s)
      Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
    • Journal Title

      Mitochondrion

      Volume: 12: 4 Pages: 465-471

    • Related Report
      2013 Final Research Report
  • [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1a gene2012

    • Author(s)
      Koga Y, Povalko N, Katayama K, Kakimoto N, Matsuishi T, Naito E, Tanaka M
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 2 Pages: 87-91

    • DOI

      10.1016/j.braindev.2011.03.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin2012

    • Author(s)
      Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
    • Journal Title

      J Pineal Res

      Volume: 52 Issue: 1 Pages: 93-106

    • DOI

      10.1111/j.1600-079x.2011.00923.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An alternative model for the early peopling of southern South america revealed by analyses of three mitochondrial DNA haplogroups.2012

    • Author(s)
      Michelle de de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e43486-e43486

    • DOI

      10.1371/journal.pone.0043486

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 29C T Polymorphism in the Transforming Growth Factor-β1 Gene with Lean Body Mass in Community-Dwelling Japanese Population2012

    • Author(s)
      Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12 Issue: 2 Pages: 292-297

    • DOI

      10.1111/j.1447-0594.2011.00768.x

    • NAID

      10031147995

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mitochondrial T1095C mutation increases gentamicin-mediated apoptosis2012

    • Author(s)
      Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
    • Journal Title

      Mitochondrion

      Volume: 12 Issue: 4 Pages: 465-471

    • DOI

      10.1016/j.mito.2012.06.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss.2012

    • Author(s)
      Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M.
    • Journal Title

      J Hum Genet

      Volume: 57 Issue: 12 Pages: 772-775

    • DOI

      10.1038/jhg.2012.109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome2012

    • Author(s)
      Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
    • Journal Title

      Int J Mol Med

      Volume: 30 Pages: 185-192

    • DOI

      10.3892/ijmm.2012.976

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans2011

    • Author(s)
      Yoko Honda, Yasunori Fujita, Hiroe Maruyama, Yoko Araki, Kenji Ichihara, Akira Sato, Toshio Kojima, Masashi Tanaka, Yoshinori Nozawa, Masafumi Ito, Shuji Honda
    • Journal Title

      PLoS One

      Volume: 6: 8 Pages: 8-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations2011

    • Author(s)
      Yoshiji Yamada, Tamotsu Nishida, Sahoko Ichihara, Motoji Sawabe, Noriyuki Fuku, Yutaka Nishigaki, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Fujiwara, Hiroto Yoshida, Shoji Shinkai, Kei Satoh, Kimihiko Kato, Tetsuo Fujimaki, Kiyoshi Yokoi, Mitsutoshi Oguri, Tetsuro Yoshida, Sachiro Watanabe, Yoshinori Nozawa, Aki Hasegawa, Toshio Kojima, Bok-Ghee Han, Younjin Ahn, Meehee Lee, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang
    • Journal Title

      Atherosclerosis

      Volume: 215: 1 Pages: 145-152

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease2011

    • Author(s)
      Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
    • Journal Title

      Int J Mol Med

      Volume: 27: 5 Pages: 745-752

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles2011

    • Author(s)
      Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
    • Journal Title

      Mol Med Report

      Volume: 4: 3 Pages: 511-518

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals2011

    • Author(s)
      Hideki Horibe, Kimihiko Kato, Mitsutoshi Oguri, Tetsuro Yoshida, Tetsuo Fujimaki, Toshiki Kawamiya, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Toyoaki Murohara, Yoshiji Yamada
    • Journal Title

      Am J Hypertens

      Volume: 24: 8 Pages: 924-929

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals2011

    • Author(s)
      M Hiramatsu, M Oguri, K Kato, T Yoshida, T Fujimaki, H Horibe, K Yokoi, S Watanabe, K Satoh, Y Aoyagi, M Tanaka, H Yoshida, S Shinkai, Y Nozawa, T Murohara, Y Yamada
    • Journal Title

      Diabet Med

      Volume: 28: 11 Pages: 1381-1387

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations2011

    • Author(s)
      Mitsutoshi Oguri, Kimihiko Kato, Tetsuro Yoshida, Tetsuo Fujimaki, Hideki Horibe, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Dong-jik Shin, Jon Ho Lee, Yangsoo Jang, Yoshiji Yamada
    • Journal Title

      J Med Genet

      Volume: 48: 11 Pages: 787-792

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status2011

    • Author(s)
      Eri Mikami, Noriyuki Fuku, Hideyuki Takahashi, Nao Ohiwa, Robert A Scott, Yannis P Pitsiladis, Mitsuru Higuchi, Takashi Kawahara, Masashi Tanaka
    • Journal Title

      Br J Sports Med

      Volume: 45: 15 Pages: 1179-1183

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients2011

    • Author(s)
      Motoji Sawabe, Masashi Tanaka, Kouji Chida, Tomio Arai, Yutaka Nishigaki, Noriyuki Fuku, Makiko Naka Mieno, Aya Kuchiba, Noriko Tanaka
    • Journal Title

      J Atheroscler Thromb

      Volume: 18: 2 Pages: 166-175

    • NAID

      130004444492

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity2011

    • Author(s)
      Yasuhiro Kitazoe, Hirohisa Kishino, Masami Hasegawa, Atsushi Matsui, Nick Lane, Masashi Tanaka
    • Journal Title

      Genome Biol Evol

      Volume: 3 Pages: 1233-1244

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial DNA analysis of Hokkaido Jomon skeletons: remnants of archaic maternal lineages at the southwestern edge of former Beringia2011

    • Author(s)
      Noboru Adachi, Ken-ichi Shinoda, Kazuo Umetsu, Takashi Kitano, Hirofumi Matsumura, Ryuzo Fujiyama, Junmei Sawada, Masashi Tanaka
    • Journal Title

      Am J Phys Anthropol

      Volume: 146: 3 Pages: 346-360

    • Related Report
      2013 Final Research Report
  • [Journal Article] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status2011

    • Author(s)
      Eri Mikami
    • Journal Title

      Scand J Med Sci Sports

      Volume: (Epub ahead of print) Issue: 5 Pages: 593-599

    • DOI

      10.1111/j.1600-0838.2011.01424.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status2011

    • Author(s)
      Mikami E, Fuku N, Takahashi H, Ohiwa N, Scott RA, Pitsiladis YP, Higuchi M, Kawahara T, Tanaka M
    • Journal Title

      Br J Sports Med

      Volume: 45 Issue: 15 Pages: 1179-83

    • DOI

      10.1136/bjsm.2010.072371

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : An autopsy study of 1,536 patients2011

    • Author(s)
      Sawabe M., et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 166-175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA analysis of Hokkaido Jomon skeletons : Remnants of archaic maternal lineages at the southwestern edge of former Beringia2011

    • Author(s)
      Adachi N., et al.
    • Journal Title

      Am J Phys Anthropol

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations2011

    • Author(s)
      Fujimaki T., et al.
    • Journal Title

      Exp Ther Med

      Volume: 2 Pages: 745-749

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry2011

    • Author(s)
      Deason M., et al.
    • Journal Title

      Scand J Med Sci Sports

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups associated with elite Japanese athlete status2011

    • Author(s)
      Mikami E., et al.
    • Journal Title

      Scand J Med Sci Sports

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E 1α gene2011

    • Author(s)
      Koga Y., et al.
    • Journal Title

      Brain Dev

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals2011

    • Author(s)
      Hiramatsu M., et al.
    • Journal Title

      Diabetic Med

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals2011

    • Author(s)
      Horibe H., et al.
    • Journal Title

      Am J Hypertens

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus, or chronic kidney disease2011

    • Author(s)
      Yoshida T., et al.
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 745-752

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus2011

    • Author(s)
      Yoshida T., et al.
    • Journal Title

      Mol Med Rep

      Volume: 4 Pages: 511-518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A 1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus2011

    • Author(s)
      Yoshida T., et al.
    • Journal Title

      Exp Ther Med

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations2011

    • Author(s)
      Yamada Y., et al.
    • Journal Title

      Atherosclerosis

      Volume: 215 Pages: 145-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 人類の遺伝的多様性と運動能力2011

    • Author(s)
      田中雅嗣
    • Journal Title

      体育の科学

      Volume: 61 Pages: 351-356

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ミトコンドリア病ならびにシトリン欠損症に対するピルビン酸ナトリウム療法2011

    • Author(s)
      田中雅嗣
    • Journal Title

      日本先天性代謝異常学会雑誌

      Volume: 27 印刷中

    • NAID

      10031002727

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Trehalose extends longevity in the nematode Caenorhabditis elegans2010

    • Author(s)
      Yoko Honda, Masashi Tanaka, Shuji Honda
    • Journal Title

      Aging Cell

      Volume: 9: 4 Pages: 558-569

    • Related Report
      2013 Final Research Report
  • [Journal Article] Redox regulation, gene expression and longevity2010

    • Author(s)
      Yoko Honda, Masashi Tanaka, Shuji Honda
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • NAID

      10027273063

    • Related Report
      2013 Final Research Report
  • [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5KgammaActivity through Deacetylation of Specific LysineResidues in Mammals2010

    • Author(s)
      Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou
    • Journal Title

      PLoS One

      Volume: 5: 7 Pages: 7-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis2010

    • Author(s)
      Seijiro Mori, Noriyuki Fuku, Yuko Chiba, Fumiaki Tokimura, Takayuki Hosoi, Yoshiyuki Kimbara, Yoshiaki Tamura, Atsushi Araki, Masashi Tanaka, Hideki Ito
    • Journal Title

      J Bone Miner Metab

      Volume: 28: 4 Pages: 446-450

    • Related Report
      2013 Final Research Report
  • [Journal Article] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males2010

    • Author(s)
      Robert A Scott, Mark E S Bailey, Colin N Moran, Richard H Wilson, Noriyuki Fuku, Masashi Tanaka, Athanasios Tsiokanos, Athanasios Z Jamurtas, Evangelia Grammatikaki, George Moschonis, Yannis Manios, Yannis P Pitsiladis
    • Journal Title

      Eur J Hum Genet

      Volume: 18: 12 Pages: 1339-1343

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency2010

    • Author(s)
      Hirofumi Komaki, Yutaka Nishigaki, Noriyuki Fuku, Hiroko Hosoya, Kei Murayama, Akira Ohtake, Yu-Ichi Goto, Hiroyuki Wakamoto, Yasutoshi Koga, Masashi Tanaka
    • Journal Title

      Biochim Biophys Acta

      Volume: 1800: 3 Pages: 313-315

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease2010

    • Author(s)
      Noriko Tanaka, Yu-ichi Goto, Jun Akanuma, Mayuko Kato, Toru Kinoshita, Fumio Yamashita, Masashi Tanaka, Takashi Asada
    • Journal Title

      Mitochondrion

      Volume: 10: 1 Pages: 32-37

    • Related Report
      2013 Final Research Report
  • [Journal Article] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells2010

    • Author(s)
      Takamitsu Yano, Masashi Tanaka, Noboru Fukuda, Takuya Ueda, Hiroki Nagase
    • Journal Title

      Int J Mol Med

      Volume: 25: 1 Pages: 153-158

    • Related Report
      2013 Final Research Report
  • [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations2010

    • Author(s)
      Yutaka Nishigaki, Hitomi Ueno, Jorida Coku, Yasutoshi Koga, Tatsuya Fujii, Ko Sahashi, Kazutoshi Nakano, Makoto Yoneda, Michiko Nonaka, Linya Tang, Chia-Wei Liou, Veronique Paquis-Flucklinger, Yasuo Harigaya, Tohru Ibi, Yu-ichi Goto, Hiroko Hosoya, Salvatore DiMauro, Michio Hirano, Masashi Tanaka
    • Journal Title

      Mitochondrion

      Volume: 10: 3 Pages: 300-308

    • Related Report
      2013 Final Research Report
  • [Journal Article] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss2010

    • Author(s)
      Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Hitomi Ueno, Hiroko Hosoya, Taku Ito, Yurika Kimura, Ken Kitamura, Masashi Tanaka
    • Journal Title

      J Hum Genet

      Volume: 55: 3 Pages: 147-154

    • NAID

      10030733907

    • Related Report
      2013 Final Research Report
  • [Journal Article] Macrophages that survive hyperoxia exposure have higher superoxide dismutase activities in their mitochondria2010

    • Author(s)
      Kenichi Kokubo, Saki Soeda, Toshihiro Shinbo, Minoru Hirose, Noriyuki Fuku, Yutaka Nishigaki, Masashi Tanaka, Hirosuke Kobayashi
    • Journal Title

      Adv Exp Med Biol

      Volume: 662 Pages: 63-69

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population2010

    • Author(s)
      Yutaka Nishigaki, Noriyuki Fuku, Masashi Tanaka
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • NAID

      10027274092

    • Related Report
      2013 Final Research Report
  • [Journal Article] Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function2010

    • Author(s)
      I-Chien Wu, Ikuroh Ohsawa, Noriyuki Fuku, Masashi Tanaka
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1201 Pages: 111-120

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Journal Article] Energy States in mitochondrial cardiomyopathy. In vivo functional imaging and L-arginine therapy2010

    • Author(s)
      Masamichi Ikawa, Makoto Yoneda, Masashi Tanaka
    • Journal Title

      Circ J

      Volume: 74: 12 Pages: 2560-2561

    • NAID

      10027424125

    • Related Report
      2013 Final Research Report
  • [Journal Article] Trehalose extends longevity in the nematode Caenorhabditis elegans2010

    • Author(s)
      Honda Y., et al.
    • Journal Title

      Aging Cell

      Volume: 9 Pages: 145-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population2010

    • Author(s)
      Nishigaki Y., et al.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulation, gene expression and longevity2010

    • Author(s)
      Honda Y., et al.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations2010

    • Author(s)
      Komaki H., et al.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1800 Pages: 313-315

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations2010

    • Author(s)
      Nishigaki Y., et al.
    • Journal Title

      Mitochondrion

      Volume: 10 Pages: 300-308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss2010

    • Author(s)
      Kato T., et al.
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 300-308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells2010

    • Author(s)
      Yano T., et al.
    • Journal Title

      Int J Mol Med

      Volume: 25 Pages: 153-158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリアゲノム多型と健康・長寿2010

    • Author(s)
      福典之・田中雅嗣
    • Journal Title

      公衆衛生

      Volume: 9 Pages: 754-760

    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial DNA in human longevity and in age-associated diseases2010

    • Author(s)
      Tanaka M.
    • Organizer
      The 6th Conference of Asian Society of Mitochondrial Research and Medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ピルビン酸療法2010

    • Author(s)
      田中雅嗣
    • Organizer
      第52回日本先天性代謝異常学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitopenia contributes to sarcopenia, osteopenia, diabetes, and metabolic syndrome : Practical approaches to verify this hypothesis2010

    • Author(s)
      Tanaka M.
    • Organizer
      The 12th Asian-Pacific Conference of Clinical Biochemistry
    • Place of Presentation
      Seoul
    • Year and Date
      2010-10-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミトコンドリアと光感受性2010

    • Author(s)
      田中雅嗣
    • Organizer
      第32回日本光医学・光生物学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://publicationslist.org/masashi.tanaka

    • Related Report
      2013 Final Research Report
  • [Remarks] Masashi Tanaka Journal articles

    • URL

      http://publicationslist.org/masashi.tanaka

    • Related Report
      2011 Annual Research Report
  • [Remarks] Human Mitochondrial Genome Polymorphism Database

    • URL

      http://mtsnp.tmig.or.jp/mtsnp/index_e.shtml

    • Related Report
      2011 Annual Research Report
  • [Remarks] 健康長寿ゲノム探索研究チーム

    • URL

      http://www.tmig.or.jp/J_TMIG/j_research/A40.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://mtsnp.tmig.or.jp/mtsnp/index.shtml

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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