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Regulation of tumor growth via intracellular membrane compartments

Research Project

Project/Area Number 22240088
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor biology
Research InstitutionOsaka University

Principal Investigator

OKADA Masato  大阪大学, 微生物病研究所, 教授 (10177058)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2010: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Keywords腫瘍増殖 / シグナル伝達 / リソソーム / ラフト / mTOR / 足場タンパク質 / 細胞増殖 / がん化 / mTORC1 / オートファジー / MAPK / がん / エンドソーム / 脂質 / p18 / チロシンキナーゼ / がん遺伝子 / Src / 分子構造
Research Abstract

Tumor growth is promoted by persistent activation of growth signaling, which is caused by mutations of various proto-oncogenes. In this study, we investigated the function and regulation mechanisms of the major growth signaling pathways, the MAPK and mTOR pathways, via the scaffold protein p18 that is anchored to the surface of lysosomes. Using p18 knockout cells and mice, we found that p18 forms a regulatory complex (Ragulator) required for activation of mTORC1, and plays crucial roles in regulating cell growth, proliferation, differentiation, and tumor growth. We also clarified the roles of the p18-mTORC1 pathway in the regulation of cell cycle via the transcription factor FoxO3a and lysosome-mediated catabolism. These finding shed new lights on the roles of the intracellular membrane compartments, e.g. lysosomes, in the regulation of tumor promoting signaling.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (62 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results,  Open Access: 3 results) Presentation (33 results) Book (1 results) Remarks (2 results)

  • [Journal Article] The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase2014

    • Author(s)
      Mori S, Nada S, Kimura H, Tajima S, Takahashi Y, Kitamura A, Oneyama C, Okada M.
    • Journal Title

      PLos ONE

      Volume: 9(2) Issue: 2 Pages: e88891-e88891

    • DOI

      10.1371/journal.pone.0088891

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions2014

    • Author(s)
      Kajiwara K, Yamada T, Bamba T, Fukusaki E, Imamoto F, Okada M, Oneyama C.
    • Journal Title

      Biochem J.

      Volume: 458(1) Issue: 1 Pages: 81-93

    • DOI

      10.1042/bj20130527

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p18/LAMTOR1 : a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway2014

    • Author(s)
      Nada S, Mori S, Takahashi Y, Okada M.
    • Journal Title

      Methods Enzymol

      Volume: 535 Pages: 249-63

    • DOI

      10.1016/b978-0-12-397925-4.00015-8

    • ISBN
      9780123979254
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of NPC1L1 by ezetimibe activates autophagy in human hepatocyte and reduces mutant α1-antitrypsin Z deposition.2014

    • Author(s)
      Yamamura T, Ohsaki Y, Suzuki M, Shinohara Y, Tatematsu T, Cheng J, Okada M, Ohmiya N, Hirooka Y, Goto H, Fujimoto T
    • Journal Title

      Hepatology

      Volume: 59 Issue: 4 Pages: 1591-1599

    • DOI

      10.1002/hep.26930

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes2013

    • Author(s)
      Soma-Nagae T, Nada S, Kitagawa M, Takahashi Y, Mori S, Oneyama C, Okada M
    • Journal Title

      J Cell Sci 2013

      Volume: 126(Pt 16) Pages: 3575-84

    • DOI

      10.1242/jcs.121913

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression2013

    • Author(s)
      Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
    • Journal Title

      PLos ONE 2013

      Volume: 8(11) Issue: 11 Pages: e80300-e80300

    • DOI

      10.1371/journal.pone.0080300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains2013

    • Author(s)
      Tanaka H, Akagi K, Oneyama C, Tanaka M, Sasaki Y, Kanou T, Lee YH, Yokogawa D, Dobenecker MW, Nakagawa A, Okada M, Ikegami T
    • Journal Title

      J Biol Chem 2013

      Volume: 288(21) Issue: 21 Pages: 15240-54

    • DOI

      10.1074/jbc.m112.439075

    • NAID

      120006770869

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] p18/LAMTOR1: a late endosome/ lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway2013

    • Author(s)
      Nada S
    • Journal Title

      Methods Enzymology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes2012

    • Author(s)
      Takahashi Y, Nada S, Mori S, Soma-Nagae T, Oneyama C, Okada M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417(4) Issue: 4 Pages: 1151-7

    • DOI

      10.1016/j.bbrc.2011.12.082

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Src family kinases by Csk2012

    • Author(s)
      Okada M
    • Journal Title

      Int J Bio. Sci

      Volume: 8(10) Issue: 10 Pages: 1385-97

    • DOI

      10.7150/ijbs.5141

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression2012

    • Author(s)
      Oneyama C, Morii E, Okuzaki D, Takahashi Y, Ikeda J, Wakabayashi N, Akamatsu H, Tsujimoto M, Nishida T, Aozasa K, Okada M
    • Journal Title

      Oncogene 2012

      Volume: 31(13) Issue: 13 Pages: 1623-35

    • DOI

      10.1038/onc.2011.367

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans2012

    • Author(s)
      Masuda H, Nakamura, Takata N, Itoh B, Hirose T, Moribe H, Mekada E, Okada M
    • Journal Title

      FEBS Lett 2012

      Volume: 586(6) Issue: 6 Pages: 740-6

    • DOI

      10.1016/j.febslet.2012.01.031

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the SRC family kinases by Csk.2012

    • Author(s)
      Okada M
    • Journal Title

      Int J Biol Sci

      Volume: 8 Pages: 1385-1397

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation2011

    • Author(s)
      Kuroiwa, Oneyama C, Nada S, Okada M
    • Journal Title

      J Cell Sci 2011

      Volume: 124(Pt 10) Issue: 10 Pages: 1726-38

    • DOI

      10.1242/jcs.080291

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of the tumor suppressor Cbp/PAG1 is mediated by epigenetic histone modifications via the MAPK/ PI3K pathway2011

    • Author(s)
      Suzuki K, Oneyama C, Kimura H, Tajima S, Okada M
    • Journal Title

      J Biol Chem 2011

      Volume: 286(18) Issue: 18 Pages: 15698-706

    • DOI

      10.1074/jbc.m110.195362

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways2011

    • Author(s)
      Oneyama C, Ikeda J, Okuzaki D, Suzuki K, Kanou T, Shintani Y, Morii E, Okumura M, Aozasa K, Okada M
    • Journal Title

      Oncogene 2011

      Volume: 30(32) Issue: 32 Pages: 3489-501

    • DOI

      10.1038/onc.2011.63

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway2011

    • Author(s)
      Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K
    • Journal Title

      J Biol Chem 2011

      Volume: 286(37) Issue: 37 Pages: 32651-60

    • DOI

      10.1074/jbc.m111.238014

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation2011

    • Author(s)
      Kanou T, Oneyama C, Kawahara K, Okimura A, Ohta M, Ikeda N, Shintani Y, Okumura M, Okada M
    • Journal Title

      Mol Cancer Res

      Volume: 9(1) Issue: 1 Pages: 103-14

    • DOI

      10.1158/1541-7786.mcr-10-0340

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of the tumor suppressor Cbp/PAG1 is mediated by epigenetic histone modifications via the MAPK/PI3K pathway.2011

    • Author(s)
      Oneyama C
    • Journal Title

      J.Biol.Chem.

      Volume: (印刷中 未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated downregulation of mTOR/FGFR3 contros tumor growth induced by Src-related oncogenic pathways.2011

    • Author(s)
      Oneyama C
    • Journal Title

      Oncogene

      Volume: (印刷中 未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A guanine nucleotide exchange factor Arhgef5 plays crucial roles in c-Src-induced podosome formation.2011

    • Author(s)
      Kuroiwa M
    • Journal Title

      J.Cell.Sci

      Volume: (印刷中 未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.2011

    • Author(s)
      Mukai E
    • Journal Title

      Diabetes

      Volume: 60 Pages: 218-226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of functional domains and novel binding partners of STIM proteins.2011

    • Author(s)
      Saitoh N
    • Journal Title

      J.Cell Biochem.

      Volume: 112 Pages: 147-156

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transmembrane adaptor Cbp/PAG1 controls the malignant potential of huma non-small cell lung cancers that have c-src upregulation.2011

    • Author(s)
      Kanou T
    • Journal Title

      Mol.Cancer Res.

      Volume: 9 Pages: 103-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional transition of Pak proto-oncogene during early evolution of metazoans.2010

    • Author(s)
      Watari A
    • Journal Title

      Oncogene

      Volume: 29 Pages: 3815-3826

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.2010

    • Author(s)
      Hikita T
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 1051-1062

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] リソソーム上の mTORキナーゼを介する細胞の分化増殖制御2013

    • Author(s)
      岡田雅人
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] リソソームタンパク質動態の網羅的解析2013

    • Author(s)
      森俊介
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      愛知県産業労働センター
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2013

    • Author(s)
      梶原健太郎、小根山千歳、岡田雅人
    • Organizer
      がん研究分野の特性等を踏まえた支援活動公開シンポジウム
    • Place of Presentation
      学術総合センター
    • Year and Date
      2013-01-30
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス表皮形成には p18-mTORC1経路を介したリソソーム代謝が必要である2012

    • Author(s)
      長江多恵子、北川真理、名田茂之、森俊介、高橋祐介、岡田雅人
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞膜ミクロドメイン "脂質ラフト"を介した c-Srcがん形質発現シグナル制御機構の解明2012

    • Author(s)
      吉川由利子、小根山千歳、飯野琢也、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Alteration of ceramide metabolism is required for c-Src redistribution to focal adhesions and following activation of signal transduction pathways during cell transformation2012

    • Author(s)
      Kentaro Kajiwara, Chitose Oneyama, Masato Okada
    • Organizer
      The 4th EMBO meeting
    • Place of Presentation
      Nice Acropolis, France
    • Year and Date
      2012-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス表皮形成にはp18-mTORC1経路を介したリソソーム代謝が必要である2012

    • Author(s)
      長江 多恵子
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Src活性化に伴うセラミドの増加はがん形質発現を促進する2012

    • Author(s)
      梶原健太郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞膜ミクロドメイン脂質ラフトを介したc-Srcがん形質発現シグナル制御機構の解明2012

    • Author(s)
      吉川由利子
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of c-Src-induced oncogenic pathways via membrane microdomain2012

    • Author(s)
      吉川由利子
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞増殖における後期エンドソームアンタータンパク質 p18の役割2011

    • Author(s)
      森俊介、小根山千歳、名田茂之、岡田雅人
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] スフィンゴミエリン分解酵素nSMase2によるがん形質発現制御機構の解析2011

    • Author(s)
      安藤雄哉
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞増殖における後期エンドソームアンタータンパク質p18の役割2011

    • Author(s)
      森俊介
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolic alteration of lipid components in membrane microdomain by c-Src-induced transformation2011

    • Author(s)
      Kentaro Kajiwara, Chitose Oneyama, Fumio Imamoto, Masato Okada
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] LAMTOR1(p18) is required for epidermal barrier formation2011

    • Author(s)
      Taeko Soma-Nagae, Mari Kitagawa, Shigeyuki Nada, Kentaro Kajiwara, Masato Okada
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] LAMTOR1(p18)is required for epidermal barrier formation2011

    • Author(s)
      Soma-Nagae T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍増殖における後期エンドソーム -MAPKアンカータンパク質 p18の役割2011

    • Author(s)
      森俊介、小根山千歳、岡田雅人
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍増殖における後期エンドソーム-MAPKアンカータンパク質p18の役割2011

    • Author(s)
      森俊介
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 後期エンドソーム膜上蛋白 LAMTOR1の表皮バリア形成への必要不可欠性2011

    • Author(s)
      長江(相馬)多恵子、名田茂之、北川真理、高橋佑介、森俊介、岡田雅人
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 後期エンドソーム膜上蛋白LAMTOR1の表皮バリア形成への必要不可欠性2011

    • Author(s)
      長江(相馬)多恵子
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] The late endosomal signaling of mTOR and MAPK takes differential roles in the cellular proliferation and the membrane trafficking2011

    • Author(s)
      Shigeyuki Nada, Shunsuke Mori, Taeko Soma-Nagae, Yusuke Takahashi, Masato Okada
    • Organizer
      第63回日本細胞生物学会大
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] The late endosomal signaling of mTOR and MAPK takes differential roles in the cellular proliferation and the membrane trafficking2011

    • Author(s)
      Nada S
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] c-Srcによるがん化の初期シグナル解析Analysis of early-phase signals in c-Src-mediated cell transformation2010

    • Author(s)
      赤松元輝
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍増殖における後期エンドソーム -MAPKアンカータンパク質 p18の役割2010

    • Author(s)
      森俊介、小根山千歳、名田茂之、岡田雅人
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Srcによるがん形質発現のmicroRNAによる調節機構(MicroRNA involvement in c-Src-induced transformation)2010

    • Author(s)
      小根山千歳
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍細胞増殖における後期エンドソーム-MAPKアンカータンパクp18の役割(Role of the late endosomal MAPK anchoring protein p18 in tumor growth)2010

    • Author(s)
      森俊介
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Srcによるポドソーム(浸潤突起)形成の分子メカニズム(Molecular mechanisms of Src-mediated podosome/Invadopodia formation)2010

    • Author(s)
      黒岩美帆
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍細胞増殖における後期エンドソーム-MAPKアンカータンパクp18の役割(Role of the late endosomal MAPK anchoring protein p18 in tumor growth)2010

    • Author(s)
      森俊介
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] リソソームタンパク質動態の網羅的解析

    • Author(s)
      森俊介
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      愛知県産業労働センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] mTORC1アンカーp18によるリソソームの機能制御

    • Author(s)
      岡田雅人
    • Organizer
      第5回シグナルネットワーク研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] mTORC1アンカーp18による細胞増殖制御

    • Author(s)
      森俊介、岡田雅人
    • Organizer
      第5回シグナルネットワーク研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] リソソーム上のmTORキナーゼを介する細胞の分化増殖制御

    • Author(s)
      岡田雅人
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Book] 「タンパク質実験ノート」改訂第4版2011

    • Author(s)
      岡田雅人、宮崎香編
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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