Development of immuno-stimulatory antibody therapy against cancer

• Project/Area Number: 22240089
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Juntendo University
• Principal Investigator: YAGITA Hideo 順天堂大学, 医学部, 先任准教授 (30182306)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2011: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2010: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
• Keywords: がん / 免疫 / 抗体療法 / キラーT細胞 / 4-1BB / CD27 / CTLA-4 / PD-1 / TIM-3 / Fn14 / MFG-E8 / aV integrin / HMGB1 / IL-13Rα2 / αVβ3インテグリン / ErbB-2 / DR5 / CD40 / Notch2 / OX40

Research Abstract

We have developed novel strategies to induce immunogenic cell death of cancer cells. We have also developed novel strategies to augment anti-tumor immunity by using antibodies activating the immunostimulatory pathways (such as 4-1BB, CD27, and Notch2) and those blocking the immunosuppressive pathways (such as CTLA-4, PD-1, TIM-3) in combination with standard chemotherapy, radiotherapy, and antibody therapy targeting cancer cells.

Research Products

• [Journal Article] Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo (2013)
  • Author(s): Yasuda S
  • Journal Title: Clin Exp Immunol Volume: 172 Issue: 3 Pages: 500-6
  • DOI: 10.1111/cei.12069
  • Peer Reviewed
• [Journal Article] Host immunity contributes to the anti-melanoma activity of BRAF inhibitors (2013)
  • Author(s): Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Greber TG, Ribas A, McArthur GA, Smyth MJ
  • Journal Title: J Cin Inves Volume: 123 Issue: 3 Pages: 1371-1381
  • DOI: 10.1172/jci66236
  • Peer Reviewed
• [Journal Article] Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas (2013)
  • Author(s): Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
  • Journal Title: Cancer Immunol Immunother Volume: 62 Issue: 4 Pages: 629-637
  • DOI: 10.1007/s00262-012-1371-9
  • Peer Reviewed
• [Journal Article] The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment (2013)
  • Author(s): Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB,Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG
  • Journal Title: J Invest Dermatol Volume: 133 Pages: 1052-1062
  • Peer Reviewed
• [Journal Article] Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T cell tolerance (2013)
  • Author(s): Berrien-Elliott MM, Jackson SR, Meyer JM, Rouskey CJ, Nguyen TL, Yagita H, Greenberg P, Dipaolo RJ, Teague RM
  • Journal Title: Cancer Res Volume: 73 Issue: 2 Pages: 605-616
  • DOI: 10.1158/0008-5472.can-12-2179
  • Peer Reviewed
• [Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia. (2013)
  • Author(s): Kuroda I
  • Journal Title: Oncogene Volume: 32 Issue: 13 Pages: 1670-1681
  • DOI: 10.1038/onc.2012.186
  • Peer Reviewed
• [Journal Article] The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment. (2013)
  • Author(s): Zhou H
  • Journal Title: J Invest Dermatol Volume: 133 Issue: 4 Pages: 1052-1062
  • DOI: 10.1038/jid.2012.402
  • Peer Reviewed
• [Journal Article] Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy (2012)
  • Author(s): Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G
  • Journal Title: Blood Volume: 120 Issue: 11 Pages: 2229-2239
  • DOI: 10.1182/blood-2011-12-398321
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S. (2012)
  • Author(s): Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
  • Journal Title: Nat. Immunol. Volume: 13 Issue: 9 Pages: 832-842
  • DOI: 10.1038/ni.2376
  • Peer Reviewed
• [Journal Article] The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions (2012)
  • Author(s): Feau S, Garcia Z, Arens R, Yagita H, Borst J, Schoenberger SP
  • Journal Title: Nat Commun Volume: 3 Issue: 1 Pages: 948-948
  • DOI: 10.1038/ncomms1948
  • Peer Reviewed
• [Journal Article] Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation (2012)
  • Author(s): Gupta A, Probst HC, Vuong V, Landshammer A, Muth S, Yagita H, Schwendener R, Pruschy M, Knuth A, van den Broek M
  • Journal Title: J Immunol Volume: 189 Issue: 2 Pages: 558-566
  • DOI: 10.4049/jimmunol.1200563
  • Peer Reviewed
• [Journal Article] Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies (2012)
  • Author(s): Verbrugge I, Hagekyriakou J, Sharp LL, Galli M, West AC, McLaughlin NM, Duret H, Yagita H, Johnstone RW, Smyth MJ, Haynes NM
  • Journal Title: Cancer Res Volume: 72 Issue: 13 Pages: 3163-3174
  • DOI: 10.1158/0008-5472.can-12-0210
  • Peer Reviewed
• [Journal Article] Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells (2012)
  • Author(s): Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
  • Journal Title: Cancer Res Volume: 72 Issue: 11 Pages: 2757-2767
  • DOI: 10.1158/0008-5472.can-11-3379
  • Peer Reviewed
• [Journal Article] Induction of pro-apoptotic antibodies to triple negative breast cancer by vaccination with TRAIL death receptor DR5 DNA (2012)
  • Author(s): Piechocki MP, Wu GS, Jones RF, Jacob JB, Gibson H, Ethier SP, Abrams1 J, Yagita H, Venuprasad K, Wei WZ
  • Journal Title: Int J Cancer Volume: 131 Issue: 11 Pages: 2562-2572
  • DOI: 10.1002/ijc.27534
  • Peer Reviewed
• [Journal Article] ATM-mediated DNA damage signals mediate immune escape through integrin αvβ3-dependent mechanisms. (2012)
  • Author(s): Jinushi M
  • Journal Title: Cancer Res Volume: 72 Issue: 1 Pages: 56-65
  • DOI: 10.1158/0008-5472.can-11-2028
  • Peer Reviewed
• [Journal Article] Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction (2012)
  • Author(s): Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
  • Journal Title: Aging Cell Volume: 11 Issue: 1 Pages: 128-138
  • DOI: 10.1111/j.1474-9726.2011.00764.x
  • Peer Reviewed
• [Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment (2012)
  • Author(s): Ishihara M, Heissig B, Nishida C, Rosenkvist J, Tashiro Y, Ohki M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K
  • Journal Title: Leukemia Volume: 26 Issue: 2 Pages: 332-339
  • DOI: 10.1038/leu.2011.203
  • Peer Reviewed
• [Journal Article] CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8+ T cell memory in the absence of CD4+ T cell help. (2012)
  • Author(s): Dong H
  • Journal Title: J Immunol Volume: 188 Issue: 8 Pages: 3829-3838
  • DOI: 10.4049/jimmunol.1103329
  • Peer Reviewed
• [Journal Article] Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. (2012)
  • Author(s): Elyaman W
  • Journal Title: Immunity Volume: 36 Issue: 4 Pages: 623-634
  • DOI: 10.1016/j.immuni.2012.01.020
  • Peer Reviewed
• [Journal Article] Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. (2012)
  • Author(s): Zhang X
  • Journal Title: Leukemia Volume: 26 Issue: 12 Pages: 2483-2493
  • DOI: 10.1038/leu.2012.139
  • Peer Reviewed
• [Journal Article] A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. (2012)
  • Author(s): Baumgartner CK
  • Journal Title: J Immunol Volume: 189 Issue: 5 Pages: 2309-2317
  • DOI: 10.4049/jimmunol.1200453
  • Peer Reviewed
• [Journal Article] PD-1 blockade enhances T cell migration to tumors by elevating IFN-γ inducible chemokines. (2012)
  • Author(s): Peng W
  • Journal Title: Cancer Res Volume: 72 Issue: 20 Pages: 5209-5218
  • DOI: 10.1158/0008-5472.can-12-1187
  • Peer Reviewed
• [Journal Article] Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment (2012)
  • Author(s): Ishihara M, et al
  • Journal Title: Leukemia Volume: 26 Pages: 332-339
  • Peer Reviewed
• [Journal Article] Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells (2011)
  • Author(s): Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
  • Journal Title: J Biol Chem Volume: 286 Issue: 50 Pages: 43383-43393
  • DOI: 10.1074/jbc.m111.309377
  • Peer Reviewed
• [Journal Article] Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells (2011)
  • Author(s): Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.
  • Journal Title: Proc Natl Acad Sci USA Volume: 108巻 Issue: 30 Pages: 12425-30
  • DOI: 10.1073/pnas.1106645108
  • NAID: 10030575946
  • Peer Reviewed
• [Journal Article] IL-18 induces PD-1-dependent immunosuppression in cancer (2011)
  • Author(s): Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye NF, Viaud S, Ryffel B, Yagita H, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Chaput N, Zitvogel L
  • Journal Title: Cancer Res Volume: 71 Issue: 16 Pages: 5412-5422
  • DOI: 10.1158/0008-5472.can-11-0993
  • Peer Reviewed
• [Journal Article] Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells (2011)
  • Author(s): Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, Winkles JA
  • Journal Title: Mol Cancer Ther Volume: 10 Pages: 1276-1288
  • Peer Reviewed
• [Journal Article] Combination of lentivector immunization and low dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity (2011)
  • Author(s): Sierro SR, Donda A, Perret R, Guillaume P, Yagita H, Levy F, Romero P
  • Journal Title: Eur J Immunol Volume: 41 Issue: 8 Pages: 2217-2228
  • DOI: 10.1002/eji.201041235
  • Peer Reviewed
• [Journal Article] TLR2-dependent induction of IL-10 and Foxp3+CD25+CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo. (2011)
  • Author(s): Yamazaki, S., K. Okada, A. Maruyama, M. Matsumoto, and T. Seya.
  • Journal Title: PLoS ONE. Volume: 6(4) Issue: 4 Pages: e18833-e18833
  • DOI: 10.1371/journal.pone.0018833
  • Peer Reviewed
• [Journal Article] Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy (2011)
  • Author(s): Stagg J, Loi S, Divisekera U, Ngiow SF, Duret H, Yagita H, Teng MW, Smyth MJ
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 17 Pages: 7142-7147
  • DOI: 10.1073/pnas.1016569108
  • Peer Reviewed
• [Journal Article] FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer (2011)
  • Author(s): Watkins SK, Zhu Z, Riboldi E, Shafer-Weaver KA, Stagliano KE, Sklavos MM, Ambs S, Yagita H, Hurwitz AA
  • Journal Title: J Clin Invest Volume: 121 Issue: 4 Pages: 1361-1372
  • DOI: 10.1172/jci44325
  • Peer Reviewed
• [Journal Article] Anti-TIM3 antibody promotes T cell IFN-γ-mediated anti-tumor immunity and suppresses established tumors (2011)
  • Author(s): Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
  • Journal Title: Cancer Res Volume: 71 Issue: 10 Pages: 3540-3551
  • DOI: 10.1158/0008-5472.can-11-0096
  • Peer Reviewed
• [Journal Article] Epigenetic modulation enhances the therapeutic effect of anti-IL13Ralpha2 antibody in human mesothelioma xenografts (2011)
  • Author(s): Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H, Kato K
  • Journal Title: Clin Cancer Res Volume: 17 Issue: 9 Pages: 2819-2829
  • DOI: 10.1158/1078-0432.ccr-10-2986
  • Peer Reviewed
• [Journal Article] Anti-tumor activities and on-target toxicities mediated by TRAIL receptor agonist following co-treatment with panobinostat (2011)
  • Author(s): Martin BP, J Frew A, Bots M, Fox S, Long F, Takeda K, Yagita H, Atadja P, Smyth MJ, Johnstone RW
  • Journal Title: Int J Cancer Volume: 128 Issue: 11 Pages: 2735-2747
  • DOI: 10.1002/ijc.25594
  • Peer Reviewed
• [Journal Article] Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer (2011)
  • Author(s): Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, Takayama T, Matsumoto S, Wakatsuki K, Migita K, Yagita H, Nakajima Y
  • Journal Title: Exp Ther Med Volume: 2 Pages: 103-108
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22977477
  • Peer Reviewed
• [Journal Article] Anti-tumor activities and oil-target toxicities mediated by TRAIL receptor agonist following co-treatment with panobinostat (2011)
  • Author(s): Martin BP, et al
  • Journal Title: Int J Cancer Volume: 128 Pages: 2735-2747
  • Peer Reviewed
• [Journal Article] The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants (2011)
  • Author(s): Thangavelu G, et al
  • Journal Title: Immunobiology Volume: 216 Pages: 918-924
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis (2011)
  • Author(s): Zhang X, et al
  • Journal Title: Leuk Res Volume: 35 Pages: 940-949
  • Peer Reviewed
• [Journal Article] Bone marrow-derived endothelial progenitors expressing delta-like 4 (dll4) regulate tumor angiogenesis (2011)
  • Author(s): Real C, et al
  • Journal Title: PLoS One Volume: 6(4) Issue: 4 Pages: e18323-e18323
  • DOI: 10.1371/journal.pone.0018323
  • Peer Reviewed
• [Journal Article] CD70 is selectively expressed on Th1 but not Th2 cells and is required for Th1-type immune responses (2011)
  • Author(s): Kawamura T, et al
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 1252-1261
  • Peer Reviewed
• [Journal Article] Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice (2011)
  • Author(s): Gaspal FM, et al
  • Journal Title: J Exp Med Volume: 208 Pages: 1579-1584
  • Peer Reviewed
• [Journal Article] Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization (2010)
  • Author(s): Zhou Q, Xiao H, Liu Y, Peng Y, Hong Y, Yagita H, Chandler P, Munn DH, Mellor A, Fu N, He Y
  • Journal Title: J Immunol Volume: 185 Issue: 9 Pages: 5082-5092
  • DOI: 10.4049/jimmunol.1001821
  • Peer Reviewed
• [Journal Article] Spatiotemporal basis of CTLA-4-mediated negative regulation of T-cell activation (2010)
  • Author(s): Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Yagita H, Tokunaga M, Saito T
  • Journal Title: Immunity Volume: Vol.33 Issue: 3 Pages: 326-339
  • DOI: 10.1016/j.immuni.2010.09.006
  • Peer Reviewed
• [Journal Article] Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence,and reduced PD-1 expression of tumor infiltrating CD8+ T cells (2010)
  • Author(s): Roberts DJ, Franklin NA, Kingeter LM, Yagita H, Tutt AL, Glennie MJ, Bullock TN
  • Journal Title: J Immunother Volume: 33 Issue: 8 Pages: 769-779
  • DOI: 10.1097/cji.0b013e3181ee238f
  • Peer Reviewed
• [Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells (2010)
  • Author(s): Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
  • Journal Title: J Immunol Volume: 185 Issue: 6 Pages: 3768-3776
  • DOI: 10.4049/jimmunol.0903649
  • Peer Reviewed
• [Journal Article] Darcy PK, Smyth MJ: CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors (2010)
  • Author(s): Haynes NM, Hawkins ED, Li M, McLaughlin NM, Hammerling GJ, Schwendener R, Winoto A, Wensky A, Yagita H, Takeda K, Kershaw MH
  • Journal Title: J Immunol Volume: 185 Issue: 1 Pages: 532-541
  • DOI: 10.4049/jimmunol.0903624
  • Peer Reviewed
• [Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules (2010)
  • Author(s): Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MWL, Yoshizawa H, Yagita H, Geyjo F, Okumura K, Smyth MJ
  • Journal Title: J Immunol Volume: 184 Issue: 10 Pages: 5493-5501
  • DOI: 10.4049/jimmunol.0903033
  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo (2010)
  • Author(s): Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K
  • Journal Title: J Immunol Volume: 184 Issue: 9 Pages: 4673-4678
  • DOI: 10.4049/jimmunol.0903661
  • Peer Reviewed
• [Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors (2010)
  • Author(s): Lee S, Yagita H, Sayers TJ, Celis E
  • Journal Title: Cancer Immunol Immunother Volume: 59 Issue: 7 Pages: 1073-1081
  • DOI: 10.1007/s00262-010-0834-0
  • Peer Reviewed
• [Journal Article] lockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer (2010)
  • Author(s): Oishi H, Sunamura M. Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H
  • Journal Title: Pancreas Volume: 39 Issue: 6 Pages: 897-903
  • DOI: 10.1097/mpa.0b013e3181ce7185
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice (2010)
  • Author(s): Sakanishi T, Yagita H
  • Journal Title: Biochem Biophys Res Commun Volume: 393 Issue: 4 Pages: 829-835
  • DOI: 10.1016/j.bbrc.2010.02.092
  • Peer Reviewed
• [Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts (2010)
  • Author(s): Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP
  • Journal Title: J Exp Med Volume: 207 Issue: 3 Pages: 637-650
  • DOI: 10.1084/jem.20091918
  • Peer Reviewed
• [Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis (2010)
  • Author(s): Chan CJ, Andrew DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ
  • Journal Title: J Immunol Volume: 184 Issue: 2 Pages: 902-911
  • DOI: 10.4049/jimmunol.0903225
  • Peer Reviewed
• [Journal Article] PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. (2010)
  • Author(s): Curran MA, et al
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 4275-4280
  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for potent antitumor immunity in vivo. (2010)
  • Author(s): Sugimoto K, et al
  • Journal Title: J Immunol Volume: 184 Pages: 4673-4678
  • Peer Reviewed
• [Journal Article] PD-1/B7-H1 interaction contributes to the spontaneous acceptance of mouse liver allograft. (2010)
  • Author(s): Morita M, et al
  • Journal Title: Am J Transplant Volume: 10 Pages: 40-46
  • Peer Reviewed
• [Journal Article] Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. (2010)
  • Author(s): Kenna TJ, et al
  • Journal Title: J Immunol Volume: 184 Pages: 598-606
  • Peer Reviewed
• [Journal Article] Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. (2010)
  • Author(s): Kassner N, et al
  • Journal Title: J Immunol Volume: 184 Pages: 550-554
  • Peer Reviewed
• [Journal Article] Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. (2010)
  • Author(s): Oishi H, et al
  • Journal Title: Pancreas Volume: 39 Pages: 897-903
  • Peer Reviewed
• [Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis. (2010)
  • Author(s): Chan CJ, et al
  • Journal Title: J Immunol Volume: 184 Pages: 902-911
  • Peer Reviewed
• [Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. (2010)
  • Author(s): Quezada SA, et al
  • Journal Title: J Exp Med Volume: 207 Pages: 637-650
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice. (2010)
  • Author(s): Sakanishi T, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 393 Pages: 829-835
  • Peer Reviewed
• [Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors. (2010)
  • Author(s): Lee S, et al
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 1073-1081
  • Peer Reviewed
• [Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8 T cells by rapid induction of multiple inhibitory receptors. (2010)
  • Author(s): Takamura S, et al
  • Journal Title: J Immunol Volume: 184 Pages: 4696-4707
  • Peer Reviewed
• [Journal Article] Combined treatment with dendritic cells and 5-fluorourasil elicits augmented NK cell-mediated antitumor activity through the tumor necrosis factor-alpha pathway. (2010)
  • Author(s): Nagasaki E, et al
  • Journal Title: J Immunother Volume: 33 Pages: 467-474
  • Peer Reviewed
• [Journal Article] CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. (2010)
  • Author(s): Haynes NM, et al
  • Journal Title: J Immunol Volume: 185 Pages: 532-541
  • Peer Reviewed
• [Journal Article] Resistance of T-cell acute lymphoblastic leukemia (T-ALL) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. (2010)
  • Author(s): Akahane K, et al
  • Journal Title: Exp Hematol Volume: 38 Pages: 885-895
  • Peer Reviewed
• [Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells. (2010)
  • Author(s): Muraoka D, et al
  • Journal Title: J Immunol Volume: 185 Pages: 3768-3776
  • Peer Reviewed
• [Journal Article] Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8+ T cells. (2010)
  • Author(s): Roberts DJ, et al
  • Journal Title: J Immunother Volume: 33 Pages: 769-779
  • Peer Reviewed
• [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. (2010)
  • Author(s): Yokosuka T, et al
  • Journal Title: Immunity Volume: 33 Pages: 326-339
  • Peer Reviewed
• [Journal Article] Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization. (2010)
  • Author(s): Zhou Q, et al
  • Journal Title: J Immunol Volume: 185 Pages: 5082-5092
  • Peer Reviewed
• [Journal Article] TIM-3 : A novel regulatory molecule of alloimmune activation. (2010)
  • Author(s): Boenisch O, et al
  • Journal Title: J Immunol Volume: 185 Pages: 5806-5819
  • Peer Reviewed
• [Presentation] アジュバントとしての免疫賦活化抗体 (2012)
  • Author(s): 八木田秀雄
  • Organizer: 日本がん免疫学会
  • Place of Presentation: 北海道大学学術交流会館
  • Invited
• [Presentation] TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms. (2012)
  • Author(s): Baghdadi M
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Tumor associated dendritic cells suppresses the nucleic acids-mediated innate immune response in a TIM-3-dependent manner. (2012)
  • Author(s): Chiba S
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Simultaneous blockade of PD-1 and VEGFR-2 induces synergistic antitumor effect (2012)
  • Author(s): Yasuda S
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Therapeutic effect of cytolytic anti-pan HLA class II mAb on Hodgkin, non-Hodgkin lymphoma and adult T cell leukemia (2012)
  • Author(s): Matsuoka S
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Notch ligands differentially regulate the adhesion of immune cells (2012)
  • Author(s): Murata S
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation (2012)
  • Author(s): Kamachi F
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Therapeutic effect of anti-pan HLA class II mAb on Hodgkin, non-Hodgkin lymphoma and adult T cell leukemia (2012)
  • Author(s): Matsuoka S
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Dual functions of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application (2012)
  • Author(s): Ohno T
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] RORgt-dependent NKT cells and innate lymphoid cells regulate hepatic immune responses in a distinct way during the development of the acute hepatitis (2012)
  • Author(s): Matsumoto A
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms (2012)
  • Author(s): Baghdadi M
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Aberrant accumulation of IL-10-producing Gr1+CD11b+ neutrophils in Traf2-/- mice (2011)
  • Author(s): Jiang-Hu Piao
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] TLR2-dependent induction of IL-10 and Foxp3^+CD25^+CD4^+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo (2011)
  • Author(s): Sayuri Yamazaki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] An essential role for cellular FLICE inhibitory protein in the postnatal development and protection of hepatocytes from necrosis and apoptosis (2011)
  • Author(s): Xuehua Piao
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] Tescalcin contributes to maturation of mucosal-type mast cells (2011)
  • Author(s): Nobuhiro Nakano
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] Differential regulation of cell adhesion by Notch ligands (2011)
  • Author(s): Akihiko Murata
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] TIM-4 has two different functions in mouse models of arthritis (2011)
  • Author(s): Yoshiyuki Abe
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Blockade of Delta-like 1 suppresses osteoclastogenesis and arthritis (2011)
  • Author(s): Chiyoko Sekine
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Notch signal is required for the differentiation of CD4^+CD11c^+ cells in the small intestinal lamina propria (2011)
  • Author(s): Chieko Ishifune
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] Tumor-associated dendritic cells suppress nucleic acids-mediated innate immune recognition by TIM-3-dependent mechanism (2011)
  • Author(s): Masahisa Jinushi
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] Tumor-associated dendritic cells suppress nucleic acids-mediated innate immune recognition in a TIM-3-dependent manner (2011)
  • Author(s): Shigeki Chiba
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] ATM-mediated DNA damage signals suppress antitumor immunity by integrin-αVβ3-dependent mechanism (2011)
  • Author(s): Masahisa Jinushi
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] APC-derived TIM3 is a novel target for stimulating innate and adaptive antitumor immunity (2011)
  • Author(s): Muhammad Baghdadi
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] 腫瘍免疫の基礎理論 (2010)
  • Author(s): 八木田秀雄
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] 癌増殖における繊維素溶解系因子の役割と新規治療法の開発 (2010)
  • Author(s): 石原誠人
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] 悪性中皮腫移植モデルに対するエピジェネティクス調節による抗IL-13受容体α2抗体の抗腫瘍増強効果 (2010)
  • Author(s): 竹之内信
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] Function of Delta-like 1 as an adhesion molecule. (2010)
  • Author(s): Murata A
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議揚
  • Year and Date: 2010-08-27
• [Presentation] Antibodies against B7-DC with differential binding properties exert opposite effects : Implication of dual functions in PD-1 and B7-DC interactions. (2010)
  • Author(s): Azuma M
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-26
• [Presentation] Molecular regulation of T help for CTL. (2010)
  • Author(s): Feau S
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-26
• [Presentation] RANKL is a critical factor for the differentiation, maintenance, and survival of antigen-sampling M cells in the intestine. (2010)
  • Author(s): Knoop KA
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-26
• [Presentation] TNF pathway in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. (2010)
  • Author(s): Onizawa M
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-25
• [Presentation] Premature terminal exhaustion of Friend virus-specific effector CD8 T cells by rapid induction of multiple inhibitory receptors. (2010)
  • Author(s): Takamura S
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-25
• [Presentation] Involvement of NK-TRAIL in inter-DC antigen transfer and cross-priming after HSV infection. (2010)
  • Author(s): Kumaraguru U
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-24
• [Book] 標準免疫学 (2013)
  • Author(s): 八木田秀雄
  • Total Pages: 459
  • Publisher: 医学書院