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Development of a new method to analyzethe micro-distribution of 10B in tissues and its application to BNCT research

Research Project

Project/Area Number 22240091
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical oncology
Research InstitutionKyoto University

Principal Investigator

ONO Koji  京都大学, 原子炉実験所, 教授 (90122407)

Co-Investigator(Kenkyū-buntansha) SUZUKI Minoru  京都大学, 原子炉実験所, 准教授 (20273534)
KIRIHATA Mitsunori  大阪府立大学, 21世紀科学研究機構, 教授 (60128767)
TANAKA Hiroki  京都大学, 原子炉実験所, 助教 (70391274)
KINASHI Yuko  京都大学, 原子炉実験所 (80252534)
鈴木 実  京都大学, 原子炉実験所, 准教授 (00319724)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
Fiscal Year 2012: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2011: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Keywordsαオートラジオグラフィ / ホウ素化合物 / ミクロ分布 / 中性子 / 抗腫瘍効果 / BNCT / αオートラジオグラフィー / α粒子 / CR-39 / 10B化合物
Research Abstract

In boron neutron capture therapy (BNCT) research, an examination of 10B distribution in tissue is very important. The a-autoradiography is useful as an imaging method for this purpose. We have developed a simple and rapid new method to precisely identify the position of 10B using the shape of etched pits such as a circularity. In this method, no special track detectors or special microscope is needed. By this new method, it is possible to identify a real position of 10B in um tissue specimen within 1.7um error.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2013 2012 2011 2010

All Journal Article (23 results) (of which Peer Reviewed: 11 results) Presentation (10 results)

  • [Journal Article] Effects of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor2013

    • Author(s)
      Y. Liu, K. Ono, et al
    • Journal Title

      J Radiat Res

      Volume: 54(2) Pages: 260-267

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor2013

    • Author(s)
      Y. Liu
    • Journal Title

      J Radiat Res.

      Volume: 54(2) Issue: 2 Pages: 260-267

    • DOI

      10.1093/jrr/rrs102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological evaluation of dodecaborate-containing L -amino acids for boron neutron capture therapy2012

    • Author(s)
      Y. Hattori, M. Kirihata et al
    • Journal Title

      J Med Chem

      Volume: 55(5) Pages: 6980-6984

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effects of Emplying a 10B-carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy2012

    • Author(s)
      S. Masunaga
    • Journal Title

      Br. J. Radiol.

      Volume: 85 Issue: 1011 Pages: 249-258

    • DOI

      10.1259/bjr/20974899

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological evaluation of dodecaborate-containing L-amino acids for boron neutron capture therapy.2012

    • Author(s)
      Y. Hattori
    • Journal Title

      J Med Chem.

      Volume: 55(5) Issue: 15 Pages: 6980-6984

    • DOI

      10.1021/jm300749q

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 射線治療・粒子線治療と日本における医学物理士教育 第2回ホウ素中性子捕捉療法(BNCT)2012

    • Author(s)
      小野公二
    • Journal Title

      ATOMOΣ 原子力学会誌

      Volume: 54(9) Pages: 47-51

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BNCTの課題と展望2012

    • Author(s)
      小野公二
    • Journal Title

      PET Journal

      Volume: 18 Pages: 25-27

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte Carlo treatment planning with pixel based voxel model2011

    • Author(s)
      H. Kumada,K. Saito,T. Nakamura,T. Sa kae, H. Sakurai,A. Matsumura,K. Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1866-1869

    • Related Report
      2012 Final Research Report
  • [Journal Article] BNCT for locally recurrent head and neck cancer : Preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor2011

    • Author(s)
      L. W. Wang,S. J.Wang,P. Y. C h u,C. Y. Ho, ,S.H.Jiang,Y.W.H.Li u,Y.H.Li u,H.M. Liu,J. J. Peir, F. I . Cho u,S.H. Yen, Y. L. Lee,C. W. Chang,C. S. Liu, Y. W. Che n,K. Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1803-1806

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] The optimization study of Bonnersphere in the epithermal neutron irradiation field2011

    • Author(s)
      H. Ueda,H. Tanaka,A. Maruhashl,K. Ono, Y. Sakurai
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1657-1659

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation for activities of component of Cyclotron-Based Epithermal Neutron Source (C-BENS) and the surface of concrete wall in irradiation room2011

    • Author(s)
      M. Imoto,H. Tanaka,K. Fujitac,T. Mi t sumto,K. Ono,A. Maruhashi,Y. Sa kura I
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1646-1648

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-8ENS)2011

    • Author(s)
      H. Tanaka,Y. Sakurai,M. Suzuki,S. Masunaga,T. Mi tsumoto,K. Fujita,G. Kashinoa,Y. Ki na shi, Y. Liu, M. Takada,K.Ono,A. Maruhashi
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1642-1645

    • Related Report
      2012 Final Research Report
  • [Journal Article] Induction of multi-nucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy2011

    • Author(s)
      Y. Fuji t a,N. Yamamoto,1. Kato,S. lwai,K. Ono,Y. Sakurai,K. Ohni5hi,Y. Yura
    • Journal Title

      Int. J. Radiat. Biol

      Volume: 87 Pages: 293-301

    • Related Report
      2012 Final Research Report
  • [Journal Article] Experimental verication of beam characteristics for cyclotron-based epithermal neutron source (C-BENS)2011

    • Author(s)
      H.Tanaka, Y.Sakurai, M.Suzuki, S.Masunaga, T.Mitsumoto, K.Fujita, G.Kashinoa, Y.Kinashi, Y.Liu, M.Takada, K.Ono, A.Maruhashi
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1642-1645

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The optimizations tudy of Bonnersphere in the epi-thermal neutron irradiation field for BNCT2011

    • Author(s)
      H.Ueda, H.Tanaka, A.Maruhashi, K.Ono, Y.Sakurai
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1657-1659

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2011

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, A.Matsumura, K.Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1866-1869

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy2011

    • Author(s)
      Y.Fujita, N.Yamamoto, I.Kato, S.Iwai, K.Ono, Y.Sakurai, K.Ohnishi, Y.Yura
    • Journal Title

      Int.J.Radiat.Biol.

      Volume: 87 Pages: 293-301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ascorbic acid 2-g1ucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation2010

    • Author(s)
      Y. Ki nashi,H. Tanaka,S. Masunaga,M. Suzuki,G. Kashino,Y Liu,S. Takahashi. K. Ono
    • Journal Title

      Mutation Research

      Volume: 695 Pages: 69-74

    • Related Report
      2012 Final Research Report
  • [Journal Article] A General and Practical Access to Chiral Quinoxalinones with Low Coppe r-Catalyst Loading2010

    • Author(s)
      Tanimori,H. Kashiwagi,T. Ni shi mura,M. Kirihata
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 352 Pages: 2531-2537

    • Related Report
      2012 Final Research Report
  • [Journal Article] Increase in irradiation beam intensity by using a hybrid target system in cyclotron based neutron capture therapy2010

    • Author(s)
      Takata,H. Tanaka,Y.Sakurai and A. Maruhashi
    • Journal Title

      J. Nucl. Sci. Technol

      Volume: 47 Pages: 575-581

    • NAID

      10026452037

    • Related Report
      2012 Final Research Report
  • [Journal Article] Ascorbic acid 2-glucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation.2010

    • Author(s)
      Y.Kinashi, H.Tanaka, S.Masunaga, M.Suzuki, G.Kashino, Y.Liu, S.Takahashi, K.Ono
    • Journal Title

      Mutation Research

      Volume: 695 Pages: 69-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A General and Practical Access to Chiral Quinoxalinones with Low Copper-Catalyst Loading2010

    • Author(s)
      S.Tanimori, H.Kashiwagi, T.Nishimura, M.Kirihata
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 352 Pages: 2531-2537

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase in irradiation beam intensity by using a hybrid target system in cyclotron-based neutron capture therapy2010

    • Author(s)
      T.Takata, H.Tanaka, Y.Sakurai, A.Maruhashi
    • Journal Title

      J.Nucl.Sci.Technol.

      Volume: 47 Pages: 575-581

    • NAID

      10026452037

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of Accelerator Neutron Source for BNCT -Present in KURRI and Future Prospects2011

    • Author(s)
      K. Ono
    • Organizer
      (Invited Speaker) 2011 BNCT Workshop on Clinical Applications
    • Place of Presentation
      VGH Taipei, Taiwan
    • Year and Date
      2011-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] DEVELOPMENT OF ACCELERATOR NEUTRON SOURCE FOR BNCT-Present in KURRI and Future Prospects2011

    • Author(s)
      K.Ono
    • Organizer
      2011 BNCT Workshop on Clinical Applications
    • Place of Presentation
      VGH Taipei, Taiwan(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] BNCT 1N JAPAN.Experiences in Kyoto University Research Reactor Institute (KURRI)2011

    • Author(s)
      K. Ono
    • Organizer
      (Invited Speaker) 6th Young Researchers BNCT Meeting
    • Place of Presentation
      Tsing Hua, Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] Boron Neutron Capture Therapy (BNCT) past, present and subjects in the future2011

    • Author(s)
      K. Ono
    • Organizer
      (Invited Speaker) 6th Young Researchers BNCT Meeting, Tsing Hua Univ.,Taiwan International Congress of Radiation Research 2011
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2012 Final Research Report
  • [Presentation] Boron Neutron Capture Therapy for Cancers in Kyoto University Research Reactor Institute (KURRI) (Invited Speaker)2011

    • Author(s)
      K. Ono
    • Organizer
      International Symposium for Radiation Research and Medical Physics
    • Place of Presentation
      Shanghai,China
    • Related Report
      2012 Final Research Report
  • [Presentation] Boron Neutron Capture Therapy for Cancers in Kyoto University Research Reactor Institute (KURRI)2011

    • Author(s)
      K.Ono
    • Organizer
      International Symposium for Radiation Research and Medical Physics
    • Place of Presentation
      Shanghai, China(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Boron Neutron Capture Therapy (BNCT)-past, present and subjects in the future-2011

    • Author(s)
      K.Ono
    • Organizer
      International Congress of Radiation Research 2011
    • Place of Presentation
      Warsaw, Poland(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BNCT IN JAPAN-Experiences in Kyoto University Research Reactor Institute (KURRI)2011

    • Author(s)
      K.Ono
    • Organizer
      6th Young Researchers BNCT Meeting
    • Place of Presentation
      Tsing Hua Univ., Taiwan(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BNCT Research in Japan -Present and Future2010

    • Author(s)
      K. Ono
    • Organizer
      Hatanaka Award Lecture in 14ThInternational Congress of Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires
    • Year and Date
      2010-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] BNCT Research in Japan-Present and Future-2010

    • Author(s)
      K.Ono
    • Organizer
      14^<th> International Congress of Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires(Hatanaka Award受賞講演)(招待講演)
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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