| Project/Area Number |
22240092
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | Japanese Foundation For Cancer Research |
|---|
Principal Investigator |
YAMORI Takao 公益財団法人がん研究会, がん化学療法センター分子薬理部, 客員研究員 (60200854)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
DAN Shingo 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 副部長 (70332202)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAWADA Manabu 公益財団法人微生物化学研究会, 微生物化学研究センター・沼津創薬医科学研究所・創薬基盤研究ユニット, ユニット長 (20300808)
NAKAMURA Hiroyuki 学習院大学, 理学部, 教授 (30274434)
SHIINA Isamu 東京理科大学, 理学部, 教授 (40246690)
KOJIMA Naoto 京都薬科大学, 創薬科学系・薬品製造学, 講師 (90420413)
HIRONO Syuichi 北里大学, 薬学部, 教授 (30146328)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
|
|---|
| Keywords | がん治療 / 分子標的薬 / 分子薬理学 / 情報システム |
|---|
| Research Abstract |
We improved Cancer Cell Informatics that we originally developed to discover new anticancer drugs, and found a novel anticancer compound AMF-26. It destroyed Golgi apparatus, which controls membrane traffic, and inhibit the growth of cancer cells. AMF-26 induced complete regression of BSY-1 human breast cancer xenograft in nude mice by oral administration. Its toxicity was weak and recoverable. Therefore, AMF-26 is a promising novel anticancer drug candidate targeting Golgi apparatus
|
