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Risk evaluation of environmental carcinogenesis

Research Project

Project/Area Number 22240093
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cancer epidemiology and prevention
Research InstitutionJuntendo University

Principal Investigator

HINO Okio  順天堂大学, 医学部, 教授 (90127910)

Co-Investigator(Kenkyū-buntansha) ADACHI Shuichi  相模女子大学, 栄養科学部, 教授 (90129148)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2012: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2011: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2010: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Keywordsがん研究と社会の接点 / アスベスト / ナノマテリアル / 環境発がん / 中皮腫 / 発症前診断
Research Abstract

We reported N-ERC/mesothelin might be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for an early diagnosis in a mass examination, we started a large-scale pilot research screening in Japan for construction workers with the risk of asbestos exposure. In conclusion, it is indicated that the blood tumor marker is useful for an early diagnosis in a mass examination and may lead to the prolongation of their survival. We havedemonstrated that plasma N-ERC levels of rats administered multi-wall carbon nanotube, man-made mineral fibers or chrysotile were continuously higher even at 10 weeks after intraperitoneal (i.p.) injection than the other non-carcinogenic materials.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (28 results) (of which Peer Reviewed: 13 results) Presentation (2 results)

  • [Journal Article] The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma.2013

    • Author(s)
      Mori T
    • Journal Title

      J. Thoracic Disease

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2013

    • Author(s)
      Akatsuka S
    • Journal Title

      PloSONE

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma.2013

    • Author(s)
      Kawamata F
    • Journal Title

      J. Gastroenterology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The utility of serum N-ERC/mesothelin as biomarker of ovarian carcinoma2012

    • Author(s)
      Saeki H., Hashizume A., Izumi H., Suzuki F., Ishi K., Nojima M., Maeda M. and Hino O.
    • Journal Title

      Oncology Letters

      Volume: 4 Pages: 637-641

    • Related Report
      2012 Final Research Report
  • [Journal Article] The utility of serum N-ERC/mesothelin as biomarker of ovarian carcinoma.2012

    • Author(s)
      Saeki H
    • Journal Title

      Oncology Letters

      Volume: 4 Pages: 637-641

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Erc/mesothelingene ameliorates renal carcinogenesis in Tsc2 knockout mice2011

    • Author(s)
      Zhang D., Kobayashi T., Kojima T., Kanenishi K., Hagiwara Y., Abe M., Okura H., Hamano Y., Sun G., Maeda M., Jishage K., Noda T. and Hino O.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 720-727

    • Related Report
      2012 Final Research Report
  • [Journal Article] Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma2011

    • Author(s)
      Imashimizu K., Shiomi K., Maeda M., Aoki N., Igarashi K., Suzuki F., Koizumi M., Suzuki K. and Hino O.
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 2 Pages: 409-411

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and Osteopontin2011

    • Author(s)
      Shiomi K., Shiomi S., Ishinaga Y., Sakuraba M., Hagiwara Y., Miyashita K., Maeda M., Suzuki K., Takahashi K. and Hino O.
    • Journal Title

      Anticancer Research

      Volume: 31 Pages: 1427-1430

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] LRR4 and UPK3B are markers of primary mesothelial cells2011

    • Author(s)
      Kanamori-Katayama M., Kaiho A., Ishizu Y., Okamura-Oho Y., Hino O., Abe M., Kishimoto T., Sekihara H., Nakamura Y., Suzuki H., Forrest A.R.R. and Hayashizaki Y.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcino genesis in Tsc2 knockout mice2011

    • Author(s)
      Zhang D., Kobayashi T., et.al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 720-727

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of large-scale screening using N-ERG/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma2011

    • Author(s)
      Imashimizu K., Shiomi K., et.al.
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 2 Pages: 409-411

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LRR4 and UPK3B are markers of primary mesothelial cells2011

    • Author(s)
      Kanamori-Katayama M., Kaiho A., et.al.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to Polycyclic Aromatic Hydrocarbons, Arsenic and Environmental Tobacco Smoke, Nutrient Intake, and Oxidative Stress in Japanese Preschool Children2011

    • Author(s)
      Mori T., Yoshinaga J., et al
    • Journal Title

      Science of the Total Environment

      Volume: 409 Pages: 2881-2887

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological Effect of Nitrous Acid with Secondary Products of Nitrogen Dioxide and Nitric Oxide Exposure on Pulmonary Tissue in Mice2011

    • Author(s)
      Ohyama M., Oka K., et al
    • Journal Title

      Journal of Clinical Toxicology

      Volume: 1 Pages: 103-103

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum level of expressed in renal carcinoma (ERC)/mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)2010

    • Author(s)
      Sakamoto Y., Nakae D., Hagiwara Y., Satoh K., Ohashi N., Fukamachi K., Tsuda H., Hirose A., Nishimura T., Hino O. and Ogata A.
    • Journal Title

      The Jounal of Toxicological Sciences

      Volume: 35 Pages: 265-270

    • NAID

      10026193564

    • Related Report
      2012 Final Research Report
  • [Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo2010

    • Author(s)
      Inami K., Abe M., Takeda K., Hagiwara Y., Maeda M., Segawa T., Suyama M., Watanabe S. and Hino O.
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 969-974

    • NAID

      10026591120

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model2010

    • Author(s)
      Yoshida C., Sogawa C., Tsuji A., Sudo H., Sugyo A., Uehara T., Hino O., Yoshii Y., Fujibayashi Y., Fukumura T., Koizumi M., Arano Y. and Saga T.
    • Journal Title

      Nuclear Medicine Communications

      Volume: 31 Pages: 380-388

    • Related Report
      2012 Final Research Report
  • [Journal Article] Knockdown of COPA, identified by loss-of-functiuon screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse mode2010

    • Author(s)
      Sudo H., Tuji A., Sugyo A., Kohda M., Sogawa C., Yoshida C., Harada Y., Hino O. and Saga T.
    • Journal Title

      Genomics

      Volume: 95 Pages: 210-216

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010

    • Author(s)
      Tan K., Kajino K., Momose S., Masaoka A., Sasahara K., Shiomi K., Izumi H., Abe M., Ohtsuji N., Wang T., Hino O. and Fujii H.
    • Journal Title

      Human Pathol

      Volume: 41 Pages: 1330-1338

    • Related Report
      2012 Final Research Report
  • [Journal Article] Suppression of cell death by the secretory form of N-terminal ERC/mesothelin2010

    • Author(s)
      Wang T., Kajino K., Abe M., Tan K., Maruo M., Sun G., Hagiwara Y., Maeda M. and Hino O.
    • Journal Title

      Int. J. Molecular Med

      Volume: 26 Pages: 185-191

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors2010

    • Author(s)
      Obulhasim G., Fujii H., Matsumoto T., Yasen M., Abe M., Matsuoka S., Ohtsuji N. and Hino O.
    • Journal Title

      Eur. J. Gynaec. Oncol.

      Volume: 31 Pages: 63-71

    • Related Report
      2012 Final Research Report
  • [Journal Article] ntitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo.2010

    • Author(s)
      Inami K., et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 969-974

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma

    • Author(s)
      Mori T., Tajima K., Hirama M., Sato T., Kido K., Iwakami S., Sasaki S., Iwase A., Shiomi K., Maeda M., Hino O. and Takahashi K.
    • Journal Title

      J. Thoracic Disease

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

    • Author(s)
      Akatsuka S., Yamashita Y., Ohara H., Liu Y-T., Izumiya M., Abe K., Ochiai M., Jiang L., Nagai H., Okazaki Y., Murakami H., Sekido Y., Arai E., Kanai Y., Hino O., Takahashi T., Nakagama H. and Toyokuni S.
    • Journal Title

      PloSONE

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma

    • Author(s)
      Kawamata F., Homma S., Kamachi H., Einama T., Kato Y., Tsuda M., Tanaka S., Maeda M., Kajino K., Hino O., Takahashi N., Kamiyama T., Nishihara H., Taketomi A. and Todo S.
    • Journal Title

      J. Gastroenterology

      Volume: (in press)

    • NAID

      120005537455

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model.

    • Author(s)
      Yoshida C., et al.
    • Journal Title

      Nuclear Medicine Communications

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice.

    • Author(s)
      Zhang D., et al.
    • Journal Title

      Cancer Science

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent activation of Nrf2 p62 in hepatocellular carcinoma cells.

    • Author(s)
      Imashimizu K., et al.
    • Journal Title

      J.Cell Biology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Early lesions in rats after an intraperitoneal administration of nanomaterials including multi-wall carbon nanotube2011

    • Author(s)
      Mizoi M., Nakatani E., et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋・名古屋国際会議場
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rat ERC/mesothelin and early lesions of tumorigenic and non-tumorigenic fibrous materials including multi-wall carbon nanotube.2010

    • Author(s)
      安達修一
    • Organizer
      10^<th> International Conference of Mesothelioma Interest Group
    • Place of Presentation
      京都・国立京都国際会館
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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