| Project/Area Number |
22241032
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SASAKI Yuji 東京大学, 大学院・新領域創成科学研究科, 教授 (30344401)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIYANAGI Kohei 東京大学, 大学院・新領域創成科学研究科, 助教 (70435618)
SEKIGUCHI Hiroshi 東京大学, 大学院・新領域創成科学研究科, 特任助教 (00401563)
YAGI Naoto 高輝度光科学研究センター, 利用研究促進部門, 副部門長 (80133940)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2010: ¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
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| Keywords | 1分子イメージング / ナノ計測 / １分子計測 / 放射光 / ナノバイオ / X線 / 1分子計測 / X線集光 / 分子内運動 |
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| Research Abstract |
In 2000, we successfully conducted in vitro time-resolved X-ray observations of picometer-scale slow Brownian motions of individual protein molecules in aqueous solutions. In this single-molecule detection system, which we call diffracted X-ray tracking (DXT), we observed the rotating motions of an individual nanocrystal labeled to a specific site in individual protein molecules by using the time-resolved Laue diffraction technique. It is the purpose of this research that we perform the compact DXT instrumentation which enables measurement of the single molecule of this high precision pursuing method on a laboratory level. There were three technical points for realization. We succeeded in the new nanocrystal’s production, x-ray condensing, and a background’s reduction.
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