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A MEMS cantilever for stimulus response measurements of single cells

Research Project

Project/Area Number 22241033
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMOYAMA Isao  東京大学, 情報理工学(系)研究科, 教授 (60154332)

Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Kiyoshi  東京大学, IRT 研究機構, 特任教授 (10282675)
KAN Tetsuo  東京大学, 大学院情報理工学系研究科, 助教 (30504815)
TAKEI Yusuke  東京大学, 大学院情報理工学系研究科, 特任助教 (00513011)
NODA Kentaro  東京大学, 大学院情報理工学系研究科, 特任助教 (00547482)
TAKAHASHI Hidetoshi  東京大学, IRT 研究機構, 特任研究員 (90625485)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2010: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Keywordsマイクロセンサー / MEMS / 3軸力センサ / ピエゾ抵抗型カンチレバー
Research Abstract

In this project, a triaxial MEMS force sensing cantilever was studied. The sensor is equipped with a piezoresistor for force sensing at the root of the cantilever so that a quantitative mechanical stimuli could be applied to biological cells. The MEMS cantilever was made from an SOI wafer. A piezoresistive layer was formed by thermal diffusion on the surface of either cantilever root or the sidewall of the beam structure so that the corresponding three dimensional forces can be detected simultaneously. The resolution of the measurable force was as small as 1 uN for all the three directional forces, and the triaxial force could be independently measured with the device.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (16 results) Remarks (3 results)

  • [Journal Article] Differential pressure distribution measurement for the development of insect-sized wings2013

    • Author(s)
      Hidetoshi Takahashi, Kiyoshi Matsumoto and Isao Shimoyama
    • Journal Title

      Measurement Science and Technology

      Volume: vol.24, no.5, (article no.055304) Issue: 5 Pages: 055304-055304

    • DOI

      10.1088/0957-0233/24/5/055304

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A photoresponse -compensated parallel piezoresistive cantilever for cellular force measurements2013

    • Author(s)
      Uijin G. Jung, Kenta Kuwana, Yoshiharu Ajiki, Hidetoshi Takahashi, Tetsuo Kan, Yusuke Takei, Kentaro Noda, Eiji Iwase, Kiyoshi Matsumoto and Isao Shimoyama
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: vol.23, no.5, (article no.045015) Issue: 4 Pages: 45015-45015

    • DOI

      10.1088/0960-1317/23/4/045015

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of a piezoresistive triaxial force sensor probe using the sidewall doping method2013

    • Author(s)
      Tetsuo Kan, Hidetoshi Takahashi, Nguyen Binh-Khiem, Yuichiro Aoyama, Yusuke Takei, Kentaro Noda, Kiyoshi Matsumoto and Isao Shimoyama
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: vol.23, no.3, (article no.035027) Issue: 3 Pages: 035027-035027

    • DOI

      10.1088/0960-1317/23/3/035027

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Quantitative evaluation of the influence of dopaminergic neuron on flapping locomotion2013

    • Author(s)
      Koki Azuma, Hidetoshi Takahashi, Tetsuo Kan, Jun Tanimura, Kei Ito, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 26th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2013)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] A piezoresistive cellular traction force sensor2013

    • Author(s)
      Uijin G. Jung, Hidetoshi Takahashi, Tetsuo Kan, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 26th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2013)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] A Piezoresistive Cellular Traction Force Sensor2013

    • Author(s)
      U. G. Jung
    • Organizer
      The 26th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '13)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative Evaluation of The Influence of Dopaminergic Neuron on Flapping Locomotion2013

    • Author(s)
      K. Azuma
    • Organizer
      The 26th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '13)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 50nm-thick piezo-resistive cantilever2012

    • Author(s)
      Takanori Usami, Akihito Nakai, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 7th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS2012)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Triaxial force sensor with strain concentration notch beam for measurement of insect flight force2012

    • Author(s)
      Koki Azuma, Hidetoshi Takahashi, Tetsuo Kan, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 25th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2012)
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] DIFFERENTIAL PRESSURE DISTRIBUTION MEASUREMENT OF A FREE-FLYING BUTTERFLY WING2012

    • Author(s)
      Hidetoshi Takahashi, Kiyoshi Matsumoto, Isao Shimoyama
    • Organizer
      IEEE 16th International Conference on Solid-State Sensors,Actuators and Microsystems (Transducers'11)
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] SI NANO-PILLARS FOR MEASURING TRACTION FORCE EXERTED BY FILOPODIA2012

    • Author(s)
      Uijin Jung, Tetsuo Kan, Kenta Kuwana, Kiyoshi Matsumoto, Isao Shimoyama
    • Organizer
      IEEE 16th International Conference on Solid-state Sensors, Actuators and Microsystems (Transducers'11)
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIAXIAL FORCE SENSOR WITH STRAIN CONCENTRATION NOTCH BEAM FOR MEASUREMENT OF INSECT FLIGHT FORCE2012

    • Author(s)
      Koki Azuma, Hidetoshi Takahashi, Tetsuo Kan, Kiyoshi Matsumoto, Isao Shimoyama
    • Organizer
      IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS2012)
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] 50nm-Thick Piezo-Resistive Cantilever2012

    • Author(s)
      Takanori Usami, Akihito Nakai, Kiyoshi Matsumoto, Isao Shimoyama
    • Organizer
      IEEE 7th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS2012)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイドウォールドーピングを用いたピエゾ抵抗型三軸力センサ2011

    • Author(s)
      菅哲朗 ,高橋英俊 ,青山雄一郎 ,竹井裕介,野田堅太郎 ,松本潔 ,下山勲
    • Organizer
      第28回「センサ・マイクロマシンと応用システム」シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Si nano-pillars for measuring traction force exerted by filopodia2011

    • Author(s)
      Uijin Jung, Tetsuo Kan, Kenta Kuwana, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 16th IEEE International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '11)
    • Place of Presentation
      Beijin, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential pressure distribution measurement of a free-flying butterfly wing2011

    • Author(s)
      Hidetoshi Takahashi, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 16th IEEE International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '11)
    • Place of Presentation
      Beijin, China
    • Related Report
      2013 Final Research Report
  • [Presentation] A Gas Sensor Based on Viscosity Change of Ionic Liquid2011

    • Author(s)
      Kazuharu Ohsawa, Hidetoshi Takahashi, Kentaro Noda, Tetsuo Kan, Kiyoshi Matsumoto and Isao Shimoyama
    • Organizer
      The 24th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2011)
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2013 Final Research Report
  • [Presentation] サイドウォールドーピングを用いたピエゾ抵抗型三軸カセンサ2011

    • Author(s)
      菅哲朗, 高橋英俊, 青山雄一郎, 竹井裕介, 野田堅太郎, 松本潔, 下山勲
    • Organizer
      第28回「センサ・マイクロマシンと応用システム」シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Gas Sensor Based on Viscosity Change of Ionic Liquid2011

    • Author(s)
      Kazuharu Ohsawa, Hidetoshi Takahashi, Kentaro Noda, Tetsuo Kan,, Kiyoshi Matsumoto, Isao Shimoyama
    • Organizer
      IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS2011)
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.leopard.t.u-tokyo.ac.jp/research.html

    • Related Report
      2013 Final Research Report
  • [Remarks] Shimoyama lab

    • URL

      http://www.leopard.t.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.leopard.t.u-tokyo.ac.jp/research.html

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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