Expression-pattern based studies on gene regulation network in the nemetode C.elegans
Project/Area Number |
22241047
|
Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Genome biology
|
Research Institution | National Institute of Genetics |
Principal Investigator |
KOHARA Yuji 国立遺伝学研究所, 系統生物研究センター, 特任教員 (70135292)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2012: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2010: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
|
Keywords | 遺伝子 / 発現調節 / ゲノム / 発生分化 / mRNA / 3'-UTR / 局在化 / シグナル伝達 |
Research Abstract |
We have found the cis- and trans-elements for the localization of pos-1 mRNA to the posterior side and mex-3 mRNA to the anterior side in the 2 cell stage embryo of C.elegans, and have obtained the clue to understand the mechanisms of mRNA localization. 2) Based on the analysis of β-catenin HMP-2 in C.elegans early embryos, we have proposed that HMP-2 functioned downstream of the Src signaling pathway and contributed to endoderm induction and ABar spindle orientation, in parallel with the Wnt signaling pathway. 3) We identified the regions of promoter activity for gcy-8 and gcy-18 , essential genes for the thermosensory neuron AFD, and found that the transcription factors CEH-11 and TTX-1 functioned in the regulation of the gene expression coordinately
|
Report
(4 results)
Research Products
(22 results)
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[Journal Article] Convey and H. Niki: Multi-Decadal Survival of an Antarctic Nematode, Plectus Murrayi, in a -20°C Stored Moss Sample.2012
Author(s)
H. Kagoshima, K. Kito, T. Aizu, T. Shin-i, H. Kanda, S. Kobayashi, A. Toyoda, A. Fujiyama,Y. Kohara.P
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Journal Title
CryoLetters
Volume: Volume 33, No 4
Related Report
Peer Reviewed
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[Journal Article] K. C. Gunsalus, J. K. Kim: The Landscape of C. elegans 3'UTRs2010
Author(s)
M. Mangone, A. P. Manoharan, D. Thierry-Mieg, J. Thierry-Mieg, T. Han, S. Mackowiak, E. Mis, C. Zegar, M. R. Gutwein, V. Khivansara, O. Attie, K. Chen, K. Salehi-Ashtiani, M. Vidal, T. T. Harkins, P. Bouffard, Y. Suzuki, S. Sugano, Y. Kohara, N. Rajewsky, F. Piano,
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Journal Title
Science
Volume: 329
Issue: 5990
Pages: 432-435
DOI
Related Report
Peer Reviewed
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