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Search for molecular-targeted anti-cancer agents acting on the microenvironment in tumor and analysis of their target molecules

Research Project

Project/Area Number 22241053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

KOBAYASHI MOTOMASA  大阪大学, 薬学研究科(研究院), 教授 (40116033)

Co-Investigator(Renkei-kenkyūsha) ARAI Masayoshi  大阪大学, 大学院薬学研究科, 准教授 (80311231)
KOTOKU Naoyuki  大阪大学, 大学院薬学研究科, 助教 (20362618)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywords抗がん剤 / 活性天然物 / 微小環境 / 標的分子 / 海洋生物 / 海洋微生物 / 血管新生 / 低酸素環境適応
Outline of Final Research Achievements

We explored bioactive natural products from the extract library of marine medicinal resources by the constructed screening systems focusing on the metabolic and phenotypic changes of the cells on the microenvironment in tumor, which largely contribute to the pathological progression of cancer. We succeeded in isolation of the bioactive natural products, which are expected to be a medicinal seed, and in synthesis of the analog compounds, which showed the activities better than those of natural products. In addition, several responsible molecules expected as new drug targets for cancer chemotherapy were figured out through the target identification of the isolated bioactive compounds. The designed new probe molecule and its synthetic strategy enhanced generality of the method for identifying target molecule of bioactive compound.

Report

(5 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (66 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Acknowledgement Compliant: 4 results) Presentation (42 results) (of which Invited: 6 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.2014

    • Author(s)
      M. Arai, T. Kawachi, H. Sato, A. Setiawan, M. Kobayashi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 14 Pages: 3155-3157

    • DOI

      10.1016/j.bmcl.2014.04.116

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth Inhibitor.2014

    • Author(s)
      N. Kotoku, C. Nakata, T. Kawachi, T. Sato, X.H. Guo, A. Ito, Y. Sumii, M. Arai, M. Kobayashi
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 7 Pages: 2102-2112

    • DOI

      10.1016/j.bmc.2014.02.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Creation of Readily Accessible Analogue of Cortistatin A as an Antitumor Drug Lead2013

    • Author(s)
      古徳直之
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 133 Issue: 8 Pages: 867-872

    • DOI

      10.1248/yakushi.13-00159

    • NAID

      130003361979

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2013-08-01
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D<sub>2</sub>2013

    • Author(s)
      N. Kotoku, K. Mizushima, S. Tamura, M. Kobayashi
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 61 Issue: 10 Pages: 1024-1029

    • DOI

      10.1248/cpb.c13-00375

    • NAID

      130004137256

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Creation of Readily Accessible and Orally Active Analogue of Cortistatin A.2012

    • Author(s)
      Kotoku, N.; Sumii, Y.; Hayashi, T.; Tamura, S.: Kawachi, T.; Shiomura, S.; Arai, M.; Kobayashi, M.
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 3 Issue: 8 Pages: 673-677

    • DOI

      10.1021/ml300143d

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp2012

    • Author(s)
      Masayoshi Arai
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 22(4) Issue: 4 Pages: 1818-1821

    • DOI

      10.1016/j.bmcl.2011.10.023

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Total Synthesis of (―)-Stenine and 9a-epi-Stenine.2012

    • Author(s)
      Fujioka, H.; Nakahara, K.; Kotoku, N.; Ohba, Y.; Nagatomi, Y.; Wang, T.-L.; Sawama, Y.; Murai, K.; Hirano, K.; Oki, T.; Wakamatsu, S.; Kita, Y.
    • Journal Title

      Chem. Eur. J.

      Volume: 18 Issue: 43 Pages: 13861-13870

    • DOI

      10.1002/chem.201200376

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.2012

    • Author(s)
      Yamano, Y,; Arai, M,; Kobayashi, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 14 Pages: 1877-4881

    • DOI

      10.1016/j.bmcl.2012.05.071

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge2011

    • Author(s)
      Naoyuki Kotoku
    • Journal Title

      Tetrahedron

      Volume: 67(35) Issue: 35 Pages: 6673-6678

    • DOI

      10.1016/j.tet.2011.05.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenic effect of triterpenoidal saponins from Polygala senega2011

    • Author(s)
      Masayoshi Arai
    • Journal Title

      J. Nat. Med.

      Volume: 65(1) Issue: 1 Pages: 149-156

    • DOI

      10.1007/s11418-010-0477-7

    • NAID

      10029460687

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of Core Structure of Cortistatin A2011

    • Author(s)
      Naoyuki Kotoku
    • Journal Title

      Org. Lett.

      Volume: 13(13) Issue: 13 Pages: 3514-3517

    • DOI

      10.1021/ol201327u

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.2011

    • Author(s)
      荒井雅吉、小林資正, ら
    • Journal Title

      J.Nat.Med.

      Volume: 65 Pages: 149-156

    • NAID

      10029460687

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia-Selective Growth Inhibition of Cancer Cells by Furospinosulin-1, a Furanosesterterpene Isolated from an Indonesian Marine Sponge.2010

    • Author(s)
      荒井雅吉、小林資正, ら
    • Journal Title

      ChemMedChem

      Volume: 5 Pages: 1919-1926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity.2010

    • Author(s)
      古徳直之、小林資正, ら
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 4152-4155

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria2010

    • Author(s)
      Patamaporn PRUKSAKORN、荒井雅吉、小林資正, ら
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 3658-3663

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海洋生物からの医薬シーズの探索2010

    • Author(s)
      荒井雅吉、小林資正
    • Journal Title

      有機合成化学協会誌

      Volume: 68 Pages: 470-479

    • NAID

      10026868871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] プローブ分子を用いたcortistatin A の標的分子の解析研究2014

    • Author(s)
      伊藤 葵,古徳直之,住井裕司,角居雄太,小林資正
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学等(熊本市)
    • Year and Date
      2014-03-27 – 2014-03-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製2013

    • Author(s)
      古徳直之
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      アステールプラザ(広島市)
    • Year and Date
      2013-11-20 – 2013-11-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の標的分子の解明2013

    • Author(s)
      荒井雅吉,河内崇志,中田千晶,古徳直之,小林資正
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      同志社大学(京都市)
    • Year and Date
      2013-09-18 – 2013-09-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1のin vivo評価2013

    • Author(s)
      荒井雅吉,河内崇志,古徳直之,遠藤洋子,井上正宏,小林資正
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道医療大学(北海道)
    • Year and Date
      2013-09-07 – 2013-09-08
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新しい医薬シーズの探索と標的分子探索2013

    • Author(s)
      小林資正
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道医療大学(北海道)
    • Year and Date
      2013-09-07 – 2013-09-08
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管新生阻害物質cortistatin Aのアナログ化合物の効率的合成研究2013

    • Author(s)
      竹島 亜季
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の作用メカニズム解析2013

    • Author(s)
      荒井 雅吉
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管新生阻害物質cortistatin A由来の抗がん剤リード化合物の創製研究2012

    • Author(s)
      古徳 直之
    • Organizer
      日本がん分子標的治療学会第16回学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製2012

    • Author(s)
      古徳 直之
    • Organizer
      日本生薬学会 第59回年会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] インドネシア産海綿由来N-isopentenyladenosineのHUVEC選択的増殖阻害作用2012

    • Author(s)
      塩村 昌
    • Organizer
      第62回日本薬学会近畿支部大会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cortistatin Aをモチーフとする抗腫瘍活性リード化合物の創製2012

    • Author(s)
      古徳 直之
    • Organizer
      第62回日本薬学会近畿支部大会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製研究2012

    • Author(s)
      古徳 直之
    • Organizer
      第19回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海洋天然物furospinosulin-1を基盤とする新規がん分子標的治療薬の開発2012

    • Author(s)
      荒井 雅吉
    • Organizer
      第19回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1のケミカルバイオロジー研究による新規薬剤標的分子の創出2012

    • Author(s)
      荒井 雅吉
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製2012

    • Author(s)
      古徳 直之
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海綿由来の新しい医薬シーズの探索2012

    • Author(s)
      小林 資正
    • Organizer
      中西シンポジウム2012
    • Place of Presentation
      慶応義塾大学 日吉キャンパス(東京)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の作用メカニズム解析2011

    • Author(s)
      河内崇志、荒井雅吉、小林資正, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(グランシップ静岡)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海綿由来抗腫瘍性環状デプシペプチドarenastatin Aの作用機序解明を目指したプローブ分子の合成2011

    • Author(s)
      高市伸宏、古徳直之、小林資正, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(グランシップ静岡)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海綿由来血管新生阻害物質cortistatin Aの全合成研究2011

    • Author(s)
      住井裕司、古徳直之、小林資正, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(グランシップ静岡)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の作用メカニズムと構造活性相関2011

    • Author(s)
      河内 崇志
    • Organizer
      第15回日本がん分子標的治療学会
    • Place of Presentation
      ホテル日航東京(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Search for New Medicinal Seeds for Cancer Chemotherapy from Marine Organisms.2011

    • Author(s)
      Motomasa Kobayashi
    • Organizer
      Tetrahedron Prize for Creativity in Organic Chemistry Symposium
    • Place of Presentation
      Denver(米国)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 海綿由来血管新生阻害物質cortistatin A およびanalog化合物の合成研究2011

    • Author(s)
      住井 裕司
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪国際交流センター (大阪)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海洋天然物cortistatin A をモチーフとする新規抗がんリード化合物の創製2011

    • Author(s)
      古徳 直之
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 腫瘍微小環境で作用する新規抗がん剤の探索2011

    • Author(s)
      荒井 雅吉
    • Organizer
      第4回食品薬学シンポジウム
    • Place of Presentation
      慶応義塾大学 薬学部 (東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん転移抑制を指向した細胞接着阻害天然物の探索2011

    • Author(s)
      戸田 和成
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Furospinosulin-1由来の新規抗腫瘍リード化合物の合成と活性評価2011

    • Author(s)
      中田 千晶
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of Action-mechanism and Analogue Synthesis of Furospinosulin-1, a Hypoxia-selective Growth Inhibitor of Cancer Cells.2011

    • Author(s)
      Takashi Kawachi
    • Organizer
      The 8th AFMC International Medicinal Chemistry Symposium (AIMECS)
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Medicinal Seeds for Cancer Chemotherapy from Marine Organisms.2011

    • Author(s)
      Motomasa Kobayashi
    • Organizer
      7th U.S.-Japan Seminar on Marine Natural Products
    • Place of Presentation
      沖縄コンベンションセンター (沖縄)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の作用メカニズムと構造活性相関2010

    • Author(s)
      荒井雅吉、小林資正, ら
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然薬物資源からの低酸素環境選択的に作用する新規抗がん剤の開発研究2010

    • Author(s)
      小林資正, ら
    • Organizer
      第18回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      東京(北里大学薬学部)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生阻害物質cortistatin Aの合成研究2010

    • Author(s)
      古徳直之、小林資正, ら
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      名古屋(ウイングあいち)
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ボロン酸基を捕捉補助基とする新規プローブ分子の合成と機能2010

    • Author(s)
      郭修〓、古徳直之、小林資正, ら
    • Organizer
      第60回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪(摂南大学薬学部)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素環境選択的増殖阻害物質furospinosulin-1の構造活性相関2010

    • Author(s)
      藤岡真一、古徳直之、小林資正, ら
    • Organizer
      第60回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪(摂南大学薬学部)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Studies of Furospinosulin-1, A Hypoxia-Selective Growth Inhibitor From Marine Sponge2010

    • Author(s)
      古徳直之、小林資正, ら
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Hilton Phuket, Phuket (Thailand)
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] HYPOXIA-SELECTIVE GROWTH INHIBITOR, FUROSPINOSULIN-1, FROM THE MARINE SPONGE DACTYLOSPONGIA ELEGANS2010

    • Author(s)
      荒井雅吉、小林資正, ら
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Hilton Phuket, Phuket(Thailand)
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] CORTISTATINS, NOVEL ANTI-ANGIOGENIC STEROIDAL ALKALOIDS, FROM MARINE SPONGE2010

    • Author(s)
      古徳直之、小林資正, ら
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Hilton Phuket, Phuket (Thailand)
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Studies of Cortistatin A, An Anti-Angiogenic Steroidal Alkaloid From Marine Sponge2010

    • Author(s)
      古徳直之、小林資正, ら
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Hilton Phuket, Phuket (Thailand)
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素環境選択的増殖阻害物質furospinosulin-1のアナログ化合物の合成と作用メカニズム解析2010

    • Author(s)
      古徳直之、荒井雅吉、小林資正, ら
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡(グランシップ静岡)
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] インドネシア産海綿由来の新規環状ペプチドaxinellin Dのがん細胞浸潤阻害作用2010

    • Author(s)
      山野喜、荒井雅吉、小林資正, ら
    • Organizer
      日本生薬学会学会第57回年会
    • Place of Presentation
      徳島(徳島文理大学)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海洋天然物由来の医薬シーズの探索2010

    • Author(s)
      小林資正
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都(京都薬科大学)(招待講演)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生薬Polygala senega由来サポニンsenegin類の血管新生阻害作用2010

    • Author(s)
      河内崇志、荒井雅吉、小林資正, ら
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京(タワーホール船堀)
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypoxia-selective Growth Inhibitor, Furospinosulin-1, from the Marine Sponge Dactylospongia elegans2010

    • Author(s)
      河内崇志、荒井雅吉、小林資正, ら
    • Organizer
      2010 World Pharmaceutical Congress
    • Place of Presentation
      Hilton Philadelphia, Philadelphia(USA)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Book] Chembiomolecular Science: At the Frontier of Chemistry and Biology2013

    • Author(s)
      M. Kobayashi, N. Kotoku, M. Arai
    • Total Pages
      270
    • Publisher
      Springer-Verlag GmbH, Deutschland
    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学大学院薬学研究科 天然物化学分野 ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 天然物化学分野ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学大学院薬学研究科 天然物化学分野 ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん物質のスクリーニング方法2012

    • Inventor(s)
      小林資正, 荒井雅吉, 古徳直之, 河内崇志
    • Industrial Property Rights Holder
      小林資正, 荒井雅吉, 古徳直之, 河内崇志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-184400
    • Filing Date
      2012-08-23
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規プレニルアレーン化合物およびその用途2010

    • Inventor(s)
      小林資正、古徳直之、荒井雅吉、河内崇志
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2010-209131
    • Filing Date
      2010-05-07
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規コルチスタチンA類似体およびその用途2010

    • Inventor(s)
      小林資正、古徳直之、荒井雅吉、田村理
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2010-209131
    • Filing Date
      2010-09-17
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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