|Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
|Outline of Final Research Achievements
We explored bioactive natural products from the extract library of marine medicinal resources by the constructed screening systems focusing on the metabolic and phenotypic changes of the cells on the microenvironment in tumor, which largely contribute to the pathological progression of cancer. We succeeded in isolation of the bioactive natural products, which are expected to be a medicinal seed, and in synthesis of the analog compounds, which showed the activities better than those of natural products. In addition, several responsible molecules expected as new drug targets for cancer chemotherapy were figured out through the target identification of the isolated bioactive compounds. The designed new probe molecule and its synthetic strategy enhanced generality of the method for identifying target molecule of bioactive compound.