Coupling between Deformations of Vesicle and Chemical Stimuli: Approach from Soft Matter toward Cellular Life
| Project/Area Number |
22244053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Tohoku University (2012-2013)
Ochanomizu University (2010-2011) |
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Principal Investigator |
MASAYUKI Imai 東北大学, 理学(系)研究科(研究院), 教授 (60251485)
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| Co-Investigator(Kenkyū-buntansha) |
URAKAMI Naohito 山口大学, 大学院理工学研究科, 准教授 (50314795)
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| Project Period (FY) |
2010-05-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2010: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 生命現象の物理 / ミニマルセル / ベシクル変形 / 自己生産 / 化学刺激 / ３次元計測 / 自己駆動 / 人工細胞 / 3次元形態観察 / 膜弾性エネルギー / チューブ形成 / DNAの自己複製 / Minimal Cell / ベシクル / 自発曲率 / 相分離 / 分裂 / ドメインダイナミクズ / シミュレーション |
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| Research Abstract |
We have investigated vesicle deformations triggered by chemical stimuli to reveal the pathway from vesicles (molecular assemblies of lipids) to cellular life. First we established an experimental technique to examine vesicle deformation triggered by the chemical stimuli and then revealed a mechanism of a tubular membrane formation induced by pH gradient. In addition we found that chemical stimuli drive vesicles toward the chemical source, so-called chemophoresis. These observations clearly show that the chemical stimuli play important roles to develop cellular life from vesicle. In addition we succeeded to reproduce a self-production of vesicle using binary vesicles, which shed light on the pathway toward the protopcell.
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Report
(4 results)
Research Products
(79 results)
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[Presentation] 化学刺激によるベシクル膜変形2013
Author(s)
佐久間由香,A.-F. Bitbol, N. Puff,今井正幸,J.-B. Fournier, M. I. Angelova
Organizer
日本物理学会第68回年次大会
Place of Presentation
広島, (口頭)
Year and Date
2013-03-28
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[Presentation] Self-Reproduction of Lipid Vesicles2012
Author(s)
Y. Sakuma and M. Imai
Organizer
ECI conference : Association in Solution III Self-Assembly : From Bio-Colloids to Nano-Engineering
Place of Presentation
Bifröst, Iceland, (Poster)
Year and Date
2012-07-25
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[Presentation] Slow Dynamics of Soft Spheres2012
Author(s)
M. Imai, M. Kurimoto, F. Matsuura, T. Kawakatsu and Y.Sakuma
Organizer
International Association of Colloid and Interface Scientists Conference 2012
Place of Presentation
Sendai, Japan
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[Presentation] Self-Birthing Vesicle2010
Author(s)
Y. Sakuma and M. Imai
Organizer
Wilhelm and Else Heraeus Seminar : BIOPHYSICS OF MEMBRANE TRANSFORMATIONS Workshop
Place of Presentation
Bad Honnef, Germany, (Poster)
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