Novel electrode array device for electrochemical imaging
| Project/Area Number |
22245011
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Analytical chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
MATSUE Tomokazu 東北大学, 原子分子材料科学高等研究機構, 教授 (70173797)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIKU Hitoshi 東北大学, 大学院・環境科学研究科, 准教授 (10361164)
INO Kosuke 東北大学, 大学院・環境科学研究科, 助教 (00509739)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
|
|---|
| Keywords | バイオセンサー / 電気化学 / 分析化学 / マイクロ・ナノシステム / MEMS / バイオイメージング / 細胞解析 / 電気化学測定 / 微小電極 / 生体分子 / 細胞機能解析 / 網羅的解析 / 細胞 / 酵素 / DNA / 網羅的解析法 |
|---|
| Research Abstract |
In this study, we have proposed a novel method for electrochemical imaging using local redox cycling-based electrochemical (LRC-EC) devices and systems. In the device, two arrays of microelectrodes are orthogonally arranged to fabricate an n × n array of crossing points (measurement points) with only 2n bonding pads for external connection. The crossing points of the column and row electrodes can easily be addressed by setting the proper potentials at the column and row electrodes to induce local redox cycling at desired crossing points. Therefore, the crossing points can be used as individual electrochemical sensors. This addressable and multiple detection system successfully applied for the detection of enzyme activity, gene-expression analysis, cell differentiation analysis, DNA detection and dynamic analyses of droplets. The present LRC-EC system will be widely applicable for various bioimaging and biosensing.
|
Report
(4 results)
Research Products
(223 results)
-
-
-
-
-
-
-
-
[Journal Article] Topographical and electrochemical nanoscale imaging of living cells using voltage switching mode scanning electrochemical microscopy2012
Author(s)
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Babak Babakinejad, Julie Macpherson, Patrick R. Unwind, Hitoshi Shiku, Julia Gorelik, David Klenerman, Yuri E. Korchev, Tomokazu Matsue
-
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: Vol. 109, No. 29
Issue: 29
Pages: 11540-11545
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] David Klenerman, Yuri E. Korchev1, Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces2011
Author(s)
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Yanjun Zhang, Neil Ebejer, Julie V. Macpherson, Patrick R. Unwin, Andrew J. Pollard, Debdulal Roy, Charles A. Clifford, Hitoshi Shiku, Tomokazu Matsue
-
Journal Title
Angewandte Chemie International Edition
Volume: 50
Issue: 41
Pages: 9638-9642
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Quantitative characterization of reporter gene expression at single-cell level with real-time RT-PCR, chemluminescence, fluorescence, and electrochemical imaging2010
Author(s)
Hitoshi Shiku, Daisuke Okazaki, Junya Suzuki, Yasufumi Takahashi, Tatsuya Murata, Hidetaka Akita, Hideyoshi Harashima, Kosuke Ino, Tomokazu Matsue
-
Journal Title
FEBS Letters
Volume: 584
Pages: 4000-4008
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Observation of localized area by SICM2012
Author(s)
Komachi Ito, Yasuhumi Takahashi, Hirokazu Komaki, Hitoshi Shiku, Kosuke Ino, Tomokazu Matsue
Organizer
2012 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT2012)
Place of Presentation
Tainan, Taiwan
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Patent(Industrial Property Rights)] ウェルユニット及び電気化学的分 析方法2010
Inventor(s)
青柳重夫, 内海陽介, 末永智一, 珠 玖仁, 阿部宏之, 河野浩之, 柏崎 寿宣, 星宏良, 星翼
Industrial Property Rights Holder
青柳重夫, 内海陽介, 末永智一, 珠 玖仁, 阿部宏之, 河野浩之, 柏崎 寿宣, 星宏良, 星翼
Industrial Property Number
2010-208817
Filing Date
2010-09-17
Related Report
