Structural basis for cell signaling mediated by lipoprotein receptors
| Project/Area Number |
22247010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Kenji 大阪大学, 蛋白質研究所, 准教授 (20342751)
NOGI Terukazu 大阪大学, 蛋白質研究所, 助教 (40379102)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGI Terukazu 横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 (40379102)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2011: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2010: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Keywords | リポ蛋白質受容体 / X線結晶構造解析 / 電子顕微鏡 / エンドサイトーシス / リポタンパク質 / 受容体 / 構造生物学 / LRP6 / LR11 / reelin |
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| Research Abstract |
We have utilized X-ray crystallography and electron microscopy to decipher the structural mechanism underlying signaling through the lipoprotein receptor family proteins. We have gained information about reelin signal transduction in brain development and Wnt signal transduction implicated in cancer and bone formation. Also, we have unraveled a previously undescribed molecular interaction involving LR11 which is implicated in Alzheimer disease
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin2012
Author(s)
Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
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Journal Title
Cell Reports
Volume: 2(1)
Issue: 1
Pages: 101-110
DOI
Related Report
Peer Reviewed
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[Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin2012
Author(s)
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
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Journal Title
Oncogene
Volume: 31
Issue: 6
Pages: 787-79
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural basis for semaphorin signalling through the plexin receptor2010
Author(s)
Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
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Journal Title
Nature
Volume: 467(7319)
Issue: 7319
Pages: 1123-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison of the envelope architecture of E. coli using two methods: CEMOVIS and cryo-electron tomography2010
Author(s)
Kishimoto-Okada, A., Murakami, S., Ito, Y., Horii, N., Furukawa, H., Takagi, J., Iwasaki, K
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Journal Title
J. Electron Microsc
Volume: 59
Issue: 5
Pages: 419-426
DOI
Related Report
Peer Reviewed
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