Structural basis for cell signaling mediated by lipoprotein receptors

• Project/Area Number: 22247010
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural biochemistry
• Research Institution: Osaka University
• Principal Investigator: TAKAGI Junichi 大阪大学, 蛋白質研究所, 教授 (90212000)
• Co-Investigator(Kenkyū-buntansha): IWASAKI Kenji 大阪大学, 蛋白質研究所, 准教授 (20342751) ; NOGI Terukazu 大阪大学, 蛋白質研究所, 助教 (40379102)
• Co-Investigator(Renkei-kenkyūsha): NOGI Terukazu 横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 (40379102)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000); Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000); Fiscal Year 2011: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2010: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
• Keywords: リポ蛋白質受容体 / X線結晶構造解析 / 電子顕微鏡 / エンドサイトーシス / リポタンパク質 / 受容体 / 構造生物学 / LRP6 / LR11 / reelin

Research Abstract

We have utilized X-ray crystallography and electron microscopy to decipher the structural mechanism underlying signaling through the lipoprotein receptor family proteins. We have gained information about reelin signal transduction in brain development and Wnt signal transduction implicated in cancer and bone formation. Also, we have unraveled a previously undescribed molecular interaction involving LR11 which is implicated in Alzheimer disease

Research Products

• [Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration (2013)
  • Author(s): Nojima S, et al.
  • Journal Title: Nat Commun Volume: 4 Issue: 1 Pages: 1406-1406
  • DOI: 10.1038/ncomms2420
  • Peer Reviewed
• [Journal Article] セマフォリン関連分子群の立体構造 (2013)
  • Author(s): 松永 幸子
  • Journal Title: 実験医学 Volume: 31 Pages: 523-530
• [Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用 (2012)
  • Author(s): 北郷 悠、高木淳一
  • Journal Title: The Lipid Volume: 23(4) Pages: 56-62
• [Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling (2012)
  • Author(s): Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Proc. Natl Acad. Sci. U. S. A. Volume: 109 Issue: 42 Pages: 16876-16881
  • DOI: 10.1073/pnas.1208017109
  • Peer Reviewed
• [Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin (2012)
  • Author(s): Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
  • Journal Title: Cell Reports Volume: 2(1) Issue: 1 Pages: 101-110
  • DOI: 10.1016/j.celrep.2012.06.009
  • Peer Reviewed
• [Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1 (2012)
  • Author(s): Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Acta Crystallogr Volume: F68 Issue: 7 Pages: 778-782
  • DOI: 10.1107/s1744309112019306
  • Peer Reviewed
• [Journal Article] Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer (2012)
  • Author(s): M.Matoba, et al
  • Journal Title: J.Electron.Microsc. Volume: 61(3) Pages: 193-198
  • DOI: 10.1093/jmicro/dfs034
  • Peer Reviewed
• [Journal Article] Crystal structure of α5β1 integrin ectodomain : Atomic details of the fibronectin receptor (2012)
  • Author(s): Nagae, M., et al.
  • Journal Title: The Journal of Cell Biology Volume: 197 Issue: 1 Pages: 131-140
  • DOI: 10.1083/jcb.201111077
  • Peer Reviewed
• [Journal Article] Schwann cell myelination requires integration of laminin activities (2012)
  • Author(s): Karen K. McKee
  • Journal Title: Journal of Cell Science Volume: 125 Pages: 4609-4619
  • DOI: 10.1242/jcs.107995
  • Peer Reviewed
• [Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用 (2012)
  • Author(s): 北郷 悠
  • Journal Title: The Lipid Volume: 23 Pages: 56-62
• [Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin (2012)
  • Author(s): Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
  • Journal Title: Oncogene Volume: 31 Issue: 6 Pages: 787-79
  • DOI: 10.1038/onc.2011.265
  • Peer Reviewed
• [Journal Article] Functional importance of covalent homodimer of reelin linked via its central region (2011)
  • Author(s): Yasui, N., et al.
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 40 Pages: 35247-35256
  • DOI: 10.1074/jbc.m111.242719
  • Peer Reviewed
• [Journal Article] Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin (2011)
  • Author(s): Tanaka, H., et al.
  • Journal Title: PLoS One Volume: 6 Issue: 4 Pages: e19411-e19411
  • DOI: 10.1371/journal.pone.0019411
  • Peer Reviewed
• [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators (2011)
  • Author(s): Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O
  • Journal Title: Nat Struct Mol Biol Volume: 18 Issue: 2 Pages: 205-212
  • DOI: 10.1038/nsmb.1998
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary crystallographic anal-ysis of human LR11 Vps10p domain (2011)
  • Author(s): Nakata Z, Nagae M, Yasui N, Bujo H, Nogi T, Takagi J
  • Journal Title: Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 67 Issue: 1 Pages: 129-132
  • DOI: 10.1107/s1744309110048153
  • Peer Reviewed
• [Journal Article] Structural basis for semaphorin signalling through the plexin receptor (2010)
  • Author(s): Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
  • Journal Title: Nature Volume: 467(7319) Issue: 7319 Pages: 1123-7
  • DOI: 10.1038/nature09473
  • Peer Reviewed
• [Journal Article] Comparison of the envelope architecture of E. coli using two methods: CEMOVIS and cryo-electron tomography (2010)
  • Author(s): Kishimoto-Okada, A., Murakami, S., Ito, Y., Horii, N., Furukawa, H., Takagi, J., Iwasaki, K
  • Journal Title: J. Electron Microsc Volume: 59 Issue: 5 Pages: 419-426
  • DOI: 10.1093/jmicro/dfq056
  • Peer Reviewed
• [Journal Article] Structural basis for specific recognition of reelin by its receptors. (2010)
  • Author(s): Yasui N, Nogi T, Takagi J.
  • Journal Title: Structure Volume: 18 Pages: 320-331
  • Peer Reviewed
• [Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclopal antibodies specific for the native conformation (2010)
  • Author(s): Yasui N, Takagi J., et al.
  • Journal Title: J.Immunol.Methods Volume: 352 Pages: 153-160
  • Peer Reviewed
• [Journal Article] Laminin-121-Recombinant expression and interactions with integrins. (2010)
  • Author(s): Sasaki, T., Takagi J., et al.
  • Journal Title: Matrix Biology Volume: 29 Pages: 484-493
  • Peer Reviewed
• [Journal Article] Comparison of the envelope architecture of E.coli using two methods : CEMOVIS and cryo-electron tomography. (2010)
  • Author(s): Kishimoto-Okada, A., Takagi J., et al.
  • Journal Title: J.Electron Microsc. Volume: 59 Pages: 419-493426
  • Peer Reviewed
• [Journal Article] Structural basis for semaphorin signaling through the plexin receptor. (2010)
  • Author(s): Nogi, T., Takagi J., et al.
  • Journal Title: Nature Volume: 467 Pages: 1123-1127
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary crystallographic analysis of human LR11 Vps10p domain (2010)
  • Author(s): Nakata, Z., Takagi J., et al.
  • Journal Title: Acta Crystallographica.F Volume: 67 Pages: 129-132
  • Peer Reviewed
• [Journal Article] Tomosyn Inhibits Synaptotagmin-1-mediated Step of Ca2+-dependent Neurotransmitter Release through Its N-terminal WD40 Repeats. (2010)
  • Author(s): Yamamoto, Y.Iwasaki, K., et al.
  • Journal Title: J Biol Chem Volume: 285 Pages: 40943-40955
  • Peer Reviewed
• [Presentation] Superimposition of a crystal structure over EM images, KeyStone Symposia (2013)
  • Author(s): Iwasaki, K.
  • Organizer: Structural Analysis of Supramolecular Assemblies by Hybrid Methods
  • Place of Presentation: Lake Tahoe (USA)
  • Year and Date: 2013-03-05
• [Presentation] Multi-faceted approach to analyze structure and function of integrins. (2013)
  • Author(s): Takagi, J
  • Organizer: Gordon Research Conference
  • Place of Presentation: Ventura (USA)
  • Year and Date: 2013-02-14
• [Presentation] In situ molecular analysis by electron microscopy (2012)
  • Author(s): Iwasaki, K
  • Organizer: IPR International Symposium 2012, -Toward the Molecular Comprehension of Life System
  • Place of Presentation: Osaka
  • Year and Date: 2012-11-22
• [Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ (2012)
  • Author(s): 高木淳一
  • Organizer: 第12回日本抗加齢医学会 シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-24
• [Presentation] Wnt共受容体LRP6の電子顕微鏡単粒子解析 (2012)
  • Author(s): 的場京子
  • Organizer: 第12回日本蛋白質科学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-06-21
• [Presentation] Cutinaseタグを用いた生細胞上での分子間相互作用解析 (2012)
  • Author(s): 松永幸子, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-03-30
• [Presentation] Structural basis for peptide ligand recognition by LR11/sorLA Vps10p domain (2012)
  • Author(s): Takagi, J
  • Organizer: Keystone Symposia "ApoE, Alzheimer's and Lipoprotein Biology"
  • Place of Presentation: Key Stone (USA)
  • Year and Date: 2012-02-28
• [Presentation] Structural basis for peptide ligand recognition by LR11/sorLA Vps10p domain (2012)
  • Author(s): Takagi, Junichi
  • Organizer: Keystone Symposia "ApoE, Alzheimer's and Lipoprotein Biology"
  • Place of Presentation: Keystone Resort, CO, USA(招待講演)
  • Year and Date: 2012-02-28
• [Presentation] LR11 Vps10pドメインのリガンド認識機構 (2011)
  • Author(s): 北郷 悠 他
  • Organizer: 2011年度日本結晶学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2011-11-24
• [Presentation] リーリンN末端断片の精製及び結晶化 (2011)
  • Author(s): 長江 雅倫 他
  • Organizer: 2011年度日本結晶学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2011-11-24
• [Presentation] ソーティング受容体LR11の持つ"弱くて特異性の低い (2011)
  • Author(s): 高木淳一
  • Organizer: 相互作用の秘密、第2回 「神経科学と構造生物学の融合」セミナー
  • Place of Presentation: 岡崎
  • Year and Date: 2011-11-21
• [Presentation] ソーティング受容体LR11の持つ"弱くて特異性の低い"相互作用の秘密 (2011)
  • Author(s): 高木、淳一
  • Organizer: 第2回「神経科学と構造生物学の融合」セミナー
  • Place of Presentation: 岡崎コンファレンスセンター(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] Structural basis for semaphorin signaling through the plexin receptor (2011)
  • Author(s): Takagi, Junichi
  • Organizer: The 9th Taiwan-JapanJoint Seminar on Crystallography
  • Place of Presentation: Taiwan National University, Taiwan(招待講演)
  • Year and Date: 2011-11-07
• [Presentation] Structural basis for peptide ligand recognition by LR11 Vps10p domain (2011)
  • Author(s): Kitago, Y. et al
  • Organizer: PDB40 symposium
  • Place of Presentation: New York (USA)
  • Year and Date: 2011-10-28
• [Presentation] フィブロネクチン受容体(インテグリンα5β1)の立体構造 (2011)
  • Author(s): 高木、淳一
  • Organizer: 第84回日本生化学会大会シンポジウム"蛋白質の高分解能構造と細胞機能発現のメカニズム"
  • Place of Presentation: 京都国際会議場(招待講演)
  • Year and Date: 2011-09-22
• [Presentation] Structures of β1 and β4 integrins determined by electron microsocpy (2011)
  • Author(s): Miyazaki, N., et al
  • Organizer: 第7回ASO International Meeting
  • Place of Presentation: ホテルグリーンピア南阿蘇
  • Year and Date: 2011-07-30
• [Presentation] In situ visualization and dynamics of internalized membrane proteins (2011)
  • Author(s): 松永幸子, 他
  • Organizer: 第7回ASO International Meeting
  • Place of Presentation: ホテルグリーンピア南阿蘇
  • Year and Date: 2011-07-30
• [Presentation] 神経シナプスにおける接着複合体の準安定な二次元クラスター形成 (2011)
  • Author(s): 高木、淳一
  • Organizer: 新学術領域「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京大学薬学部(招待講演)
  • Year and Date: 2011-07-21
• [Presentation] α5β1インテグリンの結晶構造とそのリガンド結合機構 (2011)
  • Author(s): 長江雅倫, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2011-06-08
• [Presentation] Cutinase融合タンパク質を用いた分子標識と生細胞イメージング:Dkk1-LRP6相互作用ドメインの同定 (2011)
  • Author(s): 松永幸子, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2011-06-08
• [Presentation] 神経シナプス接着複合体のマルチモード構造解析 (2011)
  • Author(s): 高木、淳一
  • Organizer: 日本蛋白質科学会第11回年会シンポジウム「生命機能を原子分子レベルで探る-細胞システムレベルでの蛋白質科学をめざして-」
  • Place of Presentation: ホテル阪急エキスポパーク(招待講演)
  • Year and Date: 2011-06-07
• [Presentation] 多様なアイソフォームを持つ接着蛋白質ニューレキシン・ニューロリギンの相互作用メカニズム (2011)
  • Author(s): 田中宏樹, 他
  • Organizer: 第11回日本蛋白質科学会年会
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2011-06-07
• [Presentation] Structural basis for semaphorin signaling through the plexin receptor (2011)
  • Author(s): Takagi, Junichi
  • Organizer: Research Seminar at IRCC
  • Place of Presentation: Torino, Italy(招待講演)
  • Year and Date: 2011-05-06
• [Presentation] Structural analyses of b1 integrins by means of electron microscopy and X-ray crystallography (2011)
  • Author(s): Takagi, Junichi
  • Organizer: Gordon Research Conference (Fibronectin, Integrins & Related Molecules)
  • Place of Presentation: Ill Ciocco, Italy(招待講演)
  • Year and Date: 2011-05-01
• [Presentation] セマフォリンシグナルを伝達するプレキシン受容体活性化の構造的基盤 (2011)
  • Author(s): 高木淳一
  • Organizer: 平成23年度細胞外環境シンポジウム
  • Place of Presentation: 京都大学芝蘭会館(招待講演)
  • Year and Date: 2011-02-16
• [Presentation] 脳の層構造形成を制御するリーリンシグナルの分子機構 (2011)
  • Author(s): 禾 晃和
  • Organizer: 蛋白質研究所セミナー・細胞表面受容体と細胞内輸送
  • Place of Presentation: 大阪
  • Year and Date: 2011-01-12
• [Presentation] 脳の層構造形成を制御するリーリンシグナルの分子機構 (2011)
  • Author(s): 禾晃和
  • Organizer: 蛋白質研究所セミナー・細胞表面受容体と細胞内輸送
  • Place of Presentation: 大阪大学蛋白質研究所(招待講演)
  • Year and Date: 2011-01-12
• [Presentation] Structural basis for peptide ligand recognition by LR11 Vps10p domain (2011)
  • Author(s): 北郷悠, 他
  • Organizer: PDB40 symposium
  • Place of Presentation: Cold Spring Harbor Laboratory, USA
• [Presentation] LR11 Vps10pドメインのリガンド認識機構 (2011)
  • Author(s): 北郷悠, 他
  • Organizer: 2011年度日本結晶学会年会
  • Place of Presentation: 北海道大学学術交流会館
• [Presentation] リーリンN末端断片の精製及び結晶化 (2011)
  • Author(s): 長江雅倫, 他
  • Organizer: 2011年度日本結晶学会年会
  • Place of Presentation: 北海道大学学術交流会館
• [Presentation] Structural basis for semaphorin signaling through the plexin receptor. (2010)
  • Author(s): Takagi, Junichi
  • Organizer: International GCOE Symposium
  • Place of Presentation: Hyogo, Japan(招待講演)
  • Year and Date: 2010-11-09
• [Presentation] Combination of Correlative Light-Electron Microscopy and X-ray Crystallography Revealed a Unique Trans-Synaptic Adhesion Architecture. (2010)
  • Author(s): Takagi, Junichi
  • Organizer: The 2010 Asian Crystallographic Association Conference(AsCA2010)
  • Place of Presentation: Busan, (韓国)(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] EM imaging technique for molecular resolution in a cellular context (2010)
  • Author(s): Iwasaki, Kenji
  • Organizer: Microscopy of Soft and Hybrid Materials, A joint NUANCE-Hitachi workshop on correlative & multiplexed microscopy at the interface of biology and materials
  • Place of Presentation: Northwestern University, Evanston, IL, (米国)(招待講演)
  • Year and Date: 2010-10-25
• [Presentation] 電子顕微鏡イメージングー細胞・組織における分子分解能観察を目指して- (2010)
  • Author(s): 岩崎憲治
  • Organizer: グローバルCOE「細胞運命決定」主催 第5回構造生物学・先端技術講演会
  • Place of Presentation: 九州大学馬出病院キャンパス総合研究棟(招待講演)
  • Year and Date: 2010-09-29
• [Presentation] 電子顕微鏡イメージング-細胞・組織における分子分解能観察を目指して- (2010)
  • Author(s): 岩崎憲治
  • Organizer: 第6回連携大学院セミナー京都「生体分子の機能構造解析-最新のトピックスと今後の展望」
  • Place of Presentation: 京都府立大学(招待講演)
  • Year and Date: 2010-09-17
• [Presentation] Tags for easy detection, purification, and soluble expression of mammalian extracellular proteins (2010)
  • Author(s): Takagi, Junichi
  • Organizer: The Bioprocessing Summit, "Affinity Tag Protein Purification"
  • Place of Presentation: Boston Marriott Long Wharf, Boston, (米国)(招待講演)
  • Year and Date: 2010-08-24
• [Presentation] Structural and functional analysis of LR11 Vps10p domain (2010)
  • Author(s): Nakata, Z., Takagi, J. et al
  • Organizer: American Crystallographic Association
  • Place of Presentation: Chicago(USA)
  • Year and Date: 2010-07-25
• [Presentation] Structural and functional analysis of LR11 Vps10p domain (2010)
  • Author(s): Nakata, Z., Takagi, J., et al
  • Organizer: American Crystallographic Association
  • Place of Presentation: Sheraton Chicago Hotel & Towers(米国)
  • Year and Date: 2010-07-25
• [Presentation] Ligand binding mechanism of lipoprotein receptor family proteins revealed by three-dimensional structure analyses. (2010)
  • Author(s): Takagi, Junichi
  • Organizer: Gordon Research Conference (Lipoproteinmetabolism)
  • Place of Presentation: Waterville Valley, (米国)(招待講演)
  • Year and Date: 2010-06-23
• [Presentation] 大腸菌での可溶性発現と簡便な精製を可能にするFATTタグ (2010)
  • Author(s): 田畑早苗, 高木淳一
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2010-06-18
• [Presentation] 光一電子相関顕微鏡観察(CLEM)を用いた細胞間超分子構造の解明 (2010)
  • Author(s): 田中宏樹, 高木淳一
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2010-06-18
• [Presentation] 抗原ペプチド結合前後のモノクローナル抗体P20.1の立体構璋 (2010)
  • Author(s): 寒川剛, 高木淳一
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2010-06-17
• [Presentation] Single molecule studies on structure and function of photoactivated adenylyl cyclase (PAC), a sensor for photomovement in Euglena (2010)
  • Author(s): 岩崎憲治
  • Organizer: Gordon Research Conference, Photosensory Receptors & Signal Transduction
  • Place of Presentation: Lucca(Barga), (イタリア)(招待講演)
• [Presentation] 電子顕微鏡イメージングによる分子分解能観察 (2010)
  • Author(s): 岩崎憲治
  • Organizer: 第57回トキシン(毒素)シンポジウム
  • Place of Presentation: 長浜ロイヤルホテル(招待講演)
• [Presentation] 電子線トモグラフィーを用いたネガティブ染色試料における染色剤の厚さ測定 (2010)
  • Author(s): 的場京子, 岩崎憲治
  • Organizer: 日本顕微鏡学会第66回学術講演会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Utilization of a covalent probe and genetically-coded probe-acceptor in adual-purpose labeling system for light and electron microscopy (2010)
  • Author(s): Matsunaga, Y., Takagi, J., et al
  • Organizer: 17th International Microscopy Congress
  • Place of Presentation: Windsor Barra Convention Center, Rio de Janeiro, (ブラジル)
• [Presentation] 遺伝子導入型プローブによる分子標識 (2010)
  • Author(s): 松永幸子, 高木淳一
  • Organizer: 日本顕微鏡学会第66回学術講演会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Cutinase融合タンパク質を用いた部位特異的、共有結合的、一段階分子標識法の開発 (2010)
  • Author(s): 松永幸子, 高木淳一
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] PPI阻害物質探索のためのprotein-based screening
  • Author(s): 高木淳一
  • Organizer: 第12回日本蛋白質科学会年会
  • Place of Presentation: 名古屋国際会議場
  • Invited
• [Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ
  • Author(s): 高木淳一
  • Organizer: 第12回日本抗加齢医学会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging
  • Author(s): Junichi Takagi
  • Organizer: "International Integrin Signaling Meeting"
  • Place of Presentation: Universitaetszentrum Obergurgl, Tirol - Austria
  • Invited
• [Presentation] “構造神経科学”のすすめ－立体構造情報を使いこなすクールなニューロサイエンティストになろう－
  • Author(s): 高木淳一
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋国際会議場
  • Invited
• [Presentation] 免疫学研究における構造生物学のインパクト
  • Author(s): 高木淳一
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸ポートアイランド
  • Invited
• [Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin
  • Author(s): Junichi Takagi
  • Organizer: 第35回日本分子生物学会大会
  • Place of Presentation: 福岡国際会議場
  • Invited
• [Presentation] Multi-faceted approach to analyze structure and function of integrins
  • Author(s): Junichi Takagi
  • Organizer: Gordon Research Conference (Fibronectin, Integrins, & Related molecules)
  • Place of Presentation: Ventura Beach Marriott, USA
  • Invited
• [Book] タンパク質間相互作用の検出-表面プラズモン共鳴法、「タンパク質実験ノート(下)」(岡田雅人、三木裕明、宮崎 香 編) (2011)
  • Author(s): 寒川 剛、高木淳一
  • Publisher: 羊土社
• [Book] タンパク質実験ノート(下)(岡田雅人、三木裕明、宮崎香編) (2011)
  • Author(s): 寒川剛、高木淳一
  • Total Pages: 221
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.protein.osaka-u.ac.jp/rcsfp/synthesis/index.html
• [Remarks] 脳・神経系に発現する細胞外因子とそのレセプターに関する研究
  • URL: http://www.protein.osaka-u.ac.jp/rcsfp/synthesis/research1.html
• [Patent(Industrial Property Rights)] タグペプチド及びその利用 (2013)
  • Inventor(s): 高木淳一
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Acquisition Date: 2013-05-02
• [Patent(Industrial Property Rights)] TAG PEPTIDE HAVING A PROTEASE RECOGNITION SEQUENCE AND USE THEREOF (2012)
  • Inventor(s): 高木淳一
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Acquisition Date: 2012-12-26
  • Overseas