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Mechanisms that regulate remodeling and life-long maintenance ofadult-type neural circuits

Research Project

Project/Area Number 22247034
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionKyoto University

Principal Investigator

UEMURA Tadashi  京都大学, 大学院・生命科学研究科, 教授 (80213396)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2012: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords神経回路 / 樹状突起 / リモデリング / 神経変性 / 次世代シーケンサー / ショウジョウバエ
Research Abstract

For the establishment of functional neural circuits that support a wide range of animal behaviors, initial circuits formed in early development have to be reorganized. One way to achieve this is local remodeling of the circuitry hardwiring. We genetically investigated the underlying mechanisms of this remodeling, and discovered a gene that scales the size of dendritic arbors with that of the adult body.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (25 results) (of which Invited: 3 results)

  • [Journal Article] High-resolution in vivo imaging of regenerating dendrites of Drosophila sensory neurons during metamorphosis: local filopodial degeneration and heterotypic dendrite-dendrite contacts2012

    • Author(s)
      Daisuke Satoh*, Ritsuko Suyama*, Ken-ichi Kimura, Tadashi Uemura (*: equal contribution).
    • Journal Title

      Genes to Cells

      Volume: 12 Issue: 12 Pages: 939-951

    • DOI

      10.1111/gtc.12008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dendritic arborization: input processing, life-long maintenance, and allometry2013

    • Author(s)
      Tadashi Uemura
    • Organizer
      国際シンポジウム「感覚受容と神経回路」
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular mechanisms controlling size of neuronal dendritic arbors2012

    • Author(s)
      Kohei Shimono
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      博多
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 遺伝子ネットワークから細胞ジオメトリーを解く2012

    • Author(s)
      Tadashi Uemura
    • Organizer
      文部科学省数学・数理科学と諸科学・産業との連携研究ワークショップ
    • Place of Presentation
      博多
    • Year and Date
      2012-11-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Roles of a Drosophila homolog of Amyotrophic Lateral Sclerosis 2 (ALS2), a Rab5 GEF,in neuronaldendrite formation2012

    • Author(s)
      Yuta Takayama
    • Organizer
      第10回日本ショウジョウバエ研究集会
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Remodeling and Life-long Maintenance of Dendritic Arbors of Neurons2012

    • Author(s)
      Kohei Shimono
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      Nagoya
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Remodeling and Life-long Maintenance of Dendritic Arbors of Neurons2012

    • Author(s)
      Kohei Shimono
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      Kobe
    • Year and Date
      2012-05-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of Drosophila homolog of Amyotrophic Lateral Scelrosis 2 (ALS2), a Rab5 GEF, in neuronaldendritet formation2012

    • Author(s)
      Yuta Takayama
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      Kobe
    • Year and Date
      2012-05-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Towards applications of ATeam to monitor ATP levels at single cell resolution in Drosophilamelanogaster2011

    • Author(s)
      Taiichi Tsuyama
    • Organizer
      発生過程におけるエネルギー代謝を考える会
    • Place of Presentation
      Okazaki
    • Year and Date
      2011-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Linking global tissue asymmetry to cell polarity. Developmental Control of Sex, Growth and Cellular Fate2011

    • Author(s)
      Tadashi Uemura
    • Organizer
      Cold Spring Harbor Asia
    • Place of Presentation
      China
    • Year and Date
      2011-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Linking global tissue asymmetry to cell polarity2011

    • Author(s)
      Tadashi Uemura
    • Organizer
      Cellulardevelopment: Biology at the interface
    • Place of Presentation
      Kobe
    • Year and Date
      2011-09-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経細胞樹状突起パターンのリモデリングと維持を支える分子機構の解明2011

    • Author(s)
      下野耕平
    • Organizer
      新学術「ゲノム支援」拡大班会議
    • Place of Presentation
      新大阪ワシントンホテルプラザ
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] A Potential Role of Dendro-Dendritic Interaction in Remodeling into an Adult-type Arbor2011

    • Author(s)
      Ritsuko Suyama
    • Organizer
      the 1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Taipei
    • Related Report
      2012 Final Research Report
  • [Presentation] In Vivo Roles of the Drosophila Homolog of ALS2 Gene2011

    • Author(s)
      Yuta Takayama
    • Organizer
      the 1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Taipei
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Hunting for Genes that Regulate Remodeling and Life-long Maintenance of Dendritic Arbor2011

    • Author(s)
      Kohei Shimono
    • Organizer
      the 1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Taipei
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] In Vivo Roles of the Drosophila Homolog of ALS2 Gene2011

    • Author(s)
      Yuta Takayama
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hunting for Genes that Regulate Remodeling and Life-long Maintenance of Dendritic Arbors2011

    • Author(s)
      Kohei Shimono
    • Organizer
      the 1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Potential Role of Dendro-Dendritic Interaction in Remodeling into an Adult-type Arbor2011

    • Author(s)
      Ritsuko Suyama
    • Organizer
      the 1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of Drosophila homolog of Amyotrophic Lateral Scelrosis 2 (ALS2), a Rab5 GEF, in neuronal dendritet formation

    • Author(s)
      Yuta Takayama
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Remodeling and Life-long Maintenance of Dendritic Arbors of Neurons

    • Author(s)
      Kohei Shimono
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Remodeling and Life-long Maintenance of Dendritic Arbors of Neurons

    • Author(s)
      Kohei Shimono
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Roles of a Drosophila homolog of Amyotrophic Lateral Sclerosis 2 (ALS2), a Rab5 GEF,in neuronal dendrite formation

    • Author(s)
      Yuta Takayama
    • Organizer
      第10回日本ショウジョウバエ研究集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dendritic arborization: input processing, life-long maintenance, and allometry

    • Author(s)
      Tadashi Uemura
    • Organizer
      国際シンポジウム「感覚受容と神経回路」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Linking global tissue asymmetry to cell polarity

    • Author(s)
      Tadashi Uemura
    • Organizer
      Developmental Cell 創刊10周年記念シンポジウム “Cellular development: Biology at the interface”
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Linking global tissue asymmetry to cell polarity. Developmental Control of Sex, Growth and Cellular Fate.

    • Author(s)
      Tadashi Uemura
    • Organizer
      Cold Spring Harbor Asia
    • Place of Presentation
      中国
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Towards applications of ATeam to monitor ATP levels at single cell resolution in Drosophila melanogaster

    • Author(s)
      Taiichi Tsuyama
    • Organizer
      発生過程におけるエネルギー代謝を考える会
    • Place of Presentation
      岡崎
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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