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Elucidation of Evidence-based Physiological Functions of Small Peptides

Research Project

Project/Area Number 22248014
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKyushu University

Principal Investigator

MATSUI TOSHIRO  九州大学, (連合)農学研究科(研究院), 教授 (20238942)

Co-Investigator(Kenkyū-buntansha) SATO Masao  九州大学, 大学院農学研究院, 准教授 (90294909)
TSUDA Takanori  中部大学, 応用生物学部, 准教授 (90281568)
NAMBU Nobutaka  上智大学, 理工学部, 教授 (00249955)
Project Period (FY) 2010-05-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords低分子ペプチド / 生活習慣病予防 / 機能性食品 / カルシウムシグナル / MSシミュレーション / 血管系疾患 / MDシミュレーション / カルシウムブロッカー / ペプチド / 血管機能改善 / カルモジュリン / カルシムプロッカー
Research Abstract

In order to get new insights on physiological functions of small peptides, their potentials in tissues such as vessels and muscles were investigated in this study. As a result, it was clarified that basic di-peptides could relax contracted thoraces aorta in an endothelium-independent manner through the suppression of Ca2+-related signaling pathways by cell -line experiments and in silica analyses. Furthermore, we have demonstrated for the first time that the potent vasorelaxation power of basic do-peptides was ameliorated with aging and hypertension. We further got new evidence that basic di-peptides could absorb intact across intestinal membrane by our proposed new visualization technique (MADL-MS), and show anti-diabetic effect in muscle cells.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (69 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (24 results) (of which Peer Reviewed: 16 results) Presentation (34 results) (of which Invited: 7 results) Book (7 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Identification of Peptides from Soybean Protein, Glycinin, Possessing Suppression of Intracellular Ca^<2+> Concentration in Vascular Smooth Muscle Cells2014

    • Author(s)
      T.Kumrungsee, Z.-Q.Wang, S.Matsumura, T.Saiki, M.Tanaka, T.Matsui
    • Journal Title

      Food Chem.

      Volume: 152 Pages: 218-224

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of Peptides from Soybean Protein, Glycinin, Possessing Suppression of Intracellular Ca2+ Concentration in Vascular Smooth Muscle Cells.2014

    • Author(s)
      T. Kumrungsee
    • Journal Title

      Food Chemistry

      Volume: 152 Pages: 218-224

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of L-type Ca2+ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats2014

    • Author(s)
      T.Fukuda et al
    • Journal Title

      PLoS ONE

      Volume: 9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly-sensitive detection of free advanced glycation end-products by liquid chromatography-electrospray ionization tandem mass spectrometry with 2,4,6-trinitrobenzene sulfonate derivatization2013

    • Author(s)
      C.Hashimoto, Y.Iwaihara, S.J.Chen, M.Tanaka, T.Watanabe, T.Matsui
    • Journal Title

      Anal. Chem.

      Volume: 85 Pages: 4289-4295

    • Related Report
      2013 Final Research Report
  • [Journal Article] Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT12013

    • Author(s)
      J.Takeda et al
    • Journal Title

      Food Chemistry

      Volume: 138 Pages: 1240-1245

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly-sensitive detection of free advanced glycation end-products by liquid chromatography-electrospray ionization tandem mass spectrometry with 2,4,6-trinitrobenzene sulfonate derivatization2013

    • Author(s)
      C.Hashimoto et al.
    • Journal Title

      Analytical Chemistry

      Volume: 85 Pages: 4289-4295

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of liquid chromatography-tandem mass spectrometric detection of di-peptides by 2,4,6-trinitrobenzene sulfonate derivatization.2013

    • Author(s)
      E.Nakashima et al.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77 Pages: 2094-2099

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced visualization of small peptides absorbed in rat small intestine by phytic-acid-aided MALDI-imaging mass spectrometry2013

    • Author(s)
      S.M.Hong et al.
    • Journal Title

      Analytical Chemistry

      Volume: 85 Pages: 10033-10039

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells.2013

    • Author(s)
      J.Qiu et al.
    • Journal Title

      Biochemical Pharmacology

      Volume: 87 Pages: 344-351

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncharged imidazolium moiety in adenine is responsible for endothelium-independent relaxation in contracted thoracic aorta of Sprague-Dawley rats2012

    • Author(s)
      S.Tokuda, T.Fukuda, Y.Kobayashi, M.Tanaka, T.Matsui
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 76(4) Pages: 828-830

    • Related Report
      2013 Final Research Report
  • [Journal Article] The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca^<2+> channels in rat vascular smooth muscle cells2012

    • Author(s)
      Y.Kobayashi, T.Fukuda, M.Tanaka, T.Matsui
    • Journal Title

      FEBS Open Bio

      Volume: 2 Pages: 83-88

    • Related Report
      2013 Final Research Report
  • [Journal Article] The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca^<2+> channels in rat vascular smooth muscle cells2012

    • Author(s)
      Yutaro K, et al.
    • Journal Title

      FEBS Open Bio

      Volume: 2 Issue: 1 Pages: 83-88

    • DOI

      10.1016/j.fob.2012.04.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncharged imidazolium moiety in adenine is responsible for endothelium-independent relaxation in contracted thoracic aorta of Sprague-Dawley rats2012

    • Author(s)
      Shinji, Tokuda, Toshihiko Fukuda, Yutaro Kobayashi, Mitsuru Tanaka and Toshiro Matsui
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76 Pages: 828-830

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization and PI3K/Akt pathways2012

    • Author(s)
      Eui-Baek Byun, Teruaki Ishikawa, Aki Suyama, Masaya Kono, Shohei Nakashima, Tomomasa Kanda, Takahisa Miyamoto, Toshiro Matsui
    • Journal Title

      Eur. J. Pharm.

      Volume: 692 Issue: 1-3 Pages: 52-60

    • DOI

      10.1016/j.ejphar.2012.07.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigallocatechin gallate promotes the vasorelaxation power of the anti-atherosclerotic dipeptide Trp-His in contracted rat aorta2012

    • Author(s)
      Mitsuru Tanaka, Jian Zhao, Aki Suyama, Toshiro Matsui
    • Journal Title

      J. Agric. Food Chem

      Volume: 60 Pages: 8036-8043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anthocyanins as Functional Food Factors― Chemistry, Nutrition and Health Promotion2012

    • Author(s)
      T.Tsuda
    • Journal Title

      Food Sci. Technol. Res

      Volume: 18 Pages: 315-324

    • NAID

      10030922596

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genistein and daidzein, typical soy isoflavones, inhibit TNF-a-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes2012

    • Author(s)
      M. Yanagisawa, M. Sugiya, H. Iijima, I. Nakagome, S. Hirono, T. Tsuda
    • Journal Title

      Mol. Nutr. Food Res

      Volume: 56 Pages: 1783-1793

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncharged imidazolium moiety in adenine is responsible for endothelium-independent relaxation in contracted thoracic aorta of SD rats2012

    • Author(s)
      Tokuda, et al
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of ^<13>C-stable-isotope labeling LC-MRM-MS/MS method for determining intact absorption of bioactive di-peptides in rats2011

    • Author(s)
      E.M.N.Nakashima, A.Kudo, Y.Iwaihara, M.Tanaka, K.Matsumoto, T.Matsui
    • Journal Title

      Anal. Biochem.

      Volume: 414 Pages: 109-116

    • Related Report
      2013 Final Research Report
  • [Journal Article] 血管機能とペプチド2011

    • Author(s)
      松井利郎、田中充
    • Journal Title

      New Food Industry

      Volume: 53 Pages: 22-30

    • NAID

      40018729449

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Vasodilating di-peptide Trp-His can prevent atherosclerosis in apolipoprotein E-deficient mice2010

    • Author(s)
      T.Matsui, M.Sato, M.Tanaka, Y.Yamada, S.Watanabe, Y.Fujimoto, K.Imaizumi, K.Matsumoto
    • Journal Title

      Br. J. Nutr.

      Volume: 103(3) Pages: 309-313

    • Related Report
      2013 Final Research Report
  • [Journal Article] Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca^<2+> entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca^<2+> channels2010

    • Author(s)
      Z.Wang, S.Watanabe, Y.Kobayashi, M.Tanaka, T.Matsui
    • Journal Title

      Peptides

      Volume: 31 Pages: 2060-2066

    • NAID

      120005227108

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Journal Article] Vasodilating di-peptide Trp-His can prevent atherosclerosis in apolipoprotein E-deficient mice2010

    • Author(s)
      Matsui, T, et al
    • Journal Title

      Br.J.Nutr.

      Volume: 103 Pages: 309-313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherosclerotic di-peptide, Trp-His, can suppress intracellular [Ca^<2+>] in vascular smooth muscle cells in a similar manner to dihydropyridine type Ca^<2+> channel blocker2010

    • Author(s)
      Z.Wang, et al
    • Journal Title

      J.Hypertension

      Volume: S2010 Pages: 1221-1221

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血管機能改善ペプチドと腸管吸収2013

    • Author(s)
      松井利郎
    • Organizer
      平成25年度食品流通問題別研究会講演会
    • Year and Date
      2013-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] High-sensitive detection and visualization of vasoactive small peptides2013

    • Author(s)
      T.Matsui
    • Organizer
      2013 Symposium on Analysis and Efficacy of Functional Foods in East Asia Region
    • Year and Date
      2013-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管弛緩ペプチド2013

    • Author(s)
      松井利郎
    • Organizer
      第67回日本栄養・食糧学会シンポジウム
    • Year and Date
      2013-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管弛緩性ペプチドTrp-His(WH)によるAMP キナーゼ活性化作用とその機序2013

    • Author(s)
      曽我 実, 大橋彩加, 谷口恵美, 滝川雅仁, 松井 利郎, 津田孝範
    • Organizer
      第67回日本栄養・食糧学会
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体組織中低分子ペプチドのMALDI-MS Imaging感度向上に対する有機酸添加効果の検証2013

    • Author(s)
      田中 充ら
    • Organizer
      第73回日本分析化学会討論会
    • Place of Presentation
      北海道大学水産学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] Adenineは血管平滑筋細胞でのPLC/PKC経路の抑制を介して血管弛緩作用を発現する2013

    • Author(s)
      福田俊彦ら
    • Organizer
      第67回日本栄養食糧学会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管弛緩ペプチド2013

    • Author(s)
      松井利郎
    • Organizer
      第67回日本栄養食糧学会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ペプチド吸収の可視化と高感度検出2013

    • Author(s)
      松井利郎
    • Organizer
      第38回機能性食品用ペプチド研究会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] MALDI-MS imaging法による低分子ペプチドの腸管吸収動態の可視化2013

    • Author(s)
      田中 充ら
    • Organizer
      第60回日本食品科学工学会大会
    • Place of Presentation
      実践女子大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Physiological potentials of condensed polyphenols in intestine and muscle tissues2013

    • Author(s)
      松井利郎
    • Organizer
      2013 Int. Meeting of the Korean Society of Food Science and Nutrition
    • Place of Presentation
      Gwangju (Korea)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管機能改善ペプチドと腸管吸収2013

    • Author(s)
      松井利郎
    • Organizer
      平成25年度食品流通問題別研究会
    • Place of Presentation
      善通寺市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低分子ペプチドTrp-HisとEgCgとの相乗的血管弛緩作用はNO/cGMP系賦活活性を介して発現する2012

    • Author(s)
      田中 充、須山 晶、趙 健、松井利郎
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗動脈硬化ペプチドTrp-Hisは血管平滑筋細胞でのL型チャンネルのリン酸化を抑制する2012

    • Author(s)
      福田俊彦、小林優多郎、田中 充、松井利郎
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ポリフェノール類の吸収と腸管での作用2012

    • Author(s)
      松井利郎
    • Organizer
      第22回西日本食品産業創造展
    • Place of Presentation
      福岡市マリンメッセ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血管内皮細胞におけるダッタンソバ由来新規血管弛緩成分osbekkic acidの作用メカニズム解明2012

    • Author(s)
      幸野将也、徳田信二、松井利郎
    • Organizer
      第59回日本食品科学工学会大会
    • Place of Presentation
      藤女子大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ペプチド科学の未来を探る2012

    • Author(s)
      松井利郎
    • Organizer
      第34回日本薬学会九州支部コロキウム
    • Place of Presentation
      長崎大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ペプチドによる生活習慣病予防2012

    • Author(s)
      松井利郎
    • Organizer
      第2回新アミノ酸研究会
    • Place of Presentation
      東京大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Epigallocatechin gallate enhances the endothelium-independent vasorelaxation of the anti-atherosclerotic Ca2+ channel blocking peptide, Trp-His, in thoracic aorta from Splague-Dawley rats2012

    • Author(s)
      田中 充、須山 晶、趙 健、松井利郎
    • Organizer
      24th Meeting of the International Society of Hypertension
    • Place of Presentation
      Sydney
    • Related Report
      2012 Annual Research Report
  • [Presentation] Vasorelaxant dipeptide, Trp-His, regulates Ca2+-signialing pathway by inhibiting the phosphorylation of voltage-dependent L-type Ca2+ channel in vascular smooth muscle cells2012

    • Author(s)
      福田俊彦、小林優多郎、田中 充、松井利郎
    • Organizer
      24th Meeting of the International Society of Hypertension
    • Place of Presentation
      Sydney
    • Related Report
      2012 Annual Research Report
  • [Presentation] アデニン及びそのアナログ体のラット大動脈摘出血管に対する弛緩作用の発現2011

    • Author(s)
      徳田信二、福田俊彦、松井利郎
    • Organizer
      日本栄養食糧学会九州沖縄支部大会
    • Place of Presentation
      佐賀市(佐賀大)
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管平滑筋細胞における抗動脈硬化ペプチドTrp-Hisの細胞内Ca^<2+>シグナル系抑制機構の解明2011

    • Author(s)
      小林優多郎, ら
    • Organizer
      日本栄養食糧学会九州沖縄支部大会
    • Place of Presentation
      佐賀市(佐賀大)
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] グリシニン酵素加水分解物からの血管平滑筋細胞内Ca^<2+>流入阻害ペプチドの検索2011

    • Author(s)
      松村慎也, ら
    • Organizer
      日本栄養食糧学会九州沖縄支部大会
    • Place of Presentation
      佐賀市(佐賀大)
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血圧降下ペプチド2011

    • Author(s)
      松井利郎
    • Organizer
      日本栄養食糧学会中部支部
    • Place of Presentation
      岐阜市(岐阜大)(招待講演)
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Potentials of peptide functionality2011

    • Author(s)
      T.Matsui
    • Organizer
      Int.Symposium on Phytochemicals
    • Place of Presentation
      Taiwan (Taipei Med.Univ.)(招待講演)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食品分析学から視た食機能学2011

    • Author(s)
      松井利郎
    • Organizer
      日本農芸化学会西日本支部例会
    • Place of Presentation
      熊本市(サントリー)(招待講演)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低分子ペプチドの生理機能相乗作用に関する研究2011

    • Author(s)
      田中充、松井利郎
    • Organizer
      第65回日本栄養食糧学会
    • Place of Presentation
      東京都(お茶の水女子大)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高血圧・糖尿病対策トクホの作用2011

    • Author(s)
      松井利郎
    • Organizer
      栄養情報担当者(NR)協会講習会
    • Place of Presentation
      福岡
    • Year and Date
      2011-02-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本の食品機能性研究の動向2010

    • Author(s)
      松井利郎
    • Organizer
      中日食品科学工学会産官学交流シンポジウム
    • Place of Presentation
      北京、中国
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-atherosclerotic di-peptide, Trp-His, can suppress intracellular [Ca^<2+>] in vascular smooth muscle cells in a similar manner to dihydropyridine type Ca^<2+> channel blocker2010

    • Author(s)
      Z.Wang, et al
    • Organizer
      23^<rd>国際高血圧学会
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管平滑筋細胞を用いた血管機能改善ジペプチドTrp-HisのL型Ca^<2+>チャンネルに対する結合部位の解明2010

    • Author(s)
      小林優多郎, ほか
    • Organizer
      第57回日本食品科学工学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ペプチドの疾病予防作用2010

    • Author(s)
      松井利郎
    • Organizer
      福岡県新生活クラブ講演会
    • Place of Presentation
      福岡
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管弛緩性ペプチドによる細胞内Ca^<2+>調節機構の解明2010

    • Author(s)
      小林優多郎, ほか
    • Organizer
      日本分析化学会北海道支部セミナー
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ペプチド機能の最前線2010

    • Author(s)
      松井利郎
    • Organizer
      日本分析化学会北海道支部セミナー
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological functionalities of small peptides2010

    • Author(s)
      松井利郎
    • Organizer
      2010 International Meeting of the Microbiological Society of Korea
    • Place of Presentation
      Korea, Inju
    • Year and Date
      2010-05-07
    • Related Report
      2010 Annual Research Report
  • [Book] Bioactive Natural Products : Opportunities & Challenges in Medicinal Chemistry2013

    • Author(s)
      Ju Qiu, Norihiko Terahara, T.Matsui
    • Publisher
      World Scientific Publishing
    • Related Report
      2013 Final Research Report
  • [Book] Bioactive Natural Products : Opportunities & Challenges in Medicinal Chemistry2012

    • Author(s)
      T.Matsui, Z.Wang, M.Tanaka
    • Publisher
      World Scientific Publishing
    • Related Report
      2013 Final Research Report
  • [Book] Bioactive Natural Products: Opportunities & Challenges in Medicinal Chemistry2012

    • Author(s)
      T.Matsui
    • Total Pages
      670
    • Publisher
      World Scientific Publishing
    • Related Report
      2012 Annual Research Report
  • [Book] Bioactive Natural Products2012

    • Author(s)
      T.Matsui, Z.Wang, M.Tanaka
    • Publisher
      World Scientific Publishing
    • Related Report
      2011 Annual Research Report
  • [Book] Biologically Active Food Proteins and Peptides in Health- Fundamental and Clinical aspects-2010

    • Author(s)
      T.Matsui, M.Tanaka
    • Publisher
      Wiley Blackwell
    • Related Report
      2013 Final Research Report
  • [Book] 大豆のすべて,サイエンスフォーラム,第5章2010

    • Author(s)
      松井利郎
    • Related Report
      2013 Final Research Report
  • [Book] Bioactive Proteins and Peptides as Functional Foods and Nutraceutical2010

    • Author(s)
      Matsui, T, et al
    • Total Pages
      420
    • Publisher
      IFT Book Series, Wiley Blackwell
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.agr.kyushu-u.ac.jp/biosci-biotech/bunseki/

    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] AMPキナーゼ活性化剤及びその用途2013

    • Inventor(s)
      松井利郎、津田孝範
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Number
      2013-024082
    • Filing Date
      2013-02-21
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] アミノ化合物およびその高感度質量分析法2013

    • Inventor(s)
      松井利郎、渡辺俊明
    • Industrial Property Rights Holder
      松井利郎、渡辺俊明
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-11
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] アミノ化合物およびその高感度質量分析法2012

    • Inventor(s)
      松井利郎、渡辺俊明
    • Industrial Property Rights Holder
      九州大学
    • Industrial Property Number
      2012-156746
    • Filing Date
      2012-07-12
    • Related Report
      2013 Final Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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