Artificial promotion of fish growth and reproduction via brain function in response to a photic environment

• Project/Area Number: 22248023
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General fisheries
• Research Institution: Kitasato University
• Principal Investigator: TAKAHASHI Akiyoshi 北里大学, 海洋生命科学部, 教授 (10183849)
• Co-Investigator(Kenkyū-buntansha): MORIYAMA Shunsuke 北里大学, 海洋生命科学部, 教授 (50222352) ; AMANO Masafumi 北里大学, 海洋生命科学部, 教授 (10296428) ; MIZUSAWA Kanta 北里大学, 海洋生命科学部, 講師 (70458743) ; ASAHINA Kiyoshi 日本大学, 生物資源科学部, 教授 (10147671) ; ANDO Hironori 新潟大学, 自然科学系, 教授 (60221743) ; OHIRA Tsuyoshi 神奈川大学, 理学部, 准教授 (10361809)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000); Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2010: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
• Keywords: 魚類 / 成長 / 特定波長光 / 発光ダイオード / メラニン凝集ホルモン / 黒色素胞刺激ホルモン / マツカワ / キンギョ / 水圏生命科学 / 生理学 / 光環境 / 成熟 / 視物質 / 摂餌量 / 日間成長率 / 生殖腺刺激ホルモン放出ホルモン / トラフグ / MCH / GnRH

Research Abstract

We found that, compared to the growth of fish under ambient lighting, the somatic growth of the barfin flounder (Verasper moseri) was stimulated by irradiation with a specific wavelength of light from a light-emitting diode (LED). The significant effects of LED light, especially green LED light, on growth promotion were observed even under low water temperature when body weight decreased because of reduced food intake during the experimental period. Our results suggest that irradiation with a specific wavelength of light could be useful in improving fish growth in aquaculture. Unexpected fluctuations were observed in the expression of hormonal genes associated with growth and feeding behavior. Thus, further experiments are necessary to understand the neuroendocrine mechanisms linking LED light and fish growth.

Research Products

• [Journal Article] Multifunctional roles of melanocyte-stimulating hormone and melanin-concentrating hormone in fish : evolution from classical body color change (2014)
  • Author(s): Takahashi, A., Mizusawa, K., Amano, M.
  • Journal Title: Aqua-BioScience Monographs Volume: 7 Issue: 1 Pages: 1-46
  • DOI: 10.5047/absm.2014.00701.0001
  • Peer Reviewed
• [Journal Article] Posttranslational modification of intercellular messenger systems (2014)
  • Author(s): Kakizawa, S., Kaiya, H., Takahashi, A.
  • Journal Title: Frontiers in Endocrinology (Lausanne) Volume: 5 Pages: 27-27
  • DOI: 10.3389/fendo.2014.00027
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effects of beta-endorphin on cortisol release from goldfish (Carassius auratus) head kidney: an in vitro study (2014)
  • Author(s): Kobayashi, Ｙ., Mizusawa, K., Arai, Y., Chiba, H., Takahashi, A.
  • Journal Title: General and Comparative Endocrinology Volume: in press
  • Peer Reviewed
• [Journal Article] Pituitary control of branchial NCC, NKCC and Na(+), K (+)-ATPase α-subunit gene expression in Nile tilapia, Oreochromis niloticus (2014)
  • Author(s): Breves, J.P., Seale, A.P., Moorman, B.P., Lerner, D.T., Moriyama, S., Hopkins, K.D., Grau, E.G.
  • Journal Title: Journal of Comparative Physiology B Volume: in press
  • Peer Reviewed
• [Journal Article] Identification of mRNA coding for corticotropin-releasing hormone (CRH) and immunohistochemical detection of CRH peptide in the brain of the Japanese eel paying special attention to its relationship with gonadotropin-releasing hormone (2014)
  • Author(s): Amano, M., Mizusawa, N., Okubo, K., Amiya, N., Mizusawa, K., Chiba H., Yamamoto, N., Takahashi, A.
  • Journal Title: Cell and Tissue Research Volume: 356 Issue: 1 Pages: 243-251
  • DOI: 10.1007/s00441-013-1784-6
  • Peer Reviewed
• [Journal Article] Characterization of gonadotropin-releasing hormone and gonadotropin in jack mackerel (Trachurus japonicus) : Comparative gene expression analysis with respect to reproductive dysfunction in captive and wild fish. (2014)
  • Author(s): Yui Imanaga, Mitsuo Nyuji, et al.
  • Journal Title: Aquaculture Volume: 428-429 Pages: 226-235
  • DOI: 10.1016/j.aquaculture.2014.03.003
  • Peer Reviewed
• [Journal Article] Parentage assessment of incomplete ossification in larval Japanese flounder by microsatellite DNA markers (2014)
  • Author(s): Sawayama, E., Asahina, K., Takagi, M.
  • Journal Title: Aquaculture Volume: 420-421 Pages: S98-S103
  • DOI: 10.1016/j.aquaculture.2013.06.006
  • Peer Reviewed
• [Journal Article] N-methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish (2014)
  • Author(s): Okihara, R.S.Ｎ., Saito, T., Ogata, H., Ohsaki, A., Iida, T., Asahina, K., Mitamura, K., Ikegawa, S., Hofmann, A.E., Hagey, L.R.
  • Journal Title: Steroids Volume: 80 Pages: 15-23
  • DOI: 10.1016/j.steroids.2013.11.014
  • Peer Reviewed / Open Access
• [Journal Article] Larval pufferfish protected by maternal tetrodotoxin (2014)
  • Author(s): Itoi, S., Yoshikawa, S., Asahina, K., Suzuki, M., Ishizuka, K., Takimoto, N., Mitsuoka, R., Yokoyama, N., Detake, A., Takayanagi, C., Eguchi, M., Tatsuno, R., Kawane, M., Kokubo, S., Takanashi, S., Miura, A., Suitoh, K., Takatani, T., Arakawa, O., Sakakura, Y., Sugita, H.
  • Journal Title: Toxicon Volume: 78 Pages: 35-40
  • DOI: 10.1016/j.toxicon.2013.11.003
  • NAID: 120006986794
  • Peer Reviewed / Open Access
• [Journal Article] Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance (2013)
  • Author(s): Takahashi, A., Mizusawa K.
  • Journal Title: Frontiers in Endocrinology (Lausanne) Volume: 4 Pages: 143-143
  • DOI: 10.3389/fendo.2013.00143
  • Peer Reviewed
• [Journal Article] The pituitary-interrenal axis of fish : A review focusing on the lamprey and flounder. (2013)
  • Author(s): Takahashi A, Kobayashi Y, Mizusawa K.
  • Journal Title: Gen Comp Endocrinol. Volume: (掲載決定) Pages: 54-59
  • DOI: 10.1016/j.ygcen.2013.03.005
  • Peer Reviewed
• [Journal Article] Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change : roles emerging from barfin flounder Verasper moseri. (2013)
  • Author(s): Mizusawa K, Kobayashi Y, Yamanome T, Saito Y, Takahashi A.
  • Journal Title: Gen Comp Endocrinol. Volume: 181 Pages: 229-234
  • DOI: 10.1016/j.ygcen.2012.09.026
  • Peer Reviewed
• [Journal Article] 水産業への光技術の応用 (2013)
  • Author(s): 渡部俊広，岡内正典，清水大輔，長谷川英一，稲田博史，高橋明義
  • Journal Title: 月刊オプトロニクス Volume: 32 Pages: 105-110
• [Journal Article] 魚類の成長と特定波長光照射～発光ダイオードの効果～ (2013)
  • Author(s): 高橋明義，水澤寛太，古藤澄久，菊地重人
  • Journal Title: アクアネット Volume: 181 Pages: 18-23
• [Journal Article] Developmental changes in melanophores and their asymmetrical responsiveness to melanin-concentrating hormone during metamorphosis in barfin flounder (Verasper moseri) (2013)
  • Author(s): Yoshikawa, N., Matsuda, T., Takahashi, A., Tagawa, M.
  • Journal Title: General and Comparative Endocrinology Volume: 194 Pages: 118-123
  • DOI: 10.1016/j.ygcen.2013.09.006
  • NAID: 120005341898
  • Peer Reviewed
• [Journal Article] Diurnal changes in salmon GnRH secretion in the brain of masu salmon (Oncorhynchus masou) (2013)
  • Author(s): Fukaya, K., Amano, M., Ueda, H.
  • Journal Title: General and Comparative Endocrinology Volume: 192 Pages: 77-80
  • DOI: 10.1016/j.ygcen.2013.02.027
  • NAID: 120005350094
  • Peer Reviewed
• [Journal Article] Accumulation of organotins in wharf roach (Ligia exotica Roux) and its ability to serve as a biomonitoring species for coastal pollution (2013)
  • Author(s): Undap S.L., Matsunaga, S., Honda, M., Sekiguchi, T., Suzuki, N., Khalil, F., Qiu, X., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Sunobe, T., Takeda, S., Munehara, H., Oshima, Y.
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 96 Pages: 75-79
  • DOI: 10.1016/j.ecoenv.2013.06.019
  • Peer Reviewed
• [Journal Article] The saccus vasculosus of fish is a sensor of seasonal changes in day length (2013)
  • Author(s): Nakane, Y., Ikegami, K., Iigo, M., Ono, H., Takeda, K., Takahashi, D., Uesaka, M., Kimijima, M., Hashimoto, R., Arai, N., Suga, T., Kosuge, K., Abe, T., Maeda, R., Senga, T., Amiya, N., Azuma, T., Amano, M., Abe, H., Yamamoto, N., Yoshimura, T.
  • Journal Title: Nature Communications Volume: 4, Article 2108 Issue: 1 Pages: 1-7
  • DOI: 10.1038/ncomms3108
  • Peer Reviewed
• [Journal Article] Molecular evolution of Kiss2 genes and peptides in vertebrates (2013)
  • Author(s): T. Osugi, N. Ohtaki, Y. Sunakawa, Y. L. Son, M. Ohkubo, M. Iigo, M. Amano, K. Tsutsui
  • Journal Title: Endocrinology Volume: VOL.154 Issue: 11 Pages: 4270-4280
  • DOI: 10.1210/en.2012-2267
  • Peer Reviewed
• [Journal Article] Central administration of prolactin-releasing peptide shifts the utilities of metabolic fuels from carbohydrate to lipids in chicks. (2013)
  • Author(s): Tachibana, T., Moriyama, S., Khan, M.S., Sakamoto, T.
  • Journal Title: Physiology and Behavior Volume: 120 Pages: 40-45
  • DOI: 10.1016/j.physbeh.2013.06.017
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• [Journal Article] Molecular neuroendocrine basis of lunar-related spawning in grass puffer (2013)
  • Author(s): Ando H
  • Journal Title: General and Comparative Endocrinology Volume: 181 Pages: 211-214
  • DOI: 10.1016/j.ygcen.2012.07.027
  • Peer Reviewed
• [Journal Article] The octadecaneuropeptide ODN stimulates somatolactin release from cultured goldfish pituitary cells. (2013)
  • Author(s): Azuma M, Wada K, Leprince J, Tonon MC, Uchiyama M, Takahashi A, Vaudry H, Matsuda K.
  • Journal Title: Journal of neuroendocrinology Volume: 25 Issue: 3 Pages: 312-321
  • DOI: 10.1111/jne.12005
  • Peer Reviewed
• [Journal Article] Food deprivation increases the expression of the prepro-orexin gene in the hypothalamus of the barfin flounder (2012)
  • Author(s): Amiya N, Mizusawa K, Kobayashi Y, Yamanome T, Amano M, Takahashi A
  • Journal Title: Verasper moseri. Zool. Sci. Volume: 29 Issue: 1 Pages: 42-48
  • DOI: 10.2108/zsj.29.43
  • Peer Reviewed
• [Journal Article] Melanocortinsystemsonpigmentdispersioninfishchromatophores (2012)
  • Author(s): 小林勇喜
  • Journal Title: frontiers in ENDOCINOLOGY Volume: 3-9 Pages: 1-6
  • DOI: 10.3389/fendo.2012.00009
  • Peer Reviewed
• [Journal Article] Regulation of growth hormone (GH) receptor (GHR1 and GHR2) mRNA level by GH and metabolic hormones in primary cultured tilapia hepatocytes (2012)
  • Author(s): Pierce AL
  • Journal Title: General and Comparative Endocrinology Volume: 179 Issue: 1 Pages: 22-29
  • DOI: 10.1016/j.ygcen.2012.07.010
  • Peer Reviewed
• [Journal Article] Identification and gene expression analyses of ghrelin in the stomach of Pacific bluefin tuna (Thunnus orientalis) (2012)
  • Author(s): Suda A
  • Journal Title: General and Comparative Endocrinology Volume: 178 Issue: 1 Pages: 89-97
  • DOI: 10.1016/j.ygcen.2012.04.026
  • Peer Reviewed
• [Journal Article] Identification of mRNAs coding for mammalian-type melanin-concentrating hormone and its receptors in the scalloped hammerhead shark Sphyrna lewini (2012)
  • Author(s): Mizusawa K
  • Journal Title: General and Comparative Endocrinology Volume: 179 Issue: 1 Pages: 78-87
  • DOI: 10.1016/j.ygcen.2012.07.023
  • Peer Reviewed
• [Journal Article] Polymorphism of somatolactin-producing cells in the goldfish pituitary: immunohistochemical investigation for somatolactin-α and -β (2012)
  • Author(s): Azuma M
  • Journal Title: Cell and Tissue Research Volume: 350 Issue: 1 Pages: 167-176
  • DOI: 10.1007/s00441-012-1435-3
  • Peer Reviewed
• [Journal Article] Increased expression of kisspeptin and GnRH forms in the brain of scombroid fish during final ovarian maturation and ovulation (2012)
  • Author(s): Selvaraj S., et al.
  • Journal Title: Reprod. Biol. Endocrinol. Volume: 10 Issue: 1 Pages: 64-74
  • DOI: 10.1186/1477-7827-10-64
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• [Journal Article] Molecular characterization and expression profiles of three GnRH formsin the brain and pituitary of adult chub mackerel (Scomber japonicus) (2012)
  • Author(s): Selvaraj S., et al.
  • Journal Title: Aquaculture Volume: 356-357 Pages: 200-210
  • DOI: 10.1016/j.aquaculture.2012.05.015
  • Peer Reviewed
• [Journal Article] Chum salmon fry grow faster in seawater, exhibit greater activity of the GH/IGF axis, higher Na+, K+-ATPase activity, and greater gill chloride cell development (2012)
  • Author(s): Iwata M
  • Journal Title: Aquaculture Volume: 362-363 Pages: 101-108
  • DOI: 10.1016/j.aquaculture.2010.10.035
  • Peer Reviewed
• [Journal Article] Involvement of sex steroids and thyroid hormones in upstream and downstream behaviors in masu salmon, Oncorhynchus masou (2012)
  • Author(s): Munakata A
  • Journal Title: Aquaculture Volume: 362-363 Pages: 158-166
  • DOI: 10.1016/j.aquaculture.2010.11.027
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• [Journal Article] Involvement of sex steroids, luteinizing hormone and thyroid hormones in upstream and downstream swimming behaviors in land-locked sockeye salmon Oncorhynchus nerka (2012)
  • Author(s): Munakata A., Amano M., Ikuta K., Kitamura S., and Aida K
  • Journal Title: Fisheries Science Volume: 78, 1 Issue: 1 Pages: 81-90
  • DOI: 10.1007/s12562-011-0436-6
  • NAID: 10030025064
  • Peer Reviewed
• [Journal Article] Physiological and molecular endocrine changes in maturing wild sockeye salmon, Oncorhynchus nerka, during ocean and river migration (2012)
  • Author(s): Flores, A.M.
  • Journal Title: Journal of Comparative Physiology B Volume: 182 Issue: 1 Pages: 77-90
  • DOI: 10.1007/s00360-011-0600-4
  • Peer Reviewed
• [Journal Article] Effects of growth hormone on the salmon pituitary proteome (2012)
  • Author(s): Kurata, Y.
  • Journal Title: Journal of Proteomics Volume: 75 Issue: 6 Pages: 1718-1731
  • DOI: 10.1016/j.jprot.2011.12.009
  • Peer Reviewed
• [Journal Article] Chum salmon fry grow faster in seawater, exhibit greater activity of the GH/IGF axis, higher Na^+K^+-ATPase activity, and greater gill chloride cell development (2012)
  • Author(s): Iwata, M.
  • Journal Title: Aquaculture Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Further evidence on acetylation-induced inhibition of the pigment-dispersing activity of α-melanocyte-stimulating hormone (2011)
  • Author(s): 小林勇喜
  • Journal Title: General and Comparative Endocrinology Volume: 176 Issue: 1 Pages: 9-17
  • DOI: 10.1016/j.ygcen.2011.12.001
  • Peer Reviewed
• [Journal Article] Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri (2011)
  • Author(s): Mizusawa, K., Kobayashi, Y., Sunuma, T., Asahida, T., Saito, Y., Takahashi, A.
  • Journal Title: General and Comparative Endocrinology Volume: 171 Issue: 1 Pages: 75-81
  • DOI: 10.1016/j.ygcen.2010.12.008
  • Peer Reviewed
• [Journal Article] Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2 (2011)
  • Author(s): Hamamoto A, Mizusawa K, Takahashi A, Saito Y
  • Journal Title: Regul. Pept. Volume: 169 Issue: 1-3 Pages: 6-12
  • DOI: 10.1016/j.regpep.2011.04.001
  • Peer Reviewed
• [Journal Article] Pigment-dispersing activities and cortisol-releasing activities of melanocortins and their receptors in xanthophores and head kidneys of the goldfish Carassius auratus (2011)
  • Author(s): 小林勇喜
  • Journal Title: General and Comparative Endocrinology Volume: 173 Issue: 3 Pages: 438-446
  • DOI: 10.1016/j.ygcen.2011.06.019
  • Peer Reviewed
• [Journal Article] Synchronised expressions of LPXRFamide peptide and its receptor genes : seasonal, diurnal and circadian changes during spawning period in grasspuffer (2011)
  • Author(s): M.Shahjahan, K.Tsutsui, et al
  • Journal Title: J.Endocrinol. Volume: 23 Issue: 1 Pages: 39-51
  • DOI: 10.1111/j.1365-2826.2010.02081.x
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• [Journal Article] Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish (2011)
  • Author(s): Onuma, T.A.
  • Journal Title: Journal of Neuroscience Volume: 31 Issue: 33 Pages: 11814-11824
  • DOI: 10.1523/jneurosci.6804-10.2011
  • Peer Reviewed
• [Journal Article] Neuropeptide Y in tiger puffer (Takifugu rubripes) : distribution, cloning, characterization and mRNA expression responses to prandial condition (2011)
  • Author(s): Kamijo M, et.al., 他8名
  • Journal Title: Zoological Science Volume: 28 Issue: 12 Pages: 882-890
  • DOI: 10.2108/zsj.28.882
  • Peer Reviewed
• [Journal Article] Diversity of the hypothalamo-neurohypophysial system and its hormonal genes (2011)
  • Author(s): Urano, A.
  • Journal Title: General and Comparative Endocrinology Volume: 170 Issue: 1 Pages: 41-56
  • DOI: 10.1016/j.ygcen.2010.09.016
  • Peer Reviewed
• [Journal Article] Role of LPXRFamide peptide in the neuroendocrine regulation of reproduction in fish (2011)
  • Author(s): Shahjahan, Md
  • Journal Title: Central European Journal of Biology Volume: 6 Pages: 853-860
  • Peer Reviewed
• [Journal Article] Development of a time-resolved fluoroimmunoassay for octopus gonadotropin-releasing hormone (2011)
  • Author(s): Amano, M.
  • Journal Title: Fisheries Science Volume: 77 Issue: 6 Pages: 953-959
  • DOI: 10.1007/s12562-011-0402-3
  • NAID: 10029654541
  • Peer Reviewed
• [Journal Article] Anatomical relations between neuropeptide Y, galanin, and gonadotropin-releasing hormone in the brain of chondrostean, the Siberian sturgeon Acipenser baeri (2011)
  • Author(s): Amiya, N., Amano, M., Tabuchi, A., and Oka, Y.
  • Journal Title: Neuroscience Letters Volume: 503 Issue: 2 Pages: 87-92
  • DOI: 10.1016/j.neulet.2011.08.008
  • Peer Reviewed
• [Journal Article] Differential regulation of Igf1 and Igf2 mRNA levels in tilapia hepatocytes : effects of insulin and cortisol on GH sensitivity (2011)
  • Author(s): Pierce, A.L.
  • Journal Title: Journal of Endocrinology Volume: 211 Issue: 2 Pages: 201-210
  • DOI: 10.1530/joe-10-0456
  • Peer Reviewed
• [Journal Article] Isolation and characterization of prolactin-releasing peptide in chicks and its effect on prolactin release and feeding behavior (2011)
  • Author(s): Tachibana, T.
  • Journal Title: Neuroendocrinology Volume: 23 Pages: 74-81
  • Peer Reviewed
• [Journal Article] Melanocortin receptor subtypes in interrenal cells and corticotropic activity of α- melanocyte-stimulating hormones in barfin flounder, Verasper moseri. (2011)
  • Author(s): Kobayashi, Y.
  • Journal Title: General and Comparative Endocrinology Volume: 170 Pages: 558-568
  • Peer Reviewed
• [Journal Article] Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder (2010)
  • Author(s): Kobayashi, Y., Tsuchiya, K., Yamanome, T., Schioth, H.B., Takahashi, A.
  • Journal Title: General and Comparative Endocrinology Volume: 168 Issue: 1 Pages: 133-142
  • DOI: 10.1016/j.ygcen.2010.04.017
  • Peer Reviewed
• [Journal Article] Biochemical and immunohistochemical analyses of a GnRH-like peptide in the neural ganglia of the pacific abalone haliotis discus hannai (Gastropoda) (2010)
  • Author(s): Amano, M.
  • Journal Title: Zoological Sciences Volume: 27 Pages: 656-661
  • NAID: 40017358626
  • Peer Reviewed
• [Journal Article] Evolutionary origin of a functional gonadotropin in the pituitary of the most primitive vertebrate, hagfish. (2010)
  • Author(s): Uchida, K.
  • Journal Title: Proceedings of the national academy of Sciences of the United States of America Volume: 107 Pages: 15832-15837
  • Peer Reviewed
• [Journal Article] 光環境と魚類の成長～カレイ目マツカワが教えてくれること (2010)
  • Author(s): 高橋明義
  • Journal Title: Jasco Report Volume: 52 Pages: 20-29
  • NAID: 40017373822
• [Presentation] Relationship between a specific wavelength of light and the neuroendocrine system in fish (2014)
  • Author(s): Takahashi, A., Kasagi, S., Mizusawa, M.
  • Organizer: 27th Conference of European Comparative Endodcrinologists
  • Place of Presentation: University of Rennes (Rennes)
  • Invited
• [Presentation] カレイ目魚類における視覚オプシンの構造と機能の特性 (2014)
  • Author(s): 笠木聡、水澤寛太、高橋明義
  • Organizer: 平成26年度日本水産学会春季大会
  • Place of Presentation: 北海道大学水産学部（函館市）
• [Presentation] ゼブラフィッシュ仔魚の黒色素胞の消長と色素拡散速度に対するLED光の効果 (2014)
  • Author(s): 水澤寛太、大谷冴葉、屋代大貴、高橋明義
  • Organizer: 平成26年度日本水産学会春季大会
  • Place of Presentation: 北海道大学水産学部（函館市）
• [Presentation] キンギョの背地応答に伴う体色変化およびメラノトロピン類の動態 (2014)
  • Author(s): 山村豊、水澤寛太、高橋明義
  • Organizer: 平成26年度日本水産学会春季大会
  • Place of Presentation: 北海道大学水産学部（函館市）
• [Presentation] ヤマメの海水適応とメラニン凝集ホルモン遺伝子発現に及ぼす背景色影響 (2014)
  • Author(s): 石塚光、千葉洋明、水澤寛太、田畑満生、高橋明義
  • Organizer: 平成26年度日本水産学会春季大会
  • Place of Presentation: 北海道大学水産学部（函館市）
• [Presentation] Pleiotropic functions of proopiomelancortin in fish (2014)
  • Author(s): Takahashi, A., Kobayashi, Y., Mizusawa, K.
  • Organizer: 7th Intercongress symposium of the Asia and Oceania Society of Comparative Endocrinology
  • Place of Presentation: National Taiwan Ocean University (Keelung)
  • Invited
• [Presentation] Biological significance of the N-terminal acetyl group of α-melanocyte-stimulating hormone (2013)
  • Author(s): Takahashi, A., Kobayashi, Y., Mizusawa, K., Saito, Y.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona
  • Year and Date: 2013-07-16
• [Presentation] Light wavelength-specific response of melanin-concentrating hormone expression and skin melanophore in zebrafish larva (2013)
  • Author(s): Mizusawa, K., Takahashi, A.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona
  • Year and Date: 2013-07-16
• [Presentation] Isolation and functional analysis of flounder opsins (2013)
  • Author(s): Kasagi, S., Mizusawa, K., Murakami, N., Andoh, T., Kawamura, S., Takahashi, A.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona
  • Year and Date: 2013-07-16
• [Presentation] 特定波長光を活用した魚類養殖技術の開発 (2013)
  • Author(s): 高橋明義,水澤寛太,古藤澄久,菊地重人
  • Organizer: シンポジウム : 水産における光利用技術と基礎研究の動向 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2013-03-30
• [Presentation] 発光ダイオード光照射によるマツカワの成長促進とホルモン遺伝子発現 (2013)
  • Author(s): 高橋明義、笠木聡、水澤寛太、古藤澄久、村上直人
  • Organizer: 平成25年度日本水産学会東北支部大会
  • Place of Presentation: 盛岡市大通会館リリオ（盛岡市）
• [Presentation] Biological significance of the N-terminal acetyl group of alpha-melanocyte-stimulating (2013)
  • Author(s): Takahashi, A., Kobayashi, Y., Mizusawa, K., Saito, Y.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona University (Barcelona)
  • Invited
• [Presentation] Light Wavelength-Specific Response of Melanin-Concentrating Hormone Expression and Skin Melanophore in Zebrafish Larva (2013)
  • Author(s): Mizusawa, M., Takahashi, A
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona University (Barcelona)
• [Presentation] Isolation and functional analysis of flounder opsins (2013)
  • Author(s): Kasagi, S., Mizusawa, M. Murakami, N., Andoh, T., Kawamura, S., Takahashi, A.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona University (Barcelona)
• [Presentation] Expression of melanotropin-related genes in goldfish brain, pituitary gland, and skin in response to background color (2013)
  • Author(s): Yamamura, Y., Mizusawa, K., Cerda-Reverter, J.M., Takahashi, A.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona University (Barcelona)
• [Presentation] Inhibitory effect of beta-endorphin on cortisol release in the goldfish, Carassius auratus (2013)
  • Author(s): Kobayashi, Y., Mizusawa, K., Arai, Y., Chiba, H., Takahashi, A.
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona University (Barcelona)
• [Presentation] MSHとMCH：独自作用と相互作用 (2013)
  • Author(s): 高橋明義、水澤寛太
  • Organizer: シンポジウム：海洋生物のさまざまな適応戦略
  • Place of Presentation: 東京大学大気海洋研究所（柏市）
• [Presentation] 小型魚類における特定波長選好性 (2013)
  • Author(s): 水澤寛太、高橋明義
  • Organizer: 第38回日本比較内分泌学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎市）
• [Presentation] ブリにおける水温と脳内オレキシン含量の関係 (2013)
  • Author(s): 阿見彌典子、京極一憧、外山義典、横山佐一郎、越塩俊介、天野勝文、高橋明義、奥宏海
  • Organizer: 第38回日本比較内分泌学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎市）
• [Presentation] サクラマスのメラノコルチン受容体の発現組織 (2013)
  • Author(s): 笠木聡、荒井洸介、野村洋輔、水澤寛太、千葉洋明、高橋明義
  • Organizer: 平成25年度日本水産学会秋季大会
  • Place of Presentation: 三重大学（津市）
• [Presentation] メラノトロピンの活性に対する受容体ヘテロダイマーの関与の可能性 (2013)
  • Author(s): 高橋明義、小林勇喜、水澤寛太、斎藤祐見子
  • Organizer: シンポジウム：比較内分泌学から臨床内分泌学へのメッセージ 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] 特定波長光を活用した魚類養殖技術の開発 (2013)
  • Author(s): 高橋明義
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] マツカワおよびヒラメに発現する視物質遺伝子の機能解析 (2013)
  • Author(s): 笠木聡
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] キンギョ皮膚におけるメラノトロピン類受容体の動態 (2013)
  • Author(s): 山村豊
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] ゼブラフィッシュ仔魚のメラニン凝集ホルモン遺伝子発現に対する単色光の効果 (2013)
  • Author(s): 水澤寛太
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] カレイ目マツカワにおけるメラノコルチン受容体（MCR）のヘテロダイマー形成と体色調節の関係 (2013)
  • Author(s): 小林勇喜
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] クサフグ脳内におけるGnRH，キスペプチンおよびGPR54遺伝子の周期的発現変動 (2013)
  • Author(s): 安東宏徳
  • Organizer: 平成25年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] Roles of two simultaneously expressed melanocortin receptor subtypes on the activity of α-MSH (2012)
  • Author(s): Takahashi, A., Kobayashi, Y., Mizusawa K.
  • Organizer: 26th Conference of European Comparative Endocrinologists
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2012-08-22
• [Presentation] 特定波長光が魚類の神経内分泌系に影響を及ぼす可能性について (2012)
  • Author(s): 高橋明義,山野目健,阿見彌典子,水澤寛太,天野勝文
  • Organizer: シンポジウム : 魚類における神経内分泌現象研究の最新動向.日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
  • Year and Date: 2012-08-11
• [Presentation] マツカワ網膜オプシンの成長にともなう発現変動 (2012)
  • Author(s): 水澤寛太
  • Organizer: 平成24年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2012-03-27
• [Presentation] The MCH system of shark is more closely related to the MCH system of mammals than that of teleosts (2012)
  • Author(s): Mizusawa, K
  • Organizer: The 7th AOSCE Congress
  • Place of Presentation: Kuala Lumpur
  • Year and Date: 2012-03-05
• [Presentation] Effect of melanocortin systems on pigment dispersion in fish chromatophores : deciphering the roles of the acetyl group in α-melanocyte-stimulating hormone (2012)
  • Author(s): Takahashi, A
  • Organizer: The 7th AOSCE Congress
  • Place of Presentation: Kuala Lumpur
  • Year and Date: 2012-03-04
• [Presentation] 深海魚ザラビクニンにおけるメラニン凝集ホルモンの分布 (2012)
  • Author(s): 阿見彌典子
  • Organizer: 日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
• [Presentation] 背地適応時におけるキンギョ下垂体中葉のソマトラクチン2分子種の発現動態 (2012)
  • Author(s): 東森生
  • Organizer: 日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
• [Presentation] 月周産卵魚クサフグにおけるGnRH、キスペプチンおよびGPR54遺伝子の周期的発現 (2012)
  • Author(s): 安東宏徳
  • Organizer: 日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
• [Presentation] 魚類メラノトロピンに関する研究 吉村賞受賞講演 (2012)
  • Author(s): 高橋明義
  • Organizer: 日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
  • Invited
• [Presentation] 特定波長光が魚類の神経内分泌系に影響を及ぼす可能性について (2012)
  • Author(s): 高橋明義
  • Organizer: 日本下垂体研究会第27回学術集会
  • Place of Presentation: 天童
  • Invited
• [Presentation] Roles of two simultaneously expressed melanocortin receptor subtypes on the activity of alpha-MSH (2012)
  • Author(s): Takahashi A
  • Organizer: 26th Conference of European Comparative Endocrinologists
  • Place of Presentation: スイス チューリッヒ
  • Invited
• [Presentation] ナメクジウオの性ステロイド代謝酵素の遺伝子発現部位 (2012)
  • Author(s): 窪川かおる
  • Organizer: 日本動物学会第83回大会
  • Place of Presentation: 大阪
• [Presentation] 洞窟魚ブラインドケープカラシンにおけるMCHとMSHの産生細胞 (2012)
  • Author(s): 阿見彌典子
  • Organizer: 平成24年度日本水産学会秋季大会
  • Place of Presentation: 下関
• [Presentation] Synchronized diurnal and circadian expressions of kisspeptin and GPR54 genes in the diencephalon of a puffer fish with lunar-related spawning cycles (2012)
  • Author(s): Ando N
  • Organizer: 2nd World Conference on Kisspeptin Signaling in the Brain
  • Place of Presentation: 東京
• [Presentation] 魚類色素胞に対する黒色素胞刺激ホルモン（MSH）の作用とその受容体の関係 (2012)
  • Author(s): 小林勇喜
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] 深海魚ザラビクニンにおけるメラニン凝集ホルモンの体循環 (2012)
  • Author(s): 阿見彌典子
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] マツカワにおけるメラニン凝集ホルモン（MCH）反応性は変態後期に左右差を生じる (2012)
  • Author(s): 吉川尚樹
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] キンギョ稚魚の体色変化とソマトラクチン2分子種の発現変動 (2012)
  • Author(s): 東森生
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] アカエイにおけるメラノコルチン受容体の構造 (2012)
  • Author(s): 荒井洸介
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] マツカワ眼球に発現する視物質遺伝子の機能解析 (2012)
  • Author(s): 笠木聡
  • Organizer: 第37回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 福井
• [Presentation] クサフグの産卵期における下垂体ホルモン遺伝子の発現上昇とLPXRFaペプチドによる調節 (2012)
  • Author(s): 安東宏徳
  • Organizer: 第37回日本比較内分泌学会大会
  • Place of Presentation: 福井
• [Presentation] メラノトロピン(α-MSH)の活性発現に対するアミノ末端アセチル化と受容体分子の関係 (2011)
  • Author(s): 高橋明義
  • Organizer: 第36回日本比較内分泌学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-23
• [Presentation] 軟骨魚類におけるメラニン凝集ホルモンの機能 (2011)
  • Author(s): 水澤寛太
  • Organizer: 第36回日本比較内分泌学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-23
• [Presentation] キンギョ脳内のODN産生細胞の特徴付けとODNの向下垂体作用 (2011)
  • Author(s): 今坂宏章
  • Organizer: 第36回日本比較内分泌学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-23
• [Presentation] トラフグの成長に対する背景色(白黒)の影響 (2011)
  • Author(s): 今永由惟
  • Organizer: 第36回日本比較内分泌学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-23
• [Presentation] サクラマスにおけるメラニン凝集ホルモン遺伝子発現に対する水槽色の効果 (2011)
  • Author(s): 栗栖亮
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎
  • Year and Date: 2011-09-30
• [Presentation] 魚類オレキシンの時間分解蛍光免疫測定法の確立とマツカワへの応用 (2011)
  • Author(s): 阿見彌典子
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎
  • Year and Date: 2011-09-29
• [Presentation] 黒色素胞刺激ホルモン～魚類における構造と機能の多様性 (2011)
  • Author(s): 高橋明義
  • Organizer: 第84回日本生化学会大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] PACAPによるキンギョ下垂体初代培養細胞のSL-β遺伝子発現制御機構の解析 (2011)
  • Author(s): 東森生
  • Organizer: 日本下垂体研究会第26回学術集会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-08-25
• [Presentation] 魚類の皮膚におけるメラノコルチンの活性と受容体の関係 (2011)
  • Author(s): 高橋明義
  • Organizer: 第24回北里大学バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2011-08-23
• [Presentation] アカシュモクザメにおけるメラニン凝集ホルモン (2011)
  • Author(s): 水澤寛太
  • Organizer: 第24回北里大学バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2011-08-23
• [Presentation] 魚類における脳内オレキシン時間分解蛍光免疫測定法の確立 (2011)
  • Author(s): 阿見彌典子
  • Organizer: 第24回北里大学バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2011-08-23
• [Presentation] 魚類オレキシンの時間分解蛍光免疫測定法の確立 (2011)
  • Author(s): 阿見彌典子
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] アカシュモクザメ視床下部におけるメラニン凝集ホルモン (2011)
  • Author(s): 水澤寛太
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] キンギョにおけるメラニン凝集ホルモン遺伝子発現に対する特定波長光の効果 (2011)
  • Author(s): 西野佑哉
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] ヒラメの皮膚における黒色素胞刺激ホルモンの活性と受容体の関係 (2011)
  • Author(s): 小林勇喜
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] メダカの摂餌行動と脳内オレキシン量の関連 (2010)
  • Author(s): 阿見彌典子
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-19
• [Presentation] キンギョの頭腎におけるオピオイド受容体の機能 (2010)
  • Author(s): 小林勇喜
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-19
• [Presentation] キンギョにおけるメラニン凝集ホルモン遺伝子発現に対する特定波長光の効果 (2010)
  • Author(s): 西野佑哉
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-19
• [Presentation] マツカワ体色調節における2型メラニン凝集ホルモンの役割 (2010)
  • Author(s): 水澤寛太
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-19
• [Presentation] 原始脊椎動物・ヌタウナギ類の糖タンパク質ホルモンとその進化 (2010)
  • Author(s): 内田勝久
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-19
• [Presentation] マツカワのメラニン凝集ホルモンは2型受容体を介して体色を明化する (2010)
  • Author(s): 水澤寛太
  • Organizer: 日本下垂体研究会第25回学術集会
  • Place of Presentation: 田原
  • Year and Date: 2010-08-20
• [Presentation] メラニン凝集ホルモン2型受容体を介したマツカワの体色明化 (2010)
  • Author(s): 水澤寛太
  • Organizer: 第23回バイオサイエンスフォーラム
  • Place of Presentation: 十和田
  • Year and Date: 2010-08-05
• [Presentation] カレイ目マツカワの頭腎におけるメラノコルチン受容体の機能 (2010)
  • Author(s): 小林勇喜
  • Organizer: 第23回バイオサイエンスフォーラム
  • Place of Presentation: 十和田
  • Year and Date: 2010-08-05
• [Presentation] キンギョにおけるメラニン凝集ホルモン遺伝子発現に対する特定波長光の効果 (2010)
  • Author(s): 西野佑哉
  • Organizer: 第23回バイオサイエンスフォーラム
  • Place of Presentation: 十和田
  • Year and Date: 2010-08-05
• [Presentation] Acetylation-induced changes in α-MSH activity may be related to concomitant expression of different melanocortin receptor subtypes (2010)
  • Author(s): Takahashi, A., Kobayashi, Y.
  • Organizer: 6th international melanocortin meeting
  • Place of Presentation: Utrecht, The Netherlands
  • Year and Date: 2010-07-10
• [Presentation] Acetylation-induced changes in α-MSH activity may be related to concomitant expression of different melanocortin receptor subtypes (2010)
  • Author(s): Takahashi, A.
  • Organizer: 6th international melanocortin meeting
  • Place of Presentation: Utrecht
  • Year and Date: 2010-07-10
• [Presentation] 視覚機能を活用した成長促進の可能性-光と音を用いた水産生物の行動把握と行動制御の可能性
  • Author(s): 高橋明義
  • Organizer: 平成25年度水産工学関係研究開発推進会議 水産業システム研究部会
  • Place of Presentation: 南青山会館（東京）
• [Book] Sexual plasticity and gametogenesis in fishes (2013)
  • Author(s): Amano, M.
  • Total Pages: 456
  • Publisher: Nova Science Publishers
• [Book] Prolactin (2013)
  • Author(s): Takahashi H
  • Total Pages: 230
  • Publisher: InTech
• [Book] ナマコ学―生物・産業・文化― (2012)
  • Author(s): 高橋明義,奥村誠一(共編)
  • Publisher: 成山堂書店,東京
• [Book] ナマコ学―生物・産業・文化― (2012)
  • Author(s): 高橋明義（編集）
  • Total Pages: 227
  • Publisher: 成山堂書店
• [Remarks] 北里大学海洋生命科学部 海洋分子生物学研究室ホームページ
  • URL: http://www.kitasato-u.ac.jp/fish/contents/lab/l12/index.html
• [Remarks] 北里大学 海洋生命科学部 海洋分子生物学研究室ホームページ
  • URL: http://www.kitasato-u.ac.jp/fish/contents/lab/l12/index.html
• [Patent(Industrial Property Rights)] 多段式濾過装置 (2014)
  • Inventor(s): 村上圭佑,高橋明義
  • Industrial Property Rights Holder: 学校法人北里研究所,株式会社ケイ・エムアクト
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2014-04-25
• [Patent(Industrial Property Rights)] 特定波長光照射によるカレイ目魚類の養殖方法 (2012)
  • Inventor(s): 高橋明義,水澤寛太,古藤澄久,菊地重人
  • Industrial Property Rights Holder: 学校法人北里研究所,スタンレー電気株式会社,株式会社ケイ・エムアクト
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-068668
  • Filing Date: 2012-03-26
• [Patent(Industrial Property Rights)] 特定波長光照射によるカレイ目魚類の養殖方法 (2012)
  • Inventor(s): 高橋明義, 他3名
  • Industrial Property Rights Holder: 学校法人北里研究所, 他2社
  • Industrial Property Number: 2012-068668
  • Filing Date: 2012-03-26