| Budget Amount *help |
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2012: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2011: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2010: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Research Abstract |
Among the family of protein arginine methyltransferases, PRMT1 accounts for over 85% of the total arginine methyltransferase activities in cells, and it is localized in the cytoplasm and nucleus. Although PRMT8 that has 83% amino acid homology to PRMT1, its biological significance and substrate remain unclear. In the present study, we tried to examine the enzymatic activity of PRMT8 and its cellular function.
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