| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2012: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2011: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2010: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
|
|---|
| Research Abstract |
We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have achieved the total syntheses of oxazolomycin A and kitocephalin, and the formal synthesis of welwistatin. In addition, we have developed a new methodology for the construction of heterocycles which relies on a Rh(II)-catalyzed C-H amination reaction, and have achieved the total syntheses of NW-G01, englerin A, and inthomycin A, B, C.
|
