| Project/Area Number |
22249003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
UTSUMI Hideo 九州大学, 先端融合医療レドックスナビ研究拠点, 特任教授 (20101694)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Kazuhiro 九州大学, 先端融合医療創成センター, 教授 (10271115)
YAMADA Ken-ichi 九州大学, 薬学研究院, 准教授 (60346806)
HYODO Fuminori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIROOKA Yoshitaka 九州大学, 医学研究院, 教授 (90284497)
YASUKAWA Keiji 九州大学, 薬学研究院, 助教 (80372738)
YAMATO Mayumi 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30380695)
KATO Takahiro 九州大学, 先端融合医療レドックスナビ研究拠点, 特任准教授 (70546465)
NUTTAVUT Kosem 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (60532851)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2011: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2010: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
|
|---|
| Keywords | 薬学 / 生物物理 / 生体分子 / 可視化 / 血圧 / 交感神経系 / 酸化ストレス |
|---|
| Research Abstract |
Novel imaging technique Overhauser-MRI (OMRI) enables visualization of tissue redox status in animals based on dynamic nuclear polarization (DNP) with higher spatial resolution compared with electron spin resona nce imaging (ESRI). In this study, we applied OMRI to various oxidative disease models such as dopaminergic neurotoxicity , indomethacin-induced gastric damage and schizophrenic disorder. As a noninvasive technique, combining OMRI imaging with redox probes to monitor tissue redox status may be useful in acquiring valuable information regarding organ function for preclinical and clinical studies of oxidative diseases.
|
