Clarification of (epi)genetic causes leading to the development of human imprinting disorders

• Project/Area Number: 22249010
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Hamamatsu University School of Medicine (2011-2012); National Research Institute for Child Health and Development (2010)
• Principal Investigator: OGATA Tsutomu 浜松医科大学, 医学部, 教授 (40169173)
• Co-Investigator(Kenkyū-buntansha): KAGAMI Masayo (独)国立成育医療研究センター研究所, 分子内分泌研究部, 室長 (70399484) ; NAKABAYASHI Kazuhiko (独)国立成育医療研究センター研究所, 周産期病態研究部, 室長 (10415557)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000); Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2010: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
• Keywords: エピジェネティクス / インプリンティング / ヒト疾患 / メチル化可変領域 / 個体 / 胎盤 / 分子生物学的解析 / 生殖補助医療 / 高齢出産

Research Abstract

We have attempted to clarify underlying (epi)genetic mechanisms and clinical characteristics in human imprinting disorders. Representative results in uniparental disomy for chromosome 14 (upd(14)pat) and its related disorders include:
(1) clarification of underlying causes and establishment of molecular approaches;
(2) risk assessment of the advanced maternal childbearing age in the development of monosomy-rescue type upd(14)pat;
(3) identification of the imprinting centers in the body and the placenta and that of the most causative gene in the phenotypic development;
(4) repressor effects of maternally expressed RTL1as-encoded microRNAs on the paternally expressed RTL1 expression;
(5) clarification of the characteristics of the placental histopathology;
and (6) establishment of radiological diagnostic clues.
Representative results in Prader-Willi syndrome (PWS) include:
(1) clarification of underlying causes and establishment of molecular approaches;
(2) risk assessment of the advanced maternal childbearing age in the development of trisomy-rescue type upd(15)mat;
and (3) risk assessment of the medially assisted reproduction in the development of PWS.
Representative results in Silver-Russell syndrome (SRS) include:
(1) clarification of underlying causes and establishment of molecular approaches;
and (2) establishment of detailed (epi)genotype-phenotype correlations.
Furthermore, we identified a parthenogenetic chimera and an androgentic mosaic. These findings will advance the human imprinting studies.

Research Products

• [Journal Article] Advanced maternal age at childbirth and the development of uniparental disomy. A commentary on the proportion of uniparental disomy is increased in Prader-Willi syndrome due to an advanced maternal childbearing age in Korea.J Hum Genet (2013)
  • Author(s): Matsubara K, Ogata T*
  • Journal Title: J Hum Genet. Volume: 58 Pages: 118-119
  • DOI: 10.1038/jhg.2013.4
  • Peer Reviewed
• [Journal Article] Neuromuscular symptoms in a patient with familial pseudohypoparathyroidism type Ib diagnosed by methylation-specific multiplex ligation-dependent probe amplification. (2013)
  • Author(s): Nagasaki K*, Tsuchuya S, Saitoh A, Ogata T, Fukami M
  • Journal Title: Endocr J Volume: accepted
  • NAID: 10031156746
  • Peer Reviewed
• [Journal Article] Molecular and clinical studies in 138 Japanese patients with silver-russell syndrome. (2013)
  • Author(s): T. Fuke, S. Mizuno, T. Nagai, T. Hasegawa, R. Horikawa, Y. Miyoshi, K. Muroya, T. Kondoh, C. Numakura, S. Sato, K. Nakabayashi, C. Tayama, K. Hata, S. Sano, K. Matsubara, M. Kagami, K. Yamazawa, T. Ogata
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0060105
  • Peer Reviewed
• [Journal Article] Birth seasonality in Prader-Willi syndrome resulting from chromosome 15 microdeletion. (2013)
  • Author(s): Ayabe T, Matsubara K, Ogata T, Ayabe A, Murakami N, Nagai T, Fukami M*
  • Journal Title: Am J Med Genet A Volume: accepted
  • Peer Reviewed
• [Journal Article] Relative frequency of underlying genetic causes for the development of UPD(14)pat-like phenotype (2012)
  • Author(s): Kagami M, Kato F, Matsubara K, Sato T, Nishimura G, Ogata T*
  • Journal Title: Eur J Hum Genet20 Volume: 9 Pages: 928-932
• [Journal Article] Mosaic upd(7)mat in a patient with Silver-Russell syndrome: correlation between phenotype and mosaic ratio in the body and the placenta (2012)
  • Author(s): Fuke-Sato T, Yamazawa K, Nakabayashi K, Matsubara K, Matsuoka K, Hasegawa T, Dobashi K, Ogata T*
  • Journal Title: Am J Med Genet A158A Volume: 2 Pages: 465-468
• [Journal Article] Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies (2012)
  • Author(s): Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Van De Pette M, John RM, Kagami M, Nakai K, Soejima H, Ogata T,Arima T*
  • Journal Title: Hum Reprod 27 Volume: 8 Pages: 2541-2548
• [Journal Article] Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations (2012)
  • Author(s): Kagami M, Matsuoka K, Nagai T, Yamanaka M, Kurosawa K, Suzumori N, Sekita Y, Miyado M, Matsubara K, Fuke T, Kato F, Fukami M, Ogata T*
  • Journal Title: Epigenetics 7 Volume: 10 Pages: 1142-1150
• [Journal Article] Relative frequency of underlying genetic causes for the development of UPD(14)pat-like phenotype. (2012)
  • Author(s): Kagami M, Ogata T, et al
  • Journal Title: European Journal of Human Genetics Volume: (accepted)(Epub ahead of print) Pages: 928-932
  • DOI: 10.1038/ejhg.2012.26
  • Peer Reviewed
• [Journal Article] Mosaic upd(7)mat in a patient with Silver-Russell syndrome: correlation between phenotype and mosaic ratio in the body and the placenta. (2012)
  • Author(s): Fuke-Sato T, Yamazawa K, Nakabayashi K, Matsubara K, Matsuoka K, Hasegawa T, Dobashi K, Ogata T*
  • Journal Title: Am J Med Genet A Volume: 158A (2) Pages: 465-468
  • Peer Reviewed
• [Journal Article] Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. (2012)
  • Author(s): H. Hiura, H. Okae, N. Miyauchi, F. Sato, A. Sato, M. Van De Pette, R.M. John, M. Kagami, K. Nakai, H. Soejima, T. Ogata, T. Arima.
  • Journal Title: Hum Reprod Volume: 27 Pages: 2541-2548
  • Peer Reviewed
• [Journal Article] Paternal uniparental disomy 14 and related disorders : placental gene expression analyses and histological examinations (2012)
  • Author(s): M. Kagam, K. Matsuoka, T. Nagai, M. Yamanaka, K. Kurosawa, N. Suzumori, Y. Sekita, M. Miyado, K. Matsubara, T. Fuke, F. Kato, M. Fukami, T. Ogata.
  • Journal Title: Epigenetics. Volume: 7 Pages: 1142-1150
  • DOI: 10.4161/epi.21937
  • Peer Reviewed
• [Journal Article] ARTにおけるインプリンティング異常 (2012)
  • Author(s): 緒方勤
  • Journal Title: Medical Science Digest Volume: 38 (6) Pages: 249-252
• [Journal Article] Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency (2012)
  • Author(s): Inoue H, Ogata T, et al
  • Journal Title: Clin Endocrinol Volume: 76(1) Pages: 78-87
  • Peer Reviewed
• [Journal Article] Genetic characteristics on HLA-cass II and class I among Japanese type 1A and type 1B diabetic children and their families (2012)
  • Author(s): Sugihara S, Ogata T, et al
  • Journal Title: Pediatr Diabetes Volume: 13(1) Pages: 33-44
  • Peer Reviewed
• [Journal Article] Mosaic upd(7)mat in a patient with Silver-Russell syndrome : correlation between phenotype and mosaic ratio in the body and the placenta (2012)
  • Author(s): Fuke-Sato T, Ogata T, et al
  • Journal Title: Am J Med Genet A Volume: 158A(2) Pages: 465-8
  • Peer Reviewed
• [Journal Article] Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan: findings from a nationwide epidemiological survey. (2012)
  • Author(s): Abe Y, Aoki Y, Ogata T, et al
  • Journal Title: Am J Med Genet A. Volume: (accepted)(Epub ahead of print) Pages: 1083-1094
  • DOI: 10.1002/ajmg.a.35292
  • Peer Reviewed
• [Journal Article] Two-step biochemical differential diagnosis of classical 21-hydroxylase deficiency and cytochrome P450 oxidoreductase deficiency in Japanese infants using uUrinary Pregnanetriolone/Tetrahydroxycortisone Ratio and 11β-hydroxyandrosterone by Gas chromatography-mass spectrometry (2012)
  • Author(s): Koyama Y, Ogata T, et al
  • Journal Title: Clin Chem Volume: 58(4) Pages: 741-7
  • Peer Reviewed
• [Journal Article] Screening of MAMLD1 mutations in 70 children with 46, XY DSD : Identification and functional analysis of 2 new mutations (2012)
  • Author(s): Kalfa N, Ogata T, et al
  • Journal Title: PLoS ONE Volume: 7(3)
  • Peer Reviewed
• [Journal Article] Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd(14)pat-like phenotypes (2011)
  • Author(s): Yamazawa K, Nakabayashi K, Matsuoka K, Matsubara K, Hata K, Horikawa R, Ogata T*
  • Journal Title: J Hum Genet56 Volume: 1 Pages: 91-93
  • NAID: 10030657597
• [Journal Article] Radiological evaluation of dysmorphic thorax in paternal uniparental disomy for chromosome 14 (2011)
  • Author(s): Miyazaki O*, Nishimura G, Kagami M, Ogata T
  • Journal Title: Ped Radiol41 Volume: 8 Pages: 1013-1019
• [Journal Article] Maternal age effect on the developmentof Prader-Willi syndrome resulting from upd(15)mat through meiosis 1 errors (2011)
  • Author(s): Matsubara K, Murakami N, Nagai T, Ogata T*
  • Journal Title: J Hum Genet 56 Volume: 8 Pages: 566-71
• [Journal Article] Methylation screening of reciprocal genome-wide UPDs identifies novel human specific imprinted genes (2011)
  • Author(s): Nakabayashi K*, Trujillo AM, Tayama C, Camprubi C, Yoshida W, Lapunzina P, Sanchez A, Soejima H, Aburatani H, Nagae G, Ogata T, Hata K, David Monk D
  • Journal Title: Hum Mol Genet20 Volume: 16 Pages: 3188-97
• [Journal Article] Advanced maternal age and the development of Prader-Willi syndrome resulting from upd(15)mat through non-disjunction at meiosis 1 (2011)
  • Author(s): Ogata T*, Matsubara K, Nagata E, Sano S, Murakami N, Nagai T
  • Journal Title: J Mamm Ova Res28 Volume: 3 Pages: 96-102
  • NAID: 10029898301
• [Journal Article] Identification and functional analysis of novel human growth hormone-releasing honnone receptor (GHRHR) gene mutations in Japanese subjects with short stature (2011)
  • Author(s): Inoue H, Ogata T, et al
  • Journal Title: Clin Endocrinol Volume: 74(2) Pages: 223-233
  • Peer Reviewed
• [Journal Article] Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd (14) pat-like phenotypes (2011)
  • Author(s): Yamazawa K, Ogata T, et al
  • Journal Title: J Hum Genet Volume: 56(1) Pages: 91-93
  • NAID: 10030657597
  • Peer Reviewed
• [Journal Article] Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature (2011)
  • Author(s): Inoue H, Ogata T, et al
  • Journal Title: J Clin Endocrinol Metab Volume: 96(2)
  • Peer Reviewed
• [Journal Article] GATA3 abnormalities in six patients with HDR syndrome (2011)
  • Author(s): Fukami M, Ogata T, et al
  • Journal Title: Endocr J Volume: 58(2) Pages: 117-121
  • NAID: 10029587700
  • Peer Reviewed
• [Journal Article] Identification of chromosome 15q terminal deletion with telomere sequences and its bearing on genotype-phenotype analysis (2011)
  • Author(s): Dateki S, Ogata T, et al
  • Journal Title: Endocr J Volume: 58(3) Pages: 155-159
  • Peer Reviewed
• [Journal Article] MAMLD1 (Mastermind-Like Domain Containing 1) Homozygous Gain-of-Function Missense Mutation Causing 46,XX Disorder of Sex Development in a Virilized Female (2011)
  • Author(s): Brandao MP, Ogata T, et al
  • Journal Title: Adv Exp Med Biol Volume: 707(10) Pages: 129-31
  • Peer Reviewed
• [Journal Article] Radiological evaluation of dysmorphic thorax in paternal uniparental disomy for chromosome 14 (2011)
  • Author(s): Miyazaki O, Ogata T, et al
  • Journal Title: Ped Radiol Volume: 41(8) Pages: 1013-1019
  • Peer Reviewed
• [Journal Article] Aromatase excess syndrome : identification of cryptic duplications and deletions leading to gain-of-function of CYP19A1 and assessment of phenotypic determinants (2011)
  • Author(s): Fukami, M, Ogata T, et al
  • Journal Title: J Clin Endocrinol Metab Volume: 96(6)
  • Peer Reviewed
• [Journal Article] Steroid 5α-reductase-2 deficiency and fertility (2011)
  • Author(s): Ogata T, Matsubara K
  • Journal Title: Fertil Steril Volume: 95(7)
  • Peer Reviewed
• [Journal Article] Mamld1 knockdown reduces testosterone production and Cyp17al expression in mouse Leydig tumor cells (2011)
  • Author(s): Nakamura M, Ogata T, et al
  • Journal Title: PLoS ONE Volume: 6(4)
  • Peer Reviewed
• [Journal Article] Maternal age effect on the development of Prader-Willi syndrome resulting from upd(15)mat through meiosis 1 errors (2011)
  • Author(s): Matsubara K, Ogata T, et al
  • Journal Title: J Hum Genet Volume: 56(8) Pages: 566-71
  • NAID: 10030660380
  • Peer Reviewed
• [Journal Article] Methylation screening of reciprocal genome-wide UPDs identifies novel human specific imprinted genes (2011)
  • Author(s): Nakabayashi K, Ogata T, et al
  • Journal Title: Hum Mol Genet Volume: 20(16) Pages: 3188-97
  • Peer Reviewed
• [Journal Article] Analysis of expression and structure of the rat GH secretagogue/ghrelin receptor (Ghsr) gene : roles of epigenetic modifications in transcriptional regulation (2011)
  • Author(s): Inoue H, Ogata T, et al
  • Journal Title: Mol Cell Endocrinol Volume: 345 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Proximal promoter of the cytochrome P450 oxidoreductase gene : identification of microdeletions involving the untranslated exon 1 and critical function of the SP1 binding site (2011)
  • Author(s): Soneda S, Ogata T, et al
  • Journal Title: J Clin Endocrinol Metab Volume: 96(11)
  • Peer Reviewed
• [Journal Article] Number of CGG repeats in the FMR1 gene of Japanese patients with primary ovanan insufficiency (2011)
  • Author(s): Ishizuka B, Ogata T, et al
  • Journal Title: Fertil Steril Volume: 96(5) Pages: 1170-1174
  • Peer Reviewed
• [Journal Article] Association of primary ovarian insufficiency with a specific HLA haplotype (A*24:02-C*03:03-B*35:01) in Japanese patients (2011)
  • Author(s): Ayabe T, Ogata T, et al
  • Journal Title: Sex Dev Volume: 5(5) Pages: 235-240
  • Peer Reviewed
• [Journal Article] Polymorphisms of MAMLD1 gene in hypospadias (2011)
  • Author(s): Kalfa N, Ogata T, et al
  • Journal Title: J Pediatr Urol Volume: 7(6) Pages: 585-591
  • Peer Reviewed
• [Journal Article] Advanced maternal age and the development of Prader-Willi syndrome resulting from upd(15)mat through non-disjunction at meiosis 1 (2011)
  • Author(s): Ogata T, Matsubara K, et al
  • Journal Title: J Mamm Ova Res Volume: 28(3) Pages: 96-102
  • NAID: 10029898301
  • Peer Reviewed
• [Journal Article] The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers (2010)
  • Author(s): Kagami M, O'Sullivan MJ, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T*
  • Journal Title: PLoS Genet6 Volume: 6
• [Journal Article] Parthenogenetic chimaerism/mosaicism with a Silver-Russell Syndrome-like Phenotype (2010)
  • Author(s): Yamazawa K, Nakabayashi K, Kagami M,Sato T, Saitoh S, Horikawa R, Hizuka N, Ogata T*
  • Journal Title: J Med Genet47 Volume: 11 Pages: 782-785
• [Journal Article] Prenatal diagnosis of paternal uniparental disomy 14:delineation of further patient (2010)
  • Author(s): Suzumori N*, Ogata T, Mizutani E, Hattori Y, Matsubara K, Kagami M, Suguhara-Ogasawara M
  • Journal Title: Am J Med Genet A152A Volume: 12 Pages: 3189-3192
• [Journal Article] Uniparental disomy and human disease: an overview (2010)
  • Author(s): Yamazawa K, Ogata T, Ferguson-Smith AC*
  • Journal Title: Am J Med Genet C(Seminars in Medical Genetics) 154C Volume: 3 Pages: 329-334
• [Journal Article] The IG-DMR and the MEG3-DMR at human chromosome 14q32.2 : hierarchical interaction and distinct functional properties as imprinting control centers (2010)
  • Author(s): Kagami M, Ogata T, 他
  • Journal Title: PLoS Genet Volume: 6(6)
  • Peer Reviewed
• [Journal Article] Parthenogenetic chimaerism/mosaicism with a Silver-Russell Syndrome-like Phenotype (2010)
  • Author(s): Yamazawa K, Nakabayashi K, Kagami M, Ogata T, 他
  • Journal Title: J Med Genet Volume: 47(11) Pages: 782-785
  • Peer Reviewed
• [Journal Article] Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd (14) pat-like phenotypes (2010)
  • Author(s): Yamazawa K, Nakabayashi K, Ogata T, 他
  • Journal Title: J Hum Genet Volume: 56(1) Pages: 91-93
  • NAID: 10030657597
  • Peer Reviewed
• [Journal Article] Prenatal diagnosis of paternal uniparental disomy 14 : delineation of further patient (2010)
  • Author(s): Suzumori N, Ogata T, 他
  • Journal Title: Am J Med Genet A Volume: 152A(12) Pages: 3189-3192
  • Peer Reviewed
• [Journal Article] Radiological evaluation of dysmorphic thorax in paternal uniparental disomy for chromosome 14 (2010)
  • Author(s): Miyazaki O, Nishimura G, Kagami M, Ogata T
  • Journal Title: Ped Radiol Volume: (Accepted)
  • Peer Reviewed
• [Journal Article] 成長ホルモン分泌不全を来し、H19-DMRの低メチル化を認めたSilver-Russell症候群の1例 (2010)
  • Author(s): 勝島由利子、山澤一樹、緒方勤、勝島史夫
  • Journal Title: ホルモンと臨 Volume: 58(Accepted)
  • Peer Reviewed
• [Journal Article] 生殖補助医療とインプリンティング異常 (2010)
  • Author(s): 緒方勤
  • Journal Title: Horm Front Gynecol Pages: 361-368
  • NAID: 10020355007
• [Journal Article] Neuromuscular symptoms in a patient with familial pseudohypoparathyroidism type Ib diagnosed by methylation-specific multiplex ligation-dependent probe amplification
  • Author(s): Nagasaki K*, Tsuchuya S, Saitoh A, Ogata T, Fukami M
  • Journal Title: Endocr J (accepted)
  • NAID: 10031156746
• [Journal Article] Molecular and clinical studies in 138 Japanese patients with Silver-Russell syndrome
  • Author(s): Fuke T, Mizuno S, Nagai T, Hasegawa T, Horikawa R, Miyoshi Y, Muroya K, Kondoh T, Numakura C, Sato S, Nakabayashi K, Tayama C, Hata K, Sano S, Matsubara K, Kagami M, Tamazawa K, Ogata T*
  • Journal Title: PLoS One (accepted)
• [Journal Article] 46, XY gonadal dysgenesis : new SRY point mutation in two siblings with paternal germ line mosaicism
  • Author(s): Stoppa-Vaucher S, Ogata T, et al
  • Journal Title: Clin Genet Volume: (in press)
  • Peer Reviewed
• [Journal Article] Polymorphisms of MAMLD1 gene in bypospadias
  • Author(s): Kalfa N, Ogata T, et al
  • Journal Title: J Pediatr Urol Volume: 7(6) Pages: 585-91
  • Peer Reviewed
• [Journal Article] Association between fetal myocardial tissue Doppler indices before birth and gestational age-specific birth weight in low-risk term pregnancies
  • Author(s): Sekii K, Ogata T, et al
  • Journal Title: Ultrasound Obstet Gynecol Volume: (accepted)
  • Peer Reviewed
• [Journal Article] Complex genomic rearrangements in the SOX95' region in a patient with Pierre Robin sequence and hypoplastic left scapula
  • Author(s): Fukami M, Ogatata T, et al
  • Journal Title: Am J Med Genet A Volume: (accepted)
  • Peer Reviewed
• [Journal Article] Haplotype analysis of ESR2 in Japanese patients with spermatogenic failure : Implications for genetic susceptibility to estrogenic environmental endocrine disruptors
  • Author(s): Ogata T, Fukami M, et al
  • Journal Title: Int J Androl Volume: (accepted)
  • Peer Reviewed
• [Journal Article] Molecular bases and phenotypic determinants of aromatase excess syndrome
  • Author(s): Fukami M, Shozu M, Ogata T
  • Journal Title: Int J Endocrinol Volume: (accepted)
  • Peer Reviewed
• [Journal Article] MAMLD1 and 46, XY disorders of sex development
  • Author(s): Ogata T, Sano S, et al
  • Journal Title: Seminars in Reproductive Medicine Volume: (accepted)
  • Peer Reviewed
• [Presentation] 性とインプリンティング (2013)
  • Author(s): 緒方勤
  • Organizer: 新学術領域研究「配偶子幹細胞制御機構」第7回領域会議特別講演
  • Place of Presentation: 東京
• [Presentation] インプリンティング疾患研究アップデート (2012)
  • Author(s): 緒方勤
  • Organizer: 第45回新潟小児内分泌懇話会
  • Place of Presentation: 新潟
  • Year and Date: 2012-06-08
• [Presentation] 小児内分泌関連疾患におけるインプリンティングにかかわる最近の話題 (2012)
  • Author(s): 緒方勤
  • Organizer: JCR研修会
  • Place of Presentation: 芦屋
  • Year and Date: 2012-02-17
• [Presentation] ゲノムインプリンティングと個体・胎盤成長発達 (2012)
  • Author(s): 緒方勤
  • Organizer: 第42回九州小児内分泌懇話会
  • Place of Presentation: 福岡
  • Year and Date: 2012-02-04
• [Presentation] 生殖補助医療における遺伝的安全性の検討 (2012)
  • Author(s): 緒方勤
  • Organizer: 浜松市医師会生涯教育研修会
  • Place of Presentation: 浜松
  • Year and Date: 2012-01-26
• [Presentation] エピジェネティクスと小児成長発達 (2012)
  • Author(s): 緒方勤
  • Organizer: 第115回日本小児科学会学術集会教育講演
  • Place of Presentation: 福岡
• [Presentation] ART in reproductive disorders (2011)
  • Author(s): Ogata T
  • Organizer: FIGO Workshp
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-12-08
• [Presentation] 先天奇形症候群とゲノムインプリンティング (2011)
  • Author(s): 緒方勤
  • Organizer: 第2回生殖医療研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] 第14染色体父性ダイソミー症候群の発症機序と出生前診断 (2011)
  • Author(s): 緒方勤
  • Organizer: 第18回遺伝性疾患に関する出生前診断研究会学術集会
  • Place of Presentation: 佐賀
  • Year and Date: 2011-10-01
• [Presentation] 胎児・胎盤発育とゲノムインプリンティング (2011)
  • Author(s): 緒方勤
  • Organizer: 第5回新生児内分泌研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] Genetic susceptibility to endocrine disrupters: Estrogen receptor polymorphisms (2011)
  • Author(s): Ogata T
  • Organizer: Hamamatsu DOHaD Conference
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2011-07-08
• [Presentation] 子どもの成長と成熟 (2011)
  • Author(s): 緒方勤
  • Organizer: 国際医療福祉大学熱海病院学術講演会
  • Place of Presentation: 熱海
  • Year and Date: 2011-07-01
• [Presentation] 生殖補助医療におけるインプリンティング疾患発症について (2011)
  • Author(s): 緒方勤
  • Organizer: 第18回セント・ルカセミナー
  • Place of Presentation: 大分
  • Year and Date: 2011-06-19
• [Presentation] SGA性低身長症の発症機序:インプリンティング疾患を主として (2011)
  • Author(s): 緒方勤
  • Organizer: 第134回臨床小児研究会
  • Place of Presentation: 越谷
  • Year and Date: 2011-02-14
• [Presentation] 親由来特異的遺伝子発現制御:ヒトインプリンティング疾患解析研究から (2011)
  • Author(s): 緒方勤
  • Organizer: 第3回性差生物医学研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-01-16
• [Presentation] 小児成長発達とゲノムインプリンティング (2011)
  • Author(s): 緒方勤
  • Organizer: 第114回日本小児科学会学術集会特別講演
  • Place of Presentation: 東京
• [Presentation] 生殖補助医療における遺伝的安全性の検討:インプリンティング疾患を主として (2011)
  • Author(s): 緒方勤
  • Organizer: 第14回日本IVF学会基礎教育講演
  • Place of Presentation: 東京
• [Presentation] シルバーラッセル症候群の分子遺伝的メカニズム (2011)
  • Author(s): 緒方勤
  • Organizer: 第84回日本内分泌学会学術総会ミニシンポジウム:SGA性低身長をめぐって
  • Place of Presentation: 神戸
• [Presentation] 生殖補助医療におけるインプリンティング疾患発症リスクについて (2011)
  • Author(s): 緒方勤
  • Organizer: 第56回日本生殖医学会総会教育講演:生殖医療の新たな展開-最終成果について考える
  • Place of Presentation: 東京
• [Presentation] Prader-Willi Syndrome:Recent Progress. Invited Special Lecture (2010)
  • Author(s): Ogata T
  • Organizer: The 8th Korean PWS (Prader-Willi syndrome) Symposium
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2010-10-02
• [Presentation] Prader-Willi Syndrome : Recent Progress.Invited Special Lecture. (2010)
  • Author(s): Ogata T
  • Organizer: The 8th Korean PWS (Prader-Willi syndrome) Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-10-02
• [Presentation] 胎児成長発達とゲノムインプリンティング (2010)
  • Author(s): 緒方勤
  • Organizer: 第13回胎児遺伝子診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-20
• [Presentation] インプリンティング疾患の基礎と臨床 (2010)
  • Author(s): 緒方勤
  • Organizer: 両毛地区小児科講演会
  • Place of Presentation: 足利
  • Year and Date: 2010-01-18
• [Presentation] Molecular and clinical analysis in Silver-Russell syndrome. In: Genetic Diagnosis and Treatment of SGA Short Children (2010)
  • Author(s): Yamazawa K, Ogata T
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] SGA性低身長症の発症機序:インプリンティング疾患を主として (2010)
  • Author(s): 緒方勤
  • Organizer: SGA性低身長症の発症機序:インプリンティング疾患を主として
  • Place of Presentation: 大宮
• [Presentation] ヒトインプリンティング疾患の発症機序 (2010)
  • Author(s): 緒方勤
  • Organizer: 第4回日本エピジェネティクス研究会大会学術集会
  • Place of Presentation: 米子
• [Presentation] インプリンティング異常と胎盤 (2010)
  • Author(s): 松岡健太郎,中澤温,林聡,左合治彦,鏡雅代,緒方勤
  • Organizer: 第18回日本胎盤学会学術集会(第28回日本絨毛性疾患研究会と併催)ワークショップ基調講演:Placental Mesenchymal Dysplasia (PMD)とBeckwith-Wiedemann syndrome (BMD)
  • Place of Presentation: 熊本
• [Presentation] エコチル調査における遺伝医学研究 (2010)
  • Author(s): 緒方勤
  • Organizer: 日本人類遺伝学会第55回大会シンポジウム:小児環境疫学(エコチル)調査と遺伝医学
  • Place of Presentation: 大宮
• [Presentation] 生殖補助医療とインプリティグ異常 (2010)
  • Author(s): 緒方勤
  • Organizer: 日本人類遺伝学会第55回大会シンポジウム:臨床遺伝学のプロフェッショナルは、生殖補助医療-とくに着床前診断-にどうかかわればよいのか?
  • Place of Presentation: 大宮
• [Presentation] 身長を規定する遺伝子・ゲノム (2010)
  • Author(s): 緒方勤
  • Organizer: 第83回日本内分泌学会学術総会教育講演
  • Place of Presentation: 京都
• [Presentation] SGA性低身長症の発症機序 : インプリンティング疾患を主として (2010)
  • Author(s): 緒方勤
  • Organizer: 日本人類遺伝学会第55回大会共催セミナー
  • Place of Presentation: 大宮
• [Presentation] インプリンティング異常と胎盤 (2010)
  • Author(s): 松岡健太郎, 中澤温, 林聡, 左合治彦, 鏡雅代, 緒方勤
  • Organizer: 第18回日本胎盤学会学術集会(第28回日本絨毛性疾患研究会と併催)ワークショップ
  • Place of Presentation: 熊本 基調講演
• [Presentation] 生殖補助医療とインプリンティング異常 (2010)
  • Author(s): 緒方勤
  • Organizer: 日本人類遺伝学会第55回大会シンポジウム
  • Place of Presentation: 大宮
• [Book] Uniparental disomy and human disease : an overview.Am J Med Genet C(Seminars in Medical Genetics) (2010)
  • Author(s): Yamazawa K, Oeata T, Fergus on-Smith A C
  • Total Pages: 70
  • Publisher: Wiley
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/w1b/pediatr/patient/index.html
• [Remarks]
  • URL: http://www.nch.go.jp/endocrinology/index.htm
• [Remarks] 浜松医科大学小児科
  • URL: http://www2.hama-med.ac.jp/w1b/pediatr/patient/index.html
• [Remarks] 国立成育医療研究センター研究所分子内分泌研究部
  • URL: http://www.nch.go.jp/endocrinology/index.htm
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/wlb/pediatr/patient/index.html
• [Remarks]
  • URL: http://www.nch.go.jp/endocrinology/index.htm
• [Remarks]
  • URL: http://www.nch.go.jp/endocrinology/index.htm