Cellular interaction in liver development and pathogenesis
| Project/Area Number |
22249011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Minoru 東京大学, 分子 細胞生物学研究所, 准教授 (80321909)
ITOH Tohru 東京大学, 分子細胞 生物学研究所, 講師 (50396917)
MIYAOKA Yuichiro 東京大学, 分子細胞生物学研究所, 助教 (20549521)
SAIJOU Eiko 東京大学, 分子 細胞生物学研究所, 技術職員 (60376647)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2012: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2011: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2010: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | 発生 / 再生 / 肝炎 / 線維化 / 細胞増殖 / サイトカイン / 細胞分裂 / 細胞肥大 / 細胞周期 / FGF / 幹細胞 / 肝障害 / ニッチ |
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| Research Abstract |
Liver is a unique organ with an extraordinary capacity to regenerate. This study showed importance of cellular hypertrophy of hepatocytes and proposes a revised model of liver regeneration after partial hepatectomy. Liver progenitor cells develop around the portal veins in some types of liver injuries, we found that FGF7 is essential for the induction of liver progenitors, and that they are important for the recovery from the liver injuries.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Inhibition of Stabilin-2 elevates the circulating hyaluronic acid level and prevents tumor metastasis.2012
Author(s)
Hirose Y., Saijou E., Sugano Y., Takeshita F., Nishimura S., Nonaka H., Chen Y.-R., Sekine K., Kido T., Nakamura T., Kato S., Kanke T., Nakamura K., Nagai R., Ochiya T. and Miyajima A.
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 109
Pages: 4263-4268
Related Report
Peer Reviewed
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[Journal Article] Dlk-1, a cell surface antigen on hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency.2010
Author(s)
Yanai H., Nakura K., Hijioka S., Kamei A., Ikari T., Ishikawa,Y., Shinozaki E., Mizunuma N., Hatake K., and Miyajima A.
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Journal Title
J.Biochem
Volume: 148
Pages: 85-92
Related Report
Peer Reviewed
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[Journal Article] Dlk-1, a cell surface antigen on hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency2010
Author(s)
Yanai H, Nakura K, Hijioka S, Kamei A, Ikari T, Ishikawa, Y, Shinozaki E, Mizunuma N., Hatake K, Miyajima A
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Journal Title
J.Biochem.
Volume: 148
Pages: 85-92
Related Report
Peer Reviewed
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