Establishment of laboratory medicine of lipid mediators

• Project/Area Number: 22249017
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: The University of Tokyo
• Principal Investigator: YATOMI Yutaka 東京大学, 医学部附属病院, 教授 (60200523)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2010: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
• Keywords: 臨床検査医学 / リゾリン脂質 / スフィンゴシン1-リン酸 / リゾホスファチジン酸 / リゾホスファチジルセリン / オートタキシン / 臨床検査 / 生理活性脂質 / リゾホスファチジン

Research Abstract

Through the elucidation of functional roles and metabolic regulation of lysophospholipids, i.e., sphingosine 1-phosphate, lysophosphatidic acid, and lysophosphatidylserine, introduction into laboratory medicine of the assay of these lipid mediators has been pursued.

Research Products

• [Journal Article] Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study. (2013)
  • Author(s): Enooku, K., Kato, R., Ikeda, H., Kurano, M., Kume, Y., Yoshida, H., Ono, T., Aizawa, K., Suzuki, T., Yamazaki, T., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 421 Pages: 147-151
• [Journal Article] Plasma lysophosphatidic acid levels and hepatocellular carcinoma (Letter). (2013)
  • Author(s): Ikeda, H., Enooku, K., Ohkawa, R., Koike, K., and Yatomi, Y.
  • Journal Title: Hepatology Volume: 57 Pages: 417-418
• [Journal Article] Sphingosine1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine1-phosphate concentration. (2013)
  • Author(s): Ono, Y., Kurano, M., Ohkawa, R., Yokota, H., Igarashi, K., Aoki, J., Tozuka, M., and Yatomi, Y.
  • Journal Title: Lipids HealthDis Volume: 12 Pages: 20-20
• [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone. (2013)
  • Author(s): Sumida, H., Nakamura, K., Yanagida, K., Ohkawa, R., Asano, Y., Kadono, T., Tamaki, K., Igarashi, K., Aoki, J., Sato, S., Ishii, S., Shimizu, T., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 415 Pages: 74-80
• [Journal Article] Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study (2013)
  • Author(s): Enooku K
  • Journal Title: Clin Chim Acta Volume: 421C Pages: 147-151
  • DOI: 10.1016/j.cca.2013.03.012
  • Peer Reviewed
• [Journal Article] Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA-1 whole blood (2013)
  • Author(s): Nagura Y
  • Journal Title: Transfusion Volume: 印刷中 Issue: 12 Pages: 3139-3148
  • DOI: 10.1111/trf.12152
  • Peer Reviewed
• [Journal Article] Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration (2013)
  • Author(s): Ono Y
  • Journal Title: Lipids Health Dis Volume: 12 Issue: 1 Pages: 20-20
  • DOI: 10.1186/1476-511x-12-20
  • Peer Reviewed
• [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone (2013)
  • Author(s): Sumida H
  • Journal Title: Clin Chim Acta Volume: 415 Pages: 74-80
  • DOI: 10.1016/j.cca.2012.10.003
  • Peer Reviewed
• [Journal Article] Plasma lysophosphatidic acid levels and hepatocellular carcinoma (2013)
  • Author(s): Ikeda H
  • Journal Title: Hepatology Volume: 57 Issue: 1 Pages: 417-8
  • DOI: 10.1002/hep.25886
  • Peer Reviewed
• [Journal Article] H. Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography. (2012)
  • Author(s): Dohi, T., Miyauchi, K., Ohkawa, R., Nakamura, K., Thuboi, S., Ogita, M., Miyazaki, T., Nishino, A., Yokoyama, K., Kurata, T., Yatomi, Y., and Daida
  • Journal Title: Ann. Clin. Biochem Volume: 49 Pages: 527-533
• [Journal Article] Identification and biochemical characterization of a novel autotaxin isoform, ATXdelta, with a four-amino acid deletion. (2012)
  • Author(s): Hashimoto, T., Okudaira, S., Igarashi, K., Hama, K., Yatomi, Y., and Aoki, J.
  • Journal Title: J. Biochem Volume: 151 Pages: 89-97
• [Journal Article] Y. Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. (2012)
  • Author(s): Kageyama, Y., Ikeda, H., Watanabe, N., Nagamine, M., Kusumoto, Y., Yashiro, M., Satoh, Y., Shimosawa, T., Shinozaki, K., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Yokota, H., Koyama, T., Ishimaru, K., Okamoto, Y., Takuwa, Y., Koike, K., and Yatomi
  • Journal Title: Hepatology Volume: 56 Pages: 1427-1438
• [Journal Article] Serum autotaxin is not a useful biomarker for ovarian cancer. (2012)
  • Author(s): Nakamura, K., Igarashi, K., Ohkawa, R., Yokota, H., Masuda, A., Nakagawa, S., Yano, T., Ikeda, H., Aoki, J., and Yatomi, Y.
  • Journal Title: Lipids Volume: 47 Pages: 927-930
• [Journal Article] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms. (2012)
  • Author(s): Norimatsu, Y., Ohmori, T., Kimura, A., Madoiwa, S., Mimuro, J., Seichi, A., Yatomi, Y., Hoshino, Y., and Sakata, Y.
  • Journal Title: Am. J. Pathol Volume: 180 Pages: 1625-1635
• [Journal Article] Development of an enzymatic assay for sphingomyelin with rapid and automatable performances: Analysis in healthy subjects and coronary heart disease patients. (2012)
  • Author(s): Ohkawa, R., Kishimoto, T., Kurano, M., Dohi, T., Miyauchi, K., Daida, H., Nagasaki, M., Uno, K., Hayashi, N., Sakai, N., Matsuyama, N., Nojiri, T., Nakamura, K., Okubo, S., Yokota, H., Ikeda, H., and Yatomi, Y.
  • Journal Title: Clin. Biochem. Volume: 45 Pages: 1463-1470
• [Journal Article] H. Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence. (2012)
  • Author(s): Soroida, Y., Ohkawa, R., Nakagawa, H., Satoh, Y., Yoshida, H., Kinoshita, H., Tateishi, R., Masuzaki, R., Enooku, K., Shiina, S., Sato, T., Obi, S., Hoshino, T., Nagatomo, R., Okubo, S., Yokota, H., Koike, K., Yatomi, Y., and Ikeda
  • Journal Title: J. Hepatology Volume: 57 Pages: 330-336
• [Journal Article] Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. (2012)
  • Author(s): Sugiura, T., Dohi, Y., Yamashita, S., Ohte, N., Ito, S., Iwaki, S., Hirowatari, Y., Ohkawa, R., Mishima, Y., Yatomi, Y., Kimura, G., and Fujii, S.
  • Journal Title: Coron. Artery Dis., 2012 Volume: 23 Pages: 234-238
• [Journal Article] Autotaxin in liver fibrosis. (2012)
  • Author(s): Ikeda, H. and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 413 Pages: 1817-1821
• [Journal Article] Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography (2012)
  • Author(s): Dohi T
  • Journal Title: Ann Clin Biochem Volume: 49 Issue: 6 Pages: 527-33
  • DOI: 10.1258/acb.2012.011252
  • Peer Reviewed
• [Journal Article] Development of an enzymatic assay for sphingomyelin with rapid and automatable performances: Analysis in healthy subjects and coronary heart disease patients (2012)
  • Author(s): Ohkawa R
  • Journal Title: Clin Biochem Volume: 45 Issue: 16-17 Pages: 1463-70
  • DOI: 10.1016/j.clinbiochem.2012.07.093
  • Peer Reviewed
• [Journal Article] Autotaxin in liver fibrosis (2012)
  • Author(s): Ikeda H
  • Journal Title: Clin Chim Acta Volume: 413 Issue: 23-24 Pages: 1817-21
  • DOI: 10.1016/j.cca.2012.07.014
• [Journal Article] Serum autotaxin is not a useful biomarker for ovarian cancer (2012)
  • Author(s): Nakamura K
  • Journal Title: Lipids Volume: 47 Issue: 9 Pages: 927-30
  • DOI: 10.1007/s11745-012-3691-0
  • Peer Reviewed
• [Journal Article] Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome (2012)
  • Author(s): Dohi, T., et al.
  • Journal Title: Clin.Chim.Acta Volume: 413 Pages: 207-212
  • Peer Reviewed
• [Journal Article] Identification and biochemical characterization of a novel autotaxin isoform, ATXdelta, with a four-amino acid deletion (2012)
  • Author(s): Hashimoto, T., et al.
  • Journal Title: J.Biochem. Volume: 151 Pages: 89-97
  • Peer Reviewed
• [Journal Article] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodul atory mechanisms (2012)
  • Author(s): Norimatsu, Y., et al.
  • Journal Title: Am.J.Pathol. Volume: 180 Pages: 1625-1635
  • Peer Reviewed
• [Journal Article] Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis (2012)
  • Author(s): Sugiura, T., et al.
  • Journal Title: Coron.Artery Dis. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rats (2012)
  • Author(s): Kegeyama, Y., et al.
  • Journal Title: Hepatology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome. (2011)
  • Author(s): Dohi, T., Miyauchi, K., Okazaki, S., Yokoyama, T., Ohkawa, R., Nakamura, K., Yanagisawa, N., Tsuboi, S., Ogita, M., Yokoyama, K., Kurata, T., Yatomi, Y., and Daida, H.
  • Journal Title: Atherosclerosis Volume: 219 Pages: 907-912
• [Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C. (2011)
  • Author(s): Ikeda, H., Tateishi, R., Enooku, K., Yoshida, H., Nakagawa, H., Masuzaki, R., Kondo, Y., Goto, T., Shiina, S., Kume, Y., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Ono, T., Koike, K., and Yatomi, Y.
  • Journal Title: Cancer Epidemiol. Biomarkers Prev Volume: 20 Pages: 2204-2211
• [Journal Article] Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension. (2011)
  • Author(s): Masuda, A., Fujii, T., Iwasawa, Y., Nakamura, K., Ohkawa, R., Igarashi, K., Okudaira, S., Ikeda, H., Kozuma, S., Aoki, J., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 412 Pages: 1944-1950
• [Journal Article] Autotaxin as a novel serum marker of liver fibrosis. (2011)
  • Author(s): Nakagawa, H., Ikeda, H., Nakamura, K., Ohkawa, R., Masuzaki, R., Tateishi, R., Yoshida, H., Watanabe, N., Tejima, K., Kume, Y., Iwai, T., Suzuki, A., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Omata, M., Igarashi, K., Aoki, J., Koike, K., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 412 Pages: 1201-1206
• [Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer. (2011)
  • Author(s): Nakai, Y., Ikeda, H., Nakamura, K., Kume, Y., Fujishiro, M., Sasahira, N., Hirano, K., Isayama, H., Tada, M., Kawabe, T., Komatsu, Y., Omata, M., Aoki, J., Koike, K., and Yatomi, Y.
  • Journal Title: Clin. Biochem. Volume: 44 Pages: 576-581
• [Journal Article] Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome (2011)
  • Author(s): Dohi, T., et al.
  • Journal Title: Atherosclerosis Volume: 219 Pages: 907-912
  • Peer Reviewed
• [Journal Article] Serum autotaxin measurements in pregnant women : application for the differentiation of normal pregnancy and pregnancy-induced hypertension (2011)
  • Author(s): Masuda, A., et al.
  • Journal Title: Clin.Chim.Acta Volume: 412 Pages: 1944-1950
  • Peer Reviewed
• [Journal Article] Autotaxin as a novel serum marker of liver fibrosis (2011)
  • Author(s): Nakagawa, H., et al.
  • Journal Title: Clin.Chim.Acta Volume: 412 Pages: 1201-1206
  • Peer Reviewed
• [Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer (2011)
  • Author(s): Nakai, Y., et al.
  • Journal Title: Clin.Biochem. Volume: 44 Pages: 576-581
  • Peer Reviewed
• [Journal Article] Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. (2010)
  • Author(s): Ikeda, H., Ohkawa, R., Watanabe, N., Nakamura, K., Kume, Y., Nakagawa, H., Yoshida, H., Okubo, S., Yokota, H., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Koike, K., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 411 Pages: 765-770
• [Journal Article] Unbalanced expression of sphingosine1-phosphate receptors in diabetic nephropathy. (2010)
  • Author(s): Imasawa, T., Kitamura, H., Ohkawa, R., Satoh, Y., Miyashita, A., and Yatomi, Y.
  • Journal Title: Exp. Toxicol. Pathol. Volume: 62 Pages: 53-60
• [Journal Article] Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis ofpancreatic beta-cells. Biochem. (2010)
  • Author(s): Imasawa, T., Koike, K., Ishii, I., Chun, J., and Yatomi, Y.
  • Journal Title: Biophys. Res. Commun Volume: 392 Pages: 207-211
• [Journal Article] A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples. (2010)
  • Author(s): Nakamura, K., Igarashi, K., Ohkawa, R., Saiki, N., Nagasaki, M., Uno, K., Hayashi, N., Sawada, T., Syukuya, K., Yokota, H., Arai, H., Ikeda, H., Aoki, J., and Yatomi, Y.
  • Journal Title: Clin. Chim. Acta Volume: 411 Pages: 1090-1094
• [Journal Article] Liquid chromatography/mass spectrometry analysis revealing preferential occurrence of non-arachidonate-containing phosphatidylinositol bisphosphate species in nuclei and changes in their levels during cell cycle. (2010)
  • Author(s): Ogiso, H., Nakamura, K., Yatomi, Y., Shimizu, T., and Taguchi, R.
  • Journal Title: Rapid Commun. Mass Spectrom Volume: 24 Pages: 436-442
• [Journal Article] Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. (2010)
  • Author(s): Qi, X., Okamoto, Y., Murakawa, T., Wang, F., Oyama, O., Ohkawa, R., Yoshioka, K., Du, W., Sugimoto, N., Yatomi, Y., Takuwa, N., and Takuwa, Y.
  • Journal Title: Eur. J. Pharmacol. Volume: 634 Pages: 121-131
  • NAID: 120002086439
• [Journal Article] Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome. (2010)
  • Author(s): Dohi, T., Miyauchi, K., Ohkawa, R., Nakamura, K., Kishimoto, T., Miyazaki, T., Nishino, A., Nakajima, N., Yaginuma, K., Tamura, H., Kojima, T., Yokoyama, K., Kurata, T., Shimada, K., Yatomi, Y., and Daida, H.
  • Journal Title: Clin. Chim. Acta Volume: 413 Pages: 207-212
• [Journal Article] Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C (2010)
  • Author(s): Ikeda, H., et al
  • Journal Title: Clin.Chim.Acta. Volume: 411 Pages: 765-770
  • Peer Reviewed
• [Journal Article] Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy (2010)
  • Author(s): Imasawa, T., et al
  • Journal Title: Exp.Toxicol.Pathol. Volume: 62 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells (2010)
  • Author(s): Imasawa, T., et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 392 Pages: 207-211
  • Peer Reviewed
• [Journal Article] A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples (2010)
  • Author(s): Nakamura, K., et al
  • Journal Title: Clin.Chim.Acta Volume: 411 Pages: 1090-1094
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate recepto r-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in ApoE-deficient mice (2010)
  • Author(s): Wang, F, et al
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 3979-3995
  • Peer Reviewed
• [Journal Article] Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M.
  • Author(s): Kurano, M., Tsukamoto, K., Ohkawa, R., Hara, M., Iino, J., Kageyama, Y., Ikeda, H., and Yatomi, Y.
  • Journal Title: Atherosclerosis, in press.
• [Journal Article] Increased lysophosphatidic acid levels in culprit coronary arteries of patients withacute coronary syndrome.
  • Author(s): Dohi, T., Miyauchi, K., Ohkawa, R., Nakamura, K., Kurano, M., Kishimoto, T., Yanagisawa, N., Ogita, M., Miyazaki, T., Nishino, A., Yaginuma, K., Tamura, H., Kojima, T., Yokoyama, K., Kurata, T., Shimada, K., Daida, H., and Yatomi, Y.
  • Journal Title: Atherosclerosis, in press.
• [Journal Article] Lysophosphatidic acid receptor LPA is essential for development of arthritis.
  • Author(s): Miyabe, Y., Miyabe, C., Iwai, Y., Takayasu, A., Fukuda, S., Yokoyama, W., Nagai, J., Jona, M., Tokuhara, Y., Ohkawa, R., Albers, H.M., Ovaa, H., Aoki, J., Chun, J., Yatomi, Y., Ueda, H., Miyasaka, M., Miyasaka, N., and Nanki, T.
  • Journal Title: Arthritis Rheum Volume: (in press)
• [Journal Article] Inhibition of Lysophosphatidic Acid (LPA) Increase by Pre-storage Whole-Blood Leukocyte Reduction in Autologous CPDA-1 Whole Blood.
  • Author(s): Nagura, Y., Tsuno, N.H., Ohkawa, R., Nojiri, T., Tokuhara, Y., Matsuhashi, M., Yatomi, Y., and Takahashi, K.
  • Journal Title: Transfusion, in press.
• [Presentation] Hepatic Apolipoprotein M Overexpression Increased Total Sphingosine 1-phosphate Mass and Ameliorate Insulin Resistance in Diet Induced Obesity Mice. (2012)
  • Author(s): Kurano, M., Tsukamoto, K., Ohkawa, R., Hara, M., Iino, J., Ikeda, H., and Yatomi, Y.
  • Organizer: Scientific Session of the American Heart Association.
  • Place of Presentation: CA, USA.
• [Presentation] Possible Usefulness of the Assay of Choline and Choline-containing Phospholipids in Clinical Laboratory Medicine in the Fields of Dyslipidemia and Atherosclerosis. Scientific Session of the American Heart Association. (2012)
  • Author(s): Ohkawa, R., Kishimoto, T., Kurano, M., Dohi, T., Miyauchi, K., Daida, H., Nagasaki, M., Uno, K., Hayashi, N., Sakai, N., Matsuyama, N., Nojiri, T., Nakamura, K., Okubo, S., Yokota, H., Ikeda, H., and Yatomi, Y.
  • Organizer: AHA Scientific Sessions
  • Place of Presentation: CA, USA.
• [Presentation] Serum phosphatidylserine-specific phospholipase A1 (PS-PLA1) identified as a novel biomarker for systemic lupus erythematosus (SLE). (2012)
  • Author(s): Sawada, T., Nakamura, K., Ohkawa, R., Shoji, A., Tahara, K., Hayashi, H., Kimura, E., Igarashi, K., Aoki, J., and Yatomi, Y.
  • Organizer: American College of Rheumatology 76th Annual Meeting
  • Place of Presentation: Washington DC, USA.
• [Presentation] Metabolism of lysophospholipids in the blood. (2011)
  • Author(s): Yatomi, Y.
  • Organizer: XXIIIrd Congress of the International Society on Thrombosis and Haemostasis.
  • Place of Presentation: Kyoto Japan.
• [Presentation] Metabolism of lysophospholipids in the blood (2011)
  • Author(s): Yatomi, Y.
  • Organizer: XXIIIrd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto, Japan(招待講演)
• [Presentation] Clinical laboratory medicine of lysophospholipid mediators. (2010)
  • Author(s): Yatomi, Y.
  • Organizer: The 7th Seoul National University College of Medicine ?The University of Tokyo Faculty of Medicine Joint Conference.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-05-28
• [Presentation] Lipid mediators and atherothrombosis. (2010)
  • Author(s): Yatomi, Y.
  • Organizer: XXth World Congress of the International Society for Heart Research.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Clinical introduction of plasma lysophosphatidic acid and serum autotaxin assays. Keystone Symposia: Bioactive Lipids (2010)
  • Author(s): Yatomi, Y.
  • Organizer: Biochemistry and Diseases.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Usefulness of the enzyme immunoassay of serum autotaxin reflecting the plasma lysophosphatidic acid level. (2010)
  • Author(s): Yatomi, Y., Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Ikeda, H., and Aoki, J.
  • Organizer: Keystone Symposia: Bioactive Lipids: Biochemistry and Diseases.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] their related molecules: its introduction into clinical laboratory medicine. (2010)
  • Author(s): Yatomi, Y., Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Ikeda, H., and Aoki, J. Analysis of lysophospholipids and
  • Organizer: The 27th Naito Conference on "Membrane Dynamics and Lipid Biology[I]".
  • Place of Presentation: Sapporo, Hokkaido, Japan
• [Presentation] Lipid mediators and atherothrombosis (2010)
  • Author(s): Yatomi, Y.
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
• [Presentation] Clinical introduction of plasma lysophosphatidic acid and serum autotax in assays (2010)
  • Author(s): Yatomi, Y.
  • Organizer: Keystone Symposia : Bioactive Lipids: Biochemistry and Diseases
  • Place of Presentation: Kyoto, Japan
• [Presentation] Analysis of lysophospholipids and their related molecules : its introduction into clinical laboratory medicine (2010)
  • Author(s): Yatomi, Y., et al
  • Organizer: The 27th Naito Conference on "Membrane Dynamics and Lipid Biology"
  • Place of Presentation: Sapporo, Hokkaido, Japan
• [Book] Lysophospholipid Receptors : Signaling and Biochemistry (2012)
  • Author(s): Yatomi, Y.
  • Publisher: Clinical Introduction of Lysophosphatidic Acid and Autotaxin Assays(印刷中)
• [Book] Lysophospholipid Receptors : Signaling and Biochemistry (2012)
  • Author(s): Yatomi, Y., et al
  • Publisher: Clinical Introduction of Lysophosphatidic Acid and Autotaxin Assays(印刷中)
• [Book] Clinical Introduction of Lysophosphatidic Acid and Autotaxin Assays.
  • Author(s): Yatomi, Y. Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Suzuki, A., Kishimoto, T., Ikeda, H., and Aoki, J.
  • Publisher: Lysophospholipid Receptors: Signaling and Biochemistry (ed., J. Chun) John Wiley, USA., in press.
• [Remarks] 東京大学医学部附属病院検査部
  • URL: http://lab-tky.umin.jp
• [Remarks]
  • URL: http://lab-tky.umin.jp/
• [Remarks]
  • URL: http://lab-tky.umin.jp/
• [Patent(Industrial Property Rights)] ホスファチジルセリン特異的ホスホリ パーゼA1測定による (2012)
  • Inventor(s): 矢冨裕,中村和宏,五十嵐浩二,青 木淳賢,沢田哲治
  • Industrial Property Rights Holder: 矢冨裕,中村和宏,五十嵐浩二,青 木淳賢,沢田哲治
  • Acquisition Date: 2012-02-16
  • Overseas
• [Patent(Industrial Property Rights)] オートタキシン測定による肝線維化の 検査方法および検査薬 (2011)
  • Inventor(s): 矢冨裕,中村和宏,池田均,五十嵐 浩二
  • Industrial Property Rights Holder: 矢冨裕,中村和宏,池田均,五十嵐 浩二
  • Acquisition Date: 2011-07-07
• [Patent(Industrial Property Rights)] オートタキシン測定による膵疾患の検 査方法および検査薬 (2010)
  • Inventor(s): 矢冨裕,池田均,中井陽介,中村和 宏,五十嵐浩二
  • Industrial Property Rights Holder: 矢冨裕,池田均,中井陽介,中村和 宏,五十嵐浩二
  • Industrial Property Number: 2010-194658
  • Filing Date: 2010-08-31
  • Overseas
• [Patent(Industrial Property Rights)] オートタキシン測定による肝線維化の検査方法および検査薬 (2010)
  • Inventor(s): 矢冨裕, 中村和宏, 池田均, 五十嵐浩二
  • Industrial Property Rights Holder: 東大TLO、東ソー株式会社
  • Filing Date: 2010-12-24
  • Acquisition Date: 2011-07-07
  • Overseas