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Analysis of mitochondrial functions in diseases

Research Project

Project/Area Number 22249018
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKyushu University

Principal Investigator

KANG Dongchon  九州大学, 医学研究院, 臨床検査医学 (80214716)

Co-Investigator(Kenkyū-buntansha) KAYAMORI Yuzo  九州大学, 大学院・医学研究院, 教授 (90398066)
UCHIUMI Takeshi  九州大学, 大学院・医学研究院, 准教授 (80253798)
KANKI Tomotake  九州大学, 大学病院, 助教 (50398088)
TAKAZAKI Shinya  九州大学, 大学院・医学研究院, 助教 (90435149)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2011: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2010: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
KeywordsミトコンドリアDNA / 遺伝子診断 / 活性酸素 / 糖尿病 / ミトコンドリア病 / 遺伝子多型 / 老化 / p32 / メタボローム / 活性酵素
Research Abstract

(1) ERAL1 and p32 of TFAM-binding proteins were essential for efficient formation of mitochondrial ribosomes, suggesting contribution of mitochondrial nucleoids to mitochondrial translation. (2) A metabolomic analysis system of cells harboring mitochondrial DNA mutations was set up. (3) Single nucleotide polymorphisms related to metabolic syndrome and Alzheimer disease were found.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (72 results)

All 2012 2011 2010 Other

All Journal Article (44 results) (of which Peer Reviewed: 19 results) Presentation (24 results) (of which Invited: 9 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Biosci Rep.

      Volume: 32 Pages: 631-639

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Biosci Rep.

    • Related Report
      2012 Final Research Report
  • [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes2012

    • Author(s)
      Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 449-458

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012

    • Author(s)
      Kurihara, Y., Kanki, T., Aoki, Y., Hirota, Y., Saigusa, T., Uchiumi, T., Kang, D.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 3265-72

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins2012

    • Author(s)
      Matsumoto, S., Uchiumi, T., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 391-398

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012

    • Author(s)
      Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
    • Journal Title

      Biochem J.

      Volume: 443 Pages: 573-84

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice2012

    • Author(s)
      Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., Minami, T., Nakamura, K., Kang, D., Yajima, T., Knowlton, K. U., Imaizumi, T.
    • Journal Title

      J Neurosci Res.

      Volume: 90 Pages: 1200-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction2012

    • Author(s)
      Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., Minami, T., Nakamura, K., Kang, D., Yajima, T., Knowlton, K. U., Imaizumi, T.
    • Journal Title

      J Am Coll Cardiol

      Volume: 59 Pages: 838-52

    • Related Report
      2012 Final Research Report
  • [Journal Article] Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding2012

    • Author(s)
      Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1818 Pages: 658-65

    • Related Report
      2012 Final Research Report
  • [Journal Article] mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored2012

    • Author(s)
      Wollen Steen, K., Doseth, B., M, P. W., Akbari, M., Kang, D., Falkenberg, M., Slupphaug, G
    • Journal Title

      DNA Repair (Amst)

      Volume: 11 Pages: 82-91

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability2012

    • Author(s)
      Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S. I., Kanki, T., Kang, D
    • Journal Title

      Nucleic Acids Res.

      Volume: 40 Pages: 9717-9737

    • Related Report
      2012 Final Research Report
  • [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability.2012

    • Author(s)
      Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D
    • Journal Title

      Nuc Acid Res

      Volume: 19 Issue: 19 Pages: 9717-37

    • DOI

      10.1093/nar/gks774

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arg901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding2012

    • Author(s)
      Takazaki, S, Abe, Y, Yamaguchi T, Yagi M, Ueda T, Kagn D, Hamasaki N
    • Journal Title

      Biochem.Biophy.Acta

      Volume: 1819 Issue: 3 Pages: 658-665

    • DOI

      10.1016/j.bbamem.2011.11.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice2012

    • Author(s)
      Morimoto, N., Miyazaki, K., Kurata, T., Ikeda, Y., Matsuura, T., Kang, D., Ide, T., Abe, K.
    • Journal Title

      J Neurosci Res

      Volume: 90 Pages: 1200-1208

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012

    • Author(s)
      Matsumoto S, Uchiumi T, et al
    • Journal Title

      Biochemical J

      Volume: 443 Issue: 2 Pages: 573-584

    • DOI

      10.1042/bj20111728

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012

    • Author(s)
      Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 5 Pages: 3265-3272

    • DOI

      10.1074/jbc.m111.280156

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes,2012

    • Author(s)
      Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 449-458

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Bioscience reports

      Volume: 32 Pages: 631-639

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism,2012

    • Author(s)
      Uchiumi, T., Kang, D.
    • Journal Title

      Biochimica et biophysica acta

      Volume: 1820 Pages: 565-570

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Genomic Disintegrity and Age-Related Diseases,2012

    • Author(s)
      Kang, D.
    • Journal Title

      Anti-Aging Medicine

      Volume: 9 Pages: 201-206

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The physiological role of mitophagy: new insights into phosphorylation events.2012

    • Author(s)
      Hirota, Y., Kang, D., Kanki, T.
    • Journal Title

      International journal of cell biology

      Volume: 2012 Pages: 354914-354914

    • DOI

      10.1155/2012/354914

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism2012

    • Author(s)
      Uchiumi T, Kang D
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820 Issue: 5 Pages: 565-570

    • DOI

      10.1016/j.bbagen.2011.08.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy2011

    • Author(s)
      Amamoto, R., Yagi, M., Song, Y., Oda, Y., Tsuneyoshi, M., Naito, S., Yokomizo, A., Kuroiwa, K., Tokunaga, S., Kato, S., Hiura, H., Samori, T., Kang, D., Uchiumi, T.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 639-47

    • NAID

      10029291485

    • Related Report
      2012 Final Research Report
  • [Journal Article] Phosphorylation of Serine 114 on Atg32 mediates mitophagy2011

    • Author(s)
      Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., Kang, D.
    • Journal Title

      Mol Biol Cell

      Volume: 22 Pages: 3206-17

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer2011

    • Author(s)
      Guo, J., Zheng, L., Liu, W., Wang, X., Wang, Z., Wang, Z., French, A. J., Kang, D., Chen, L., Thibodeau, S. N., Liu, W.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 2978-87

    • Related Report
      2012 Final Research Report
  • [Journal Article] 1,2-Dioleoylglycerol method for pancreatic lipase catalytic activity in serum2011

    • Author(s)
      Iizuka, Y., Ueda, S., Hanada, T., Tani, W., Adachi, H., Haga, R., Yamaguchi, M., Kurotani, W., Sekiguchi, M., Kang, D., Sakasegawa, S.
    • Journal Title

      Clin Chem Lab Med

      Volume: 50 Pages: 475-81

    • Related Report
      2012 Final Research Report
  • [Journal Article] IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C.2011

    • Author(s)
      Schumann, G., Klauke, R., Canalias, F., Bossert-Reuther, S., Franck, P. F., Gella, F. J., Jorgensen, P. J., Kang, D., Lessinger, J. M., Panteghini, M., Ceriotti, F.
    • Journal Title

      Clin Chem Lab Med

      Volume: 49 Pages: 1439-46

    • Related Report
      2012 Final Research Report
  • [Journal Article] Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer2011

    • Author(s)
      Guo, J., Zheng, L., Liu, W., Wang, X., Wang, Z., Wang, Z., French, A.J., Kang, D., Chen, L., Thibodeau, S.N., Liu, W.
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 8 Pages: 2978-2987

    • DOI

      10.1158/0008-5472.can-10-3482

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation2010

    • Author(s)
      Ruhanen, H., Borrie, S., Szabadkai, G., Tyynismaa, H., Jones, A. W., Kang, D., Taanman, J. W., Yasukawa, T
    • Journal Title

      Biochim Biophys Acta

      Volume: 1803 Pages: 931-939

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice2010

    • Author(s)
      Schumann, G., Canalias, F., Joergensen, P. J., Kang, D., Lessinger, J. M., Klauke, R
    • Journal Title

      Clin Chem Lab Med

      Volume: 48 Pages: 615-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] PLEDs in an infant with congenital protein C deficiency: a case report2010

    • Author(s)
      Sekiguchi, K., Akiyoshi, K., Okazaki, N., Yamada, H., Suzuki, M., Maeda, T., Suenobu, S., Izumi, T., Kang, D
    • Journal Title

      Clin Neurophysiol

      Volume: 121 Pages: 800-1

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mutation of His 834 in human anion exchanger 1 affects substrate binding2010

    • Author(s)
      Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
    • Journal Title

      Biochim Biophys Acta

      Volume: 1798 Pages: 903-908

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors2010

    • Author(s)
      Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Eriguchi, Y., Nagasaki, Y., Shimono, N., Kang, D
    • Journal Title

      Int J Antimicrob Agents

      Volume: 35 Pages: 444-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia2010

    • Author(s)
      Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Harada, Y., Kadowaki, M., Shimono, N., Kang, D.
    • Journal Title

      Int J Antimicrob Agents.

      Volume: 35 Pages: 387-91

    • Related Report
      2012 Final Research Report
  • [Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010

    • Author(s)
      Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D.
    • Journal Title

      Nucleic Acids Res.

      Volume: 38 Pages: 5554-5568

    • NAID

      120005227389

    • Related Report
      2012 Final Research Report
  • [Journal Article] Helical image reconstruction of the outward-open human erythrocyte band 3 membrane domain in tubular crystals2010

    • Author(s)
      Yamaguchi, T., Fujii, T., Abe, Y., Hirai, T., Kang, D., Namba, K., Hamasaki, N., Mitsuoka, K.
    • Journal Title

      J Struct Biol.

      Volume: 169 Pages: 406-412

    • Related Report
      2012 Final Research Report
  • [Journal Article] Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography2010

    • Author(s)
      Yamaguchi, T., Ikeda, Y., Abe, Y., Kuma, H., Kang, D., Hamasaki, N., Hirai, T.
    • Journal Title

      J Mol Biol.

      Volume: 397 Pages: 179-89

    • Related Report
      2012 Final Research Report
  • [Journal Article] Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography.2010

    • Author(s)
      Yamaguchi, T., Ikeda, Y., Abe, Y., Kuma, H., Kang, D., Hamasaki, N., Hirai, T.
    • Journal Title

      J Mol Biol

      Volume: 397 Pages: 179-189

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helical image reconstruction of the outward-open human erythro cyte band 3 membrane domain in tubular crystals2010

    • Author(s)
      Yamaguchi, T., Fujii, T., Abe, Y., Hirai, T., Kang, D., Namba, K., Hamasaki, N., Mitsuoka, K.
    • Journal Title

      J Struct Biol

      Volume: 169 Pages: 406-412

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010

    • Author(s)
      Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D
    • Journal Title

      Nucleic Acids Res

      Volume: 38 Pages: 5554-5568

    • NAID

      120005227389

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia2010

    • Author(s)
      Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Harada, Y., Kadowaki, M., Shimono, N., Kang, D.
    • Journal Title

      Int J Antimicrob Agents

      Volume: 35 Pages: 387-391

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors. Int2010

    • Author(s)
      Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Eriguchi, Y., Nagasaki, Y., Shimono, N., Kang, D.
    • Journal Title

      J Antimicrob Agents

      Volume: 35 Pages: 444-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLEDs in an infant with congenital protein C deficiency : a case report2010

    • Author(s)
      Sekiguchi, K., Akiyoshi, K., Okazaki, N., Yamada, H., Suzuki, M., Maeda, T., Suenobu, S., Izumi, T., Kang, D.
    • Journal Title

      Clin Neurophysiol

      Volume: 121 Pages: 800-801

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFCC reference procedures for measurement of the catalytic concentrations of enzymes : corrigendum, notes and useful advice2010

    • Author(s)
      Schumann, G., Canalias, F., Joergensen, P.J., Kang, D., Lessinger, J.M., Klauke, R
    • Journal Title

      Clin Chem Lab Med

      Volume: 48 Pages: 615-621

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Implications of mitochondrial oxidative stress in common diseases2012

    • Author(s)
      D. Kang
    • Organizer
      International symposium of mitochondrial biomedicine & ASMRM Council Meeting
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2012-04-08
    • Related Report
      2012 Final Research Report
  • [Presentation] RNA-binding proteins involved in mitochondrial proteins synthesis2012

    • Author(s)
      D. Kang
    • Organizer
      7th International Symposium on Genomic Medicine of CCH (Joint Symposium of Taiwan Society for Mitochondrial Research and Medicine/ Australasian College of Medical Sciences and Research) 2012
    • Place of Presentation
      Taichung, Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリアゲノムの維持とヒトの疾患:活性酸素とTFAMの意義(WS「ミトコンドリアゲノムが制御する多様な生命現象」)2012

    • Author(s)
      康東天
    • Organizer
      第84回日本遺伝学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化におけるミトコンドリアとTFAM(シンポジウム「身から出た錆:ミトコンドリアから長寿を科学する」)2012

    • Author(s)
      康東天
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリアゲノムと酸化ストレス:TFAMから見る細胞機能2012

    • Author(s)
      康東天
    • Organizer
      第22回生物試料分析科学会年次学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Implications of Mitochondrial Oxidative Stress in Common Diseases,2012

    • Author(s)
      Kang, D.
    • Organizer
      International symposium of mitochondrial biomedicine & ASMRM Council Meeting.
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Rna-Binding Proteins Involved in Mitochondrial Proteins Synthesis,2012

    • Author(s)
      Kang, D.
    • Organizer
      7th International Symposium on Genomic Medicine of CCH(Joint Symposium of Taiwan Society for Mitochondrial Research and Medicine/
    • Place of Presentation
      Taichung, Taiwan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアゲノムと酸化ストレス:Tfamから見る細胞機能,2012

    • Author(s)
      康 東天
    • Organizer
      第22回生物試料分析科学会年次学術集会.
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアゲノムの維持とヒトの疾患:活性酸素とtfamの意義(Ws「ミトコンドリアゲノムが制御する多様な生命現象」)2012

    • Author(s)
      康 東天
    • Organizer
      第84回日本遺伝学会大会.
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 検査データの現状と課題(大会企画「医療情報データベースの特性と質」)2012

    • Author(s)
      康 東天
    • Organizer
      第16回日本医療情報学会春季学術大会
    • Place of Presentation
      函館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 日本版センチネルプロジェクトにおける標準化の課題Jlac10(Helicsチュートリアル「医療情報を二次利用するための標準化」2012

    • Author(s)
      康 東天
    • Organizer
      第16回日本医療情報学会春季学術大会
    • Place of Presentation
      函館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 臨床化学の魅力:自動化の先にあるもの(会長シンポジウム「臨床検査の再生と将来展望」)2012

    • Author(s)
      康 東天
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 臨床検査項目標準コード(Jlac10)最新情報~今後の方向性(シンポジウム「臨床検査の医療情報」)2012

    • Author(s)
      康 東天
    • Organizer
      第32回日本医療情報学連合大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 老化におけるミトコンドリアとtfam(シンポジウム「身から出た錆:ミトコンドリアから長寿を科学する」)2012

    • Author(s)
      康 東天
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] MayTurner症候群に関連する血栓性閉塞と良好な下腹壁静脈の副側血行を呈した先天的AT欠損の若年症例2011

    • Author(s)
      藤波舞、伊藤和史、高岡理恵、羽室雅夫、篠原未帆、浦田美秩代、康東天、濱崎直孝
    • Organizer
      第195回日本内科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Importance of Mitochondrial genome in cellular functions:Oxidative stress and TFAM2011

    • Author(s)
      D. Kang
    • Organizer
      Mckay International symposium 0n mitochondrial medicine in human health and diseases
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-07-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Importance of Mitochondria 1 genome in cellular functions : Oxidative stress and TFAM2011

    • Author(s)
      D.Kang
    • Organizer
      2011Mckay International symposium On mitochondrial medicine in human health and diseases
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Implications of mitochondrial oxidative stress in common diseases2011

    • Author(s)
      Dongchon Kang
    • Organizer
      International symposium of mitochondrial biomedicine & ASMRM Council Meeting
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2011-04-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生化学検査標準化と共通基準範囲に向けて2011

    • Author(s)
      康東天
    • Organizer
      日常検査の現状と将来
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phosphorylation of ser114 on ATG32 mediates mitophagy2011

    • Author(s)
      Tomotake Kanki, Yoshimasa Aoki, Yusuke Kurihara, Tetsu Saigusa, Takeshi Uchiumi, Dongchon Kang
    • Organizer
      The 8th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      Kagoshima, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recombinant TFAM attenuates pathological remodeling in cardiac myocytes via inhibiting NAFAT signaling2011

    • Author(s)
      Takeo Fujino, Tomomi Ide, Masayoshi Yoshida, Atushi Tanaka, Ken Onitsuka, Yuko Hata, Takako Takehara, Shinya Takazaki, Mothohiro Nishida, Dongchon Kang, Kenji Sunagawa
    • Organizer
      The 8th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      Kagoshima, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリアDNA量と生体ホメオスターシスの維持に関するマウスモデルによる検討2011

    • Author(s)
      井手友美、康東天
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aging and mitochondrial dysfunction2010

    • Author(s)
      Kang, D.
    • Organizer
      The 11th annual meeting for Southern district of the Korean Society for Laboratory Medicine
    • Place of Presentation
      Pusan, Korea
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] TFAM-associated proteins that are involved in mitochondrial RNA metabolisms2010

    • Author(s)
      Kang, D
    • Organizer
      The 7th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2010 Annual Research Report
  • [Book] Cellular and Genetic Practices for Translational Medicine Research2011

    • Author(s)
      Kang, D
    • Publisher
      Importance of mitochondrial genome in multiple cellular functions: A central role of TFAM in its maintenance
    • Related Report
      2012 Final Research Report
  • [Book] Importance of mitochondrial genome in multiple cellular functions : A central role of TFAM in its maintenance2011

    • Author(s)
      Kang, D., (Ed.)
    • Total Pages
      20
    • Publisher
      Research Signpost, Kerala
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/cclm/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/cclm/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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