Analysis of mitochondrial functions in diseases

• Project/Area Number: 22249018
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kyushu University
• Principal Investigator: KANG Dongchon 九州大学, 医学研究院, 臨床検査医学 (80214716)
• Co-Investigator(Kenkyū-buntansha): KAYAMORI Yuzo 九州大学, 大学院・医学研究院, 教授 (90398066) ; UCHIUMI Takeshi 九州大学, 大学院・医学研究院, 准教授 (80253798) ; KANKI Tomotake 九州大学, 大学病院, 助教 (50398088) ; TAKAZAKI Shinya 九州大学, 大学院・医学研究院, 助教 (90435149)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000); Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2011: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2010: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
• Keywords: ミトコンドリアDNA / 遺伝子診断 / 活性酸素 / 糖尿病 / ミトコンドリア病 / 遺伝子多型 / 老化 / p32 / メタボローム / 活性酵素

Research Abstract

(1) ERAL1 and p32 of TFAM-binding proteins were essential for efficient formation of mitochondrial ribosomes, suggesting contribution of mitochondrial nucleoids to mitochondrial translation. (2) A metabolomic analysis system of cells harboring mitochondrial DNA mutations was set up. (3) Single nucleotide polymorphisms related to metabolic syndrome and Alzheimer disease were found.

Research Products

• [Journal Article] Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients (2012)
  • Author(s): Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
  • Journal Title: Biosci Rep. Volume: 32 Pages: 631-639
• [Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction (2012)
  • Author(s): Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., Kang, D.
  • Journal Title: Biosci Rep.
• [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes (2012)
  • Author(s): Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
  • Journal Title: Mitochondrion Volume: 12 Pages: 449-458
• [Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast (2012)
  • Author(s): Kurihara, Y., Kanki, T., Aoki, Y., Hirota, Y., Saigusa, T., Uchiumi, T., Kang, D.
  • Journal Title: J Biol Chem Volume: 287 Pages: 3265-72
• [Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins (2012)
  • Author(s): Matsumoto, S., Uchiumi, T., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
  • Journal Title: Mitochondrion Volume: 12 Pages: 391-398
• [Journal Article] Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA (2012)
  • Author(s): Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
  • Journal Title: Biochem J. Volume: 443 Pages: 573-84
• [Journal Article] Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice (2012)
  • Author(s): Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., Minami, T., Nakamura, K., Kang, D., Yajima, T., Knowlton, K. U., Imaizumi, T.
  • Journal Title: J Neurosci Res. Volume: 90 Pages: 1200-8
• [Journal Article] Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction (2012)
  • Author(s): Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., Minami, T., Nakamura, K., Kang, D., Yajima, T., Knowlton, K. U., Imaizumi, T.
  • Journal Title: J Am Coll Cardiol Volume: 59 Pages: 838-52
• [Journal Article] Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding (2012)
  • Author(s): Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
  • Journal Title: Biochim Biophys Acta. Volume: 1818 Pages: 658-65
• [Journal Article] mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored (2012)
  • Author(s): Wollen Steen, K., Doseth, B., M, P. W., Akbari, M., Kang, D., Falkenberg, M., Slupphaug, G
  • Journal Title: DNA Repair (Amst) Volume: 11 Pages: 82-91
• [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability (2012)
  • Author(s): Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S. I., Kanki, T., Kang, D
  • Journal Title: Nucleic Acids Res. Volume: 40 Pages: 9717-9737
• [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability. (2012)
  • Author(s): Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D
  • Journal Title: Nuc Acid Res Volume: 19 Issue: 19 Pages: 9717-37
  • DOI: 10.1093/nar/gks774
  • Peer Reviewed
• [Journal Article] Arg901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding (2012)
  • Author(s): Takazaki, S, Abe, Y, Yamaguchi T, Yagi M, Ueda T, Kagn D, Hamasaki N
  • Journal Title: Biochem.Biophy.Acta Volume: 1819 Issue: 3 Pages: 658-665
  • DOI: 10.1016/j.bbamem.2011.11.019
  • Peer Reviewed
• [Journal Article] Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice (2012)
  • Author(s): Morimoto, N., Miyazaki, K., Kurata, T., Ikeda, Y., Matsuura, T., Kang, D., Ide, T., Abe, K.
  • Journal Title: J Neurosci Res Volume: 90 Pages: 1200-1208
  • Peer Reviewed
• [Journal Article] Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA (2012)
  • Author(s): Matsumoto S, Uchiumi T, et al
  • Journal Title: Biochemical J Volume: 443 Issue: 2 Pages: 573-584
  • DOI: 10.1042/bj20111728
  • Peer Reviewed
• [Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast (2012)
  • Author(s): Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D
  • Journal Title: J Biol Chem Volume: 287 Issue: 5 Pages: 3265-3272
  • DOI: 10.1074/jbc.m111.280156
  • Peer Reviewed
• [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes, (2012)
  • Author(s): Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
  • Journal Title: Mitochondrion Volume: 12 Pages: 449-458
  • Peer Reviewed
• [Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients (2012)
  • Author(s): Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
  • Journal Title: Bioscience reports Volume: 32 Pages: 631-639
  • Peer Reviewed
• [Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism, (2012)
  • Author(s): Uchiumi, T., Kang, D.
  • Journal Title: Biochimica et biophysica acta Volume: 1820 Pages: 565-570
  • Peer Reviewed
• [Journal Article] Mitochondrial Genomic Disintegrity and Age-Related Diseases, (2012)
  • Author(s): Kang, D.
  • Journal Title: Anti-Aging Medicine Volume: 9 Pages: 201-206
  • Peer Reviewed
• [Journal Article] The physiological role of mitophagy: new insights into phosphorylation events. (2012)
  • Author(s): Hirota, Y., Kang, D., Kanki, T.
  • Journal Title: International journal of cell biology Volume: 2012 Pages: 354914-354914
  • DOI: 10.1155/2012/354914
  • Peer Reviewed
• [Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism (2012)
  • Author(s): Uchiumi T, Kang D
  • Journal Title: Biochim Biophys Acta Volume: 1820 Issue: 5 Pages: 565-570
  • DOI: 10.1016/j.bbagen.2011.08.014
  • Peer Reviewed
• [Journal Article] Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy (2011)
  • Author(s): Amamoto, R., Yagi, M., Song, Y., Oda, Y., Tsuneyoshi, M., Naito, S., Yokomizo, A., Kuroiwa, K., Tokunaga, S., Kato, S., Hiura, H., Samori, T., Kang, D., Uchiumi, T.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 639-47
  • NAID: 10029291485
• [Journal Article] Phosphorylation of Serine 114 on Atg32 mediates mitophagy (2011)
  • Author(s): Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., Kang, D.
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 3206-17
• [Journal Article] Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer (2011)
  • Author(s): Guo, J., Zheng, L., Liu, W., Wang, X., Wang, Z., Wang, Z., French, A. J., Kang, D., Chen, L., Thibodeau, S. N., Liu, W.
  • Journal Title: Cancer Res Volume: 71 Pages: 2978-87
• [Journal Article] 1,2-Dioleoylglycerol method for pancreatic lipase catalytic activity in serum (2011)
  • Author(s): Iizuka, Y., Ueda, S., Hanada, T., Tani, W., Adachi, H., Haga, R., Yamaguchi, M., Kurotani, W., Sekiguchi, M., Kang, D., Sakasegawa, S.
  • Journal Title: Clin Chem Lab Med Volume: 50 Pages: 475-81
• [Journal Article] IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. (2011)
  • Author(s): Schumann, G., Klauke, R., Canalias, F., Bossert-Reuther, S., Franck, P. F., Gella, F. J., Jorgensen, P. J., Kang, D., Lessinger, J. M., Panteghini, M., Ceriotti, F.
  • Journal Title: Clin Chem Lab Med Volume: 49 Pages: 1439-46
• [Journal Article] Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer (2011)
  • Author(s): Guo, J., Zheng, L., Liu, W., Wang, X., Wang, Z., Wang, Z., French, A.J., Kang, D., Chen, L., Thibodeau, S.N., Liu, W.
  • Journal Title: Cancer Res Volume: 71 Issue: 8 Pages: 2978-2987
  • DOI: 10.1158/0008-5472.can-10-3482
  • Peer Reviewed
• [Journal Article] Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation (2010)
  • Author(s): Ruhanen, H., Borrie, S., Szabadkai, G., Tyynismaa, H., Jones, A. W., Kang, D., Taanman, J. W., Yasukawa, T
  • Journal Title: Biochim Biophys Acta Volume: 1803 Pages: 931-939
• [Journal Article] IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice (2010)
  • Author(s): Schumann, G., Canalias, F., Joergensen, P. J., Kang, D., Lessinger, J. M., Klauke, R
  • Journal Title: Clin Chem Lab Med Volume: 48 Pages: 615-21
• [Journal Article] PLEDs in an infant with congenital protein C deficiency: a case report (2010)
  • Author(s): Sekiguchi, K., Akiyoshi, K., Okazaki, N., Yamada, H., Suzuki, M., Maeda, T., Suenobu, S., Izumi, T., Kang, D
  • Journal Title: Clin Neurophysiol Volume: 121 Pages: 800-1
• [Journal Article] Mutation of His 834 in human anion exchanger 1 affects substrate binding (2010)
  • Author(s): Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
  • Journal Title: Biochim Biophys Acta Volume: 1798 Pages: 903-908
• [Journal Article] Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors (2010)
  • Author(s): Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Eriguchi, Y., Nagasaki, Y., Shimono, N., Kang, D
  • Journal Title: Int J Antimicrob Agents Volume: 35 Pages: 444-50
• [Journal Article] Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia (2010)
  • Author(s): Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Harada, Y., Kadowaki, M., Shimono, N., Kang, D.
  • Journal Title: Int J Antimicrob Agents. Volume: 35 Pages: 387-91
• [Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation (2010)
  • Author(s): Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D.
  • Journal Title: Nucleic Acids Res. Volume: 38 Pages: 5554-5568
  • NAID: 120005227389
• [Journal Article] Helical image reconstruction of the outward-open human erythrocyte band 3 membrane domain in tubular crystals (2010)
  • Author(s): Yamaguchi, T., Fujii, T., Abe, Y., Hirai, T., Kang, D., Namba, K., Hamasaki, N., Mitsuoka, K.
  • Journal Title: J Struct Biol. Volume: 169 Pages: 406-412
• [Journal Article] Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography (2010)
  • Author(s): Yamaguchi, T., Ikeda, Y., Abe, Y., Kuma, H., Kang, D., Hamasaki, N., Hirai, T.
  • Journal Title: J Mol Biol. Volume: 397 Pages: 179-89
• [Journal Article] Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography. (2010)
  • Author(s): Yamaguchi, T., Ikeda, Y., Abe, Y., Kuma, H., Kang, D., Hamasaki, N., Hirai, T.
  • Journal Title: J Mol Biol Volume: 397 Pages: 179-189
  • Peer Reviewed
• [Journal Article] Helical image reconstruction of the outward-open human erythro cyte band 3 membrane domain in tubular crystals (2010)
  • Author(s): Yamaguchi, T., Fujii, T., Abe, Y., Hirai, T., Kang, D., Namba, K., Hamasaki, N., Mitsuoka, K.
  • Journal Title: J Struct Biol Volume: 169 Pages: 406-412
  • Peer Reviewed
• [Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation (2010)
  • Author(s): Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D
  • Journal Title: Nucleic Acids Res Volume: 38 Pages: 5554-5568
  • NAID: 120005227389
  • Peer Reviewed
• [Journal Article] Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia (2010)
  • Author(s): Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Harada, Y., Kadowaki, M., Shimono, N., Kang, D.
  • Journal Title: Int J Antimicrob Agents Volume: 35 Pages: 387-391
  • Peer Reviewed
• [Journal Article] Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors. Int (2010)
  • Author(s): Uchida, Y., Mochimaru, T., Morokuma, Y., Kiyosuke, M., Fujise, M., Eto, F., Eriguchi, Y., Nagasaki, Y., Shimono, N., Kang, D.
  • Journal Title: J Antimicrob Agents Volume: 35 Pages: 444-450
  • Peer Reviewed
• [Journal Article] PLEDs in an infant with congenital protein C deficiency : a case report (2010)
  • Author(s): Sekiguchi, K., Akiyoshi, K., Okazaki, N., Yamada, H., Suzuki, M., Maeda, T., Suenobu, S., Izumi, T., Kang, D.
  • Journal Title: Clin Neurophysiol Volume: 121 Pages: 800-801
  • Peer Reviewed
• [Journal Article] IFCC reference procedures for measurement of the catalytic concentrations of enzymes : corrigendum, notes and useful advice (2010)
  • Author(s): Schumann, G., Canalias, F., Joergensen, P.J., Kang, D., Lessinger, J.M., Klauke, R
  • Journal Title: Clin Chem Lab Med Volume: 48 Pages: 615-621
  • Peer Reviewed
• [Presentation] Implications of mitochondrial oxidative stress in common diseases (2012)
  • Author(s): D. Kang
  • Organizer: International symposium of mitochondrial biomedicine & ASMRM Council Meeting
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2012-04-08
• [Presentation] RNA-binding proteins involved in mitochondrial proteins synthesis (2012)
  • Author(s): D. Kang
  • Organizer: 7th International Symposium on Genomic Medicine of CCH (Joint Symposium of Taiwan Society for Mitochondrial Research and Medicine/ Australasian College of Medical Sciences and Research) 2012
  • Place of Presentation: Taichung, Taiwan
• [Presentation] ミトコンドリアゲノムの維持とヒトの疾患:活性酸素とTFAMの意義(WS「ミトコンドリアゲノムが制御する多様な生命現象」) (2012)
  • Author(s): 康東天
  • Organizer: 第84回日本遺伝学会大会
  • Place of Presentation: 福岡
• [Presentation] 老化におけるミトコンドリアとTFAM(シンポジウム「身から出た錆:ミトコンドリアから長寿を科学する」) (2012)
  • Author(s): 康東天
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Presentation] ミトコンドリアゲノムと酸化ストレス:TFAMから見る細胞機能 (2012)
  • Author(s): 康東天
  • Organizer: 第22回生物試料分析科学会年次学術集会
  • Place of Presentation: 福岡
• [Presentation] Implications of Mitochondrial Oxidative Stress in Common Diseases, (2012)
  • Author(s): Kang, D.
  • Organizer: International symposium of mitochondrial biomedicine & ASMRM Council Meeting.
  • Place of Presentation: Hangzhou, China
  • Invited
• [Presentation] Rna-Binding Proteins Involved in Mitochondrial Proteins Synthesis, (2012)
  • Author(s): Kang, D.
  • Organizer: 7th International Symposium on Genomic Medicine of CCH(Joint Symposium of Taiwan Society for Mitochondrial Research and Medicine/
  • Place of Presentation: Taichung, Taiwan
  • Invited
• [Presentation] ミトコンドリアゲノムと酸化ストレス：Ｔｆａｍから見る細胞機能, (2012)
  • Author(s): 康 東天
  • Organizer: 第２２回生物試料分析科学会年次学術集会.
  • Place of Presentation: 福岡
  • Invited
• [Presentation] ミトコンドリアゲノムの維持とヒトの疾患：活性酸素とtfamの意義（Ｗｓ「ミトコンドリアゲノムが制御する多様な生命現象」） (2012)
  • Author(s): 康 東天
  • Organizer: 第84回日本遺伝学会大会.
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 検査データの現状と課題（大会企画「医療情報データベースの特性と質」） (2012)
  • Author(s): 康 東天
  • Organizer: 第16回日本医療情報学会春季学術大会
  • Place of Presentation: 函館
  • Invited
• [Presentation] 日本版センチネルプロジェクトにおける標準化の課題Jlac10（Helicsチュートリアル「医療情報を二次利用するための標準化」 (2012)
  • Author(s): 康 東天
  • Organizer: 第16回日本医療情報学会春季学術大会
  • Place of Presentation: 函館
  • Invited
• [Presentation] 臨床化学の魅力：自動化の先にあるもの（会長シンポジウム「臨床検査の再生と将来展望」） (2012)
  • Author(s): 康 東天
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 臨床検査項目標準コード（Jlac10）最新情報～今後の方向性（シンポジウム「臨床検査の医療情報」） (2012)
  • Author(s): 康 東天
  • Organizer: 第32回日本医療情報学連合大会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 老化におけるミトコンドリアとtfam（シンポジウム「身から出た錆：ミトコンドリアから長寿を科学する」） (2012)
  • Author(s): 康 東天
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] MayTurner症候群に関連する血栓性閉塞と良好な下腹壁静脈の副側血行を呈した先天的AT欠損の若年症例 (2011)
  • Author(s): 藤波舞、伊藤和史、高岡理恵、羽室雅夫、篠原未帆、浦田美秩代、康東天、濱崎直孝
  • Organizer: 第195回日本内科学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-10
• [Presentation] Importance of Mitochondrial genome in cellular functions:Oxidative stress and TFAM (2011)
  • Author(s): D. Kang
  • Organizer: Mckay International symposium 0n mitochondrial medicine in human health and diseases
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-07-09
• [Presentation] Importance of Mitochondria 1 genome in cellular functions : Oxidative stress and TFAM (2011)
  • Author(s): D.Kang
  • Organizer: 2011Mckay International symposium On mitochondrial medicine in human health and diseases
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-07-09
• [Presentation] Implications of mitochondrial oxidative stress in common diseases (2011)
  • Author(s): Dongchon Kang
  • Organizer: International symposium of mitochondrial biomedicine & ASMRM Council Meeting
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2011-04-08
• [Presentation] 生化学検査標準化と共通基準範囲に向けて (2011)
  • Author(s): 康東天
  • Organizer: 日常検査の現状と将来
  • Place of Presentation: 東京
• [Presentation] Phosphorylation of ser114 on ATG32 mediates mitophagy (2011)
  • Author(s): Tomotake Kanki, Yoshimasa Aoki, Yusuke Kurihara, Tetsu Saigusa, Takeshi Uchiumi, Dongchon Kang
  • Organizer: The 8th Conference of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Kagoshima, Japan
• [Presentation] Recombinant TFAM attenuates pathological remodeling in cardiac myocytes via inhibiting NAFAT signaling (2011)
  • Author(s): Takeo Fujino, Tomomi Ide, Masayoshi Yoshida, Atushi Tanaka, Ken Onitsuka, Yuko Hata, Takako Takehara, Shinya Takazaki, Mothohiro Nishida, Dongchon Kang, Kenji Sunagawa
  • Organizer: The 8th Conference of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Kagoshima, Japan
• [Presentation] ミトコンドリアDNA量と生体ホメオスターシスの維持に関するマウスモデルによる検討 (2011)
  • Author(s): 井手友美、康東天
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] Aging and mitochondrial dysfunction (2010)
  • Author(s): Kang, D.
  • Organizer: The 11th annual meeting for Southern district of the Korean Society for Laboratory Medicine
  • Place of Presentation: Pusan, Korea
  • Year and Date: 2010-06-18
• [Presentation] TFAM-associated proteins that are involved in mitochondrial RNA metabolisms (2010)
  • Author(s): Kang, D
  • Organizer: The 7th Conference of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Fukuoka, Japan
• [Book] Cellular and Genetic Practices for Translational Medicine Research (2011)
  • Author(s): Kang, D
  • Publisher: Importance of mitochondrial genome in multiple cellular functions: A central role of TFAM in its maintenance
• [Book] Importance of mitochondrial genome in multiple cellular functions : A central role of TFAM in its maintenance (2011)
  • Author(s): Kang, D., (Ed.)
  • Total Pages: 20
  • Publisher: Research Signpost, Kerala
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cclm/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cclm/