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Role of Brain-Gut Peptides in Pathophysiology of Brain-Gut Interactions

Research Project

Project/Area Number 22249024
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTohoku University

Principal Investigator

FUKUDO Shin  東北大学, 医学(系)研究科(研究院), 教授 (80199249)

Co-Investigator(Kenkyū-buntansha) KANAZAWA Motoyori  東北大学, 大学院医学系研究科, 准教授 (70323003)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Keywords脳腸相関 / 過敏性腸症候群 / CRH / 消化管知覚 / 消化管運動 / 脳画像 / CRH-R1 / CRH拮抗薬 / ストレス / 生体分子 / 内科 / 生理学 / 脳神経 / 脳腸ペプチド / α-helical CRH
Outline of Final Research Achievements

In patients with irritable bowel syndrome (IBS), stress response in the central nervous system and gastrointestinal tract is exaggerated. We tested the hypothesis that corticotropin-releasing hormone (CRH) plays a major role in pathogenesis of IBS. In both humans and animals, visceral stress evoked release of brain-gut peptides especially CRH in the regional brain (e.g. amygdala, anterior cingulate cortex, insula, paraventricular nucleus, and midbrain). These results suggest that regional release of CRH in the specific sites in the brain may be the most important part of pathophysiology of IBS.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Invited: 3 results) Book (5 results) Remarks (5 results)

  • [Journal Article] Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats.2015

    • Author(s)
      Su J, Tanaka Y, Muratsubaki T, Kano M, Kanazawa M, Fukudo S.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 27 Issue: 1 Pages: 30-39

    • DOI

      10.1111/nmo.12462

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evidence-based clinical practice guidelines for irritable bowel syndrome.2015

    • Author(s)
      Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Sugano K, Shimosegawa T.
    • Journal Title

      J Gastroenterol

      Volume: 50 Issue: 1 Pages: 11-30

    • DOI

      10.1007/s00535-014-1017-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Survey of clinical practice for irritable bowel syndrome in East asian countries.2015

    • Author(s)
      Fukudo S, Hahm KB, Zhu Q, Sollano JD, Rani AA, Syam AF, Kachintorn U, Suzuki H, Kamiya T, Joh T, Uchiyama K, Naito Y, Takahashi S, Kinoshita Y, Ueno F, Yamagami H, Chan FK, Fock KM, Arakawa T; International Gastrointestinal Consensus Symposium Study Group.
    • Journal Title

      Digestion

      Volume: 91 Issue: 1 Pages: 99-109

    • DOI

      10.1159/000369078

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor.2014

    • Author(s)
      Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 24 Issue: 9 Pages: 1549-1557

    • DOI

      10.1097/igc.0000000000000269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological and psychological individual differences influence resting brain function measured by ASL perfusion.2014

    • Author(s)
      Kano M, Coen SJ, Farmer AD, Aziz Q, Williams SC, Alsop DC, Fukudo S, O'Gorman RL.
    • Journal Title

      Brain Struct Funct

      Volume: 219 Issue: 5 Pages: 1673-1684

    • DOI

      10.1007/s00429-013-0593-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Preceding stimulation affects brain activation in response to colonic distention in humans.2013

    • Author(s)
      Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
    • Journal Title

      Psychosom Med

      Volume: 75 Issue: 5 Pages: 453-462

    • DOI

      10.1097/psy.0b013e3182926682

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IBS: Autonomic dysregulation in IBS.2013

    • Author(s)
      Fukudo S
    • Journal Title

      Nat Rev Gastroenterol Hepatol

      Volume: 10 Issue: 10 Pages: 569-571

    • DOI

      10.1038/nrgastro.2013.166

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress and visceral pain: Focusing on irritable bowel syndrome.2013

    • Author(s)
      Fukudo S
    • Journal Title

      Pain

      Volume: 154 (Suppl 1) Issue: Supplement 1 Pages: S63-S70

    • DOI

      10.1016/j.pain.2013.09.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling2012

    • Author(s)
      Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
    • Journal Title

      Gastroenterology

      Volume: 143(5) Issue: 5 Pages: 1188-1198

    • DOI

      10.1053/j.gastro.2012.07.104

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced auditorybrainstem response and parental bonding style in children with gastrointestinal symptoms2012

    • Author(s)
      Seino S, Watanabe S, Ito N, Sasaki K, Shoji K, Miura S, Kozawa K, Nakai K, Sato H, Kanazawa M, Fukudo S
    • Journal Title

      PLoS One

      Volume: 7(3) Issue: 3 Pages: e32913-e32913

    • DOI

      10.1371/journal.pone.0032913

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management and pathophysiology of functional gastro-intestinal disorders2012

    • Author(s)
      Fukudo S, et al
    • Journal Title

      Digestion

      Volume: 85 Issue: 2 Pages: 85-89

    • DOI

      10.1159/000334652

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of repetitive transcranial magnetic stimulation on rectal function and emo tion in humans2011

    • Author(s)
      Aizawa Y, Morishita J, Kano M, Mori T, Izumi SI, Tsutsui K, Iijima T, Kanazawa M, Fukudo S.
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 9 Pages: 1171-1180

    • DOI

      10.1007/s00535-011-0423-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene environment, and brain-gut interactions in irritable bowel syndrome2011

    • Author(s)
      Fukudo S, Kanazawa M.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26Suppl 3 Issue: s3 Pages: 110-5

    • DOI

      10.1111/j.1440-1746.2011.06631.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men.2010

    • Author(s)
      Kanazawa M, Fukudo S, et al.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 22 Pages: 173-180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential responding of autonomic function to histamine Hl antago nism in irritable bowel syndrome.2010

    • Author(s)
      Hattori T, Fukudo S, et al.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 22 Pages: 1284-1291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain activity following esophageal acid infusion using positron emission tomography.2010

    • Author(s)
      Kobayashi S, Fukudo S, et al.
    • Journal Title

      World J Gastroenterol

      Volume: 16 Pages: 5481-5489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Irritable Bowel Syndrome: Multimodal Disorder of Brain-Gut Interactions2014

    • Author(s)
      Fukudo S.
    • Organizer
      Invited Lecture of Catholic University of Leuven
    • Place of Presentation
      Leuven, Belgium
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of Dopamine in Hypnotic Analgesia under Visceral Stimulation2014

    • Author(s)
      Fukudo S, Morishita J, Watanabe S, Kawahata K, Ishizu N, Tanaka Y, Watanuki S, Hiraoka K, Kano M, Kanazawa M, Yanai K, Tashiro M.
    • Organizer
      The 13th International Congress of Behavioral Medicine
    • Place of Presentation
      Groningen, Netherland
    • Year and Date
      2014-08-20 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evidence of Dopamine Release during Hypnotic Analgesia under Visceral Stimulation in Humans.2014

    • Author(s)
      Fukudo S, Morishita J, Watanabe S, Kawahata K, Ishizu N, Tanaka Y, Watanuki S, Hiraoka K, Kano M, Kanazawa M, Yanai K, Tashiro M.
    • Organizer
      The 115th Annual Meeting of American Gastroenterological Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Workshop: International Drug Development. Drug Development for Functional Gastrointestinal Disorders in Japan.2013

    • Author(s)
      Fukudo S.
    • Organizer
      The 10th International Symposium on Functional Gastrointestinal Disorders.
    • Place of Presentation
      Milwaukee, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Invited Plenary Sessions: Stress and Visceral Pain.2012

    • Author(s)
      Fukudo S.
    • Organizer
      The 14th World Congress on Pain, International Association for the Study of Pain.
    • Place of Presentation
      Milan, Italy
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clomipramine reduces visceral perception-related brain activation in humans2011

    • Author(s)
      Fukudo S, et al
    • Organizer
      American Gastroenterological Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene, Environment, and Brain-Gut Interactions in Irritable Bowel Synd rome.2010

    • Author(s)
      Fukudo S.
    • Organizer
      The First Asian Pacific Gastroenterology Topic Conference
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Book] Functional and GI Motility Disorders. Frontiers of Gastrointestinal Research.2014

    • Author(s)
      Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M.
    • Total Pages
      176
    • Publisher
      Karger, Basel, Switzerland
    • Related Report
      2014 Annual Research Report
  • [Book] When and how should we study colonic motility? In; Quigley EMM, Hongo M, Fukudo S (eds): Functional and GI Motility Disorders. Frontiers of Gastrointestinal Research. (DOI: 10.1159/000356745)2014

    • Author(s)
      Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M.
    • Publisher
      Karger, Basel, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Book] Hypothalamic-pituitary-adrenal axis in gastrointestinal physiology. Chapter 28, Section II: Neurogastroenterology. Wood JD Section Editor. In; Johnson L Editor. Physiology of the Gastrointestinal Tract, Fifth Edition2012

    • Author(s)
      Fukudo S.
    • Publisher
      Elsevier, Oxford, UK
    • Related Report
      2012 Annual Research Report
  • [Book] IBS診療Q&A2011

    • Author(s)
      福土審
    • Total Pages
      122
    • Publisher
      日本医事新報社
    • Related Report
      2011 Annual Research Report
  • [Book] 過敏性腸症候群.金澤一郎,永井良三編.今日の診断指針,第6版2010

    • Author(s)
      福土審
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Remarks] 東北大学病院心療内科

    • URL

      http://www.hosp.tohoku.ac.jp/sinryou/s08_sinryou.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学病院心療内科

    • URL

      http://www.hosp.tohoku.ac.jp/sinryou/s08_sinryou.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学病院心療内科

    • URL

      http://www.hosp.tohoku.ac.jp/sinryou/s08_sinryou.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.sendaibrain.org

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.sendaibrain.org

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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