| Budget Amount *help |
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
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| Outline of Final Research Achievements |
In patients with irritable bowel syndrome (IBS), stress response in the central nervous system and gastrointestinal tract is exaggerated. We tested the hypothesis that corticotropin-releasing hormone (CRH) plays a major role in pathogenesis of IBS. In both humans and animals, visceral stress evoked release of brain-gut peptides especially CRH in the regional brain (e.g. amygdala, anterior cingulate cortex, insula, paraventricular nucleus, and midbrain). These results suggest that regional release of CRH in the specific sites in the brain may be the most important part of pathophysiology of IBS.
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