Dynamics of stress-homeosurveillance and its relevance to disease control

• Project/Area Number: 22249025
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: TANAKA Yoshiya 産業医科大学, 医学部, 教授 (30248562)
• Co-Investigator(Kenkyū-buntansha): KOUNO Kimitoshi 産業医科大学, 医学部, 名誉教授 (00153479) ; UENO Youichi 産業医科大学, 医学部, 教授 (10232745) ; SAKAI Noriaki 産業医科大学, 医学部, 教授 (90248576) ; 中村 利孝 産業医科大学, 医学部, 教授 (50082235) ; 戸倉 新樹 産業医科大学, 医学部, 教授 (00172156)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000); Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000); Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000); Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000); Fiscal Year 2010: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
• Keywords: ストレス科学 / ホメオサーベイランス / 酸化ストレス / 生存脳 / 神経伝達物資 / 免疫伝達物質 / 神経伝達物質 / 免疫系 / 代謝系 / ストレス

Research Abstract

Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.

Research Products

• [Journal Article] Clinical Significance of Epithelial-Mesenchymal Transition-Associated Markers in Malignant Pleural Mesothelioma (2014)
  • Author(s): Iwanami T, Uramoto H, Nakagawa M, Shimokawa H, Yamada S, Kohno K, Tanaka F
  • Journal Title: Oncology. Volume: 86(2) Pages: 109-116
• [Journal Article] Electrophysiological effects of kainic acid on vasopressin-eGFP and oxytocin-mRFP1 neurones isolated from the supraoptic nucleus in transgenic rats (2014)
  • Author(s): Ohkubo, J. Ohbuchi, T. Yoshimura, M. Maruyama, T. Ishikura, T. Matsuura, T. Suzuki, H. & Ueta Y
  • Journal Title: Journal of Neuroendocrinology Volume: 26(1) Pages: 43-51
• [Journal Article] Effects of food deprivatation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats (2014)
  • Author(s): Yoshimura M, Hagimoto M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Toyohira Y, Yanagihara N, Ueta Y
  • Journal Title: The Journal of Physiological Science Volume: 64(2) Pages: 97-104
• [Journal Article] Circadian Disruption and Cancer Risk : A New Concept of Stromal Niche (2014)
  • Author(s): Kohno K
  • Journal Title: Int J Oncol Volume: 44 Pages: 364-370
• [Journal Article] 関節リウマチに於ける臓器障害 (2014)
  • Author(s): 田中良哉
  • Journal Title: 日本医師会雑誌 Volume: 142 Pages: 2241-2244
  • Peer Reviewed
• [Journal Article] ベリムマブ：ループス腎炎 (2014)
  • Author(s): 田中良哉
  • Journal Title: 腎と透析 Volume: 76 Pages: 96-100
  • Peer Reviewed
• [Journal Article] RAにおける抗BAFF抗体tabalumabの有効性と安全性 (2014)
  • Author(s): 齋藤和義、田中良哉
  • Journal Title: リウマチ科 Volume: 51 Pages: 118-125
  • Peer Reviewed
• [Journal Article] リウマチ・膠原病の治療の現況と将来展望 –分子標的治療薬を中心に− (2014)
  • Author(s): 高崎芳成、竹内勤、田中良哉
  • Journal Title: 最新医学 Volume: 60 Pages: 191-203
  • Peer Reviewed
• [Journal Article] JAK阻害薬 (2014)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: 最新医学 Volume: 60 Pages: 285-289
  • Peer Reviewed
• [Journal Article] トファシチニブの課題 (2014)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: 臨床リウマチ Volume: 26 Pages: 17-23
  • NAID: 130005072309
  • Peer Reviewed
• [Journal Article] 骨と関節リウマチ (2014)
  • Author(s): 田中良哉
  • Journal Title: 腎と骨代謝 Volume: 27 Pages: 121-128
  • Peer Reviewed
• [Journal Article] リウマチ・膠原病に於ける分子標的治療の最前線 序論 (2014)
  • Author(s): 田中良哉
  • Journal Title: 最新医学 Volume: 69 Pages: 189-190
  • Peer Reviewed
• [Journal Article] リウマチ・膠原病の治療の現況と将来展望—分子標的治療薬を中心に− (2014)
  • Author(s): 高崎芳成、竹内勤、田中良哉
  • Journal Title: 最新医学 Volume: 69 Pages: 189-190
  • Peer Reviewed
• [Journal Article] Syk/Btk標的治療 (2014)
  • Author(s): 中山田真吾、田中良哉
  • Journal Title: 最新医学 Volume: 69 Pages: 280-284
  • Peer Reviewed
• [Journal Article] JAK阻害薬 (2014)
  • Author(s): 田中良哉
  • Journal Title: 最新医学 Volume: 69 Pages: 285-290
  • Peer Reviewed
• [Journal Article] インフリキシマブ (2014)
  • Author(s): 齋藤和義、田中良哉
  • Journal Title: Mebio（ Volume: 31(5) Pages: 14-23
  • Peer Reviewed
• [Journal Article] JAK阻害薬： 使い方と安全性 (2014)
  • Author(s): 田中良哉
  • Journal Title: Mebio Volume: 31（５） Pages: 74-81
  • Peer Reviewed
• [Journal Article] 濾胞性ヘルパーT（Tfh）細胞と自己免疫疾患 (2014)
  • Author(s): 中山田真吾、田中良哉
  • Journal Title: 最新医学 Volume: 34 Pages: 12-16
  • Peer Reviewed
• [Journal Article] Jak/Stat now (2014)
  • Author(s): 田中良哉、山岡邦宏
  • Journal Title: 分子リウマチ治療 Volume: in press
  • Peer Reviewed
• [Journal Article] 炎症性疾患と骨代謝： 分子標的薬を中心に (2014)
  • Author(s): 田中良哉
  • Journal Title: 実験医学 Volume: in press
  • Peer Reviewed
• [Journal Article] 関節X線による関節損傷評価 (2014)
  • Author(s): 田中良哉
  • Journal Title: カレントテラピー Volume: in press
  • Peer Reviewed
• [Journal Article] 生物学的製剤 (2014)
  • Author(s): 田中良哉
  • Journal Title: 医学のあゆみ Volume: in press
  • Peer Reviewed
• [Journal Article] 生物学的製剤 (2014)
  • Author(s): 田中良哉
  • Journal Title: Osteoporosis Japan Volume: in press
  • Peer Reviewed
• [Journal Article] 生物学的製剤による関節疾患治療 (2014)
  • Author(s): 田中良哉
  • Journal Title: Clinical Calcium Volume: in press
  • Peer Reviewed
• [Journal Article] Janus kinase (JAK) inhibitors in rhematoid arthritis (2014)
  • Author(s): Yamaoka K, Tanaka Y
  • Journal Title: Curr Rheumatol Rev Volume: in press
  • Peer Reviewed
• [Journal Article] Role of JAKs in myeloid cells and autoimmune diseases. (2014)
  • Author(s): Kubo S, Yamaoka K, Tanaka Y
  • Journal Title: Inflammation and Regeneration Volume: in press
  • NAID: 130004943841
  • Peer Reviewed
• [Journal Article] The non-canonical wnt5a/rors signaling pathway in bone metabolism. (2014)
  • Author(s): Sonomoto K, Yamaoka K, Tanaka Y
  • Journal Title: Inflammation and Regeneration Volume: in press
  • Peer Reviewed
• [Journal Article] Depletion of Apoptosis Signal-Regulating Kinase 1 Prevents Bile Duct Ligation-Induced Necroinflammation and Subsequent Peribiliary Fibrosis. (2014)
  • Author(s): Noguchi H, Yamada S, Nabeshima A, Guo X, Tanimoto A, Wang KY, Kitada S, Tasaki T, Takama T, Shimajiri S, Horlad H, Komohara Y, Izumi H, Kohno K, Ichijo H, Sasaguri Y.
  • Journal Title: Am J Pathol. Volume: 184(3) Pages: 644-61
  • Peer Reviewed
• [Journal Article] : Clinical Significance of Epithelial-Mesenchymal Transition-Associated Markers in Malignant Pleural Mesothelioma. (2014)
  • Author(s): Iwanami T, Uramoto H, Nakagawa M, Shimokawa H, Yamada S, Kohno K, Tanaka F.
  • Journal Title: Oncology Volume: 86(2) Pages: 109-116
  • Peer Reviewed
• [Journal Article] 骨粗鬆症患者において他のビスホスホネート製剤からミノドロン酸水和物月1回製剤へ変更後の腰椎骨密度増加に関連する背景因子の検討 (2014)
  • Author(s): 酒井昭典、ほか
  • Journal Title: Osteoporosis Japan Volume: 22 Pages: 102-103
• [Journal Article] Dopamine D2-like receptor signaling suppresses human osteoclastogenesis (2013)
  • Author(s): Hanami K, Nakano K, Saito K, Okada Y, Yamaoka K, Kubo S, Kondo M, Tanaka Y
  • Journal Title: Bone Volume: 56 Pages: 1-8
• [Journal Article] IL-17 inhibits chondrogenic differentiation of human mesenchymal stem cells (2013)
  • Author(s): Kondo M, Yamaoka K, Sonomoto K, Fukuyo S, Oshita K, Okada Y, Tanaka Y
  • Journal Title: Plos ONE Volume: 8(11)
• [Journal Article] A c-fos-monomeric red fluorescent protein 1 fusion transgene is differentially expressed in rat forebrain and brainstem after chronic dehydration and rehydration (2013)
  • Author(s): Yoshimura, M. Ohkubo, J. Katoh, A. Ohno, M. Ishikura, T. Kakuma, T. Yoshimatsu, H. Murphy, D. & Ueta, Y
  • Journal Title: Journal of Neuroendocrinology Volume: 25(5) Pages: 478-487
• [Journal Article] Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and ibcreased cortical bone mineral density in the femoral diaphysis of mice (2013)
  • Author(s): Tsuchiya T, Nakamura T, et al
  • Journal Title: Bone Volume: 53 Pages: 358-368
• [Journal Article] Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice (2013)
  • Author(s): Shimizu Y, Nakamura T, et al
  • Journal Title: Bone Volume: 48 Pages: 1075-1086
• [Journal Article] ヒト間葉系幹細胞による破骨細胞の分化抑制作用と関節リウマチ治療への応用 (2013)
  • Author(s): 園本格子朗、田中良哉.
  • Journal Title: 産業医科大学雑誌 Volume: 35 Pages: 33-37
  • NAID: 110009593199
  • Peer Reviewed
• [Journal Article] ドパミン受容体シグナルによる破骨細胞の分化制御 (2013)
  • Author(s): 花見健太郎、中野和久、田中良哉
  • Journal Title: 日本臨床免疫学会会誌 Volume: 36 Pages: 35-39
  • NAID: 10031157133
  • Peer Reviewed
• [Journal Article] 新たな作用機序を有する骨粗鬆症、リウマチ治療薬 (2013)
  • Author(s): 田中良哉
  • Journal Title: 実験医学 Volume: 31 Pages: 877-883
  • Peer Reviewed
• [Journal Article] 低分子化合物を用いた細胞内シグナル分子を標的とする治療 (2013)
  • Author(s): 田中良哉
  • Journal Title: 最新医学 Volume: 68 Pages: 692-703
  • Peer Reviewed
• [Journal Article] Th1細胞とTfh細胞の多様性/可塑性とエピゲネティクス制御 (2013)
  • Author(s): 中山田真吾、田中良哉
  • Journal Title: 臨床免疫 Volume: 59 Pages: 500-506
  • Peer Reviewed
• [Journal Article] 関節リウマチのゲノムワイドDNAメチル化解析 (2013)
  • Author(s): 中野和久、田中良哉
  • Journal Title: リウマチ科 Volume: 49 Pages: 589-594
  • Peer Reviewed
• [Journal Article] 免疫学からみた骨代謝 (2013)
  • Author(s): 田中良哉
  • Journal Title: Clinical Calcium Volume: 23 Pages: 1265-1270
  • Peer Reviewed
• [Journal Article] 新世代の経口抗リウマチ薬 –トファシチニブの有効性と安全性 (2013)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: 薬事 Volume: 55 Pages: 1527-1530
  • Peer Reviewed
• [Journal Article] 発熱と倦怠感が主訴のリウマチ治療中の男性、鑑別診断は？ (2013)
  • Author(s): 田中良哉
  • Journal Title: Rheumatology Clinical Research Volume: 2 Pages: 153-155
  • Peer Reviewed
• [Journal Article] 細胞内シグナル分子を標的にしたRA骨破壊制御 (2013)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: Rheumatology Clinical Research Volume: 2 Pages: 104-107
  • Peer Reviewed
• [Journal Article] RA患者滑膜細胞におけるDNAメチル化 (2013)
  • Author(s): 中野和久、田中良哉
  • Journal Title: リウマチ科 Volume: 50 Pages: 370-375
  • Peer Reviewed
• [Journal Article] 新世代の経口抗リウマチ薬−トファニチニブの有効性と安全性 (2013)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: 薬事 Volume: 55 Pages: 1527-1530
  • Peer Reviewed
• [Journal Article] 中枢神経ループスの診断と治療 (2013)
  • Author(s): 田中良哉
  • Journal Title: BRAIN and NERVE Volume: 65 Pages: 1255-1267
  • Peer Reviewed
• [Journal Article] SLEの新たな治療標的 (2013)
  • Author(s): 齋藤和義、田中良哉
  • Journal Title: リウマチ科 Volume: 50 Pages: 583-590
  • Peer Reviewed
• [Journal Article] MBDAスコアによるRA活動性評価 (2013)
  • Author(s): 平田信太郎、田中良哉
  • Journal Title: リウマチ科 Volume: 50 Pages: 618-622
  • Peer Reviewed
• [Journal Article] MTX+TNF阻害薬による治療 (2013)
  • Author(s): 齋藤和義、田中良哉
  • Journal Title: Arthritis Volume: 11 Pages: 104-113
  • Peer Reviewed
• [Journal Article] 臨床的寛解の判定基準を教えて下さい (2013)
  • Author(s): 平田信太郎、田中良哉
  • Journal Title: Arthritis Volume: 25 Pages: 276-280
  • Peer Reviewed
• [Journal Article] 生物学的製剤ゴリムマブがもたらす新展開〜寛解導入と維持の実践〜 (2013)
  • Author(s): 田中良哉
  • Journal Title: 臨床リウマチ Volume: 25 Pages: 276-280
  • NAID: 130005086106
  • Peer Reviewed
• [Journal Article] JAK阻害薬と関節リウマチ (2013)
  • Author(s): 山岡邦宏、田中良哉
  • Journal Title: 感染・炎症・免疫 Volume: 43 Pages: 247-249
  • Peer Reviewed
• [Journal Article] 2013年欧州リウマチ学会議（EULAR） (2013)
  • Author(s): 田中良哉
  • Journal Title: Arthritis Volume: 11 Pages: 208-209
  • Peer Reviewed
• [Journal Article] Next stage of RA treatment: TNF-inhibitor-free remission will be a possible treatment goal ? (2013)
  • Author(s): Tanaka Y
  • Journal Title: Ann Rheum Dis Volume: 72
  • Peer Reviewed
• [Journal Article] Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions (2013)
  • Author(s): Smolen JS, Tanaka Y, et al.
  • Journal Title: Ann Rheum Dis Volume: 72 Pages: 482-492
  • Peer Reviewed
• [Journal Article] A Jak inhibitor tofacitinib for the treatment of rheumatoid arthritis from basic to clinic. (2013)
  • Author(s): Tanaka Y, Yamaoaka K
  • Journal Title: Mod Rheumatol Volume: 23 Pages: 415-424
  • Peer Reviewed
• [Journal Article] Janus kinase inhibitors in autoimmune diseases (2013)
  • Author(s): O’Shea JJ, Kontzias A, Yamaoka K, Tanaka Y, Laurence A.
  • Journal Title: Ann Rheum Dis Volume: 72
  • Peer Reviewed
• [Journal Article] Discontinuation of biologics in patients with rheumatoid arthritis (2013)
  • Author(s): Tanaka Y, Hirata S, Saleem B, Emery P
  • Journal Title: Clin Exp Rheumatol Volume: 31(Suppl. 78)
  • Peer Reviewed
• [Journal Article] Is it possible to withdraw biologics from therapy in rheumatoid arthritis? (2013)
  • Author(s): Tanaka Y, Hirata S
  • Journal Title: Clinical Therapeutics Volume: 35 Pages: 2028-2035
  • Peer Reviewed
• [Journal Article] 関節リウマチ患者の実態調査〜アンメットメディカルニーズの把握 (2013)
  • Author(s): 田中良哉
  • Journal Title: 新薬と臨床 Volume: 62 Pages: 758-777
  • Peer Reviewed
• [Journal Article] Rheumatoid arthritis患者に於ける糖尿病発症についての検討 -3施設共同研究- (2013)
  • Author(s): 今村秀基、中塚敬輔、吾妻妙子、山崎政治、小辻英明、吉田泰憲、浦本秀隆、小山倫浩、田中良哉
  • Journal Title: 臨床と研究 Volume: 90 Pages: 811-813
  • Peer Reviewed
• [Journal Article] polymyositis/dermatomyositisおよびsystemic sclerosis患者に於けるdeabetes mellitus発症についての検討 -3施設共同研究- (2013)
  • Author(s): 今村秀基、中塚敬輔、吾妻妙子、山崎政治、小辻英明、吉田泰憲、浦本秀隆、小山倫浩、田中良哉
  • Journal Title: 臨床と研究 Volume: 90 Pages: 1101-1104
  • Peer Reviewed
• [Journal Article] Systemic lupus erythematosus患者に於けるdeabetes mellitus発症についての検討 -3施設共同研究- (2013)
  • Author(s): 今村秀基、中塚敬輔、吾妻妙子、山崎政治、小辻英明、吉田泰憲、浦本秀隆、小山倫浩、田中良哉
  • Journal Title: 臨床と研究 Volume: 90 Pages: 1389-1392
  • Peer Reviewed
• [Journal Article] How Occupational Health Can Contribute in a Disaster and What We Should Prepare for the Future-Lessons Learned through Support Activities of a Medical School at the Fukushima Daiichi Nuclear Power Plant in Summer 2011. (2013)
  • Author(s): Mori, K., Tateishi, S., Hiraoka, K., Kubo, T., Okazaki, R., Suzuki, K., Kobayashi, Y., Kohno, K.
  • Journal Title: J. Occup. Health Volume: 55 Pages: 6-10
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells. (2013)
  • Author(s): Tasaki T, Yamada S, Guo X, Tanimoto A, Wang KY, Nabeshima A, Kitada S, Noguchi H, Kimura S, Shimajiri S, Kohno K, Ichijo H, Sasaguri Y
  • Journal Title: Am J Pathol Volume: 182(2) Pages: 597-609
  • Peer Reviewed
• [Journal Article] PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL (2013)
  • Author(s): Nabeshima A, Yamada S, Guo X, Tanimoto A, Wang KY, Shimajiri S, Kimura S, Tasaki T, Noguchi H, Kitada S, Watanabe T, Fujii J, Kohno K, Sasaguri Y.
  • Journal Title: Antioxid Redox Signal Volume: 19(17) Pages: 1983-98
  • Peer Reviewed
• [Journal Article] Cisplatin Resistance Associated with PARP Hyperactivation. (2013)
  • Author(s): Judith Michels,Ilio Vitale,Lorenzo Galluzzi,Julien Adam,Ken Andr e Olaussen,Oliver Kepp,Laura Senovilla,Ibtissam Talhaoui,Justine Guegan,David Pierre Enot,Monique Talbot,Ang_elique Robin,Philippe Girard,C edric Or ear,Delphine Lissa,Abdul Qader Sukkurwala,Pauline Garcia,Parviz Behnam-Motlagh,Kimitoshi Kohno,et al.
  • Journal Title: Cancer Res Volume: 73 Pages: 2271-2280
  • Peer Reviewed
• [Journal Article] Expression of Polypeptide N-acetylgalactosaminyl Transferase-3 and its Association with Clinicopathological Factors in Thyroid Carcinoma. (2013)
  • Author(s): Mochizuki Y, Ito KI, Izumi H, Kohno K, Amano J.
  • Journal Title: Thyroid Volume: 23(12) Pages: 1553-60
  • Peer Reviewed
• [Journal Article] Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma. (2013)
  • Author(s): Fumiyoshi Fushimi, Kenichi Taguchi, Hiroto Izumi, Kimitoshi Kohno, Michihiko Kuwano, Mayumi Ono, Yutaka Nakashima, Tetsuro Takesue, Seiji Naito, Yoshinao Oda
  • Journal Title: Virchows Archiv Volume: 463(4) Pages: 553-562
  • Peer Reviewed
• [Journal Article] Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. (2013)
  • Author(s): S Kitada, S Yamada, A Kuma, S Ouchi, T Tasaki, A Nabeshima, H Noguchi, K-Y Wang, S Shimajiri, R Nakano, H Izumi, K Kohno, T Matsumoto, Y Sasaguri.
  • Journal Title: British Journal of Cancer Volume: 109(2) Pages: 472-81
  • Peer Reviewed
• [Journal Article] A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients. (2013)
  • Author(s): Yoshioka T, Sakai A, et al.
  • Journal Title: J Bone Miner Metab Volume: 31 Issue: 2 Pages: 153-160
  • DOI: 10.1007/s00774-012-0393-x
  • NAID: 10031168850
  • Peer Reviewed
• [Journal Article] Why not use your own body weight to prevent falls? A randomized, controlled trial of balance therapy to prevent falls and fractures forelderly people who can stand on one leg for <15 s. (2013)
  • Author(s): Sakamoto K, Sakai A, et al.
  • Journal Title: J Orthop Sci Volume: 18 Issue: 1 Pages: 110-120
  • DOI: 10.1007/s00776-012-0328-3
  • Peer Reviewed
• [Journal Article] メカニカルストレスとWntシグナル (2013)
  • Author(s): 酒井昭典、ほか
  • Journal Title: Clinical Calcium Volume: 23 Pages: 2013-2013
• [Journal Article] ビスホスホネート製剤の現況 (2013)
  • Author(s): 酒井昭典、ほか
  • Journal Title: 医薬ジャーナル Volume: 49 Pages: 873-878
• [Journal Article] テリパラチド (2013)
  • Author(s): 酒井昭典
  • Journal Title: Rheumatology Clinical Research Volume: 2 Pages: 59-62
• [Journal Article] ビスホスホネート月1回製剤をめぐって (2013)
  • Author(s): 酒井昭典
  • Journal Title: Clinic Magazine Volume: 531 Pages: 20-22
• [Journal Article] 骨粗鬆症の骨量減少防止とカルシトニン 〜不動性骨粗鬆症、骨粗鬆症性骨折〜 (2013)
  • Author(s): 酒井昭典
  • Journal Title: 医薬ジャーナル Volume: 49 Pages: 169-174
• [Journal Article] Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and ibcreased cortical bone mineral density in the femoral diaphysis of mice. (2013)
  • Author(s): Tsuchiya T, Nakamura T, et al.
  • Journal Title: Bone Volume: 53 Issue: 2 Pages: 358-368
  • DOI: 10.1016/j.bone.2012.12.049
  • Peer Reviewed
• [Journal Article] Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears. (2013)
  • Author(s): Utsunomiya H, Nakamura T, et al.
  • Journal Title: Am J Sports Med Volume: 41 Issue: 3 Pages: 657-668
  • DOI: 10.1177/0363546512473269
  • Peer Reviewed
• [Journal Article] A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN- □ and IL-17 production by human CD4+ T cells (2012)
  • Author(s): Maeshima K, Yamaoaka K Kubo s, Nakano K, Iwata S, Saito K, Ohishi M, Miyahara H, Tanaka S, Ishi K, Yoshimatsu H, Tanaka Y
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 1790-1798
• [Journal Article] IL-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt5a/Ror2 pathway (2012)
  • Author(s): Sonomoto K, Yamaoka K, Oshita K, Fukuyo S, Zhang X, Nakano K, Okada Y, Tanaka Y
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 3353-3363
• [Journal Article] Expression of the c-fos-monomeric red fluorescent protein 1 fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after nociceptive stimulation (2012)
  • Author(s): Ishikura, T. Suzuki, H. Yoshimura, M. Ohkubo, J. Katoh, A. Ohbuchi, T. Ohno, M. Fujihara, H. Kawasaki, M. Ohnishi, H. Nakamura, T. & Ueta, Y
  • Journal Title: Brain Research Volume: 1479 Pages: 52-61
• [Journal Article] Amplification of toll-like receptor-mediated signaling through Syk in human B cell activation. (2012)
  • Author(s): Iwata S, Yamaoka K, Niiro H, Nakano K, Wang S-P, Akashi K, Tanaka Y.
  • Journal Title: J Allergy Clin Immunol Volume: 129 Pages: 1594-1601
  • NAID: 40019337340
  • Peer Reviewed
• [Journal Article] In vitro and in vivo analysis of a Jak inhibitor in rheumatoid arthritis. (2012)
  • Author(s): Tanaka Y, Maeshima Y, Yamaoaka K.
  • Journal Title: Ann Rheum Dis Volume: 71
  • Peer Reviewed
• [Journal Article] L-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt5a/Ror2 pathway. (2012)
  • Author(s): Sonomoto K, Yamaoka K, Oshita K, Fukuyo S, Zhang X, Nakano K, Okada Y, Tanaka Y.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 3355-3363
  • Peer Reviewed
• [Journal Article] A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-γ and IL-17 production by human CD4+ T cells. (2012)
  • Author(s): Maeshima K, Yamaoaka K Kubo s, Nakano K, Iwata S, Saito K, Ohishi M, Miyahara H, Tanaka S, Ishi K, Yoshimatsu H, Tanaka Y.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 1790-1798
  • Peer Reviewed
• [Journal Article] Overexpression of Peroxiredoxin 4 Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice. (2012)
  • Author(s): Guo, X., Yamada, S., Tanimoto, A., Ding, Y., Wang, K.Y., Shimajiri, S., Murata, Y., Kimura, S., Tasaki, T., Nabeshima, A., Watanabe, T., Kohno, K., Sasaguri, Y.
  • Journal Title: Antioxid Redox Signal. Volume: 17(10) Pages: 1362-1375
  • Peer Reviewed
• [Journal Article] Prognostic significance of BAF57 expression in patients with endometrial carcinoma. (2012)
  • Author(s): Kagami, S., Kurita, T., Kawagoe, T., Toki, N., Matsuura, Y., Hachisuga, T., Matsuyama, A., Hashimoto, H., Izumi, H., Kohno, K.
  • Journal Title: Histol Histopathol. Volume: 27(5) Pages: 593-599
  • Peer Reviewed
• [Journal Article] Association of Nuclear YB-1 Localization With Lung Resistance-related Protein and Epidermal Growth Factor Receptor Expression in Lung Cancer. (2012)
  • Author(s): Hyogotani, A., Ito, K., Yoshida, K., Izumi, H., Kohno, K., Amano, J.
  • Journal Title: Clin. Lung Cancer Volume: 13(5) Pages: 375-384
  • Peer Reviewed
• [Journal Article] Clinical significance of mitochondrial transcription factor A expression in patients with colorectal cancer. (2012)
  • Author(s): Nakayama, Y., Yamauchi, M., Minagawa, N., Torigoe, T., Izumi, H., Kohno, K., Yamaguchi, K.
  • Journal Title: Oncol. Rep. Volume: 27(5) Pages: 1325-1330
  • Peer Reviewed
• [Journal Article] Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer. (2012)
  • Author(s): Wu, Y., Yamada, S., Izumi, H., Li, Z., Shimajiri, S., Wang, K.Y., Liu, Y.P., Kohno, K., Sasaguri, Y
  • Journal Title: J. Surg. Oncol. Volume: 105(7) Pages: 724-730
  • Peer Reviewed
• [Journal Article] Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer. (2012)
  • Author(s): Ito, T., Kamijo, S., Izumi, H., Kohno, K., Amano, J., Ito, K.
  • Journal Title: Breast Cancer Res Treat. Volume: 133(1) Pages: 145-159
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer. (2012)
  • Author(s): Kohno, K. et al.
  • Journal Title: Cell Rep. Volume: 2(2) Pages: 257-269
  • Peer Reviewed
• [Journal Article] nduction of arginine vasopressin-enhanced green fluorescent protein expression in the locus coeruleus following kainic acid-induced seizures in rats. (2012)
  • Author(s): Ohno, M. Fujihara, H. Iwanaga, M. Todoroki, M. Katoh, A. Ohbuchi, T. Ishikura, T. Hamamura, A. Hachisuka, K. & Ueta, Y.
  • Journal Title: Stress Volume: 15(4) Pages: 435-442
  • Peer Reviewed
• [Journal Article] The effect of risedronate (17.5 mg/week) treatment on quality of life in Japanese women with osteoporosis: a prospective observational study. (2012)
  • Author(s): Nakamura T, et al.
  • Journal Title: J Bone Miner Metab Volume: 30 Issue: 6 Pages: 715-721
  • DOI: 10.1007/s00774-012-0372-2
  • NAID: 10031168830
  • Peer Reviewed
• [Journal Article] Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk. (2012)
  • Author(s): Nakamura T, et al.
  • Journal Title: J Clin Endocrinol Metab Volume: 97 Issue: 9 Pages: 3097-3106
  • DOI: 10.1210/jc.2011-3479
  • NAID: 120006985510
  • Peer Reviewed
• [Journal Article] Consistency of fracture risk reduction in Japanese and Caucasian osteoporosis patients treated with teriparatide: a meta-analysis. (2012)
  • Author(s): Nakamura T, et al.
  • Journal Title: J Bone Miner Metab Volume: 30 Issue: 3 Pages: 321-325
  • DOI: 10.1007/s00774-011-0313-5
  • NAID: 10031168783
  • Peer Reviewed
• [Journal Article] Dose-response study of denosumab on bone mineral density and bone turnover markers in Japanese postmenopausal women with osteoporosis. (2012)
  • Author(s): Nakamura T, et al.
  • Journal Title: Osteoporos Int Volume: 23 Issue: 3 Pages: 1131-1140
  • DOI: 10.1007/s00198-011-1786-8
  • Peer Reviewed
• [Journal Article] 骨折リスク評価の現状と課題 (2012)
  • Author(s): 中村利孝、ほか
  • Journal Title: Clin Calcium Volume: 22 Pages: 819-824
• [Journal Article] 骨粗鬆症治療におけるPTH製剤の効果と位置づけ (2012)
  • Author(s): 中村利孝
  • Journal Title: Clin Calcium Volume: 22 Pages: 309-314
• [Journal Article] In vitro and in vivo analysis of a Jak inhibitor in rheumatoid arthritis (2012)
  • Author(s): Tanaka Y, Maeshima Y, Yamaoaka K
  • Journal Title: Ann Rheum Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] B-cell or T-cell-dominant recurrence after rituximab therapy in patients with SLE (2012)
  • Author(s): Iwata S, Saito K, Tokunaga M, Tanaka Y
  • Journal Title: Ann Rheum Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Amplification of toll-like receptor-mediated signaling through Syk in human B cell activation (2012)
  • Author(s): Iwata S, Yamaoka K, Niiro H, Nakano K, Wang S-P, Akashi K, Tanaka Y
  • Journal Title: J Allergy Clin Immunol Volume: (in press)
  • NAID: 40019337340
  • Peer Reviewed
• [Journal Article] Cell autonomous role of TGFss and IL-2 receptor in CD4+ and CD8+ inducible regulatory T cell generation during graft-versus-host disease (2012)
  • Author(s): Sawamukai N, Satake A, Schmidt AM, Lamborn IT, Tanaka Y, Kambayashi T
  • Journal Title: Boold Volume: (in press)
  • Peer Reviewed
• [Journal Article] A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-〓 and IL-17 production by human CD4+ T cells (2012)
  • Author(s): Maeshima K, Yamaoaka K, Kubo S, Nakano K, Iwata S, Saito K, Ohishi M, Miyahara H, Tanaka S, Ishi K, Yoshimatsu H, Tanaka Y
  • Journal Title: Arthritis Rheum Volume: (in press)
  • Peer Reviewed
• [Journal Article] Clinical, radiographic, and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study- (2012)
  • Author(s): Takeuchi T, Tanaka Y, Amano K, Hoshi D, Nawata M, Nagasawa H, et al
  • Journal Title: Rheumatology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Postmarketing Surveillance of Tocilizumab for Rheumatoid Arthritis in Japan-Interim Analysis of 3,881 Patients (2012)
  • Author(s): Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Tanaka Y, Ito K, et al
  • Journal Title: Ann Rheum Dis Volume: (in press)
  • NAID: 120003660599
  • Peer Reviewed
• [Journal Article] Golimumab, a human anti-TNF-α monoclonal antibody, injected subcutaneously every 4 weeks in Japanese patients with active rheumatoid arthritis in combination with methotrexate : results of the Phase 2/3, multicenter, randomized, double-blind, placebo-controUed GO-FORTH study through 24 weeks (2012)
  • Author(s): Tanaka Y, Harigai M, Takeuchi T, Yamanaka H, Ishiguro N, Yamamoto K, et al
  • Journal Title: Ann Rheum Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Efficacy and safety of ocrelizumab in patients with active rheuamatoid arthritis with an inadequate response to at least one TNF inhibitor : results from the phase III SCRIPT trial (2012)
  • Author(s): Tak PP, Mease PJ, Genovese MC, Kremer J, Haraoui B, Tanaka Y, Bingham III CO, et al
  • Journal Title: Arthritis Rheum Volume: (in press)
  • Peer Reviewed
• [Journal Article] A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-_Y and IL-17 production by human CD4+ T cells (2012)
  • Author(s): Maeshima K, Yamaoaka K, Kubo S, Nakano K, Iwata S, Tanaka Y, et al
  • Journal Title: Arthritis Rheum Volume: (in press)
  • Peer Reviewed
• [Journal Article] GABA is excitatory in adult vasopressinergic neuroendocrine cells (2012)
  • Author(s): Haam, J., Popescu, IR., Morton, LA., Halmos, KC., Teruyama, R., Ueta, Y., Tasker, JG.
  • Journal Title: Journal of Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] Induction of arginine vasopressin-enhanced green fluorescent protein expression in the locus coeruleus following kainic acid-induced seizures in rats (2012)
  • Author(s): Ohno, M., Fujihara, H., Iwanaga, M., Todoroki, M., Katoh, A., Ohbuchi, T., Ishikura, T., Hamamura, A., Hachisuka, K., Ueta, Y.
  • Journal Title: Stress Volume: (in press)
  • Peer Reviewed
• [Journal Article] New roles of Mitochondrial Transcription Factor A in Cancer (2012)
  • Author(s): Yoshida, Y, Hoshino, S., Izumi, H., Kohno, K., Yamashita, Y.
  • Journal Title: J.phys.chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] mtTFA regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer (2012)
  • Author(s): Kurita, T., Izumi, H., Kagami, S., Kawagoe, T., Toki, N., Matsuura, Y, Hachisuga, T., Kohno, K.
  • Journal Title: Cancer Sci. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Consistency of fracture risk reduction in Japanese and Caucasian osteoporosis patients treated with teriparatide : a meta-analysis (2012)
  • Author(s): Nakamura T, Tsujimoto M, Hamaya E, Sowa H, Chen P
  • Journal Title: J Bone Miner Metab. Volume: (in press)
  • NAID: 10031168783
  • Peer Reviewed
• [Journal Article] Dose-response study of denosumab on bone mineral density and bone turnover markers in Japanese postmenopausal women with osteoporosis (2012)
  • Author(s): Nakamura T, Matsumoto T, Sugimoto T, Shiraki M
  • Journal Title: Osteoporos Int. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T-cells and a D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model (2011)
  • Author(s): Nakano K, Yamaoka K, Hanami K, Saito K, Sasaguri Y, Yanagihara N, Tanaka S, Katsuki I, Matsushita S, Tanaka Y
  • Journal Title: J Immunol Volume: 186 Pages: 3745-3752
• [Journal Article] Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production (2011)
  • Author(s): Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Tanaka Y
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 1658-1667
  • Peer Reviewed
• [Journal Article] Upregulation of arginine vasopressin synthesis in the rat hypothalamus after kainic acid-induced seizures (2011)
  • Author(s): Iwanaga, M., Ohno, M., Katoh, A., Ohbuchi, T., Ishikura, T., Fujihara, H., Nomura, M., Hachisuka, K., Ueta, Y.
  • Journal Title: Brain Research Volume: 1424 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Induction of Fos expression in the rat forebrain after intragastric administration of monosodium L-glutamate, glucose and NaCl (2011)
  • Author(s): Otsubo, H., Kondoh, T., Shibata, M., Ueta, Y., Torii, K.
  • Journal Title: Neuroscience Volume: 196 Pages: 97-103
  • Peer Reviewed
• [Journal Article] Temporal profile of arginine vasopressin release from the neurohypophysis in response to hypertonic saline and hypotension measured using a fluorescent fusion protein (2011)
  • Author(s): Yao, ST., Antunes, VR., Bradley, PM., Kasparov, S., Ueta, Y., Paton, JF., Murphy, D.
  • Journal Title: Journal of Neuroscience Methods Volume: 201 Pages: 191-195
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus (2011)
  • Author(s): Yamamoto, R., Akazawa, H., Fujihara, H., Ozasa, Y., Yasuda, N., Ito, K., Kudo, Y., Qin, Y., Ueta, Y., Komuro, I.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 21458-21465
  • Peer Reviewed
• [Journal Article] Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior (2011)
  • Author(s): Hashimoto, H., Ueta, Y.
  • Journal Title: Current Protein and Peptide Science Volume: 12 Pages: 280-287
  • Peer Reviewed
• [Journal Article] Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats (2011)
  • Author(s): Katoh, A., Fujihara, H., Ohbuchi, T., Onaka, T., Hashimoto, T., Kawata, M., Suzuki, H., Ueta, Y.
  • Journal Title: Endocrinology Volume: 152 Pages: 2768-2774
  • Peer Reviewed
• [Journal Article] Possible contribution of pannexin channel to ATP-induced currents in vitro in vasopressin neurons isolated from the rat supraoptic nucleus (2011)
  • Author(s): Ohbuchi, T., Yokoyama, T., Saito, T., Ohkubo, J., Suzuki, H., Ishikura, T., Katoh, A., Fujihara, H., Hashimoto, H., Suzuki, H., Ueta, Y.
  • Journal Title: Brain Research Volume: 1394 Pages: 71-78
  • Peer Reviewed
• [Journal Article] V2 receptor-mediated autocrine role of somato-dendritic release of arginine vasopressin in volume regulation of rat supraoptic vasopressin neurons under hypoosmotic conditions (2011)
  • Author(s): Sato, K., Numata, T., Ueta, Y., Okada, Y.
  • Journal Title: Science Signaling Volume: 157 Pages: 4-5
  • Peer Reviewed
• [Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the sipraoptic nucleus in rats (2011)
  • Author(s): Yokoyama, T., Ohbuchi, T., Saito, T., Fujihara, H., Minami, K., Nagatomo, T., Uezono, Y., Ueta, Y.
  • Journal Title: European Journal of Pharmacology Volume: 655 Pages: 31-37
  • Peer Reviewed
• [Journal Article] Hypothalamic vasopressin response to stress and various physiological stimuli : Visualization in transgenic animal models (2011)
  • Author(s): Ueta, Y., Dayanithi, G., Fujihara, H.
  • Journal Title: Hormones and Behavior Volume: 59 Pages: 221-226
  • Peer Reviewed
• [Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats (2011)
  • Author(s): Suzuki, H., Hashimoto, H., Kawasaki, M., Watanabe, M., Otsubo, H., Ishikura, T., Fuiihara, H., Ohnishi, H., Onuma, E., Yamada-Okabe, H., Takuwa, Y., Ogata, E., Nakamura, T., Ueta, Y.
  • Journal Title: International Journal of Cancer Volume: 28 Pages: 2215-2223
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells (2011)
  • Author(s): Miyamoto, N., Izumi, H., Bin, H., Miyamoto, R., Kondo, H., Tawara, A., Sasaguri, Y., Kohno, K.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. Volume: 52 Pages: 1226-1234
  • Peer Reviewed
• [Journal Article] Quercetin induces the expression of Peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway (2011)
  • Author(s): Miyamoto, N., Izumi, H., Miyamoto, R., Kondo, H., Tawara, A., Sasaguri, Y., Kohno, K.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. Volume: 52 Pages: 1055-1063
  • Peer Reviewed
• [Journal Article] Enhanced expression of nuclear factor I/B in oxaliplatin-resistant human cancer cell lines (2011)
  • Author(s): Kashiwagi, E., Izumi, H., Yasuniwa, Y., Baba, R., Doi, Y., Kidani, A., Arao, T., Nishio, K., Naito, S., Kohno, K.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 382-386
  • Peer Reviewed
• [Journal Article] Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin (2011)
  • Author(s): Hirano, G., Izumi, H., Yasuniwa, Y., Shimajiri, S., Wang, K.Y., Sasaguri, Y., Kusaba, H., Matsumoto, K., Hasegawa, T., Akimoto, M., Akashi, K., Kohno, K.
  • Journal Title: Int.J.Oncol. Volume: 38 Pages: 893-902
  • Peer Reviewed
• [Journal Article] Clinical usefulness of mitochondrial transcription factor A expression as a predictive marker in colorectal cancer patients treated with FOLFOX (2011)
  • Author(s): Yoshida, Y., Hasegawa, J., Nezu, R., Kim, Y.K., Hirota, M., Kawano, K., Izumi, H., Kohno, K.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 578-582
  • Peer Reviewed
• [Journal Article] Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells (2011)
  • Author(s): Izumi, H., Takahashi, M., Uramoto, H., Nakayama, Y., Oyama, T., Wang, K.Y., Sasaguri, Y, Nishizawa, S., Kohno, K.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 1007-1013
  • Peer Reviewed
• [Journal Article] Sasaguri, Y. : Histamine Deficiency Decreases Atherosclerosis and Inflammatory Response in Apolipoprotein E Knockout Mice Independently of Serum Cholesterol Level (2011)
  • Author(s): Wang, K.Y., Tanimoto, A., Guo, X., Yamada, S., Shimajiri, S., Murata, Y., Ding, Y., Tsutsui, M., Kato, S., Watanabe, T., Ohtsu, H., Hirano, K., Kohno, K.
  • Journal Title: ATVB Volume: 31 Pages: 800-807
  • Peer Reviewed
• [Journal Article] Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth (2011)
  • Author(s): Han, B., Izumi, H., Yasuniwa, Y, Akiyama, M., Yamaguchi, T., Fujimoto, N., Matsumoto, T., Wu, B., Tanimoto, A., Sasaguri, Y., Kohno, K.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 408 Pages: 45-51
  • Peer Reviewed
• [Journal Article] Hollingsworth, M.A. : Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth (2011)
  • Author(s): Taniuchi, K., Cerny, R.L., Tanouchi, A., Kohno, K., Kotani, N., Honke, K., Saibara, T.
  • Journal Title: Oncogene Volume: 30 Pages: 4843-4854
  • Peer Reviewed
• [Journal Article] Polypeptide N-acetylgalactos aminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival (2011)
  • Author(s): i, Z., Yamada.S., Inenaga, S., Imamura, T., Wu, Y, Wang, K.Y., Shimajiri, S., Nakano, R., Izumi, H., Kohno, K., Sasaguri, Y.
  • Journal Title: Br.J.Cancer Volume: 104 Pages: 1882-1889
  • Peer Reviewed
• [Journal Article] Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice (2011)
  • Author(s): Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T
  • Journal Title: Bone. Volume: 48 Pages: 1075-1086
  • Peer Reviewed
• [Journal Article] Lower osteocalcin and osteopontin contents of the femoral head in hip fracture patients than osteoarthritis patients (2011)
  • Author(s): Tanaka S, Narusawa K, Onishi H, Miura M, Hijioka A, Kanazawa Y, Nishida S, Ikeda S, Nakamura T
  • Journal Title: Osteoporos Int. Volume: 22 Pages: 587-597
  • Peer Reviewed
• [Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasm leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats (2011)
  • Author(s): Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y
  • Journal Title: Int J Cancer. Volume: 128 Pages: 2215-2223
  • Peer Reviewed
• [Journal Article] Hypothalamic vasopressin response to stress and various physiological stimuli : Visualization in transgenic animal models. (2011)
  • Author(s): Ueta, Y, et al.
  • Journal Title: Hormones and Behavior Volume: 59 Pages: 221-226
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of activating transcription factor 4 under oxid ative stress in retinal pigment epithelial ARPE-19/HPV-16 cells (2011)
  • Author(s): Miyamoto, N., Izumi, H., Bin, H., Miyamoto, R., Kondo, H., Tawara, A., Sasaguri, Y., Kohno, K.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. Volume: 52 Pages: 1226-1234
  • Peer Reviewed
• [Journal Article] Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. (2011)
  • Author(s): Miyamoto, N., Izumi, H., Miyamoto, R., Kondo, H., Tawara, A., Sasaguri, Y., Kohno.K.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. Volume: 52 Pages: 1055-1063
  • Peer Reviewed
• [Journal Article] Diurnal changes of arginine vasopressin-enhanced green fluorescent protein fusion transgene expression in the rat suprachiasmatic nucleus. (2010)
  • Author(s): Maruyama, T, et al.
  • Journal Title: Peptides Volume: 31(11) Pages: 2089-2093
  • Peer Reviewed
• [Journal Article] Induction of the arginine vasopressin-enhanced green fluorescent protein fusion transgene in the rat locus soerules (2010)
  • Author(s): Todoroki, M, et al.
  • Journal Title: Stress Volume: 13(4) Pages: 281-291
  • Peer Reviewed
• [Journal Article] Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake. (2010)
  • Author(s): Otsubo, H, et al.
  • Journal Title: Peptides Volume: 31(6) Pages: 1124-1130
  • Peer Reviewed
• [Journal Article] Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland. (2010)
  • Author(s): Suzuki, H, et al.
  • Journal Title: Pathophysiology Volume: 17(2)(Review) Pages: 135-140
  • Peer Reviewed
• [Journal Article] Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats. (2010)
  • Author(s): Hashimoto, H, et al.
  • Journal Title: The Journal of Physiological Sciences Volume: 60(1) Pages: 19-25
  • Peer Reviewed
• [Journal Article] Y-box binding protein-1 is a novel molecular target fortumor vessels. (2010)
  • Author(s): Takahashi, M., Shimajiri, S., Izumi, H., Hirano, G., Kashiwagi, E., Yasuniwa, Y., Ying, W., Han, B., Akiyama, M., Nishizawa, S, Sasaguri, Y., Kohno, K.
  • Journal Title: Cancer Science Volume: 101 Pages: 1367-1373
  • Peer Reviewed
• [Journal Article] Role of ZNF 143 in tumor growth through ranscriptionalregulation of DNA replication and cell-cycle-associated genes (2010)
  • Author(s): Izumi, H., Wakasugi, T., Shimajiri, S., Tanimoto, A., Sasaguri, Y., Kashiwagi, E., Yasuniwa, Y., Akiyama, M., Han, B., Wu, Y., Uchiumi, T., Arao, T., Nishio, K., Yamazaki, R., Kohno.K.
  • Journal Title: Cancer Science Volume: 101 Pages: 2538-2545
  • Peer Reviewed
• [Journal Article] Circadian disruption accelerates tumor growth and angio/stro-magenesis through a Wnt signaling pathway. (2010)
  • Author(s): Yasuniwa, Y., Izumi, H., Wang, K-Y., Shimajiri, S., Sasaguri, Y., Kawai, K., Kasai, H., Shimada, T., Miyake, K., Kashiwagi, E., Hirano, G., Kidani, A., Akiyama, M., Han, B., Wu, Y., Ieiri, I., Higuchi, S., Kohno, K.
  • Journal Title: PLoS ONE Volume: 5 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Shorter unipedal standing time and lower bone mineral density in women with distal radius fractures. (2010)
  • Author(s): Sakai A, Nakamura T, et al.
  • Journal Title: Osteoporos Int Volume: 21 Pages: 733-739
  • Peer Reviewed
• [Journal Article] Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drill-hole injury in mice. (2010)
  • Author(s): Tanaka K, Nakamura T, et al.
  • Journal Title: Bone Volume: 47 Pages: 1006-1012
  • Peer Reviewed
• [Journal Article] Unipedal standing exercise and hip bone mineral density in postmenopausal women : arandomized controlled trial. (2010)
  • Author(s): Sakai A, Nakamura T, et al.
  • Journal Title: J Bone Miner Metab Volume: 28 Pages: 42-48
  • Peer Reviewed
• [Journal Article] Lin H-S.Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipolysaccharide-stimulated NF-κB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic Ell cells. (2010)
  • Author(s): Choo Q-Y, Ho PC, Tanaka Y
  • Journal Title: Rheumatology Volume: 49 Pages: 1447-1460
  • Peer Reviewed
• [Journal Article] Discontinuation of infliximab after attaining low disease activity in patienis with rheumatoid arthritis, RRR (remission induction by remicade in RA) study. (2010)
  • Author(s): Tanaka Y, Takeuchi T, Mimori T, Saito K, Nawata M, Kameda H, Nojima T, Miyasaka N, Koike T.
  • Journal Title: Ann Rheum Dis Volume: 69 Pages: 1286-1291
  • Peer Reviewed
• [Journal Article] A calcineurin inhibitor, tacrolimus overcomes treatment-unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis. (2010)
  • Author(s): Suzuki K, Saito K, Tsujimura S, Nakayamada S, Yamaoka K, Sawamukai N, Iwata S, Nawata M, Tanaka Y.
  • Journal Title: J Rheumatol Volume: 37 Pages: 512-520
  • Peer Reviewed
• [Journal Article] Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling. (2010)
  • Author(s): Sawamukai N, Yukawa s, Saito K, Nakayamada S, Kambayashi T, Tanaka Y.
  • Journal Title: Arthritis Rheum Volume: 62 Pages: 952-959
  • Peer Reviewed
• [Journal Article] The JAK inhibitor tofacitinib reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
  • Author(s): Kubo S, Yamaoka K, Kondo M, Yamagata K, Zhao J, Iwata S, Tanaka Y
  • Journal Title: Ann Rheum Dis Volume: (in press)
  • NAID: 110010039749
• [Journal Article]
  • Author(s): Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, Kurihara R, Nakano K, Saito
• [Journal Article] V2 receptor-mediated autocrine role of somato-dendritic release of arginine vasopressin in volume regulation of rat supraoptic vasopressin neurons under hypoosmotic conditions.
  • Author(s): Sato, K, et al.
  • Journal Title: Science Signaling Volume: in press
  • Peer Reviewed
• [Journal Article] Dopamine induces IL-6-dependent IL-17 production via D1-like receptoron CD4 nalve T-cells and a D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.
  • Author(s): Nakano K, Yamaoka K, Hanami K, Saito K, Sasaguri Y, Yanagihara N, Tanaka S, Katsuki I, Matsushita S, Tanaka Y.
  • Journal Title: J Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Human mesenchymal stem cells inhibit osteoclastogenesis through osteop rotegerin production.
  • Author(s): Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, Kurihara R, Nakano K, Saito K, Okada Y, Chiba K, Tanaka Y.
  • Journal Title: Arthritis Rheum Volume: in press
  • Peer Reviewed
• [Journal Article] Phenotypic changes of lymphocytes in patients with systemic lupus eryth ematosus who are in longterm remission after B cell depletion therapy with rtuximab.
  • Author(s): Iwata S, Saito K, Tokunaga M, Yamaoka K, Nawata M, Yukawa S, Hanami K, Fukuyo S, Miyagawa I, Kubo S, Tanaka Y.
  • Journal Title: J Rheumatol Volume: in press
  • Peer Reviewed
• [Presentation] EFFECTIVENESS OF ABATACEPT AGAINST RHEUMATOID ARTHRITIS IN DAILY CLINICAL PRACTICE - ORBIT STUDY (2013)
  • Author(s): T Takeuchi, Y. Tanaka, K. Amano, J. Kikuchi, E. Tanaka, S. Hirata, H. Nagasawa, H. Yasuoka, H. Yamanaka.
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] A LARGE-SCALE PROSPECTIVE SINGLE COHORT STUDY OF WORK PRODUCTIVITY AND ACTIVITY IMPAIRMENT IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING ADALIMUMAB: ANALYSIS OF 24-WEEKS DATA FROM THE ANOUVEAU STUDY (2013)
  • Author(s): T Takeuchi, S. Komatsu, T. Muramatsu, T. Kubo, A. Kuroki, T. Tango, Y. Tanaka.
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] THE POSSIBILITY AND PREDICTIVE FACTORS OF MAINTAINING LOW DISEASE ACTIVITY AND JOINT STRUCTURE AFTER DISCONTINUATION OF INFLIXIMAB IN RA PATIENTS: RESULTS FROM 3-YEAR EXPERIENCE OF RRR STUDY (2013)
  • Author(s): Y. Tanaka, T. Takeuchi, T. Mimori, N. Miyasaka, T. Koike, RRR study investigators.
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] MMUNOGENICITY OF CERTOLIZUMAB PEGOL WITHOUT CONCOMITANT METHOTREXATE AND CLINICAL RESPONSE IN RHEUMATOID ARTHRITIS PATIENTS: POST-HOC ANALYSIS OF THE HIKARI STUDY (2013)
  • Author(s): T. Takeuchi, K. Yamamoto, H. Yamanaka, N. Ishiguro, Y. Tanaka, K. Eguchi, A. Watanabe, H. Origasa, Y. Wada, T. Shoji, N. Miyasaka, T. Koike.
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] WEEK 12 CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL PREDICTS LONG-TERM OUTCOMES REGARDLESS OF CONCOMITANT MEDICATIONS AND BASELINE DISEASE CHARACTERISTICS IN JAPANESE PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS (2013)
  • Author(s): H. Yamanaka, K. Yamamoto, T. Takeuchi, N. Ishiguro, Y. Tanaka, K. Eguchi, A. Watanabe, H. Origasa, T. Shoji, S. Onodera, N. Miyasaka.
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] ABATACEPT BIOLOGIC-FREE REMISSION STUDY IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS ORION STUDY (2013)
  • Author(s): T. Takeuchi, T. Matsubara, S. Ohta, M. Mukai, K. Amano, S. Tohma, Y. Tanaka, H. Yamanaka, N. Miyasaka, on behalf of ORION study group
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] CHARACTERISTICS ASSOCIATED WITH BETTER EFFECTIVENESS AND SAFETY IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH INTRAVENOUS TOCILIZUMAB: RESULTS FROM FULL ANALYSIS OF ALL-PATIENT POSTMARKETING SURVEILLANCE IN JAPAN (2013)
  • Author(s): M. Harigai, S. Inokuma, N. Ishiguro, J. Ryu, T. Takeuchi, S. Takei, Y. Tanaka, H. Yamanaka, Y. Sano, H. Yaguramaki, T. Koike
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] GOLIMUMAB ADMINISTERED SUBCUTANEOUSLY EVERY FOUR WEEKS IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS DESPITE METHOTREXATE THERAPY: LONG-TERM CLINICAL, RADIOGRAPHIC AND SAFETY RESULTS, INCLUDING EVALUATION OF REMISSION USING THE NEW ACR/EULAR CRITERIA (2013)
  • Author(s): Y. Tanaka, M. Harigai, T. Takeuchi, H. Yamanaka, N. Ishiguro, K. Yamamoto, Y. Murakami, T. Yoshinari, D. Baker, N. Miyasaka, T. Koike
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] GOLIMUMAB MONOTHERAPY IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS DESPITE DMARD THERAPY: WEEK 104 RESULTS OF CLINICAL, RADIOGRAPHIC AND SAFETY ASSESSMENTS INCLUDING EVALUATION OF REMISSION USING THE NEW ACR/EULAR CRITERIA (2013)
  • Author(s): T. Takeuchi, M. Harigai, Y. Tanaka, H. Yamanaka, N. Ishiguro, K. Yamamoto, Y. Murakami, T. Yoshinari, D. Baker, N. Miyasaka, T. Koike
  • Organizer: The Annual European Congress of Rheumatology 2013
  • Place of Presentation: スペイン(マドリッド)
  • Invited
• [Presentation] Efficacy Of Rituximab In Patients With Refractory Lupus Nephritis, a Post-Hoc Analysis From Phase II Trial In Japan (2013)
  • Author(s): Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Nobuyuki Miyasaka, Takayuki Sumida, Tsuneyo Mimori, Takao Koike and Kazuhiro Endo
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] Estimation Of The Effect Of Denosumab On Bone Loss From The Results Of The 12-Month Phase II Study In Patients With Rheumatoid Arthritis (RA) On Background Methotrexate (MTX). (2013)
  • Author(s): Yoshiya Tanaka, Tsutomu Takeuchi, Naoki Ishiguro, Hisashi Yamanaka, Toshiyuki Yoneda, Harry K. Genant and Desiree van der Heijde
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] Safety and Effectiveness Of Abatacept In 3985 Japanese Patients With Rheumatoid Arthritis; Japan All-Cases Post-Marketing Surveillance (2013)
  • Author(s): Takao Koike, Masayoshi Harigai, Naoki Ishiguro, Shigeko Inokuma, Junnosuke Ryu, Syuji Takei, Tsutomu Takeuchi, Y.Tanaka, Masahiko Watanabe and Hisashi Yamanaka
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] Comprehensive Disease Remission Achieved By Certolizumab Pegol Treatment, and Factors Associated With Certolizumab Pegol Comprehensive Disease Remission, In Rheumatoid Arthritis Patients With Predominantly High Disease Activity. (2013)
  • Author(s): Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Mariko Kobayashi, Toshiharu Shoji, Nobuyuki Miyasaka and Takao Koike.
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] Post–Hoc Analysis Showing Better Clinical Response With The Loading Dose Of Certolizumab Pegol In Japanese Patients With Active Rheumatoid Arthritis. (2013)
  • Author(s): Tsutomu Takeuchi, Kazuhiko Yamamoto, Hisashi Yamanaka, Naoki Ishiguro, Yoshiya Tanaka, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Mariko Kobayashi, Toshiharu Shoji, Nobuyuki Miyasaka and Takao Koike.
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] Economic Impact Of Adalimumab Treatment In Japanese Patients With Rheumatoid Arthritis: Analysis Of 24 Weeks Data From The Anouveau Study. (2013)
  • Author(s): Yoshiya Tanaka, Yasuhiko Shinmura, Ryo Nakajima, Takahiro Muramatsu, Shuichi Komatsu, Tadamichi Kubo, Aki Kuroki, Ataru Igarashi, Toshiro Tango and Tsutomu Takeuchi.
  • Organizer: 第79回米国リウマチ学会 ACR 2013
  • Place of Presentation: 米国(サンディエゴ)
  • Invited
• [Presentation] メカニカルストレスと骨髄細胞分化 (2013)
  • Author(s): 酒井昭典、ほか
  • Organizer: 第33回日本骨形態計測学会
  • Place of Presentation: 静岡県(浜松市)
  • Invited
• [Presentation] トモシンセシス骨梁解析による海綿骨微細構造の推定 −イヌ大腿骨および腰椎での検討− (2013)
  • Author(s): 山本淳也、酒井昭典
  • Organizer: 第33回日本骨形態計測学会
  • Place of Presentation: 静岡県(浜松市)
  • Invited
• [Presentation] 橈骨遠位端骨折の臨床からみた骨粗鬆症治療の問題点と課題 (2013)
  • Author(s): 酒井昭典
  • Organizer: 第15回日本骨粗鬆症学会
  • Place of Presentation: 大阪府(大阪市)
  • Invited
• [Presentation] 骨粗鬆症患者において他のビスホスホネート製剤からミノドロン酸月1回製剤へ変更後の腰椎骨密度増加に関連する背景因子の検討 (2013)
  • Author(s): 酒井昭典、ほか
  • Organizer: 第15回日本骨粗鬆症学会
  • Place of Presentation: 大阪府(大阪市）
  • Invited
• [Presentation] ラット視索上核バゾプレッシンおよびオキシトシンの蛍光タンパク遺伝子導入による同定とカイニン酸応答の検討 (2013)
  • Author(s): 大久保淳一、大淵豊明、吉村充弘、丸山 崇、石倉 透、松浦孝紀、加藤明子、鈴木秀明、上田陽一
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀(江戸川区(東京都))
• [Presentation] 急性疼痛ストレスに対する内分泌反応および行動変化へのTRPV1およびTRPV4の役割-ノックアウトマウスを用いた検討- (2013)
  • Author(s): 石倉 透、鈴木仁士、松浦孝紀、大久保淳一、吉村充弘、丸山 崇、大西英生、中村利孝、上田陽一
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀(江戸川区(東京都))
• [Presentation] The Maximization of Efficacy of Tocilizumab for the Treatment of Rheumatoid Arthritis. (2012)
  • Author(s): Y Tanaka.
  • Organizer: The 8th International Congress on Autoimmunity
  • Place of Presentation: King Hosse in Bin Talal Convent Center(グラナダ(スペイン))
  • Invited
• [Presentation] Treatment of SLE with biologics. The 15th Congress of the Asia Pacific League of Associations for Rheumatology (2012)
  • Author(s): Ｙ Tanaka
  • Organizer: APLAR 2012
  • Place of Presentation: Paseo del Vinlon(アンマン(ヨルダン)
• [Presentation] Discontinuation of Adalimumab without Functional and Radiographic Damage Progression After Achieving Sustained Remission in Patients with Rheumatoid Arthritis (the HONOR study): 1-Year Results. (2012)
  • Author(s): Y Tanaka, S Hirata, S Fukuyo, M Nawata, S Kubo, K Yamaoka, K Saito.
  • Organizer: The 78th Annual Congress of American College of Rheumatology
  • Place of Presentation: Walter E. Washington(ワシントン(米国))
  • Invited
• [Presentation] ドパミン受容体シグナルによる破骨細胞の分化制御 (2012)
  • Author(s): 田中 良哉
  • Organizer: 第33回 日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡(博多区(福岡))
  • Invited
• [Presentation] ドパミン受容体シグナルによる破骨細胞の分化制御メカニズムの解析 (2012)
  • Author(s): 田中 良哉
  • Organizer: 第３０回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル(新宿区(東京))
  • Invited
• [Presentation] ドパミン受容体シグナルによる破骨細胞の分化制御 (2012)
  • Author(s): 田中 良哉
  • Organizer: 第４０回日本臨床免疫学会
  • Place of Presentation: 京王プラザホテル(新宿区(東京))
  • Invited
• [Presentation] Effects of nociceptive stimulation on fos expression and behavior in mice. (2012)
  • Author(s): Ueta Y, Ishikura, T. Matsuura, T. Yoshimura, M. Ohkubo, J. Ohnishi, H.
  • Organizer: The 21st International Behavioral Neuroscience Society annual meeting
  • Place of Presentation: Kailua-Kona(ハワイ (米国.))
• [Presentation] Effects of kainic acid on arginine vasopressin (AVP) synthesis in vivo and an isolated AVP neuron in vitro. (2012)
  • Author(s): Ueta, Y. Iwanaga, M. Ohkubo, J.
  • Organizer: Neurophysiology of Neurosecretory Neurons Workshop
  • Place of Presentation: Tulane University(ニューオリンズ(米国))
  • Invited
• [Presentation] Drinking and feeding behavior based on peptides and TRP channels. (2012)
  • Author(s): Ueta, Y.
  • Organizer: The 3rd International Symposium of KoSCI & The 2nd AISCRIB
  • Place of Presentation: Hoam Faculty House, Seoul National University(ソウル(韓国))
  • Invited
• [Presentation] 急性疼痛ストレスに対するTRPV1およびTRPV4の役割-ノックアウトマウスを用いた検討- (2012)
  • Author(s): 石倉 透、鈴木仁士、松浦孝紀、大久保淳一、吉村充弘、大野素子、丸山 崇、大西英生、上田陽一
  • Organizer: 第22回日本病態生理学会大会
  • Place of Presentation: 湯布院厚生年金病院(湯布院(大分))
• [Presentation] カイニン酸誘発けいれんモデルラットにおける視床下部および青斑核におけるバゾプレッシン遺伝子発現 (2012)
  • Author(s): 上田陽一、大野素子、岩永 勝、吉村充弘、丸山 崇、石倉 透
  • Organizer: 第65回日本自律神経学会総会
  • Place of Presentation: 都市センターホテル(千代田区(東京都))
• [Presentation] 卵巣摘出動物におけるPTHのアナボリック作用 (2012)
  • Author(s): 酒井昭典、中村利孝、ほか
  • Organizer: 第32回 日本骨形態計測学会
  • Place of Presentation: 大阪国際会議場(大阪市北区(大阪)
  • Invited
• [Presentation] 日本人骨粗鬆症患者を対象としたカテプシンK阻害薬Odanacatib（ODN）の第2相ニ重盲検用量反応試験成績 (2012)
  • Author(s): 中村利孝、ほか
  • Organizer: 第14回 日本骨粗鬆症学会
  • Place of Presentation: 新潟コンベンションセンター(新潟市中央区(新潟))
• [Presentation] 骨粗鬆症の骨折防止対策の現状と今後 (2012)
  • Author(s): 中村利孝
  • Organizer: 第14回 日本骨粗鬆症学会
  • Place of Presentation: 新潟コンベンションセンター(新潟市中央区(新潟))
• [Presentation] 非定型骨折の疫学、海外での現状 (2012)
  • Author(s): 酒井昭典、中村利孝、ほか
  • Organizer: 第14回 日本骨粗鬆症学会
  • Place of Presentation: 新潟コンベンションセンター(新潟市中央区(新潟))
• [Presentation] Next stage of RA treatment : bio-free remission will become a possible treatment goal-RRR study update (2011)
  • Author(s): Tanaka Y
  • Organizer: The 5th Asian Congress on Autoimmunity
  • Place of Presentation: シンガポール,サンテック国際会議場(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] Signal transduction inhibitors for the treatment of rheumatoid arthritis (2011)
  • Author(s): Tanaka Y
  • Organizer: Bio-Rheumatology International Congress (BRIC) Tokyo, The 8th GARN Meeting
  • Place of Presentation: 東京商工会議所(東京都)(招待講演)
  • Year and Date: 2011-11-04
• [Presentation] Discontinuation of adalimumab after attaining remisison in patients with rheumatoid arthritis (2011)
  • Author(s): Tanaka Y S.Hirata, M.Nawata, S.Kubo, K.Saito
  • Organizer: The Annual European Congress of Rheumatology
  • Place of Presentation: イギリス、ロンドン,ExCeL LONDON(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] In vitro and in vitro analysis of a Jak inhibitor in RA (2011)
  • Author(s): Tanaka Y.
  • Organizer: Advances in Targeted Therapies
  • Place of Presentation: クロアチア(ドブロニク)(招待講演)
• [Presentation] Is biologic-free remission possible in patients with RA? (2011)
  • Author(s): Tanaka Y
  • Organizer: Advances in Targeted Therapies
  • Place of Presentation: クロアチア(ドブロニク)(招待講演)
• [Presentation] 酸化ストレスと疾病 (2010)
  • Author(s): 河野公俊
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡(アクロス福岡)(招待講演)
  • Year and Date: 2010-09-24
• [Presentation] 非荷重環境下でのTie-2受体の発現と局在の変化 (2010)
  • Author(s): 森寺邦晃、中村利孝, ほか
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2010-07-23
• [Presentation] Regulation of stress responses by peptides : New transgenic animal models (2010)
  • Author(s): Ueta, Y.
  • Organizer: The 7th International Congress of Neuroendocrinology symposium
  • Place of Presentation: Rouen, France(Law Faculty)
• [Presentation] The relationship between olfaction and stress responses in the rat brain (2010)
  • Author(s): Shibata, M, et al
  • Organizer: The 7th International Congress of Neuroendocrinology
  • Place of Presentation: Rouen, France (Law Faculty)
• [Presentation] Diurnal changes of arginine vasopressin-enhanced green fluorescent protein fusion transgene expression in the rat suprachiasmatic nucleus (2010)
  • Author(s): Maruyama, T, et al
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto, Japan (Kyoto International Conference Center)
• [Presentation] 食思不振-悪液質動物モデルにおける視床下部神経ペプチドの反応 (2010)
  • Author(s): 上田陽一
  • Organizer: 第87回日本生理学会大会シンポジウム
  • Place of Presentation: 盛岡(盛岡市民文化ホール)
• [Presentation] 急性および慢性炎症時のラット下垂体後葉におけるgalanin-like peptide遺伝子の発現誘導:炎症性サイトカインの関与 (2010)
  • Author(s): 藤原広明, et al
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州(北九州国際会議場)
• [Presentation] 関節炎モデルラットおよび担癌ラットにおける視床下部摂食関連ペプチド遺伝子発現についての検討 (2010)
  • Author(s): 鈴木仁士, et al
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州(北九州国際会議場)
• [Presentation] 侵害刺激はトランスジェニックラットの脊髄および視床下部にc-fos-mRFP遺伝子の発現を引き起こす (2010)
  • Author(s): 石倉透, et al
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸(神戸コンベンションセンター)
• [Presentation] ATF4は網膜色素上皮細胞において、酸化ストレス下でNrf2による転写制御を受ける (2010)
  • Author(s): 宮本直哉・和泉弘人・宮本理恵・河野公俊・田原昭彦
  • Organizer: 第114回日本眼科学会
  • Place of Presentation: 名古屋(名古屋国際会議場)
• [Presentation] Transcriptional regulation of activating transcription factor 4(ATF4) under oxidative stress in retinal pigment epithelial ARPE-19 cells (2010)
  • Author(s): Miyamoto, N.Izumi, H.Miyamoto, R.Bin, H.Kondo, H.Tawara, A.Sasaguri, Y.Kohno, K
  • Organizer: ARVO2010
  • Place of Presentation: Florida (Greater Fort Lauderdale/Broward County Convention Center)
• [Presentation] 転写因子ZNF143によるDNA複製および細胞周期関連因子の発現制御と腫瘍増殖 (2010)
  • Author(s): 和泉弘人・柏木英志・安庭義浩・秋山正樹・Han, B.・Wu, Y.・内海健・荒尾徳三・西尾和人・河野公俊
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京(タワーホール船堀)
• [Presentation] YB-1は新しい腫瘍血管分子標的である (2010)
  • Author(s): Wu, Y.・柏木英志・安庭義浩・秋山正樹, Han, B.・河野公俊
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京(タワーホール船堀)
• [Presentation] 概日リズムの乱れは腫瘍増殖・血管新生・間質新生を引き起こす (2010)
  • Author(s): 安庭義浩・和泉弘人・柏木英志・平野元・木谷昭彦, Han, B.・Wu, Y.・河野公俊
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京(タワーホール船堀)
• [Presentation] 転写因子ZNF143によるDNA複製および細胞周期関連因子の発現制御と腫瘍増殖 (2010)
  • Author(s): 秋山正樹・和泉弘人・柏木英志・安庭義浩・韓斌・呉瑛・内海健・荒尾徳三・西尾和人・河野公俊
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪(大阪国際会議場、リーガロイヤルホテル大阪)
• [Presentation] YB-1は新しい腫瘍血管分子標的である (2010)
  • Author(s): 呉瑛・高橋麻由・和泉弘人・平野元・柏木英志・安庭義浩・韓斌・秋山正樹・笹栗靖之・河野公俊
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪(大阪国際会議場、リーガロイヤルホテル大阪)
• [Presentation] Wnt10Aはサーカディアンリズムに関連した新規腫瘍血管・間質新生因子である (2010)
  • Author(s): 安庭義浩・和泉弘人・笹栗靖之・河井一明・葛西宏・島田隆・三宅弘一・柏木英志・木谷昭彦・秋山正樹・韓斌・呉瑛・河野公俊
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪(大阪国際会議場、リーガロイヤルホテル大阪)
• [Book] ファーマナビゲーター PTH編 (2013)
  • Author(s): 酒井昭典
  • Total Pages: 317
  • Publisher: メディカルレビュー社
• [Book] ビスホスホネート エビデンスブック (2013)
  • Author(s): 酒井昭典
  • Total Pages: 383
  • Publisher: 医薬ジャーナル社
• [Book] ステロイドの副作用と対策. 今日の治療指針 2013年版━私はこう治療している. (2013)
  • Author(s): 田中 良哉
  • Total Pages: 1890
  • Publisher: 医学書院
• [Book] ファーマナビゲーター 活性型ビタミンD3製剤編 (2012)
  • Author(s): 中村利孝
  • Total Pages: 355
  • Publisher: 骨粗鬆症の予防と治療ガイドライン2011年版
• [Book] 骨粗鬆症診療ハンドブック（改訂5版） (2012)
  • Author(s): 中村利孝
  • Total Pages: 391
  • Publisher: 骨粗鬆症の概念と病態：概念
• [Patent(Industrial Property Rights)] シスプラチン耐性ガンの治療のためのHMG-CoA 還元酵素 (2014)
  • Inventor(s): 河野公俊、和泉弘人
  • Industrial Property Rights Holder: 河野公俊、和泉弘人
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-01-28
  • Overseas
• [Patent(Industrial Property Rights)] シスプラチン耐性がんの治療のためのＨＭＧ－ＣoＡ還元酵素 (2014)
  • Inventor(s): 河野公俊、和泉弘人
  • Industrial Property Rights Holder: 河野公俊、和泉弘人
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-01-28
  • Overseas