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Mechanisms of progression of chronic kidney disease

Research Project

Project/Area Number 22249033
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

MATSUSAKA Taiji  東海大学, 医学部, 准教授 (50317749)

Co-Investigator(Kenkyū-buntansha) ICHIKAWA Iekuni  東海大学, 医学部, 客員教授 (80317768)
NIIMURA Fumio  東海大学, 医学部・小児科学, 准教授 (30282750)
NISHIYAMA Akira  香川大学, 医学部・薬理学, 教授 (10325334)
Research Collaborator CAMPBELL Duncan J.  St. Vincent's Institute of Medical Research, Australia, Professor
PASTAN Ira  National Institutes of Health, Bethesda, Maryland, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Professor
柳田 素子  京都大学医学部, 大学院医学研究科, 教授
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
KeywordsAngiotensinⅡ / Angiotensinogen / ポドサイト / 慢性腎不全 / ノックアウトマウス / Magalin / 糸球体硬化症 / ネフローゼ症候群 / 腎間質線維化 / AngiotensinII / Megalin / megalin / Angiotensin II
Outline of Final Research Achievements

In chronic kidney diseases caused by diabetes or nephritis, the key event is injury in a unique type of cells, called podocytes. Podocyte injury triggers progressive deterioration of kidney function. In the present study, we established a method to comprehensively analyze gene expression selectively in podocytes. We also revealed the mechanism underlining induction of angiotensin II within the kidney. Angiotensin II is the most potent blood pressure-raising hormone, and also may further worsen kidney injury. Podocyte injury causes leakage of angiotensinogen, the precursor protein of angiotensin II, which is reabsorbed by kidney cells, and then converted to angiotensin II. This finding provides an insight into mechanism underlining progressive worsening of kidney diseases.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (58 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 7 results,  Acknowledgement Compliant: 5 results) Presentation (38 results) (of which Invited: 5 results)

  • [Journal Article] Unilateral ureteral obstruction attenuates intrarenal angiotensin Ⅱgeneration induced by podocyte injury.2015

    • Author(s)
      Okabe M,Miyazaki Y,Niimura F,Pastan I,Nishiyama A,Yokoo T,Ichikawa I,Matsusaka T.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 308・8 Issue: 8 Pages: F932-F937

    • DOI

      10.1152/ajprenal.00444.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.2015

    • Author(s)
      Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 308・6 Issue: 6 Pages: F614-F626

    • DOI

      10.1152/ajprenal.00616.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.2015

    • Author(s)
      Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.
    • Journal Title

      J Am Soc Nephrol.

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1.2014

    • Author(s)
      Itoh M, Nakadate K, Horibata Y, Matsusaka T, Xu J, Hunziker W, Sugimoto H.
    • Journal Title

      PLoS One.

      Volume: 9・9 Issue: 9 Pages: e106621-e106621

    • DOI

      10.1371/journal.pone.0106621

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury.2014

    • Author(s)
      Hirukawa T, Wu Q, Sawada K, Matsusaka T, Saka S, Oka A, Hirawa N, Umemura S, Kakuta T, Endoh M, Inoko H, Ichikawa I, Fukagawa M.
    • Journal Title

      Nephron Extra.

      Volume: 4・1 Issue: 1 Pages: 70-81

    • DOI

      10.1159/000362451

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis.2014

    • Author(s)
      Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 25・10 Issue: 10 Pages: 2254-66

    • DOI

      10.1681/asn.2013090986

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Keap1 inhibition attenuates glomerulosclerosis2014

    • Author(s)
      YoichiMiyazaki,AkihiroShimizu,IraPastan,KeikoTaguchi,ErikoNaganuma,TakafumiSuzuki,TatsuoHosoya,TakashiYokoo,AkihikoSaito,ToshioMiyata,MasayukiYamamoto,TaijiMatsusaka.
    • Journal Title

      Nephrology Dial Transplant.

      Volume: 4 Pages: 783-791

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury.2013

    • Author(s)
      Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, Yamada R, Tanaka M, H igashi AY, Okuda T, Asada N, Fukatsu A, Kawachi H, Graf D, Muso E, Kita T, Kimura T, Pastan I, Economides AN, Yanagita M
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: 25-25

    • DOI

      10.1371/journal.pone.0089135

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury.2013

    • Author(s)
      Y Miyazaki , A Shimizu , I Ichikawa ,T Hosoya , I Pastan ,T Matsusaka.
    • Journal Title

      Nephrology Dial Transplant.

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensinIIgeneration.2013

    • Author(s)
      T Matsusaka,F Niimura,I Pastan ,A Shintani, A Nishiyama , I Ichikawa.
    • Journal Title

      Kidney Int.

      Volume: - Issue: 5 Pages: 1068-1077

    • DOI

      10.1038/ki.2013.453

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013

    • Author(s)
      Komaki F,Miyazaki Y, Niimura F,Mtsusaka T, Ichikawa I,Motojima M .
    • Journal Title

      Cells Tissues Organs.

      Volume: 198・1 Issue: 1 Pages: 22-27

    • DOI

      10.1159/000351291

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss.2013

    • Author(s)
      Ueno T, Kobayashi N, Nakayama M, Takashima Y, Ohse T, Pastan I, Pippin JW, Shankland SJ, Uesugi N, Matsusaka T, Nagata M.
    • Journal Title

      Kidney Int.

      Volume: - Issue: 6 Pages: 1065-1075

    • DOI

      10.1038/ki.2013.48

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver angiotensinogen is the primary source of renal angiotensin II.2012

    • Author(s)
      Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 23-7 Issue: 7 Pages: 1181-1189

    • DOI

      10.1681/asn.2011121159

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver Angiotensinogen Is the Primary Source of Renal Angiotensin2012

    • Author(s)
      松阪泰二、新村文男、西山成、市川家國, 他
    • Journal Title

      J.Am.Soc.Nephrology

      Volume: (in print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARB protects podocytes from HIV-1 nephropathy independently of podocyte AT12012

    • Author(s)
      清水昭博、市川家國、松阪泰二, 他
    • Journal Title

      Nephrol Dial Transplant

      Volume: (Epub ahead of print) Issue: 8 Pages: 3169-3175

    • DOI

      10.1093/ndt/gfs033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy guards against cisplatin-induced acute kidney injury2012

    • Author(s)
      高橋篤史,松阪泰二、新村文男, 他
    • Journal Title

      Am J Pathol

      Volume: 180 Issue: 2 Pages: 517-525

    • DOI

      10.1016/j.ajpath.2011.11.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte injury damages other podocytes2011

    • Author(s)
      松阪泰二、市川家國, 他
    • Journal Title

      J Am Soc Nephrol

      Volume: 22 Issue: 7 Pages: 1275-1285

    • DOI

      10.1681/asn.2010090963

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury2011

    • Author(s)
      Kimura, T.
    • Journal Title

      J.Am.Soc.Nephrol.

      Volume: 22 Issue: 5 Pages: 902-913

    • DOI

      10.1681/asn.2010070705

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside2011

    • Author(s)
      Ma Ji, 松阪泰二、市川家國, 他
    • Journal Title

      Pediatr Res

      Volume: 70 Issue: 1 Pages: 83-89

    • DOI

      10.1203/pdr.0b013e31821bdf1c

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection2011

    • Author(s)
      Taiji Matsusaka, et.Al.
    • Journal Title

      Am J Physiol

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 一部のポドサイトの傷害を誘導可能な新しいモデルマウスの解析2015

    • Author(s)
      岡部匡裕、松阪泰二
    • Organizer
      弥彦ポドサイトセミナー
    • Place of Presentation
      コープシティ花園ガレッソホール新潟
    • Year and Date
      2015-03-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A New Mosaic Mouse Model of Segmetal Podocyte Ablation.2014

    • Author(s)
      Okabe M,Matsusaka T
    • Organizer
      ASN meeting 2014
    • Place of Presentation
      Pensylvania Convention Center
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 一部のポドサイトのみ限局下傷害を誘導可能な新しいモデルマウス2014

    • Author(s)
      岡部匡裕、松阪泰二
    • Organizer
      分子腎臓フォーラム
    • Place of Presentation
      ベルサール八重洲
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎臓病の拡大機序2014

    • Author(s)
      松阪泰二
    • Organizer
      東海大学総医研糖鎖研合同シンポジウム
    • Place of Presentation
      東海大学湘南校舎17号館
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポドサイト傷害と腎臓内angiotensinⅡ2014

    • Author(s)
      松阪泰二
    • Organizer
      東京腎炎・ネフローゼ研究会
    • Place of Presentation
      経団連会館
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 糸球体線維化の再検討:糸球体硬化症における1型コラーゲン産生の変容2014

    • Author(s)
      小泉賢洋、深川雅史、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 一部のポドサイトのみに限局した傷害を誘導可能な新しいモデルマウス2014

    • Author(s)
      岡部匡裕、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nrf2はシクロスポリンにより誘導された腎の酸化ストレスを軽減する2014

    • Author(s)
      新村文男、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expansion of Podocyte Injury2014

    • Author(s)
      Taiji Matsusaka
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Podocyte Injury Enhances Filtration of Liver-derived Angiotensinogen And Renal Angiotensin II Generation.2014

    • Author(s)
      Taiji Matsusaka
    • Organizer
      アジア太平洋腎臓学会議(Asian Pacific Congress of Nephrology )
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糸球体硬化症における1型コラーゲン転写の減弱2013

    • Author(s)
      小泉賢洋、住吉秀明、稲垣豊、深川雅史、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪細胞はアンジオテンシノーゲンの血漿濃度や血圧の維持に寄与しない2013

    • Author(s)
      小泉賢洋、新村文男、深川雅史、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎特異的トランスジェニック(Tg)マウス作製の新たな方法2013

    • Author(s)
      小泉賢洋、大塚正人、深川雅史、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎臓病とアンジオテンシン2013

    • Author(s)
      松阪泰二
    • Organizer
      先端科学技術研究センター(招待講演)
    • Place of Presentation
      東京大学先端研駒場IIキャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Adipocytes do not significantly contribute to plasma angiotensinogen2013

    • Author(s)
      Koizumi M,Niimura F,Fukagawa M,Ichikawa I,Matsusaka T
    • Organizer
      国際腎臓学会ISN     (WCN meeting 2013)
    • Place of Presentation
      Hong Kong Convention and Exhibition Center (HKCEC)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アンジオテンシンIIとpodocyte障害2013

    • Author(s)
      松阪泰二
    • Organizer
      京都大学教育セミナー講演
    • Place of Presentation
      京都市左京区 関西セミナーハウス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Glomerular fibrosis revisited:podocyte injury shuts down Col1a2 mRNA,leading to abnormal collagen accumulation2013

    • Author(s)
      Koizumi M, Fugawaka M, Matsusaka T
    • Organizer
      ASN meeting 2013
    • Place of Presentation
      Atlantic City Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vicious cycle of podocyte injury and renal angiotensin II upregulation2012

    • Author(s)
      松阪泰二
    • Organizer
      CKDフロンティア
    • Place of Presentation
      名古屋キャスルプラザホテル(招待講演)
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Liver-, but Not Kidney-Specific Angiotensinogen Gene Knockout Abrogates the Enhancement of Renal Angiotensin II Synthesis that Follows Podocyte Injury in Progressive Glomerulosclerosis2012

    • Author(s)
      Taiji Matsusaka, Fumio Niimura, Masafumi Fukagawa, Akira Nishiyama, Iekuni Ichikawa.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Filtered Angiotensinogen, Not Renal Renin, Determines the Renal Angiotensin II Synthesis when Podocytes Lose Their Molecular Barrier Function.2012

    • Author(s)
      Fumio Niimura, Akira Nishiyama, Iekuni Ichikawa, Taiji Matsusaka.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Complete Regression of Existing Podocyte Injury by Mineralocorticoid Receptor Blockade in Podocyte-Specific Arhgdia Knockout Mice2012

    • Author(s)
      Miki Nagase, Kohei Ueda, Kenichi Ishizawa, Nobuhiro Ayuzawa, Shigetaka Yoshida, Takayuki Shindo, Takayuki Sakurai, Taiji Matsusaka, Masaomi Nangaku, Toshiro Fujita.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of Notch Signal Reduced Extra-Capillary PEC Lesion and Deteriorated Proteinuria in Mouse Model of Collapsing Focal Segmental Glomerulosclerosis (cFSGS)2012

    • Author(s)
      Toshiharu Ueno,1 Namiko Kobayashi, Yasutoshi Takashima, Taiji Matsusaka, Michio Nagata.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Autophagy Protects Kidney from Diseases through the Reduction of Mitochondrial Reactive Oxygen Species2012

    • Author(s)
      Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Tomoko Namba, Takeshi Yamamoto, Jun-Ya Kaimori, Isao Matsui, Fumio Niimura, Taiji Matsusaka,4 Hiromi Rakugi, Yoshitaka Isaka.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Autophagy Protects Kidney from Metabolic Stress through the Maintenance of Metabolism in Mitochondria2012

    • Author(s)
      Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Takeshi Yamamoto, Jun-Ya Kaimori, Isao Matsui, Fumio Niimura, Taiji Matsusaka, Hiromi Rakugi, Yoshitaka Isaka.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Podocytes Are Detached by PAI-1 Coupling with uPA and uPAR through the Internalization Mechanism2012

    • Author(s)
      Namiko Kobayashi, Toshiharu Ueno, Yasutoshi Takashima, Hanako Yamashita, Taiji Matsusaka, Michio Nagata.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diegoコンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] ワークショップ「ネフローゼ症候群: 新たな治療ターゲットとトランスレーショナルリサーチ」 ポドサイトの進行性傷害のメカニズム2012

    • Author(s)
      松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Keap1抑制による糸球体硬化症の軽減2011

    • Author(s)
      清水昭博、市川家國、松阪泰二, 他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] オートファジーは近位尿細管細胞のホメオスタシスを維持する2011

    • Author(s)
      新村文男、松阪泰二, 他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポドサイトの増殖とFSGS : Transgenic mouse modelによる解析2011

    • Author(s)
      松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of Increased Renal Angiotensin II in Glomerular Disease2011

    • Author(s)
      Matsusaka T, Niimura F, Ichikawa I, et al
    • Organizer
      ASN Kidney Week
    • Place of Presentation
      Philadelphiaコンベンションセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Angiotensinogen Is Filtered through the Glomerulus and Reabsorbed by the Proximal Tubule in Both Mice and Humans2011

    • Author(s)
      Niimura F, Matsusaka T, Ichikawa I, et al
    • Organizer
      ASN Kidney Week
    • Place of Presentation
      Philadelphiaコンベンションセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] ノックアウト、トランスジェニックマウス(ラット)作成のわかりやすい基本原理2010

    • Author(s)
      松阪泰二
    • Organizer
      発達腎研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポドサイト特異的傷害後のポドサイト再生はあるか?2010

    • Author(s)
      清水昭博、松阪泰二, 他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV-1によるポドサイト傷害は、ポドサイト外のAT1阻害により保護される2010

    • Author(s)
      清水昭博、松阪泰二, 他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎内アンジオテンシン系の活性化機序2010

    • Author(s)
      清水昭博、松阪泰二, 他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] ARB Protects Podocytes of HIV-1 Nephropathy Independently of Podocyte AT12010

    • Author(s)
      Shimizu A, Matsusaka T, et at
    • Organizer
      ASN Renal Week
    • Place of Presentation
      Denver
    • Related Report
      2010 Annual Research Report
  • [Presentation] Liver-specific and Kidney-specific Angiotensinogen Gene Knockout Revealed That Renal Renin Activity and JGA Hypertrophy are Dependent on Blood Pressure, Not Renal Angiotensin.2010

    • Author(s)
      Ichikawa I, Matsusaka T, et al
    • Organizer
      ASN Renal Week
    • Place of Presentation
      Denver
    • Related Report
      2010 Annual Research Report
  • [Presentation] Primary HIV injury in a fraction of podocyte population triggers secondary injury in the remaining population throughout the whole glomerulus, leading to global sclerosis : Evidence from a mosaic murine model.2010

    • Author(s)
      Taiji Matsusaka, et al
    • Organizer
      ASN Renal Week
    • Place of Presentation
      Denver
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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