To study the molecular mechanism of prion protein conversion
Project/Area Number |
22249034
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2012: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2010: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
|
Keywords | 神経分子病態学 / プリオン / 蛋白 / 異常化 / 分子機構 / CJD |
Research Abstract |
Overexpression model for Bank vole prion protein (PrP) showed clinical signs of prion disease, spongiform changes and abnormal PrP accumulations in the brain. Therefore, this transgenic mice have a possibility as an animal model for spontaneous prion diseases. We examined the transmission studies with the wild mice and the knock-in mice having bank vole PrP (Ki-Bank) There were no successful transmissions from the transgenic mouse brains. Therefore, it is clear that the PrP conversion is imperfect in this transgenic model. However, it is coming out that this Ki-Bank is a useful animal model for the experimentaltransmission.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan2013
Author(s)
Hamaguchi T, Sakai K,Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases2013
Author(s)
Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
Author(s)
Xiao X, Yuan J, Haik S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Glycoform-selective prion formation in sporadic and familial forms of prion disease2013
Author(s)
Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study2012
Author(s)
Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Katsuya Satoh K, Kitamoto T, Ihara Y, Uchitomi Y.
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Journal Title
Journal of the neurological Sciences
Volume: 312
Issue: 1-2
Pages: 108-116
DOI
Related Report
Peer Reviewed
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[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion2011
Author(s)
Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N
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Journal Title
Nat Med
Volume: 17
Issue: 2
Pages: 175-178
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] prion disease in Japan2010
Author(s)
Nozaki I, Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Sanjo N, Morikawa F, Shiga Y, Kuroiwa Y, Nishizawa M, Kuzuhara S, Inuzuka T, Takeda M, Kuroda S, Abe K, Murai H, Murayama S, Tateishi J, Takumi I, Sirabe S, Harada M
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Journal Title
Brain
Volume: 133
Issue: 10
Pages: 3043-3057
DOI
Related Report
Peer Reviewed
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