Studies on signal activating systems induced by an anorexigenicappetitekine, Nesfatin-1
Project/Area Number |
22249038
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Gunma University |
Principal Investigator |
MORI Masatomo 群馬大学, 大学院・医学系研究科, 教授 (80174382)
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Co-Investigator(Kenkyū-buntansha) |
OKADA Shuichi 群馬大学, 医学部, 講師 (20260474)
HASHIMOTO Koshi 群馬大学, 大学院・医学系研究科, 助教 (30396642)
YADA Toshihiko 自治医科大学, 医学部, 教授 (60166527)
YAMADA Masanobu 群馬大学, 大学院・医学系研究科, 准教授 (90261833)
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2012: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2010: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
|
Keywords | Nesfatin-1 / 肥満 / シグナル伝達 / 摂食抑制 / 脂肪細胞 / ネスファチン-1 / アピトサイトカイン / 遺伝子 / メラノコルチン受容体 / リン酸化CRE結合蛋白(p-CREB) / 膵β細胞 / 視床下部 / G蛋白共役型受容体 / ジーンターゲティング / 受容体 / サイクリックAMP |
Research Abstract |
Nesfatin-1 administration promoted a dose-dependent increase in CRE reporteractivities inmouse NB41A3cells,and Nesfatin-1 bound plasmamembranes derived frommouse hypothalami and NB41A3 cells in a high affinity manner. Using a CRE reporter assay ineachof 49 GPCRs, wetried to identify a receptorspecific to Nesfatin-1, but these efforts resulted in failure. Troglitazone, an activator for PPARγ, possessed a significantstabilizing activity of NUCB2 gene mRNA, and Nesfatin-1 activated EGF signaling tosuppress adipogenesis.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Troglitazone, a ligand of peroxisome proliferator-activatedreceptor-g, stabilizes NUCB2 (Nesfatin)mRNA by activating the ERK1/2 pathway:isolation and characterization of the human NUCB2 gene2010
Author(s)
Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A,Shibusawa N, Monden T, Okada S, Shimizu H, Mori M
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Journal Title
Endocrinology
Volume: 151
Pages: 2494-2503
Related Report
Peer Reviewed
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[Journal Article] Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis2010
Author(s)
Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T
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Journal Title
Aging (Albany NY)
Volume: 2(11)
Pages: 775-784
Related Report
Peer Reviewed
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[Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptor-γ, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene.2010
Author(s)
Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M.
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Journal Title
Endocrinology.
Volume: 151
Pages: 2494-2503
Related Report
Peer Reviewed
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[Journal Article] Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.2010
Author(s)
Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, Takahashi H, Okada S, Hashimoto K, Satoh T, Kojima M, Mori M.
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Journal Title
Clin Endocrinol.
Volume: 73
Pages: 484-490
Related Report
Peer Reviewed
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[Journal Article] Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.2010
Author(s)
Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T.
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Journal Title
Aging (Albany NY).
Volume: 2
Pages: 775-784
Related Report
Peer Reviewed
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