| Project/Area Number |
22249041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126)
OKAZAKI Toshiro 金沢医科大学, 医学部, 教授 (40233308)
WATANABE Ken 独立行政法人国立長寿医療研究センター, 運動器疾患研究部, 研究室リーダー (10342966)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANAMI Takafumi 金沢医科大学, 医学部, 講師 (20350762)
FUJITA Yoshimasa 金沢医科大学, 医学部, 講師 (70450880)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2012: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2010: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
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| Keywords | スフィンゴミエリン / リピッドラフト / ノックアウトマウス / 自己免疫性疾患 / 関節リウマチ / T細胞 / サイトカイン / コラーゲン誘導関節炎 |
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| Research Abstract |
We analyzed the pathogenesis of autoimmune diseases using sphingomyelin synthase 1 knockout (SMS1-KO) mouse. In vivo study showed that T cell function was impaired and cytokine production was decreased. By concanavalin A-induced hepatitis model, SMS1-KO mouse showed the amelioration of hepatitis. In addition, using collagen-induced arthritis model, we confirmed the amelioration of arthritis in SMS1-KO mouse. These results indicate that sphingomyelin has important roles in the pathogenesis of autoimmune diseases such as autoimmune hepatitis and rheumatoid arthritis through impaired functions of lipid rafts.
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