Recapitulation of phenotypes and discovery of a novel treatment with disease-specific human ES/ iPS cells from various hereditary diseases

• Project/Area Number: 22249042
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: NAKAHATA Tatsutoshi 京都大学, iPS細胞研究所, 特定拠点教授 (20110744)
• Co-Investigator(Kenkyū-buntansha): SAITO Megumu 京都大学, iPS 細胞研究所, 准教授 (90535486) ; NIWA Akira 京都大学, iPS 細胞研究所, 特定助教 (20546999) ; OSHIMA Koichi 京都大学, iPS 細胞研究所, 特定研究員 (60525377)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000); Fiscal Year 2012: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2010: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
• Keywords: 遺伝性疾患 / iPS細胞 / 遺伝子改変 / 疾患解析 / NOGマウス / 疾患特異的 / 創薬

Research Abstract

We were engaged in research to generate iPS cells from somaticcells of patients with various hereditary diseases, induced these iPS ells to differentiate appropriately into the cells the diseased organs,and thereby elucidate the etiology and the mechanisms of the diseases. We succeeded the generation of disease-specific iPS cells from patients with congenital neutropenia, Duchenne muscular dystrophy, CINCA syndrome, Nakajyo-Nishimura syndrome, spinal muscular atrophy, Chediak-Higashi syndrome, Hirschsprung disease by using conventional retroviral method. We failed to generate iPS cells from patients with Fanconi Anemia and reticular dysgenesis without gene collection at the stage of skin fibroblasts. We have confirmed recapitulation of phenotypes with several disease-specific iPS cells including CINCA syndrome, reticular dysgenesis and Chediak-Higashi syndrome.

Research Products

• [Journal Article] Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell- free conditions. (2013)
  • Author(s): Yanagimachi MD, Niwa A, Tanaka T, Ozaki F, Nishimoto S, Murata Y, Yasumi T, Ito J, Tomida S, Oshima K, Asaka I, Goto H, Heike T, Nakahata T, Saito MK
  • Journal Title: PLoS ONE Volume: 8(4) Issue: 4 Pages: e59243-e59243
  • DOI: 10.1371/journal.pone.0059243
  • NAID: 120005244458
  • Peer Reviewed
• [Journal Article] Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome. (2013)
  • Author(s): Saida, S., K. Watanabe, A. Sato-Otsubo, K. Terui, K. Yoshida, Y. Okuno, T. Toki, R. Wang, Y. Shiraishi, S. Miyano, I. Kato, T. Morishima, H. Fujino, K. Umeda, H. Hiramatsu, S. Adachi, E. Ito, S. Ogawa, M. Ito, T. Nakahata, and T. Heike.
  • Journal Title: Blood Volume: 121 Issue: 21 Pages: 4377-4387
  • DOI: 10.1182/blood-2012-12-474387
  • Peer Reviewed
• [Journal Article] 疾患特異的 iPS 細胞 (2013)
  • Author(s): 斎藤潤、中畑龍俊
  • Journal Title: 再生医療 Volume: 12(1) Pages: 19-29
  • NAID: 130000450684
  • URL: http://www.m-review.co.jp/magazine/detail/J40_12_01
• [Journal Article] Recipient seropositivity for adenovirus type 11 is highly predictive of the development of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. (2013)
  • Author(s): Nakazawa Y.
  • Journal Title: Bone Marrow Transplant. Volume: in press
  • Peer Reviewed
• [Journal Article] Clonal selection in xenografted TAM recapitulatesthe evolutionary process of myeloid leukemia in Down syndrome. (2013)
  • Author(s): Saida S.
  • Journal Title: Blood Volume: in press
  • Peer Reviewed
• [Journal Article] 疾患特異的iPS細胞 (2013)
  • Author(s): 斎藤潤
  • Journal Title: 再生医療 Volume: 12 Pages: 19-29
• [Journal Article] Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells (2012)
  • Author(s): Awaya T., Kato T., Mizuno Y., Chang H., Niwa A., Umeda K., Nakahata T., Heike T.
  • Journal Title: PLoS ONE Volume: 7(12) Issue: 12 Pages: e51638-e51638
  • DOI: 10.1371/journal.pone.0051638
  • NAID: 120005122354
  • Peer Reviewed
• [Journal Article] Multiple reversions of an IL2RG mutation restore combined immunodeficiency patient. (2012)
  • Author(s): Kawai T., Saito M., Nishikomori R., Yasumi T., Izawa K., Murakami T., Okamoto N., Mori Y., Nakagawa N., Imai K., Nonoyama S., Wada T., Yatie A., Oomori K., Nakahata T., Heike T.
  • Journal Title: J. Clin. Immunol Volume: 32(4) Issue: 4 Pages: 690-7
  • DOI: 10.1007/s10875-012-9684-1
  • Peer Reviewed
• [Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery (2012)
  • Author(s): Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
  • Journal Title: Blood Volume: 120(6) Issue: 6 Pages: 1299-308
  • DOI: 10.1182/blood-2012-03-417881
  • Peer Reviewed
• [Journal Article] Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immune- deficiency (2012)
  • Author(s): Kawai T, Imai C et al
  • Journal Title: Blood Volume: 119 Issue: 23 Pages: 5458-66
  • DOI: 10.1182/blood-2011-05-354167
  • Peer Reviewed
• [Journal Article] Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with> 99. 9% Statistical Confidence by Massively Parallel Sequencing (2012)
  • Author(s): Izawa, K., A. Hijikata, N. Tanaka, T. Kawai, M. K. Saito, R. Goldbach-Mansky, I. Aksentijevich, T. Yasumi, T. Nakahata, T. Heike, R. Nishikomori, and O. Ohara
  • Journal Title: DNA Res Volume: 19 Issue: 2 Pages: 143-52
  • DOI: 10.1093/dnares/dsr047
  • Peer Reviewed
• [Journal Article] The CD40-CD40L axis and INF-g play critical roles in Langerhans giant cell formation. (2012)
  • Author(s): Sakai H.
  • Journal Title: Int. Immunol. Volume: 24 Pages: 5-15
  • Peer Reviewed
• [Journal Article] Detection of base substitution–type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing. (2012)
  • Author(s): IzawaK.
  • Journal Title: DNA Res. Volume: 19 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Pediatric idiopathic TTP diagnosed with decreased ADAMTS13 activity. (2012)
  • Author(s): Morishima T.
  • Journal Title: Pediatr. Int. Volume: 54 Pages: 422-423
  • Peer Reviewed
• [Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice. (2012)
  • Author(s): Tsuchiya A.
  • Journal Title: Dig. Dis. Sci. Volume: 57 Issue: 11 Pages: 2892-2900
  • DOI: 10.1007/s10620-012-2239-8
  • Peer Reviewed
• [Journal Article] Acut liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome: Report of two cases. (2012)
  • Author(s): Hiejima E.
  • Journal Title: J. Pediatr. Child Health Volume: 48
  • Peer Reviewed
• [Journal Article] Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia and immunodeficiency. (2012)
  • Author(s): Kawai T.
  • Journal Title: Blood Volume: 119 Pages: 5458-5466
  • Peer Reviewed
• [Journal Article] Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease. (2012)
  • Author(s): Tsumura M.
  • Journal Title: Human Mutation Human Mutation Volume: 33 Issue: 9 Pages: 1377-1387
  • DOI: 10.1002/humu.22113
  • Peer Reviewed
• [Journal Article] Outcome of children with Refractory Anaemia with Excess of Blast (RAEB) and RAEB in Transformation (RAEB-T) in the Japanese MDS99 study. (2012)
  • Author(s): Kikuchi A.
  • Journal Title: Brit. J. Haematol. Volume: 158 Issue: 5 Pages: 657-661
  • DOI: 10.1111/j.1365-2141.2012.09210.x
  • Peer Reviewed
• [Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. (2012)
  • Author(s): Tanaka T.
  • Journal Title: Blood Volume: 120 Pages: 1299-1308
  • Peer Reviewed
• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells. (2012)
  • Author(s): Egawa N.
  • Journal Title: Sci Transl Med. Volume: 1
  • Peer Reviewed
• [Journal Article] Multiple reversions of an IL2RG mutation restore combined immunodeficiency patient. (2012)
  • Author(s): Kawai T.
  • Journal Title: J. Clin. Immunol. Volume: 32 Pages: 690-697
  • Peer Reviewed
• [Journal Article] 白血病治療の進歩と今後の展望 (2012)
  • Author(s): 中畑龍俊
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 49 Pages: 11-15
• [Journal Article] 幹細胞増幅 (2012)
  • Author(s): 中畑龍俊
  • Journal Title: カラー版内科学 Volume: 総編集 Pages: 447-450
• [Journal Article] Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing (2012)
  • Author(s): Izawa K., Hijikata A., Tanaka N., Kawai T., Saito M.K., Goldbach-Mansky R., Aksentijevich I., Yasumi T., Nakahata T., Heike T., Nishikomori R., Ohara O.
  • Journal Title: DNA Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] The CD40-CD40L axis and INF-□ play critical roles in Langerhans giant cell formation (2012)
  • Author(s): Sakai H., Okafuji I., Nishikomori R., Abe J., Izawa K., Kambe N., Yasumi T., Nakahata T., Heike T.
  • Journal Title: Int.Immunol. Volume: 24 Pages: 5-15
  • Peer Reviewed
• [Journal Article] Acut liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome : Report of two cases (2012)
  • Author(s): Hiejima E., Komatsu H., Takeda Y., Sogo T., Inui A., Okafuji I., Nishikomori R., Nakahata T., Fujisawa T.
  • Journal Title: J.Pediatr.Child Health Volume: 48 Issue: 3
  • DOI: 10.1111/j.1440-1754.2011.02213.x
  • Peer Reviewed
• [Journal Article] Neutrophil differentiation from human-induced pluripotent stem cells (2011)
  • Author(s): Morishima T, Watanabe K, Niwa A, et al.
  • Journal Title: J CellPhysiol Volume: 226(5) Issue: 5 Pages: 1283-91
  • DOI: 10.1002/jcp.22456
  • Peer Reviewed
• [Journal Article] Generation of induced pluripotent stem (iPS) cells derived from a murine model of Pompe disease and differentiation of Pompe-iPS cells into skeletal muscle cells. (2011)
  • Author(s): Kawagoe S., Higuchi T., Xing-Li M., Shimada Y., Dhimizu H., Fukuda T., Chang H., Nakahata T., Fukada S., Ida H., Ohashi T., Eto Y.
  • Journal Title: Mol. Genet. Metab. Volume: 104 Issue: 1-2 Pages: 123-128
  • DOI: 10.1016/j.ymgme.2011.05.020
  • Peer Reviewed
• [Journal Article] A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors (2011)
  • Author(s): Niwa A, Heike T, Umeda K, et al.
  • Journal Title: PloS One Volume: 6 Issue: 7 Pages: e22261-e22261
  • DOI: 10.1371/journal.pone.0022261
  • NAID: 120003324603
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of familial hemophagocytic lymphohistiocytosis type 3 (FHL3) by flow cytometric detection of intraplatelet Munc 13-4 protein. (2011)
  • Author(s): Murata Y., Yasumi T., Shirakawa R., Izawa K., Sakai H., Abe J., Tanaka N., Kawai T., Oshima K., Saito M., Nishikomori R., Ohara O.、Ishii E., Nakahata T., Horiuchi H., Heike T.
  • Journal Title: Blood Volume: 118 Issue: 5 Pages: 1225-1230
  • DOI: 10.1182/blood-2011-01-329540
  • Peer Reviewed
• [Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome (2011)
  • Author(s): Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Arostegui JI, Yague J, Merino R, Ibanez M, Pontillo A, Takada H, Imagawa T
  • Journal Title: Arthritis Rheum Volume: 63 Issue: 11 Pages: 3625-32
  • DOI: 10.1002/art.30512
  • Peer Reviewed
• [Journal Article] 小児医療をめぐる最先端医学iPS 細胞を用いた今後の医療. (特集 小児医療の最先端-これからの新たな展望) (2011)
  • Author(s): 中畑龍俊
  • Journal Title: 小児医療をめぐる最先端医学iPS 細胞を用いた今後の医療 Volume: Vol.29 No.3 Pages: 26-33
  • URL: http://tokyoped.umin.ac.jp/mokuji/mokuji100.htm
• [Journal Article] 疾患特異的 iPS 細胞を用いた遺伝子治療・個別化医療 (2011)
  • Author(s): 中畑龍俊
  • Journal Title: 小児科 Volume: Vol.52 No.12 Pages: 1743-1749
  • URL: http://www.kanehara-shuppan.co.jp/journal/detail.html?kubun=04751&code=047512011113&hakkou_nengetsu=201111
• [Journal Article] Autoinflammatory diseases-a new entity of inflammation (2011)
  • Author(s): Heike T., Saito M., Nishikomori R., Yasumi T., Nakahata T.
  • Journal Title: Inflammation and Regeneration Volume: 31 Pages: 125-136
  • NAID: 130004943778
  • Peer Reviewed
• [Journal Article] Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors (2011)
  • Author(s): Yamanaka Y., Kitano A., Takao K., Prasansuklab A., Mushiroda T., Yamazaki K., Kumada T., Shibata M., Takaoka Y., Awaya T., Kato T., Nakahata T., Heike T.
  • Journal Title: Mol.Cell.Neurosci. Volume: 46 Pages: 200-212
  • Peer Reviewed
• [Journal Article] Relapse of aplastic anemia in children after immunosuppressive therapy : a report from the Japan Childhood Aplastic Anemia Study Group (2011)
  • Author(s): Kamio T., Ito E., Ohara A., Kosaka Y., Tsuchida M., Yagasaki H., Mugishima H., Yabe H., Morimoto A., Ohga S., Muramatsu H., Hama A., Kaneko T., Nagasawa M., Kikuta A., Osugi Y., Bessho F., Nakahata T., Tsukimoto I., Kojima S.
  • Journal Title: Haematologica Volume: 96 Pages: 814-819
  • Peer Reviewed
• [Journal Article] Multilineage-differentiating Stress Enduring (Muse) cells are aprimary source of iPS cells in human fibroblasts (2011)
  • Author(s): Wakao S., Kitada M., Kuroda Y., Shigemoto T., Matsuse D., Akashi H., Tanimura Y., Tsuchiyama K., Kikuchi T., Goda M., Nakahata T., Fujiyoshi Y., Dezawa M.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Pages: 9875-9880
  • Peer Reviewed
• [Journal Article] Predicting response to immunosuppressive therapy in childhood aplastic anemia (2011)
  • Author(s): Yoshida N., Yagasaki H., Hama A., Takahashi Y., Kosaka Y., Kobayashi R., Yabe H., Kaneko T., Tsuchida M., Ohara A., Nakahata T., Kojima S.
  • Journal Title: Haematologica Volume: 96 Pages: 771-774
  • Peer Reviewed
• [Journal Article] Generation of induced pluripotent stem (iPS) cells derived from a murine model of Pompe disease and differentiation of Pompe-iPS cells into skeletal muscle cells (2011)
  • Author(s): Kawagoe S., Higuchi T., Xing-Li M., Shimada Y., Dhimizu H., Fukuda T., Chang H., Nakahata T., Fukada S., Ida H., Ohashi T., Eto Y.
  • Journal Title: Mol.Genet.Metab. Volume: 104 Pages: 123-128
  • Peer Reviewed
• [Journal Article] A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors (2011)
  • Author(s): Niwa A., Heike T., Umeda K., Oshima K., Kato I., Sakai H., Suemori H., Nakahata T., Saito M.
  • Journal Title: PLoS ONE Volume: 6
  • NAID: 120003324603
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of familial hemophagocytic lymphohistiocytosis type 3 (FHL3) by flow cytometric detection of intraplatelet Munc 13-4 protein (2011)
  • Author(s): Murata Y., Yasumi T., Shirakawa R., Izawa K., Sakai H., Abe J., Tanaka N., Kawai T., Oshima K., Saito M., Nishikomori R., Ohara O., Ishii E., Nakahata T., Horiuchi H., Heike T.
  • Journal Title: Blood Volume: 118 Pages: 1225-1230
  • Peer Reviewed
• [Journal Article] Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease (2011)
  • Author(s): Yahata N., Asai M., Kitaoka S., Takahashi K., Asaka I., Hioki H., Kaneko T., Maruyama K., Saido T.C., Nakahata T., Asada T., Yamanaka S., Iwata N., Inoue H.
  • Journal Title: PLoS ONE Volume: 6
  • NAID: 120006985000
  • Peer Reviewed
• [Journal Article] Identification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells via the SDF-1/CXCR4 Axis (2011)
  • Author(s): Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K., Hiramatsu H., Ito M., Morita M., Nishinaka Y., Adachi S., Ishikawa F., Nakahata T.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] 小児医療をめぐる最先端医学iPS細胞を用いた今後の医療(特集小児医療の最先端-これからの新たな展望) (2011)
  • Author(s): 中畑龍俊
  • Journal Title: 東京小児科医会報(100号記念号) Volume: 29 Pages: 26-33
• [Journal Article] iPS細胞の臨床応用の展望 (2011)
  • Author(s): 中畑龍俊
  • Journal Title: BIO Clinica Volume: 26 Pages: 16-17
• [Journal Article] 疾患特異的iPS細胞を用いた遺伝子治療・個別化医療 (2011)
  • Author(s): 中畑龍俊:.(Vol.52 No.12)
  • Journal Title: 小児科 Volume: 52 Pages: 1743-1749
• [Journal Article] Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. (2011)
  • Author(s): Yamanaka Y, Nakahata T., 他15名, 16番目
  • Journal Title: Mol Cell Neurosci. Volume: 46 Pages: 200-212
  • Peer Reviewed
• [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells (2010)
  • Author(s): Mizuno Y., Chang H., Umeda K., Niwa A., Iwasa T., Awaya T., Fukada S., Hiroshi Yamamoto H., Yamanaka S., Nakahata T., Heike T.
  • Journal Title: FASEB J Volume: 24 Issue: 7 Pages: 2245-2253
  • DOI: 10.1096/fj.09-137174
  • Peer Reviewed
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice (2010)
  • Author(s): Kaichi S., Hasegawa K., Takaya T., Yokoo N., Mima T., Kawamura T., Morimoto T., Baba S., Doi H., Yamanaka S., Nakahata T., Heike T.
  • Journal Title: Cardiovascular Res Volume: 88(2) Issue: 2 Pages: 314-323
  • DOI: 10.1093/cvr/cvq189
  • Peer Reviewed
• [Journal Article] Glyoxalase-1 is a novel target against Bcr-Abl^+ leukemic cells acquiring stem-like characteristics in a hypoxic environment. (2010)
  • Author(s): Takeuchi M, Nakahata T., 他14名, 14番目
  • Journal Title: Cell Death and Differentiation Volume: 17 Pages: 1211-1220
  • Peer Reviewed
• [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. (2010)
  • Author(s): Mizuno Y, Nakahata T., 他9名, 10番目
  • Journal Title: FASEB J. Volume: 24 Pages: 2245-2253
  • Peer Reviewed
• [Journal Article] Neonatal mouse testis-derived multipotent germline stem cells improve the cardiac function of acute ischemic heart mouse model. (2010)
  • Author(s): Iwasa T, Nakahata T., 他8名, 9番目
  • Journal Title: Biochem Biophys Res Commun. Volume: 400 Pages: 27-33
  • Peer Reviewed
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. (2010)
  • Author(s): Kaichi S, Nakahata T., 他11名, 9番目
  • Journal Title: Cardiovasc Res. Volume: 88 Pages: 314-323
  • Peer Reviewed
• [Journal Article] A case of early-onset sarcoidosis with a six-base deletion in the NOD2 gene. 49 (2010)
  • Author(s): Sakai H, Nakahata T., 他8名, 10番目
  • Journal Title: Rheumatology (Oxford) Volume: 49 Pages: 194-196
  • Peer Reviewed
• [Journal Article] Unique multipotent cells in adult human mesenchymal cell populations. (2010)
  • Author(s): Kuroda Y, Nakahata T., 他14名, 14番目
  • Journal Title: Proc Natl Acad Sci USA. Volume: 107 Pages: 8639-8643
  • Peer Reviewed
• [Journal Article] Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations. (2010)
  • Author(s): Matsuda K, Nakahata T., 他8名, 10番目
  • Journal Title: Blood Volume: 115 Pages: 5429-5231
  • Peer Reviewed
• [Journal Article] Ttyhl, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. (2010)
  • Author(s): Kumada T, Nakahata T., 他9名, 10番目
  • Journal Title: Dev Dyn. Volume: 239 Pages: 2233-2245
  • Peer Reviewed
• [Journal Article] Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration. (2010)
  • Author(s): Matsuse D, Nakahata T., 他12名, 9番目
  • Journal Title: J Neuropathol Exp Neurol. Volume: 69 Pages: 973-985
  • Peer Reviewed
• [Journal Article] iPS細胞と遺伝性疾患 (2010)
  • Author(s): 中畑龍俊
  • Journal Title: 日本医師会雑誌 Volume: 139 Pages: 632-634
• [Journal Article] Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.
  • Author(s): Yui Y, Nakahata T., 他9名, 10番目
  • Journal Title: Clin Exp Metastasis. Volume: (in press)
  • Peer Reviewed
• [Presentation] 難治性血液疾患とiPS 細胞.再生つばさの会(再生不良性貧血、骨髄異形成症候群、発作性夜間ヘモグロビン素尿症患者・家族の会) (2012)
  • Author(s): 中畑龍俊
  • Organizer: 横浜医療講演会
  • Place of Presentation: 神奈川県総合薬事保健センター
  • Year and Date: 2012-09-08
• [Presentation] Mesodermal development from reprogrammed Fanconi anemia cells is affected by ALDH2 enzymatic activity. (2012)
  • Author(s): Suzuki N., Hira A., Niwa A., Saito M., Matsuo K., Nakahata T., Takata M., Yabe M.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: Atlanta, USA
• [Presentation] PS 細胞研究の進展 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 小児患者におけるiPS 細胞の応用 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第49回日本小児アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 表面マーカーによる初期化成功予測因子の解析 (2012)
  • Author(s): 川村晃久、十河孝浩、上辻麻子、加藤格、長谷川浩二、戎家美紀、西田栄介、中畑龍俊
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡(ポスター)
• [Presentation] 初期化誘導過程で出現する心筋前駆様細胞を用いた安全かつ効率的な心筋再生療法の確立 (2012)
  • Author(s): 川村晃久、十河孝浩、尾野亘、加藤格、長谷川浩二、中畑龍俊
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡(ポスター)
• [Presentation] CINCA 症候群における NLRP3 体細胞モザイク変異 (2012)
  • Author(s): 井澤和司、西小森隆太、吉岡耕平、斉藤潤、中畑龍俊、平家俊男
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡(ポスター)
• [Presentation] DIFFERENTIATION OF MONOCYTIC LINEAGE CELLS FROM HUMAN IPS CELLS BY USING A SERUM AND FEEDER FREE CULTURE METHOD (2012)
  • Author(s): Yanagimachi M., Niwa A., Tanaka T., Oshima K., Saito M., Nakahata T.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama, Japan
• [Presentation] HUMAN ESC/IPSC-DERIVED MESENCHYMAL STROMA CAN SUPPORT HEMATOPOIETIC PROGENITORS. (2012)
  • Author(s): Niwa A., Saito M., Oshima K., Yanagimachi M., Tanaka T., Kato I., Nakahata,T.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama, Japan
• [Presentation] INDUCED PLURIPOTENT STEM CELL MODEL OF SEVERE CONGENITAL NEUTROPENIA WITH HAX1 GENE DEFICIENCY. (2012)
  • Author(s): Morishima T., Watanabe K., Niwa A., Tanaka T., Saida S., Kato I., UmedaK., Hiramatsu H., Matsubara K., Adachi S., Nakahata T., Heike T.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama, Japan
• [Presentation] UNDERSTANDING THE PATHOLOGY OF THE ARTHROPATHY IN CHRONIC INFANTILE NEUROLOGICAL CUTANEOUS AND ARTICULAR SYNDROME BY USING IPS CELLS TECHNOLOGY. (2012)
  • Author(s): Yokoyama K., Ikeya, M., Nasu A., Tanaka T., Saito M., Umeda K., Nishikomori R., Nakahata T., Heike T., Toguchida J.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama, Japan
• [Presentation] INDUCED PLURIPOTENT STEM CELLS FROM CINCA SYNDROME PATIENTS AS A MODEL FOR DISSECTING SOMATIC MOSAICISM AND DRUG DISCOVERY. (2012)
  • Author(s): Tanaka T., Saito MK.., Takahashi K., Yamanaka S., Nakahata T.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama, Japan
• [Presentation] iPS 細胞研究の今、その可能性と将来展望 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡国際会議場 福岡市
• [Presentation] iPS細胞研究の今、その可能性と将来展望 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第115回日本小児科学学術集会
  • Place of Presentation: 福岡国際会議場
  • Invited
• [Presentation] 次世代シーケンサーによるNLRP3体制モザイクの診断 (2012)
  • Author(s): 井澤和司
  • Organizer: 第115回日本小児科学学術集会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 白血球減少、骨髄異形成とリンパ浮腫を呈するGATA-2異常 (2012)
  • Author(s): 石田宏之
  • Organizer: 第115回日本小児科学学術集会
  • Place of Presentation: 福岡国際会議場
• [Presentation] iPS細胞を用いたこれからの小児医療の可能性 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 旭川小児科医会講演会
  • Place of Presentation: 旭川ロワジールホテル
  • Invited
• [Presentation] Differentiation of monocytic lineage cells from human iPS cells by using a serum and feeder free culture method. (2012)
  • Author(s): Yanagimachi M
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Human ESC/IPSC-Derived mesenchymal stroma can support hematopoietic progenitors. (2012)
  • Author(s): Niwa A.
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Induced pluripotent stem cell model of severe congenital neutropenia with HAX1 gene deficiency. (2012)
  • Author(s): Morishima T
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Understanding the pathology of the arthropathy in chronic infantile neurological cutaneous and articular syndrome by using iPS cells technology. (2012)
  • Author(s): Yokoyama K
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. (2012)
  • Author(s): Tanaka T
  • Organizer: 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Pacifico Yokohama
• [Presentation] 表面マーカーによる初期化成功予測因子の解析 (2012)
  • Author(s): 川村晃久
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
• [Presentation] 初期化誘導過程で出現する心筋前駆様細胞を用いた安全かつ効率的な心筋再生療法の確立 (2012)
  • Author(s): 川村晃久
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
• [Presentation] CINCA症候群におけるNLRP3体細胞モザイク変異 (2012)
  • Author(s): 井澤和司
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
• [Presentation] iPS細胞から単球・樹状細胞の分化誘導と疾患iPS細胞研究への応用 (2012)
  • Author(s): 柳町昌克
  • Organizer: 第5回自己炎症疾患研究会
  • Place of Presentation: 福岡朝日ビル
• [Presentation] 小児患者におけるiPS細胞の応用 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第49回日本小児アレルギー学会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] iPS細胞研究の進展 (2012)
  • Author(s): 中畑龍俊
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] Long-term follow-up of more than 545 chilren with myelodysplastic syndrome (MDS) and myeloproliferative neoplasms(MPN) (2012)
  • Author(s): Manabe A
  • Organizer: VI Internatonal Symposium on Myelodysplastic Syndoromes and Bone Marrow Failures in Childhood
  • Place of Presentation: Diplomat Hotel,Prague
• [Presentation] Clinic characteristics of 23 children with juvenile myelomonocytic leukemia who developed blast crisis: MDS Committee of LSPHO (2012)
  • Author(s): Honda Y
  • Organizer: VI Internatonal Symposium on Myelodysplastic Syndoromes and Bone Marrow Failures in Childhood
  • Place of Presentation: Diplomat Hotel,Prague
• [Presentation] Treatment outcome of 67 cases with refractory cytopenia of childhood(RCC): A Prostective Registration Through The Japanese Society of Pediatric Hematology/Oncology(JSPHO) (2012)
  • Author(s): Hasegawa D
  • Organizer: VI Internatonal Symposium on Myelodysplastic Syndoromes and Bone Marrow Failures in Childhood
  • Place of Presentation: Diplomat Hotel,Prague
• [Presentation] 経過中に急性転化したJMML23例の検討；MDS委員会のデータベースから (2012)
  • Author(s): 本田裕子
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] NOGマウスを用いたTAMの病態解析 (2012)
  • Author(s): 才田聡
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Treatment outcome of refractory cytopenia of childhood(RCC):A prospective registration through the Japanese Society of Pediatric Hematology/Oncology(JSPHO) between 1999 and 2008. (2012)
  • Author(s): Hasegawa D
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Outcome of Immunousuppressive therapy in children with fulminant aplastic anemia. (2012)
  • Author(s): Yagasaki H
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Excess reduction of anthracyclines results in inferior event-free survival in core binding factor acute myeloid leukemia in children; A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Tomizawa D.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: GeorGia World ConGress Center,Atlanta
• [Presentation] Mesodermal development from reprogrammed Fanconi anemia cells is affected by ALDH2 enzymatic activity. (2012)
  • Author(s): Suzuki N.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: GeorGia World ConGress Center,Atlanta
• [Presentation] Immunosuppressive therapy with antithymocyte globulin and Cyclosporine for fulminant aplastic anemia. (2012)
  • Author(s): Yagasaki H.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: GeorGia World ConGress Center,Atlanta
• [Presentation] Appropriate dose modification in induction therapy is essential for the treatment of infants with acute myeloid leukemia; A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Tomizawa D.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: GeorGia World ConGress Center,Atlanta
• [Presentation] Attempts to optimize post-induction treatment in childhood acute myeloid leukemia without core binding factors: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Hasegawa D.
  • Organizer: 54th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
  • Place of Presentation: GeorGia World ConGress Center,Atlanta
• [Presentation] 小児疾患におけるiPS細胞の応用 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] Identification of a novel type of AD-STAT1 deficiency with mutations in the SH2 domain (2011)
  • Author(s): Miyuki Tsumura, Satoshi Okada, Hidetoshi Sakai, Ryuta Nishikomori, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Toshio Heike, Tatsutoshi Nakahata, Yoshihiro Takihara, Masao Kobayashi
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-15
• [Presentation] Autophagy of Bcr-Abl+leukemias in vivo induced by TKls (2011)
  • Author(s): Makiko Morita, Yoko Nishinaka, Mika Bando, Satoshi Saida, Itaru Kato, Hiroshi Itoh, Toshio Heike, Tatsutoshi Nakahata, Souichi Adachi
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-15
• [Presentation] Refractory Cytopenia of Childhood(RCC) : A prospective study using a central review by the JSPH (2011)
  • Author(s): Daisuke Hasegawa, Xiaojuan Chen, Shinsuke Hirabayashi, Shizuka Watanabe, Yuhji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Yasushi Ishida, Tatsutoshi Nakahata
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-14
• [Presentation] Analysis of CNS Leukemic Microenviromerits through Xenograft Model In NOG Mouse (2011)
  • Author(s): Itaru Kato, Hidefumi Hiramatsu, Akira Niwa, Satoshi Saida, Mamoru Ito, Ken-ichiro Watanabe, Souichi Adachi, Fumihiko Ishikawa, Tatsutoshi Nakahata, Toshio Heike
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-14
• [Presentation] Various clinical applications of human induced pluripotent stem cells (2011)
  • Author(s): Tatsutoshi Nakahata
  • Organizer: 2011 International Symposium on Recent Advances in Pluripotent Stem Cells & 7^<th> Annual Meeting of Taiwan Society for Stem Cell Recearch. (Keynote Lecture)
  • Place of Presentation: Taipei Medical University (Taiwan)(招待講演)
  • Year and Date: 2011-10-01
• [Presentation] 疾患特異的iPS細胞を用いた今後の医療 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京国際展示場(東京都)(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] 患者特異的iPS細胞を用いたCINCA症候群体細胞モザイクでの病態の再現と解析 (2011)
  • Author(s): 田中孝之、斎藤潤、西小森隆太、平家俊男、中畑龍俊
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-08-14
• [Presentation] ヒトES/iPS細胞から骨格筋への分化誘導と筋疾患への応用 (2011)
  • Author(s): 粟屋智就、加藤竹雄、柴田実、中畑龍俊、平家俊男
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-08-13
• [Presentation] Langhans型巨細胞の形成にはCD40-CD40Lシグナルが必須である (2011)
  • Author(s): 酒井秀政、岡藤郁夫、西小森隆太、阿部純也、八角高裕、中畑龍俊、平家俊男
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-08-13
• [Presentation] NLRP3体細胞モザイクはCINCA症候群の25%以上に認められる (2011)
  • Author(s): 田中尚子、井澤和司、斎藤潤、作間未織、大嶋宏一、小原収、西小森隆太、森本剛、中畑龍俊、平家俊男
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2011-08-13
• [Presentation] iPS 細胞を用いた今後の医療 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第60回日本医学検査学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-06-05
• [Presentation] iPS細胞を用いた今後の医療 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第60回日本医学検査学会
  • Place of Presentation: 東京国際フォーラム(東京都)(招待講演)
  • Year and Date: 2011-06-05
• [Presentation] 再生医療の基礎研究に有用なヒト化動物 (2011)
  • Author(s): 中畑龍俊、伊藤守
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都テルサ(京都府)(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] 小児疾患におけるiPS 細胞の応用 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: ベイシア文化ホール(前橋市)
• [Presentation] Various clinical applications of human induced pluripotent stem cells. (2011)
  • Author(s): Nakahata T.
  • Organizer: (Keynote Lecture) 2011 International Symposium on Recent Advances in Pluripotent Stem Cells & 7th Annual Meeting of Taiwan Society for Stem Cell Recearch
  • Place of Presentation: Taipei , Taiwan
• [Presentation] 疾患特異的 iPS 細胞を用いた今後の医療 (2011)
  • Author(s): 中畑龍俊
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京国際展示場
• [Presentation] ヒト ES/iPS 細胞から骨格筋への分化誘導と筋疾患への応用 (2011)
  • Author(s): 粟屋智就、加藤竹雄、柴田実、中畑龍俊、平家俊男
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] 患者特異的 iPS 細胞を用いた CINCA 症候群体細胞モザイクでの病態の再現と解析. (2011)
  • Author(s): 田中孝之、斎藤潤、西小森隆太、平家俊男、中畑龍俊
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] iPS細胞の臨床展開 (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 国立京都国際会館(招待講演)
  • Year and Date: 2010-12-01
• [Presentation] iPS細胞と疾患モデル細胞 (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-08-05
• [Presentation] ヒトES/iPS細胞からのin vitro二次元無血清造血誘導における、分化過程の経時的解析 (2010)
  • Author(s): 丹羽明、中畑龍俊, 他5名
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-08-05
• [Presentation] Various clinical applications of human induced pluripotent stem cells(iPScells) (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第16回日本遺伝子治療学会学術集会
  • Place of Presentation: 栃木県総合文化センター(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy(DMD) and Other Diseases (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-22
• [Presentation] 疾患特異的iPS細胞を用いた今後の医療 (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第47回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-11
• [Presentation] 中畑龍俊 (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 国立京都国際会館 (京都大学医学部附属病院薬剤部)
• [Presentation] Tracing the developmental route from human ESC/iPSCs to blood via mesoderm in Serum-free 2D culture. (2010)
  • Author(s): Niwa A., Heike T., Umeda K., Ohima K., Kato I., Suemori H., Saito M., Nakahata T.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] iPS 細胞と疾患モデル細胞. (ミニシンポジウム 1:血液免疫関連疾患とiPS 細胞) (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] Various clinical applications of human induced pluripotent stem cells (iPS cells) (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第16回日本遺伝子治療学会学術集会
  • Place of Presentation: 栃木県総合文化センター(宇都宮市)
• [Presentation] Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy(DMD) and Other Diseases (2010)
  • Author(s): 中畑龍俊
  • Organizer: 51st Annual Meeting of the Japanese Society ofNeurology(第51回日本神経学会総会) Symposium 7(The Forefront of Regenerative Medicine Research)
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 再生医療の基礎研究に有用なヒト化動物 (2010)
  • Author(s): 中畑龍俊、伊藤守
  • Organizer: 第57回日本実験動物学会総会 シンポジウム 3(テーマ:再生医療の幕を開く動物実験)
  • Place of Presentation: 京都テルサ
• [Presentation] 小児における再生医療の展望. (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡市民文化ホール
• [Presentation] 疾患特異的 iPS 細胞を用いた今後の医療 (2010)
  • Author(s): 中畑龍俊
  • Organizer: 第47回日本臨床分子医学会学術集会
  • Place of Presentation: 東京国際フォーラム 東京都
• [Presentation] Neutrophil differentiation from human induced pluripotent stem(iPS)cells for disease investigation (2010)
  • Author(s): Morishima T, Nakahata T., 他4名
  • Organizer: 72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Tracing the developmental route from human ESC/iPSCs to blood cia mesoderm in Serum-free 2D culture (2010)
  • Author(s): Niwa A, Nakahata T., 他6名
  • Organizer: 72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Book] 第3 版 分子生物学 (2010)
  • Author(s): 中畑龍俊
  • Publisher: 丸善出版
• [Remarks]
  • URL: http://www.cira.kyoto-u.ac.jp/j/research/nakahata
• [Patent(Industrial Property Rights)] 多能性幹細胞から樹状細胞への分化誘導法 (2011)
  • Inventor(s): 中畑龍俊/斎藤潤/丹羽明/柳町昌克
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2011-02-23
  • Overseas