| Project/Area Number |
22249046
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAJI Hideo 京都大学, 大学院・薬学研究科, 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
TOYODA Koichi 京都大学, 大学院・医学研究科, 講師 (00447971)
UEDA Masashi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40381967)
KITAMURA Hiroyoki 京都大学, 放射性同位元素総合センター, 助教 (50437240)
KAWASHIMA Hidekazu 国立循環器病センター, 画像診断医学部, 室長 (70359438)
TEMMA Takashi 京都大学, 大学院・薬学研究科, 助教 (90378787)
小野 正博 京都大学, 薬学研究科, 准教授 (80336180)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2010: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
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| Keywords | 膵島β細胞 / 分子イメージング / 糖尿病 / 早期診断 |
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| Research Abstract |
If a decrease in the amount of pancreatic islets and the amount of pancreatic β-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic β-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic β-cell imaging, has been desired in particular. In designing a molecular probe f or imaging of pancreatic β-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the β-cells, are being researched. Among these, GLP-1R, GPR40 and GLUT2 are being researched as a target molecule.
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